3.4.15.4: Peptidyl-dipeptidase B
This is an abbreviated version!
For detailed information about Peptidyl-dipeptidase B, go to the full flat file.
Reaction
release of a C-terminal dipeptide or exceptionally a tripeptide =
Synonyms
Atrial di-(tri-)peptidyl carboxyhydrolase, Atrial dipeptidyl carboxyhydrolase, Atrial peptide convertase, Atriopeptin convertase, Dipeptidase, peptidyl-, B, Dipeptidyl carboxyhydrolase
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Substrates Products
Substrates Products on EC 3.4.15.4 - Peptidyl-dipeptidase B
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REACTION DIAGRAM
2-aminobenzoyl-Gly-Ala-(4-nitro)Phe-Arg + H2O
2-aminobenzoyl-Gly-Ala + 4-nitro-L-phenylalanyl-L-arginine
-
-
-
-
?
2-aminobenzoyl-Gly-Asn-(4-nitro)Phe-Arg + H2O
2-aminobenzoyl-Gly-Asn + 4-nitro-L-phenylalanyl-L-arginine
-
-
-
-
?
2-aminobenzoyl-Gly-Asp-(4-nitro)Phe-Arg + H2O
2-aminobenzoyl-Gly-Asp + 4-nitro-L-phenylalanyl-L-arginine
-
-
-
-
?
2-aminobenzoyl-Gly-Lys-(4-nitro)Phe-Arg + H2O
2-aminobenzoyl-Gly-Lys + 4-nitro-L-phenylalanyl-L-arginine
-
-
-
-
?
2-aminobenzoyl-Gly-Ser-(4-nitro)Phe-Arg + H2O
2-aminobenzoyl-Gly-Ser + 4-nitro-L-phenylalanyl-L-arginine
-
-
-
-
?
2-aminobenzoyl-Gly-Thr-(4-nitro)Phe-Arg + H2O
2-aminobenzoyl-Gly-Thr + 4-nitro-L-phenylalanyl-L-arginine
-
-
-
-
?
Atriopeptin II peptide Ser103-Arg125 + H2O
Atriopeptin I peptide Ser103-Ser123 + Phe-Arg
-
-
-
?
Atriopeptin III peptide Ser103-Tyr126 + H2O
Atriopeptin I + Phe-Arg-Tyr
-
-
-
?
Benzoyl-Asn-Ser-Phe-Arg-Tyr + H2O
Benzoyl-Asn-Ser-Phe + Arg-Tyr
-
-
successive dipeptidyl cleavage after longer incubation yielding benzoyl-Asn + Ser-Phe
?
[Mercaptopropionyl105,(D)Ala107]-atriopeptinIII-NH2 peptide + H2O
Analog(1-18) + Phe-Arg-Tyr-NH2
-
enzyme acts exclusively as tripeptidyl carboxyhydrolase
-
?
Atriopeptin II + H2O
Atriopeptin I + ?
-
atriopepin I is not a substrate
sequential cleavage of Asn-Ser does not occur, ? is Phe-Arg
?
?
-
-
generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC 3.4.15.1) it shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II
-
-
?