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3.4.16.5: carboxypeptidase C

This is an abbreviated version!
For detailed information about carboxypeptidase C, go to the full flat file.

Word Map on EC 3.4.16.5

Reaction

release of a C-terminal amino acid with broad specificity =

Synonyms

A-type metallocarboxypeptidase, acidic serine carboxypeptidase, AtCPY, BRS1, carboxypeptidase a, carboxypeptidase A4, carboxypeptidase C, Carboxypeptidase II, carboxypeptidase Y, carboxypeptidase YSCY, carboxypeptidase-Y, Case, CatA, CathA, cathepsin A, CaY, CP-MI, CP-MIII, CP-WIII, CPA4, CPase, CPC, CPD-Y, CPW, CPY, Cpy1p, CTSA, Cxp1, deamidase, EC 3.4.12.1, EC 3.4.16.1, EC 3.4.16.3, hCath A, HPP, lysosomal carboxypeptidase A, lysosomal protective protein, MO54, More, MpiCP-1, MpiCP-2, Phaseolin, PpcA, PRC1, proCPY, protective protein cathepsin A, protective protein/cathepsin A, retinoid-inducible serine carboxypeptidase, SCP, Scpep1, Ser carboxypeptidase, Ser carboxypeptidase-like protein, serine carboxypeptidase, serine carboxypeptidase 1, serine carboxypeptidase I, serine carboxypeptidase Scpep1, SmSCP-1, TcCBP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.16 Serine-type carboxypeptidases
                3.4.16.5 carboxypeptidase C

Activating Compound

Activating Compound on EC 3.4.16.5 - carboxypeptidase C

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-chloro-3-tosylamido-2-heptanone
-
10% increase of activity at 10 mM
3-Phenyl-1-propanol
-
inhibits hydrolysis of benzyloxycarbonyl-Phe-Leu, activates hydrolysis of benzyloxycarbonyl-Gly-Phe
antipain
-
15 increase of activity at 0.1 mM
CH3-CH2-CH2-CH2-Hg
-
mercurials inhibit the hydrolysis of the good substrate benzyloxycarbonyl-L-Phe-L-Leu, the inhibition is repressed by the competitive inhibitors benzyloxycarbonyl-D-Phe-D-Leu-Leu-Phe, trans-cinnamate and acetyl-D-Phe ethyl ester. Aromatic, methyl and ethyl mercurials do not cause complete inactivation with the poor substrates benzyloxycarbonyl-Gly-Phe and benzoyl-Gly-beta,L-phenyllactate. Propyl and butyl-mercurials enhance these activities
CH3-CH2-CH2-Hg
-
mercurials inhibit the hydrolysis of the good substrate benzyloxycarbonyl-L-Phe-L-Leu, the inhibition is repressed by the competitive inhibitors benzyloxycarbonyl-D-Phe-D-Leu-Leu-Phe, trans-cinnamate and acetyl-D-Phe ethyl ester. Aromatic, methyl and ethyl mercurials do not cause complete inactivation with the poor substrates benzyloxycarbonyl-Gly-Phe and benzoyl-Gly-beta,L-phenyllactate. Propyl and butyl-mercurials enhance these activities
EDTA
-
25% increase of activity at 10 mM
Kar2p, Pdi1p, Ero1p
-
co-expression of Kar2p, Pdi1p and Ero1p give a synergistic effect on CPY expression, of which activity is 1.7times higher than that of the control strain
-
Karp2
-
a single co-expression of Kar2p leads to a 28% enhancement in extracellular CPY activity, relative to the control strain
-
leupeptin
-
20% increase of activity at 0.1 mM
N-ethylmaleimide
-
8% increase of activity at 10 mM
o-phenanthroline
-
4% increase of activity at 5 mM
pepstatin A
-
5% increase of activity at 0.1 mM
proteinase A
-
active proteinase A is essential to the activity of carboxypeptidase Y
-
proteinase K
-
converts the proenzyme to the mature, active enzyme
-
additional information
-
FUSCA, a B3 domain transcription factor that lacks the N-terminal activation and B1 domain 3 activates the phaseolin promoter in the presence of abscisic acid
-