3.4.16.2: lysosomal Pro-Xaa carboxypeptidase

This is an abbreviated version!
For detailed information about lysosomal Pro-Xaa carboxypeptidase, go to the full flat file.

Reaction

Cleavage of a -Pro-/-Xaa bond to release a C-terminal amino acid =

Synonyms

aminoacylproline carboxypeptidase, angiotensinase C, carboxypeptidase, carboxypeptidase A6, Carboxypeptidase P, Carboxypeptidase R, carboxypeptidase, aminoacylproline, carboxypeptidase, peptidylprolylamino acid, CPA6, CPP, EC 3.4.12.4, endothelial cell prekallikrein activator, HUVEC PK activator, lysosomal carboxypeptidase, lysosomal carboxypeptidase C, lysosomal Pro-X carboxypeptidase, matrix PK activator, PCP, PKA, plasma carboxypeptidase, plasma procarboxypeptidase B, PRCP, procarboxypeptidase U, proline carboxypeptidase, proline-specific carboxypeptidase P, prolyl carboxypeptidase, prolyl-carboxypeptidase, prolylcarboxypeptidase, serine protease prolylcarboxypeptidase, TAFI, thrombin-activatable fibrinolysis inhibitor

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.16 Serine-type carboxypeptidases

                3.4.16.2 lysosomal Pro-Xaa carboxypeptidase

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Results	in table
3	Activating Compound
114	AA Sequence
8	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
521	Disease/ Diagnostics
3	Expression
8	General Information
30	IC50 Value
72	Inhibitors
1	kcat/KM [mM/s]
7	Ki Value [mM]
24	KM Value [mM]
8	Localization
6	Metals/Ions
23	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
46	Organism
1	PDB ID
15	pH Optimum
6	pH Range
1	pH Stability
1	pI Value
3	Posttranslational Modification
3	Protein Variants
11	Purification (Commentary)
1	Reaction
9	Reaction Type
46	Reference
58	Source Tissue
5	Specific Activity [micromol/min/mg]
61	Substrates and Products (Substrate)
9	Subunits
65	Synonyms
10	Temperature Optimum [°C]
6	Temperature Stability [°C]
4	Turnover Number [1/s]

Engineering

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Engineering on EC 3.4.16.2 - lysosomal Pro-Xaa carboxypeptidase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

DELTA317-496

Homo sapiens

-

an N-terminal truncated form, lacking 179 N-terminal residues of PRCP is constructed. The circular dichroism spectrum of the truncated mutant illustrates that it is structured with significant helical content as indicated by local minima at 220 and 208 nm. The main products of angiotensin III metabolized by the truncated mutant is angiotensin 2-7 plus phenylalanine as determined by LC-MS. Angiotensin I blockes the metabolism of angiotensin III by the truncated mutant. Km (mM) (Ala-Pro-4-nitroanilide) lower compared to wild-type

696003

E112D

2 entries

E112D

Homo sapiens

-

prolylcarboxypeptidase E112D (rs22988668) D allele along and jointly with chronic hypertension are associated with a significant increased risk of preeclampsia

683041

E112D

Homo sapiens

-

E112D polymorphism in the PRCP gene is associated with blood pressure response to benazepril in Chinese hypertensive patients

708136