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3.4.16.6: carboxypeptidase D

This is an abbreviated version!
For detailed information about carboxypeptidase D, go to the full flat file.

Word Map on EC 3.4.16.6

Reaction

preferential release of a C-terminal arginine or lysine residue =

Synonyms

Carboxypeptidase D, carboxypeptidase Kex1, cereal serine carboxypeptidase II, CP-MII.1, CP-MII.2, CP-MII.3, CP-WII, CPD, CPDW-II, CPW, EC 3.4.12.1, EC 3.4.16.1, EC 3.4.21.13, gene KEX1 serine carboxypeptidase, h-TLL, Kex-1 endopeptidase, Kex-1 protease, Kex1, KEX1 carboxypeptidase, Kex1 protease, KEX1 proteinase, KEX1DELTAp, Kex1p, KexA, Saccharomyces cerevisiae KEX1 gene product, serine carboxypeptidase B-like protease, wheat carboxypeptidase II

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.16 Serine-type carboxypeptidases
                3.4.16.6 carboxypeptidase D

Reference

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Reference on EC 3.4.16.6 - carboxypeptidase D

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Remington, S.J.; Breddam, K.
Carboxypeptidases C and D
Methods Enzymol.
244
231-248
1994
Saccharomyces cerevisiae, Triticum aestivum
Manually annotated by BRENDA team
Liao, D.I.; Breddam, K.; Sweet, R.M.; Bullock, T.; Remington, S.J.
Refined atomic model of wheat serine carboxypeptidase II at 2.2-A resolution
Biochemistry
31
9796-9812
1992
Triticum aestivum
Manually annotated by BRENDA team
Dmochowska, A.; Dignard, D.; Henning, D.; Thomas, D.Y.; Bussey, H.
Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and alpha-factor precursor processing
Cell
50
573-584
1987
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Shilton, B.H.; Thomas, D.Y.; Cygler, M.
Crystal structure of Kex1deltap, a prohormone-processing carboxypeptidase from Saccharomyces cerevisiae
Biochemistry
36
9002-9012
1997
Saccharomyces cerevisiae (P09620), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Latchinian-Sadek, L.; Thomas, D.Y.
Secretion, purification and characterization of a soluble form of the yeast KEX1-encoded protein from insect-cell cultures
Eur. J. Biochem.
219
647-652
1994
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Thomas, L.; Cooper, A.; Bussey, H.; Thomas, G.
Yeast KEX1 protease cleaves a prohormone processing intermediate in mammalian cells
J. Biol. Chem.
265
10821-10824
1990
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Shilton, B.H.; Li, Y.; Tessier, D.; Thomas, D.Y.; Cygler, M.
Crystallization of a soluble form of the Kex1p serine carboxypeptidase from Saccharomyces cerevisiae
Protein Sci.
5
395-397
1996
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Latchinian-Sadek, L.; Thomas, D.Y.
Expression, purification, and characterization of the yeast KEX1 gene product, a polypeptide precursor processing carboxypeptidase
J. Biol. Chem.
268
534-540
1993
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Sidyelyeva, G.; Fricker, L.D.
Characterization of Drosophila carboxypeptidase D
J. Biol. Chem.
277
49613-49620
2002
Drosophila melanogaster
Manually annotated by BRENDA team
Satoh, Y.; Kadota, Y.; Oheda, Y.; Kuwahara, J.; Aikawa, S.; Matsuzawa, F.; Doi, H.; Aoyagi, T.; Sakuraba, H.; Itoh, K.
Microbial serine carboxypeptidase inhibitors. Comparative analysis of actions on homologous enzymes derived from man, yeast and wheat. [Erratum to document cited in CA142:109255]
J. Antibiot.
57
316-325
2004
Triticum aestivum
Manually annotated by BRENDA team
