3.4.16.5: carboxypeptidase C

This is an abbreviated version!
For detailed information about carboxypeptidase C, go to the full flat file.

Reaction

release of a C-terminal amino acid with broad specificity =

Synonyms

A-type metallocarboxypeptidase, acidic serine carboxypeptidase, AtCPY, BRS1, carboxypeptidase a, carboxypeptidase A4, carboxypeptidase C, Carboxypeptidase II, carboxypeptidase Y, carboxypeptidase YSCY, carboxypeptidase-Y, Case, CatA, CathA, cathepsin A, CaY, CP-MI, CP-MIII, CP-WIII, CPA4, CPase, CPC, CPD-Y, CPW, CPY, Cpy1p, CTSA, Cxp1, deamidase, EC 3.4.12.1, EC 3.4.16.1, EC 3.4.16.3, hCath A, HPP, lysosomal carboxypeptidase A, lysosomal protective protein, MO54, More, MpiCP-1, MpiCP-2, Phaseolin, PpcA, PRC1, proCPY, protective protein cathepsin A, protective protein/cathepsin A, retinoid-inducible serine carboxypeptidase, SCP, Scpep1, Ser carboxypeptidase, Ser carboxypeptidase-like protein, serine carboxypeptidase, serine carboxypeptidase 1, serine carboxypeptidase I, serine carboxypeptidase Scpep1, SmSCP-1, TcCBP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.16 Serine-type carboxypeptidases

                3.4.16.5 carboxypeptidase C

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Results	in table
15	Activating Compound
133	AA Sequence
4	Application
1	CAS Registry Number
17	Cloned(Commentary)
1	Cofactor
9	Crystallization (Commentary)
369	Disease/ Diagnostics
1	Expression
10	General Information
8	General Stability
57	IC50 Value
221	Inhibitors
27	Ki Value [mM]
126	KM Value [mM]
28	Localization
22	Metals/Ions
40	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
6	Organic Solvent Stability
204	Organism
23	PDB ID
20	pH Optimum
6	pH Range
20	pH Stability
7	pI Value
24	Posttranslational Modification
77	Protein Variants
25	Purification (Commentary)
1	Reaction
3	Reaction Type
127	Reference
2	Renatured (Commentary)
66	Source Tissue
9	Specific Activity [micromol/min/mg]
2	Storage Stability
269	Substrates and Products (Substrate)
13	Subunits
152	Synonyms
12	Temperature Optimum [°C]
2	Temperature Range [°C]
13	Temperature Stability [°C]
122	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.16.5 - carboxypeptidase C

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0078

(3R)-3-([(5-hydroxy-1-phenyl-1H-pyrazol-3-yl)carbonyl]amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000057

(3S)-3-(([1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000357

(3S)-3-(([1-(2-fluorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(2-methoxyphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000038

(3S)-3-(([1-(2-fluorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000252

(3S)-3-(([1-(2-fluorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(3-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000274

(3S)-3-(([1-(2-fluorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(4-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000375

(3S)-3-(([1-(2-fluorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-[2-(trifluoromethyl)phenyl]propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.0001

(3S)-3-(([1-(3-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000059

(3S)-3-(([1-(3-fluorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000087

(3S)-3-(([1-(4-fluorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.00011

(3S)-3-(([4-chloro-1-(2-fluorophenyl)-5-methoxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.00003

(3S)-3-(([4-fluoro-1-(2-fluorophenyl)-5-methoxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.00006

(3S)-3-(2,4-dichlorophenyl)-3-([[5-(3,3-dimethyl-2-oxobutoxy)-1-(2-fluorophenyl)-1H-pyrazol-3-yl]carbonyl]amino)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000005 - 0.00005

(3S)-3-(2,4-dichlorophenyl)-3-[([1-(2-fluorophenyl)-5-[(2R)-2-hydroxy-3,3-dimethylbutoxy]-1H-pyrazol-3-yl]carbonyl)amino]propanoic acid

2 entries

0.00007

(3S)-3-(2,4-dichlorophenyl)-3-[([1-(2-fluorophenyl)-5-[(2S)-2-hydroxy-3,3-dimethylbutoxy]-1H-pyrazol-3-yl]carbonyl)amino]propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.00011

(3S)-3-([(4-hydroxy-1-phenyl-1H-pyrazol-3-yl)carbonyl]amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.0001

(3S)-3-([(4-methoxy-1-phenyl-1H-pyrazol-3-yl)carbonyl]amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.00007

(3S)-3-([(5-hydroxy-1-phenyl-1H-pyrazol-3-yl)carbonyl]amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000003

(3S)-3-([[5-(3,3-dimethyl-2-oxobutoxy)-1-(2-fluorophenyl)-1H-pyrazol-3-yl]carbonyl]amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000015

(3S)-3-([[5-(cyclopropylmethoxy)-1-(2-fluorophenyl)-1H-pyrazol-3-yl]carbonyl]amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000015

(3S)-3-([[5-ethoxy-1-(2-fluorophenyl)-1H-pyrazol-3-yl]carbonyl]amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.00001

(3S)-3-[([1-(2-fluorophenyl)-5-[(2S)-2-hydroxy-3,3-dimethylbutoxy]-1H-pyrazol-3-yl]carbonyl)amino]-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.0006

3,4-dichloroisocoumarin

Homo sapiens

-

-

677595

0.00538

3-(([1-(2,5-dimethylphenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(4-fluorophenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000226

3-(([1-(2-fluorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-phenylpropanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000026

3-(([1-(2-fluorophenyl)-5-methoxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(2-methylphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.03

3-(([1-(4-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)-3-(2,5-dichlorophenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.00012

