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3.4.16.2: lysosomal Pro-Xaa carboxypeptidase

This is an abbreviated version!
For detailed information about lysosomal Pro-Xaa carboxypeptidase, go to the full flat file.

Word Map on EC 3.4.16.2

Reaction

Cleavage of a -Pro-/-Xaa bond to release a C-terminal amino acid =

Synonyms

aminoacylproline carboxypeptidase, angiotensinase C, carboxypeptidase, carboxypeptidase A6, Carboxypeptidase P, Carboxypeptidase R, carboxypeptidase, aminoacylproline, carboxypeptidase, peptidylprolylamino acid, CPA6, CPP, EC 3.4.12.4, endothelial cell prekallikrein activator, HUVEC PK activator, lysosomal carboxypeptidase, lysosomal carboxypeptidase C, lysosomal Pro-X carboxypeptidase, matrix PK activator, PCP, PKA, plasma carboxypeptidase, plasma procarboxypeptidase B, PRCP, procarboxypeptidase U, proline carboxypeptidase, proline-specific carboxypeptidase P, prolyl carboxypeptidase, prolyl-carboxypeptidase, prolylcarboxypeptidase, serine protease prolylcarboxypeptidase, TAFI, thrombin-activatable fibrinolysis inhibitor

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.16 Serine-type carboxypeptidases
                3.4.16.2 lysosomal Pro-Xaa carboxypeptidase

Inhibitors

Inhibitors on EC 3.4.16.2 - lysosomal Pro-Xaa carboxypeptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(3R,4R)-4-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]-1-(2,2-dimethylpropyl)-3-(4-fluorophenyl)piperidine
2-[4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-1-(2-phenylethyl)piperidin-4-yl]pyridine
angiotensin I
-
inhibits the mutant DELTA317-496 in a dose-dependent manner
angiotensin II
angiotensin III
-
inhibits the mutant DELTA317-496 in a dose-dependent manner
anti-PRCP
-
-
-
antipain
Benzoyl-D-Phe
-
-
benzyloxycarbonyl-Pro-Pro-aldehyde dimethyl acetal
-
IC50: 0.001 mM
benzyloxycarbonyl-Pro-Pro-aldehyde-dimethyl acetal
-
-
benzyloxycarbonyl-Pro-prolinal
-
IC50: 0.5 mM, inhibits hydrolysis of H-Gly-Pro-4-nitroanilide
Benzylsuccinic acid
-
-
bradykinin
corn trypsin inhibitor
-
diisopropyl fluorophosphate
diisopropyl fluorophosphonate
ebelactone B
-
noncompetitive
HgCl2
-
IC50: 0.5 mM
leupeptin
N-(9-fluorenyl)methoxycarbonyl-Ala-Pyr-CN
-
IC50: 50 nM
N-(9-fluorenyl)methoxycarbonyl-aminoacylpyrrolidine-2-nitrile
-
IC50: 0.1 mM
N-benzyloxycarbonyl-Pro-prolinal
N-benzyloxycarbonyl-prolyl-prolinal
-
the inhibition of PRCP activity by small molecule protease inhibitors administered peripherally or centrally decreased food intake in both wild-type and obese mice
NEM
-
3 mM, 30% inhibition
o-phenanthroline
-
-
p-chloromercuriphenylsulfonic acid
-
1 mM, 15% inhibition
pepstatin
phenylmethyl sulfonyl fluoride
-
3 mM
phenylmethylsulfonyl fluoride
potato carboxypeptidase inhibitor
-
protease inhibitors of the blood plasma
-
-
-
t-butyl carbamate-prolyl-prolinal
-
the inhibition of PRCP activity by small molecule protease inhibitors administered peripherally or centrally decreased food intake in both wild-type and obese mice
Z-Pro-prolinal
-
-
Z-prolyl-prolinal
-
-
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl](4-[(1Z)-1-[(2,5-dichlorophenyl)amino]-3-iminobut-1-en-1-yl]piperidin-1-yl)methanone
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl](4-[(1Z)-1-[(3-chloro-4-fluorophenyl)amino]-3-iminoprop-1-en-1-yl]piperidin-1-yl)methanone
[4-[1-(3-chloro-4-fluorophenyl)-1H-pyrazol-5-yl]piperidin-1-yl][(1R,2R,4S)-2-(2,4-difluorophenyl)-4-(dimethylamino)-4-methylcyclopentyl]methanone
additional information
-