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3.4.17.12: carboxypeptidase M

This is an abbreviated version!
For detailed information about carboxypeptidase M, go to the full flat file.

Word Map on EC 3.4.17.12

Reaction

cleavage of C-terminal arginine or lysine residues from polypeptides =

Synonyms

carboxypeptidase M, carboxypeptidase-M, CPM, M14006 (Merops-ID), More

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.17 Metallocarboxypeptidases
                3.4.17.12 carboxypeptidase M

Source Tissue

Source Tissue on EC 3.4.17.12 - carboxypeptidase M

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
interstitial trophoblast
Manually annotated by BRENDA team
-
arterial endothelium
Manually annotated by BRENDA team
-
erythroid cell progenitor
Manually annotated by BRENDA team
very low activity
Manually annotated by BRENDA team
-
myeloid cell progenitor
Manually annotated by BRENDA team
-
megakaryocytic cell progenitor
Manually annotated by BRENDA team
-
peripheral
Manually annotated by BRENDA team
CPM mRNA expression is very low in the human pancreas
Manually annotated by BRENDA team
-
mobilized peripheral blood CD34+ cell
Manually annotated by BRENDA team
-
tumor cells of renal cell carcinoma subtypes lose carboxypeptidase M expression upon dedifferentiation. There is a correlation between low carboxypeptidase M expression and tumor cell type. Carboxypeptidase M staining is intense on phagocytotic tumor-associated macrophages, and enzyme is also detected in the tumor-associated vasculature. Coexistence of carboxypeptidase M and the epidermal growth factor receptor is detected in papillary renal cell carcinoma
Manually annotated by BRENDA team
very low activity
Manually annotated by BRENDA team
-
endovascular
Manually annotated by BRENDA team
additional information