3-(2,3-dichlorophenyl)-3-(([1-(2,4-difluorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.0001

3-(2,3-dichlorophenyl)-3-([(5-hydroxy-1-phenyl-1H-pyrazol-3-yl)carbonyl]amino)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000025

3-(4'-fluorobiphenyl-4-yl)-3-([[1-(2-fluorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl]amino)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000076

3-(5-fluoro-2-methylphenyl)-3-(([1-(2-fluorophenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl)amino)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.000803

3-(biphenyl-4-yl)-3-([[1-(2,5-dimethylphenyl)-5-hydroxy-1H-pyrazol-3-yl]carbonyl]amino)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.0002

3-[[(5-hydroxy-1-phenyl-1H-pyrazol-3-yl)carbonyl]amino]-3-(4-phenoxyphenyl)propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.0022 - 0.1

chymostatin

3 entries

0.01

diisopropyl fluorophosphate

Homo sapiens

-

-

677595

0.00002 - 0.002

ebelactone B

3 entries

0.0014 - 0.048

lactacystin

3 entries

0.000002 - 0.000099

omuralide

3 entries

0.72

Phe-Asn-Arg-Ala-Val-Asp

Homo sapiens

-

in 50 mM Tris-HCl and 0.1 M NaCl (pH 7.5)

678293

0.63

Phe-Asn-Arg-Ala-Val-Val

Homo sapiens

-

in 50 mM Tris-HCl and 0.1 M NaCl (pH 7.5)

678293

0.91

Phe-Asn-Arg-Pro-Val-Asp

Homo sapiens

-

in 50 mM Tris-HCl and 0.1 M NaCl (pH 7.5)

678293

0.71

Phe-Asn-Arg-Pro-Val-Val

Homo sapiens

-

in 50 mM Tris-HCl and 0.1 M NaCl (pH 7.5)

678293

0.0041 - 0.1

piperastatin A

3 entries

0.029 - 0.1

poststatin

3 entries

0.000005

(3S)-3-(2,4-dichlorophenyl)-3-[([1-(2-fluorophenyl)-5-[(2R)-2-hydroxy-3,3-dimethylbutoxy]-1H-pyrazol-3-yl]carbonyl)amino]propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.00005

(3S)-3-(2,4-dichlorophenyl)-3-[([1-(2-fluorophenyl)-5-[(2R)-2-hydroxy-3,3-dimethylbutoxy]-1H-pyrazol-3-yl]carbonyl)amino]propanoic acid

Homo sapiens

-

pH 6, 37°C

732302

0.0022 - 0.013

chymostatin

Triticum aestivum

-

IC50 at pH 5.6: 0.013 mM, IC50 at pH 6.5: 0.0022 mM

665316

0.092 - 0.1

chymostatin

Homo sapiens

-

IC50 at pH 5.6: 0.092 mM, IC50 at pH 6.5: above 0.1 mM

665316

0.1

chymostatin

Saccharomyces cerevisiae

-

IC50 at pH 5.6 and at pH 6.5: above 0.1 mM

665316

0.00002 - 0.00003

ebelactone B

Saccharomyces cerevisiae

-

IC50 at pH 5.6: 0.00002 mM, IC50 at pH 6.5: 0.00003 mM

665316

0.0015

ebelactone B

Triticum aestivum

-

IC50: 0.0021 mM (at pH 5.6), IC50: 0.0015 mM (at pH 6.5)

665316

0.0016 - 0.002

ebelactone B

Homo sapiens

-

IC50 at pH 5.6: 0.0016 mM, IC50 at pH 6.5: 0.002 mM

665316

0.0014 - 0.0043

lactacystin

Triticum aestivum

-

IC50 at pH 5.6: 0.0014 mM, IC50 at pH 6.5: 0.0043 mM

665316

0.0018 - 0.0052

lactacystin

Homo sapiens

-

IC50 at pH 5.6: 0.0052 mM, IC50 at pH 6.5: 0.0018 mM

665316

0.031 - 0.048

lactacystin

Saccharomyces cerevisiae

-

IC50 at pH 5.6: 0.048 mM, IC50 at pH 6.5: 0.031 mM

665316

0.000002 - 0.0000048

omuralide

Triticum aestivum

-

IC50 at pH 5.6: mM, IC50 at pH 6.5: 0.000002 mM

665316

0.000012 - 0.000099

omuralide

Homo sapiens

-

IC50 at pH 5.6: 0.000099 mM, IC50 at pH 6.5: 0.000012 mM

665316

0.000078 - 0.000096

omuralide

Saccharomyces cerevisiae

-

IC50 at pH 5.6: 0.000096 mM, IC50 at pH 6.5: 0.000078 mM

665316

0.0041 - 0.0045

piperastatin A

Saccharomyces cerevisiae

-

IC50 at pH 5.6: 0.0041 mM, IC50 at pH 6.5: 0.0045 mM

665316

0.018 - 0.032

piperastatin A

Homo sapiens

-

IC50 at pH 5.6: 0.018 mM, IC50 at pH 6.5: 0.032 mM

665316

0.1

piperastatin A

Triticum aestivum

-

IC50 at pH 5.6 and at pH 6.5: above 0.1 mM

665316

0.029 - 0.089

poststatin

Saccharomyces cerevisiae

-

IC50 at pH 5.6:0.089 mM, IC50 at pH 6.5: 0.029 mM

665316

0.1

poststatin

Homo sapiens

-

IC50 at pH 5.6 and at pH 6.5: above 0.1 mM

665316

0.1

poststatin

Triticum aestivum

-

IC50 at pH 5.6 and at pH 6.5: above 0.1 mM

665316