O'Malley, P.G.; Sangster, S.M.; Abdelmagid, S.A.; Bearne, S.L.; Too, C.K.
Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells
Biochem. J.
390
665-673
2005
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Sidyelyeva, G.; Baker, N.E.; Fricker, L.D.
Characterization of the molecular basis of the Drosophila mutations in carboxypeptidase D. Effect on enzyme activity and expression
J. Biol. Chem.
281
13844-13852
2006
Drosophila melanogaster
Manually annotated by BRENDA team
Kalinina, E.; Fontenele-Neto, J.D.; Fricker, L.D.
Drosophila S2 cells produce multiple forms of carboxypeptidase D with different intracellular distributions
J. Cell. Biochem.
99
770-783
2006
Drosophila melanogaster
Manually annotated by BRENDA team
Serviene, E.; Cepononyte, S.; Lebionka, A.; Melvydas, V.
Influence of Kex1p and Kex2p proteases on the function of Saccharomyces cerevisiae K2 preprotoxin
Biologija (Vilnius)
53
35-38
2007
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Heiman, M.G.; Engel, A.; Walter, P.
The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating
J. Cell Biol.
176
209-222
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hauptmann, P.; Lehle, L.
Kex1 protease is involved in yeast cell death induced by defective N-glycosylation, acetic acid, and chronological aging
J. Biol. Chem.
283
19151-19163
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Pozzuolo, S.; Breme, U.; Salis, B.; Taylor, G.; Tonon, G.; Orsini, G.
Efficient bacterial expression of fusion proteins and their selective processing by a recombinant Kex-1 protease
Protein Expr. Purif.
59
334-341
2008
Kluyveromyces lactis
Manually annotated by BRENDA team
Morita, H.; Tomita, S.; Maeda, H.; Okamoto, A.; Yamagata, Y.; Kusumoto, K.; Amano, H.; Ishida, H.; Takeuchi, M.
Serine-type carboxypeptidase KexA of Aspergillus oryzae has broader substrate specificity than Saccharomyces cerevisiae Kex1 and is required for normal hyphal growth and conidiation
Appl. Environ. Microbiol.
78
8154-8157
2012
Aspergillus oryzae
Manually annotated by BRENDA team
Jin, T.; Fu, J.; Feng, X.J.; Wang, S.M.; Huang, X.; Zhu, M.H.; Zhang, S.H.
SiRNA-targeted carboxypeptidase D inhibits hepatocellular carcinoma growth
Cell Biol. Int.
37
929-939
2013
Homo sapiens
Manually annotated by BRENDA team
Carmona-Gutierrez, D.; Alavian-Ghavanini, A.; Habernig, L.; Bauer, M.A.; Hammer, A.; Rossmann, C.; Zimmermann, A.S.; Ruckenstuhl, C.; Buettner, S.; Eisenberg, T.; Sattler, W.; Malle, E.; Madeo, F.
The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast
Cell Cycle
12
1704-1712
2013
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Garcia-Pardo, J.; Grana-Montes, R.; Fernandez-Mendez, M.; Ruyra, A.; Roher, N.; Aviles, F.X.; Lorenzo, J.; Ventura, S.
Amyloid formation by human carboxypeptidase D transthyretin-like domain under physiological conditions
J. Biol. Chem.
289
33783-33796
2014
Homo sapiens
Manually annotated by BRENDA team
Thomas, L.; Morehouse, T.; Too, C.
Testosterone and prolactin increase carboxypeptidase-D and nitric oxide levels to promote survival of prostate cancer cells
Prostate
72
450-460
2012
Homo sapiens
Manually annotated by BRENDA team
Hu, Z.; Zhang, H.; Haley, B.; Macchi, F.; Yang, F.; Misaghi, S.; Elich, J.; Yang, R.; Tang, Y.; Joly, J.C.; Snedecor, B.R.; Shen, A.
Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells
Biotechnol. Bioeng.
113
2100-2106
2016
Cricetulus griseus (G3HR95), Cricetulus griseus
Manually annotated by BRENDA team