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3.4.14.5: dipeptidyl-peptidase IV

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase IV, go to the full flat file.

Word Map on EC 3.4.14.5

Reaction

release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline =

Synonyms

(GLP1)-degrading enzyme, ACT3, ADA binding protein, ADA-binding protein, ADABP, adenosine deaminase binding protein, Adenosine deaminase complexing protein, adenosine deaminase-binding protein, amino acyl-prolyl dipeptidyl aminopeptidase, aminopeptidase, glycylproline, Bile canaliculus domain-specific membrane glycoprotein, CD26, CD26 peptidase, CD26/dipeptidyl peptidase, CD26/DP IV, DAP IV, DapB, dapUm, dipeptidyl aminopeptidase IV, dipeptidyl dipeptidase IV, dipeptidyl peptidase 4, dipeptidyl peptidase 8, dipeptidyl peptidase 9, dipeptidyl peptidase IV, dipeptidyl peptidase-4, dipeptidyl peptidase-IV, dipeptidyl-aminopeptidase IV, dipeptidyl-peptidase 4, dipeptidyl-peptidase IV (CD26), dipeptidyl-peptide hydrolase, dipeptidylpeptidase 4a, dipeptidylpeptidase 4b, dipeptidylpeptidase IV, dipeptidylpeptidase IV/CD26, dipeptidylpeptidase-IV, DP IV, DP-IV, DPIV, DPP, DPP IV, DPP IV/CD26, DPP-4, DPP-IV, DPP4, DPP8, DPP9, DPPIV, DppIVA, DppIVB, glucagon-like peptide 1-degrading enzyme, Gly-Pro-naphthylamidase, glycoprotein GP110, glycylproline aminopeptidase, glycylproline-dipeptidyl-aminopeptidase, glycylprolyl aminopeptidase, glycylprolyl dipeptidylaminopeptidase, GP110 glycoprotein, h-DPPIV, hDPPIV, leukocyte antigen CD26, lymphocyte, antigen CD26, More, omega DPPIV, omega enzyme, omega gene product, Pep X, peptidase, dipeptidyl, IV, PepX, postproline dipeptidyl aminopeptidase IV, prolyl-dipeptidyl-aminopeptidase, sipeptidyl peptidase IV, T cell triggering molecule Tp103, T-cell activation antigen CD26, THAM, Thymocyte-activating molecule, TP103, type IV dipeptidyl aminopeptidase, WC10, X-PDAP, X-prolyl dipeptidyl aminopeptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro-dipeptidyl-aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.5 dipeptidyl-peptidase IV

