3.4.16.6: carboxypeptidase D
This is an abbreviated version!
For detailed information about carboxypeptidase D, go to the full flat file.
Word Map on EC 3.4.16.6
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3.4.16.6
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pyrimidine
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cyclobutane
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cigarette
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smoking
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smokers
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peritoneal
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dialysis
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uv-induced
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photoproducts
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skill
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grate
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practitioner
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professionals
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acuity
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photolyase
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nurses
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vision
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gratings
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profession
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quit
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nursing
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satisfaction
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monocular
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accredit
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photopic
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photoreactivation
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career
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cotinine
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curriculum
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disproportion
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dentist
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thematic
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workforce
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diopter
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midwives
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postgraduate
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translesion
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psychophysical
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leadership
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wavefront
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mentor
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astigmatism
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stakeholder
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learner
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therapist
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logmar
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lasik
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biotechnology
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posttransfusion
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employers
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phacoemulsification
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molecular biology
- 3.4.16.6
- pyrimidine
-
cyclobutane
-
cigarette
-
smoking
- smokers
- peritoneal
- dialysis
-
uv-induced
- photoproducts
-
skill
-
grate
-
practitioner
-
professionals
-
acuity
-
photolyase
- nurses
- vision
-
gratings
-
profession
-
quit
-
nursing
-
satisfaction
-
monocular
-
accredit
-
photopic
-
photoreactivation
-
career
- cotinine
-
curriculum
- disproportion
-
dentist
-
thematic
-
workforce
-
diopter
-
midwives
-
postgraduate
-
translesion
-
psychophysical
-
leadership
-
wavefront
-
mentor
- astigmatism
-
stakeholder
-
learner
-
therapist
-
logmar
-
lasik
- biotechnology
-
posttransfusion
-
employers
-
phacoemulsification
- molecular biology
Reaction
preferential release of a C-terminal arginine or lysine residue =
Synonyms
Carboxypeptidase D, carboxypeptidase Kex1, cereal serine carboxypeptidase II, CP-MII.1, CP-MII.2, CP-MII.3, CP-WII, CPD, CPDW-II, CPW, EC 3.4.12.1, EC 3.4.16.1, EC 3.4.21.13, gene KEX1 serine carboxypeptidase, h-TLL, Kex-1 endopeptidase, Kex-1 protease, Kex1, KEX1 carboxypeptidase, Kex1 protease, KEX1 proteinase, KEX1DELTAp, Kex1p, KexA, Saccharomyces cerevisiae KEX1 gene product, serine carboxypeptidase B-like protease, wheat carboxypeptidase II
ECTree
3.4.16.6 carboxypeptidase DAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.16.6 - carboxypeptidase D
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-factor-Lys-Arg + H2O
mature active alpha-factor + Lys + Arg
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maturation takes place in sequential manner
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?
angiotensin 1 + H2O
?
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truncated KexA releases amino acid residues from the C terminus of angiotensin I
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-
?
benzoyl-Gly-Arg + H2O
benzoyl-Gly + L-arginine
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enzyme shows very low activity
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-
?
benzyloxycarbonyl-Gly-Lys + H2O
benzyloxycarbonyl-Gly + L-lysine
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enzyme shows very low activity
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-
?
benzyloxycarbonyl-Phe-Leu + H2O
benzyloxycarbonyl-Phe + L-leucine
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enzyme shows very low activity
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-
?
benzyloxycarbonyl-Phe-Tyr-Leu + H2O
benzyloxycarbonyl-Phe-Tyr + L-leucine
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-
-
-
?
benzyloxycarbonyl-Tyr-Leu + H2O
benzyloxycarbonyl-Tyr + L-leucine
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enzyme shows very low activity
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-
?
bradykinin I + H2O
?
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truncated KexA releases amino acid residues from the C terminus of bradykinin I
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-
?
furylacryloyl-Ala-Arg + H2O
furylacryloyl-Ala + Arg
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activity assay
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-
?
additional information
?
-
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activity of individual domains of the enzyme. Domain 1B is more active at neutral pH and greatly prefers C-terminal Arg over Lys, whereas domain 2 is more active at pH 5-6 and slightly prefers C-terminal Lys over Arg
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-
?
additional information
?
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the enzyme functions in processing of proteins that transit the secretory pathway
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-
?
additional information
?
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preferential release of a C-terminal arginine or lysine residue
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-
?
additional information
?
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the enzyme has a narrow specificity for lysyl ar arginyl residues at the C-terminus of the substrate
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-
?
additional information
?
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the enzyme has a narrow specificity for lysyl ar arginyl residues at the C-terminus of the substrate
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?
additional information
?
-
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role in the processing of both the alpha-pheromone and the killer toxin precursors
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-
?
additional information
?
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involved in the C-terminal processing of the lysine and arginine residues from the precursors of K1 and K2 killer toxins and alpha-factor (mating pheromone)
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?
additional information
?
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plays a role in polypeptide processing in yeast
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?
additional information
?
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specific for the removal of basic amino acids from prohormone processing intermediates, in mammalian cells
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?
additional information
?
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preferential release of a C-terminal arginine or lysine residue
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?
