3.4.15.5: Peptidyl-dipeptidase Dcp

This is an abbreviated version!
For detailed information about Peptidyl-dipeptidase Dcp, go to the full flat file.

Word Map on EC 3.4.15.5

3.4.15.5

3.4.15.1

angiotensin

angiotensin-converting

captopril

bradykinin

i-converting

dipeptide

kininase

endopeptidase

enkephalin

3.4.24.11

enkephalinase

phosphoramidon

peptidyldipeptide

thiorphan

lisinopril

enalaprilat

bestatin

met5-enkephalin

hip-his-leu

amastatin

dipeptidylaminopeptidase

metalloendopeptidase

gly3-phe4

endopeptidase-24.11

hippuryl-l-histidyl-l-leucine

Reaction

Hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyse bonds in which P1' is Pro, or both P1 and P1' are Gly =

Synonyms

DCP, Dipeptidyl carboxypeptidase, dipeptidyl carboxypeptidase II, dipeptidylcarboxypeptidase, EC 3.4.15.1, EC 3.4.15.3, K-26-DCP, LdDCP, More, peptidyl-dipeptidase K-26-DCP

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.15 Peptidyl-dipeptidases

3.4.15.5 Peptidyl-dipeptidase Dcp

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Results	in table
3030	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
2	Crystallization (Commentary)
6	General Information
1	IC50 Value
20	Inhibitors
3	kcat/KM [mM/s]
5	Ki Value [mM]
11	KM Value [mM]
1	Localization
8	Metals/Ions
4	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
186	Organism
3	PDB ID
4	pH Optimum
2	pH Range
1	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
11	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
44	Substrates and Products (Substrate)
5	Subunits
13	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.15.5 - Peptidyl-dipeptidase Dcp

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1.27

Ala-Ala-Phe-Ala

Escherichia coli

28733

0.61

Ala-Gly-Phe-Ala

Escherichia coli

28733

0.44

Ala4

Escherichia coli

28733

1.39

Gly-Ala-Phe-Ala

Escherichia coli

28733

6.06

Gly-Gly-Phe-Ala

Escherichia coli

28733

0.1

Lys4

Escherichia coli

28733

0.00066

o-aminobenzoyl-FRAK(2,4-dinitrophenyl)-OH

Escherichia coli

P24171

pH 8.0, 37°C, recombinant enzyme

707614

0.00029

o-aminobenzoyl-FRK(2,4-dinitrophenyl)P-OH

Escherichia coli

P24171

pH 8.0, 37°C, recombinant enzyme

707614

0.00255

o-aminobenzoyl-LFK(2,4-dinitrophenyl)-OH

Escherichia coli

P24171

pH 8.0, 37°C, recombinant enzyme

707614

0.71

tert-butyloxycarbonyl-Ala-Ala-Ala

Escherichia coli

28733

additional information

2 entries