KM Value

KM Value on EC 3.4.14.5 - dipeptidyl-peptidase IV

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.82 - 1
Ala-Ala-2-naphthylamide
2.74
Ala-Ala-4-nitroanilide
-
pH 7.6, 30°C, recombinant soluble enzyme
0.75
Ala-Pro-4-nitroanilide
-
pH 7.5, 37°C
0.00034 - 0.022
Ala-Pro-7-amido-4-methylcoumarin
0.0148 - 0.0172
Ala-Pro-7-amido-4-trifluoromethyl coumarin
0.013 - 0.015
Ala-Pro-7-amido-4-trifluoromethylcoumarin
0.0375
amyloid beta40
-
pH 7.4, 37°C
-
0.138
amyloid beta42
-
pH 7.4, 37°C
-
0.00009
Arg-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
0.05
Arg-Pro-Lys-Pro
-
-
0.15
Arg-Pro-Lys-Pro-Gln-Gln-Phe
-
-
0.18
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly
-
-
0.3
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
-
-
0.00324
Asn-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
0.00888
Asp-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
0.014
BRI peptide (1-23)
-
in 40 mM HEPES-buffer, pH 7.4, at 37°C
-
0.00138
Gln-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
0.714
Glu-Pro-4-nitroanilide
-
pH 7.5, 37°C
0.00298 - 0.457
Glu-Pro-7-amido-4-methylcoumarin
0.385
Gly-Ala-7-amido-4-methylcoumarin
-
-
5
Gly-L-Ala-2-naphthylamide
-
-
0.26
Gly-L-Pro-2-naphthylamide
-
-
0.076 - 0.3
Gly-L-Pro-4-nitroanilide
0.0194
Gly-L-Pro-7-amido-4-methylcoumarin
pH 8.0, 25°C
0.28
Gly-L-Pro-Gly-Gly
-
-
0.31
Gly-L-Pro-L-Ala
-
-
0.102
Gly-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.0013
Gly-L-Pro-rhodamine 110-(N-pentyl)maleimide
-
0.66
Gly-Pro-2-naphthylamide
-
-
0.17
Gly-Pro-3,5-dibromo-4-hydroxyanilide
-
-
0.018
Gly-Pro-4-methoxy-2-naphthylamide
-
-
0.5 - 1
Gly-Pro-4-methoxy-beta-naphthylamide
0.06 - 44.08
Gly-Pro-4-nitroanilide
0.00688 - 0.57
Gly-Pro-7-amido-4-methylcoumarin
0.159
Gly-Pro-glycinamide
-
-
0.05 - 3.1
Gly-Pro-p-nitroanilide
13.5
hemorphin-4
-
pH 8.0, 37°C, microsomes
6.4
hemorphin-5
-
pH 8.0, 37°C, microsomes
0.0387
hemorphin-7
-
pH 8.0, 37°C, microsomes
0.217
His-Pro-4-nitroanilide
-
pH 7.5, 37°C
0.00103
His-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
0.29
Hly-Pro-2-naphthylamide
-
-
0.0007
Ile-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
7.5
L-Ala-L-Ala-2-naphthylamide
-
-
2.5
L-Ala-L-Ala-L-Ala
-
-
0.06 - 0.4
L-Ala-L-Pro-4-nitroanilide
0.0147
L-Ala-L-Pro-7-amido-4-trifluoromethylcoumarin
-
in 100 mM Tris-HCl, pH 7.4
0.17
L-Ala-L-Pro-Gly
-
-
0.099 - 0.432
L-Ala-L-Pro-p-nitroanilide
0.014
L-Arg-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.337
L-Asn-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.524
L-Asp-L-Pro-6-aminoquinolide
-
purified CD26
1.244
L-Glu-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.24
L-Leu-L-Ala-2-naphthylamide
-
-
1.25
L-Leu-L-Leu-Gly
-
-
0.35
L-Leu-L-Leu-L-Leu
-
-
0.12
L-Leu-L-Pro-Gly-Gly
-
-
0.014 - 0.127
L-Leu-L-Pro-p-nitroanilide
0.2
L-Lys-L-Ala-2-naphthylamide
-
-
0.008 - 0.073
L-Lys-L-Pro-p-nitroanilide
0.018
L-Met-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.36
L-Phe-L-Pro-2-naphthylamide
-
-
0.189
L-Ser-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.00093
L-Thr-L-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
-
0.025
L-Val-L-Pro-6-aminoquinolide
-
purified CD26
0.03
L-Val-L-Pro-doxorubicin
-
purified CD26
0.056
L-Val-L-Pro-L-Val-L-Pro-Ara-A
-
purified CD26
0.00109 - 0.0092
Leu-Pro-7-amido-4-methylcoumarin
0.00374 - 0.231
Lys-Ala-7-amido-4-methylcoumarin
0.016
Lys-Pro-4-methoxy-2-naphthylamide
-
-
0.37
Lys-Pro-4-nitroanilide
-
pH 7.5, 37°C
0.000071 - 0.035
Lys-Pro-7-amido-4-methylcoumarin
0.09
Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
-
-
0.179
Met-Pro-4-nitroanilide
-
pH 7.5, 37°C
0.00217
Met-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
0.00058
N-(Ala-Pro)-N'-6-(3,4-dichloromaleimidyl)-hexanoyl-rhodamine 110
0.0038
N-(Gly-Pro)-N'-(4-chlorobutanoyl)-rhodamine 110
0.0011
N-(Gly-Pro)-N'-(4-chloromethyl)benzoyl-rhodamine 110
0.0015
N-(Gly-Pro)-N'-(5-bromopentanoyl)-rhodamine 110
0.0038
N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110
0.0027
N-(Gly-Pro)-N'-4-(maleimidyl)butanoyl-rhodamine 110
0.0174
N-(Gly-Pro)-N'-acetyl-rhodamine 110
0.0062
N-(Gly-Pro)-N'-chloroacetyl-rhodamine 110
0.125
N-tosyl-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
0.034
norleucine-Pro-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.035
norleucine-Pro-rhodamine
-
pH 7.5, 37°C
0.02
Phe-Ala-Pro-2-naphthylamide
-
-
0.019
Phe-Pro-2-naphthylamide
-
-
0.33
Phe-Pro-4-nitroanilide
-
pH 7.5, 37°C
0.00065 - 0.0124
Phe-Pro-7-amido-4-methylcoumarin
0.0011
Pro-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
0.217
Ser-Pro-4-nitroanilide
-
pH 7.5, 37°C
0.00126
Ser-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
0.00073
Tyr-Pro-7-amido-4-methylcoumarin
-
pH 7.2, 25°C
0.05
Tyr-Pro-Phe
-
-
0.05
Tyr-Pro-Phe-Pro
-
-
0.05
Tyr-Pro-Phe-Pro-Gly
-
-
0.025 - 0.05
Tyr-Pro-Phe-Val-Glu-Pro-Ile
additional information
additional information
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