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3.4.14.5: dipeptidyl-peptidase IV

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase IV, go to the full flat file.

Word Map on EC 3.4.14.5

Reaction

release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline =

Synonyms

(GLP1)-degrading enzyme, ACT3, ADA binding protein, ADA-binding protein, ADABP, adenosine deaminase binding protein, Adenosine deaminase complexing protein, adenosine deaminase-binding protein, amino acyl-prolyl dipeptidyl aminopeptidase, aminopeptidase, glycylproline, Bile canaliculus domain-specific membrane glycoprotein, CD26, CD26 peptidase, CD26/dipeptidyl peptidase, CD26/DP IV, DAP IV, DapB, dapUm, dipeptidyl aminopeptidase IV, dipeptidyl dipeptidase IV, dipeptidyl peptidase 4, dipeptidyl peptidase 8, dipeptidyl peptidase 9, dipeptidyl peptidase IV, dipeptidyl peptidase-4, dipeptidyl peptidase-IV, dipeptidyl-aminopeptidase IV, dipeptidyl-peptidase 4, dipeptidyl-peptidase IV (CD26), dipeptidyl-peptide hydrolase, dipeptidylpeptidase 4a, dipeptidylpeptidase 4b, dipeptidylpeptidase IV, dipeptidylpeptidase IV/CD26, dipeptidylpeptidase-IV, DP IV, DP-IV, DPIV, DPP, DPP IV, DPP IV/CD26, DPP-4, DPP-IV, DPP4, DPP8, DPP9, DPPIV, DppIVA, DppIVB, glucagon-like peptide 1-degrading enzyme, Gly-Pro-naphthylamidase, glycoprotein GP110, glycylproline aminopeptidase, glycylproline-dipeptidyl-aminopeptidase, glycylprolyl aminopeptidase, glycylprolyl dipeptidylaminopeptidase, GP110 glycoprotein, h-DPPIV, hDPPIV, leukocyte antigen CD26, lymphocyte, antigen CD26, More, omega DPPIV, omega enzyme, omega gene product, Pep X, peptidase, dipeptidyl, IV, PepX, postproline dipeptidyl aminopeptidase IV, prolyl-dipeptidyl-aminopeptidase, sipeptidyl peptidase IV, T cell triggering molecule Tp103, T-cell activation antigen CD26, THAM, Thymocyte-activating molecule, TP103, type IV dipeptidyl aminopeptidase, WC10, X-PDAP, X-prolyl dipeptidyl aminopeptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro-dipeptidyl-aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.5 dipeptidyl-peptidase IV

Source Tissue

Source Tissue on EC 3.4.14.5 - dipeptidyl-peptidase IV

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
in artery DPIV represents 92% of the total Gly-L-Pro-4-nitroanilide-hydrolyzing activity
Manually annotated by BRENDA team
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mRNA expression in ipsilateral and contralateral cortices. At day 3 post-ischemia, dipeptidyl peptidase IV, 8 and aminopeptidase N are identified in activated microglia and macrophages in the ipsilateral cortex. Seven days post artery occlusion, dipeptidyl peptidase IV immunoreactivity is found in the perikarya of surviving cortical neurons of the ipsilateral hemisphere. At the same time point, dipeptidyl peptidase IV, 8 and aminopeptidase N are targeted in astroglial cells. Total dipeptidyl peptidase IV, 8 and 9 activities remain constant in both hemispheres until day 3 post experimental ischemia, but are increased to 165% in the ipsilateral cortex at day 7
Manually annotated by BRENDA team
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in colon DPIV represents 33% of the total Gly-L-Pro-4-nitroanilide-hydrolyzing activity
Manually annotated by BRENDA team
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in contrast to the normal cornea where DPPIV activity is absent and the tear fluid where it is low, during continuous wearing of contact lenses or repeated irradiation of the cornea with UVB rays, slight DPPIV activity appeared first in the superficial layers of the corneal epithelium, while later increased activity is present in the whole epithelium.This parallels elevated DPPIV activity in the tear fluid
Manually annotated by BRENDA team
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in duodenum DPIV represents 89% of the total Gly-L-Pro-4-nitroanilide-hydrolyzing activity
Manually annotated by BRENDA team
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in heart DPIV represents 71% of the total Gly-L-Pro-4-nitroanilide-hydrolyzing activity
Manually annotated by BRENDA team
-
neuroectodermal melanoma cell line, proliferating and quiescent populations
Manually annotated by BRENDA team
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neuroectodermal glioma cell line, proliferating and quiescent populations
Manually annotated by BRENDA team
-
in ileum DPIV represents 94% of the total Gly-L-Pro-4-nitroanilide-hydrolyzing activity
Manually annotated by BRENDA team
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brush border membrane
Manually annotated by BRENDA team
-
casein-induced, intraperitoneal polymorphonuclear
Manually annotated by BRENDA team
acinar cells of mucous glands
Manually annotated by BRENDA team
-
levels of tissue DPP-4 are reduced in nasal tissue of human subjects with chronic rhinosinusitis
Manually annotated by BRENDA team
the enzyme is coexpressed with fibroblast activation protein in adult humans
Manually annotated by BRENDA team
-
from cord blood
Manually annotated by BRENDA team
-
malt from green barley
Manually annotated by BRENDA team
-
neuroectodermal, melanoma cell line, proliferating and quiescent populations
Manually annotated by BRENDA team
-
squamous lung carcinoma, enzymic activity is restricted to the connective tissue stroma surrounding the dipeptidyl peptidase IV-negative tumor foci
Manually annotated by BRENDA team
-
CEM, C8166, Molt4/C8, MT-4
Manually annotated by BRENDA team
-
in contrast to the normal cornea where DPPIV activity is absent and the tear fluid where it is low, during continuous wearing of contact lenses or repeated irradiation of the cornea with UVB rays, slight DPPIV activity appeared first in the superficial layers of the corneal epithelium, while later increased activity is present in the whole epithelium.This parallels elevated DPPIV activity in the tear fluid
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
neuroectodermal glioma cell line, proliferating and quiescent populations
Manually annotated by BRENDA team
-
neuroectodermal cell line, low activity in proliferating population, quiescent population
Manually annotated by BRENDA team
-
neuroectodermal glioma cell line, proliferating and quiescent populations
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
in vein DPIV represents 80% of the total Gly-L-Pro-4-nitroanilide-hydrolyzing activity
Manually annotated by BRENDA team
additional information