3.4.17.12: carboxypeptidase M

This is an abbreviated version!
For detailed information about carboxypeptidase M, go to the full flat file.

Word Map on EC 3.4.17.12

3.4.17.12

pain

women

lymphocyte

contralateral

children

postoperative

prophylactic

myelinolysis

mastectomy

pontine

knee

cyclophosphamide

unilateral

wave

rehabilitation

hyponatremia

decision

summation

session

flexion

accelerometer

myoelectrical

chlorpheniramine

preoperative

arthroplasty

noxious

phytohemagglutinin

3h-thymidine

maleate

pressor

pain-free

decision-making

analgesia

psychophysical

actigraph

pokeweed

moderate-to-vigorous

3h-tdr

disomy

myotomy

cuff

physiotherapy

arthroscopic

gastroparesis

suprathreshold

dysrhythmias

breast-conserving

medicine

trapezius

manometry

resting-state

diagnostics

Reaction

cleavage of C-terminal arginine or lysine residues from polypeptides =

Synonyms

carboxypeptidase M, carboxypeptidase-M, CPM, M14006 (Merops-ID), More

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.17 Metallocarboxypeptidases

3.4.17.12 carboxypeptidase M

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Results	in table
7	Activating Compound
27	AA Sequence
8	Application
1	CAS Registry Number
11	Cloned(Commentary)
2	Crystallization (Commentary)
3463	Disease/ Diagnostics
1	Expression
2	General Information
31	Inhibitors
2	Ki Value [mM]
52	KM Value [mM]
32	Localization
14	Metals/Ions
13	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
32	Organism
1	PDB ID
9	pH Optimum
3	pH Range
3	pH Stability
17	Posttranslational Modification
7	Protein Variants
9	Purification (Commentary)
3	Reaction
13	Reaction Type
32	Reference
118	Source Tissue
7	Specific Activity [micromol/min/mg]
1	Storage Stability
74	Substrates and Products (Substrate)
9	Subunits
35	Synonyms
3	Temperature Optimum [°C]
5	Temperature Stability [°C]
52	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.17.12 - carboxypeptidase M

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0.033

Ala-Ser-His-Leu-Gly-Leu-Ala-Arg

CPMwt, pH 7.4, 37°C

0.115 - 0.18

benzoyl-Ala-Arg

show

0.343

benzoyl-Asn-Arg

CPMwt, pH 7.4, 37°C

0.127

benzoyl-Gln-Arg

CPMwt, pH 7.4, 37°C

0.255 - 0.29

benzoyl-Gly-Arg

show

0.046 - 0.049

benzoyl-Gly-argininic acid

show

10.15 - 10.65

Benzoyl-Gly-Lys

show

0.239

benzoyl-His-Arg

CPMwt, pH 7.4, 37°C

0.205

benzoyl-Ile-Arg

CPMwt, pH 7.4, 37°C

0.168

benzoyl-Leu-Arg

CPMwt, pH 7.4, 37°C

0.13 - 0.138

benzoyl-Met-Arg

show

0.0584

benzoyl-Phe-Arg

CPMwt, pH 7.4, 37°C

0.219

benzoyl-Ser-Arg

CPMwt, pH 7.4, 37°C

0.192

benzoyl-Thr-Arg

CPMwt, pH 7.4, 37°C

0.069

benzoyl-Trp-Arg

CPMwt, pH 7.4, 37°C

0.048

benzoyl-Tyr-Arg

CPMwt, pH 7.4, 37°C

0.264

benzoyl-Val-Arg

CPMwt, pH 7.4, 37°C

0.016

bradykinin

show

0.0277

bradykinin(-Phe-Arg)

CPMwt, pH 7.2, 37°C

0.059 - 0.28

Dansyl-Ala-Arg

show

0.068 - 0.09

furylacryloyl-Ala-Arg

show

1.152

furylacryloyl-Ala-Lys

CPMwt, pH 7.2, 37°C

1.181

Gly-Gly-Arg

CPMwt, pH 7.2, 37°C

0.05

Gly-Leu-Ala-Arg

CPMwt, pH 7.4, 37°C

0.028

His-Leu-Gly-Leu-Ala-Arg

CPMwt, pH 7.4, 37°C

0.027

Leu-Ala-Arg

CPMwt, pH 7.4, 37°C

0.041

Leu-Gly-Leu-Ala-Arg

CPMwt, pH 7.4, 37°C

0.063

Leu5-Arg6-enkephalin

-

-

0.046

Met5-Arg6-enkephalin

-

-

0.375

Met5-Lys6-enkephalin

-

-

0.206 - 0.241

N-(4-hydroxybenzoyl)-Gly-Arg

show

0.035

Pro-Gly-Lys-Ala-Arg

CPMwt, pH 7.2, 37°C

0.051

Ser-His-Leu-Gly-Leu-Ala-Arg

CPMwt, pH 7.4, 37°C

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Release 2023.1 (January 2023)