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3.4.14.5: dipeptidyl-peptidase IV

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase IV, go to the full flat file.

Word Map on EC 3.4.14.5

Reaction

release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline =

Synonyms

(GLP1)-degrading enzyme, ACT3, ADA binding protein, ADA-binding protein, ADABP, adenosine deaminase binding protein, Adenosine deaminase complexing protein, adenosine deaminase-binding protein, amino acyl-prolyl dipeptidyl aminopeptidase, aminopeptidase, glycylproline, Bile canaliculus domain-specific membrane glycoprotein, CD26, CD26 peptidase, CD26/dipeptidyl peptidase, CD26/DP IV, DAP IV, DapB, dapUm, dipeptidyl aminopeptidase IV, dipeptidyl dipeptidase IV, dipeptidyl peptidase 4, dipeptidyl peptidase 8, dipeptidyl peptidase 9, dipeptidyl peptidase IV, dipeptidyl peptidase-4, dipeptidyl peptidase-IV, dipeptidyl-aminopeptidase IV, dipeptidyl-peptidase 4, dipeptidyl-peptidase IV (CD26), dipeptidyl-peptide hydrolase, dipeptidylpeptidase 4a, dipeptidylpeptidase 4b, dipeptidylpeptidase IV, dipeptidylpeptidase IV/CD26, dipeptidylpeptidase-IV, DP IV, DP-IV, DPIV, DPP, DPP IV, DPP IV/CD26, DPP-4, DPP-IV, DPP4, DPP8, DPP9, DPPIV, DppIVA, DppIVB, glucagon-like peptide 1-degrading enzyme, Gly-Pro-naphthylamidase, glycoprotein GP110, glycylproline aminopeptidase, glycylproline-dipeptidyl-aminopeptidase, glycylprolyl aminopeptidase, glycylprolyl dipeptidylaminopeptidase, GP110 glycoprotein, h-DPPIV, hDPPIV, leukocyte antigen CD26, lymphocyte, antigen CD26, More, omega DPPIV, omega enzyme, omega gene product, Pep X, peptidase, dipeptidyl, IV, PepX, postproline dipeptidyl aminopeptidase IV, prolyl-dipeptidyl-aminopeptidase, sipeptidyl peptidase IV, T cell triggering molecule Tp103, T-cell activation antigen CD26, THAM, Thymocyte-activating molecule, TP103, type IV dipeptidyl aminopeptidase, WC10, X-PDAP, X-prolyl dipeptidyl aminopeptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro-dipeptidyl-aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.5 dipeptidyl-peptidase IV

Turnover Number

Turnover Number on EC 3.4.14.5 - dipeptidyl-peptidase IV

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
26
Ala-Ala-4-nitroanilide
-
-
3 - 42
Ala-Pro-7-amido-4-methylcoumarin
37.3 - 43.1
Ala-Pro-7-amido-4-trifluoromethyl coumarin
9 - 19
Ala-Pro-7-amido-4-trifluoromethylcoumarin
0.063
amyloid beta40
-
pH 7.4, 37°C
-
0.027
amyloid beta42
-
pH 7.4, 37°C
-
181
Arg-Pro-4-nitroanilide
-
-
71
Arg-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
66.1
Arg-Pro-Lys-Pro
-
-
62.3
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Gly
-
-
60.3
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly
-
-
50.3
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
-
-
35
Asn-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
4.6
Asp-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
5.2
BRI peptide (1-23)
-
in 40 mM HEPES-buffer, pH 7.4, at 37°C
-
10
Gln-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
10 - 62.9
Glu-Pro-7-amido-4-methylcoumarin
2.1
Gly-Ala-7-amido-4-methylcoumarin
-
-
5.6
Gly-L-Ala-2-naphthylamide
-
-
128
Gly-L-Pro-2-naphthylamide
-
-
19.2
Gly-L-Pro-7-amido-4-methylcoumarin
pH 8.0, 25°C
31.3
Gly-L-Pro-Gly-Gly
-
-
82.3
Gly-L-Pro-L-Ala
-
-
20.3
Gly-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
810
Gly-Pro-3,5-dibromo-4-hydroxyanilide
-
-
10 - 279000
Gly-Pro-4-nitroanilide
60 - 69.8
Gly-Pro-7-amido-4-methylcoumarin
2180
Gly-Pro-Ala
-
-
0.05 - 87
Gly-Pro-p-nitroanilide
1770 - 1774
hemorphin-4
5.3
hemorphin-7
-
pH 8.0, 37°C, microsomes
41
His-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
418
His-Pro-Leu
-
-
670
His-Pro-Tyr
-
-
67
Ile-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
52.3
L-Ala-L-Ala-2-naphthylamide
-
-
15.1
L-Ala-L-Ala-L-Ala
-
-
46.2
L-Ala-L-Pro-Gly
-
-
0.6 - 33
L-Ala-L-Pro-p-nitroanilide
7.7
L-Arg-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
11
L-Asn-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
7
L-Glu-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
11.2
L-Leu-L-Ala-2-naphthylamide
-
-
1.5
L-Leu-L-Leu-Gly
-
-
2.7
L-Leu-L-Leu-L-Leu
-
-
82.8
L-Leu-L-Pro-Gly-Gly
-
-
1.9 - 6.3
L-Leu-L-Pro-p-nitroanilide
6.3
L-Lys-L-Ala-2-naphthylamide
-
-
0.4 - 5
L-Lys-L-Pro-p-nitroanilide
8.7
L-Met-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
990
L-Phe-L-Pro-2-naphthylamide
-
-
18
L-Ser-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
117
L-Thr-L-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
-
120
Leu-Ala-Pro
-
-
22 - 43.8
Leu-Pro-7-amido-4-methylcoumarin
17.1 - 92
Lys-Ala-7-amido-4-methylcoumarin
61.6 - 90
Lys-Pro-7-amido-4-methylcoumarin
88.3
Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
-
-
102
Met-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
0.55
N-(Ala-Pro)-N'-6-(3,4-dichloromaleimidyl)-hexanoyl-rhodamine 110
0.7
N-(Gly-Pro)-N'-(4-chlorobutanoyl)-rhodamine 110
3.4
N-(Gly-Pro)-N'-(4-chloromethyl)benzoyl-rhodamine 110
3.22
N-(Gly-Pro)-N'-(5-bromopentanoyl)-rhodamine 110
8
N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110
8
N-(Gly-Pro)-N'-4-(maleimidyl)butanoyl-rhodamine 110
1.6
N-(Gly-Pro)-N'-chloroacetyl-rhodamine 110
1.8 - 78.4
Phe-Pro-7-amido-4-methylcoumarin
41
Pro-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
58
Ser-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
99
Tyr-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
87.5
Tyr-Pro-Phe
-
-
90.8
Tyr-Pro-Phe-Pro
-
-
102
Tyr-Pro-Phe-Pro-Gly
-
-
71.4
Tyr-Pro-Phe-Val-Glu-Pro-Ile
-
-
103
Tyr-Pro-Phe-Val-Glu-Pro-Ileu
-
-
additional information
additional information
-
turnover-numbers for X-Pro-4-nitroanilides
-