3.4.14.5: dipeptidyl-peptidase IV

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase IV, go to the full flat file.

Reaction

release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline =

Synonyms

(GLP1)-degrading enzyme, ACT3, ADA binding protein, ADA-binding protein, ADABP, adenosine deaminase binding protein, Adenosine deaminase complexing protein, adenosine deaminase-binding protein, amino acyl-prolyl dipeptidyl aminopeptidase, aminopeptidase, glycylproline, Bile canaliculus domain-specific membrane glycoprotein, CD26, CD26 peptidase, CD26/dipeptidyl peptidase, CD26/DP IV, DAP IV, DapB, dapUm, dipeptidyl aminopeptidase IV, dipeptidyl dipeptidase IV, dipeptidyl peptidase 4, dipeptidyl peptidase 8, dipeptidyl peptidase 9, dipeptidyl peptidase IV, dipeptidyl peptidase-4, dipeptidyl peptidase-IV, dipeptidyl-aminopeptidase IV, dipeptidyl-peptidase 4, dipeptidyl-peptidase IV (CD26), dipeptidyl-peptide hydrolase, dipeptidylpeptidase 4a, dipeptidylpeptidase 4b, dipeptidylpeptidase IV, dipeptidylpeptidase IV/CD26, dipeptidylpeptidase-IV, DP IV, DP-IV, DPIV, DPP, DPP IV, DPP IV/CD26, DPP-4, DPP-IV, DPP4, DPP8, DPP9, DPPIV, DppIVA, DppIVB, glucagon-like peptide 1-degrading enzyme, Gly-Pro-naphthylamidase, glycoprotein GP110, glycylproline aminopeptidase, glycylproline-dipeptidyl-aminopeptidase, glycylprolyl aminopeptidase, glycylprolyl dipeptidylaminopeptidase, GP110 glycoprotein, h-DPPIV, hDPPIV, leukocyte antigen CD26, lymphocyte, antigen CD26, More, omega DPPIV, omega enzyme, omega gene product, Pep X, peptidase, dipeptidyl, IV, PepX, postproline dipeptidyl aminopeptidase IV, prolyl-dipeptidyl-aminopeptidase, sipeptidyl peptidase IV, T cell triggering molecule Tp103, T-cell activation antigen CD26, THAM, Thymocyte-activating molecule, TP103, type IV dipeptidyl aminopeptidase, WC10, X-PDAP, X-prolyl dipeptidyl aminopeptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro-dipeptidyl-aminopeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

                3.4.14.5 dipeptidyl-peptidase IV

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Results	in table
21	Activating Compound
3077	AA Sequence
114	Application
1	CAS Registry Number
36	Cloned(Commentary)
29	Crystallization (Commentary)
18706	Disease/ Diagnostics
11	Expression
13	General Information
9	General Stability
1445	IC50 Value
2534	Inhibitors
3	kcat/KM [mM/s]
247	Ki Value [mM]
200	KM Value [mM]
78	Localization
8	Metals/Ions
97	Molecular Weight [Da]
192	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
614	Organism
418	PDB ID
56	pH Optimum
13	pH Range
14	pH Stability
4	pI Value
51	Posttranslational Modification
56	Protein Variants
59	Purification (Commentary)
24	Reaction
1	Reaction Type
447	Reference
395	Source Tissue
46	Specific Activity [micromol/min/mg]
9	Storage Stability
806	Substrates and Products (Substrate)
77	Subunits
608	Synonyms
28	Temperature Optimum [°C]
6	Temperature Range [°C]
38	Temperature Stability [°C]
147	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.14.5 - dipeptidyl-peptidase IV

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.000013

(11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.00022

(11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.0013

(1R)-1-(4-bromophenyl)-2-(2,5-difluorophenyl)ethanamine

Homo sapiens

-

-

696624

0.000107

(1R)-1-[4-(3-chloropyridin-4-yl)phenyl]-2-(2,5-difluorophenyl)ethanamine

Homo sapiens

-

-

696624

0.000253

(1R)-2-(2,5-difluorophenyl)-1-(4-pyridin-4-ylphenyl)ethanamine

Homo sapiens

-

-

696624

0.0000055

(1R)-2-([(3R,4R)-4-amino-1-[1-(4-ethynylphenyl)ethyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile

Homo sapiens

P27487

-

678694

0.0000038

(1R)-2-([(3R,4R)-4-amino-1-[2-methyl-4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile

Homo sapiens

P27487

-

678694

0.000046

(1R)-2-([(3R,4R)-4-amino-1-[3-methyl-4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile

Homo sapiens

P27487

-

678694

0.0000035

(1R)-2-[[(3R,4R)-4-amino-1-(3,4-dihydro-2H-chromen-4-yl)pyrrolidin-3-yl]carbonyl]cyclopentanecarbonitrile

Homo sapiens

P27487

-

678694

0.000003

(1R)-2-[[(3R,4R)-4-amino-1-[1-[4-(1H-1,2,4-triazol-1-yl)phenyl]ethyl]pyrrolidin-3-yl]carbonyl]cyclopentanecarbonitrile

Homo sapiens

P27487

-

678694

0.00000021

(1R,2S)-1-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-3-cyclopentylidene-1-cyclopropyl-3-fluoropropan-2-aminium

Rattus norvegicus

-

-

678702

0.0000053

(1R,3S)-2-([(3R,4R)-4-amino-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)-3-fluorocyclopentanecarbonitrile

Homo sapiens

P27487

-

678694

0.00032

(1R,4R,6S,10S)-6,10-dihydroxy-4-methyl-2-oxabicyclo[4.3.1]dec-7-ene-8-carboxylic acid

Homo sapiens

-

pH 8.0, 37°C

679650

0.000048

(1S)-1-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethanaminium

Homo sapiens

P27487

0% human serum

678662

0.000039 - 0.000073

(1S)-1-cyclohexyl-2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethanamine

2 entries

0.00017

(1S)-1-cyclohexyl-2-(3-fluoropyrrolidin-1-yl)-2-oxoethanamine

Homo sapiens

-

pH 8.0, 37°C

679650

0.00011

(1S)-1-cyclohexyl-2-oxo-2-(3,3,4,4-tetrafluoropyrrolidin-1-yl)ethanamine

Homo sapiens

-

pH 8.0, 37°C

679650

0.000012

(1S,2R)-1-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-3-cyclopentylidene-1-cyclopropyl-3-fluoropropan-2-aminium

Rattus norvegicus

-

-

678702

0.000021

(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine

Homo sapiens

-

-

697519

0.00000019

(1S,2S)-1-(4'-fluorobiphenyl-4-yl)-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxo-1-(1H-tetrazol-1-yl)propan-2-amine

Homo sapiens

P27487

-

681506

0.000013

(1S,2S)-1-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopropyl-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxopropan-2-aminium

Rattus norvegicus

-

-

678702

0.0000034

(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile

Homo sapiens

-

-

702623

0.000023

(2R)-1-(2,4-dichlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.00000059

(2R)-1-(2,4-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.000082

(2R)-1-(2,4-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.00018

(2R)-1-(2,5-dichlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.00000027 - 0.00027

(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

2 entries

0.00013

(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(2-phenyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)butan-2-amine

Rattus norvegicus

-

-

678689

0.000065

(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(3-pyridin-4-yl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-2-amine

Rattus norvegicus

-

-

678666

0.00014

(2R)-1-(2,5-difluorophenyl)-4-oxo-4-[2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-2-amine

Rattus norvegicus

-

-

678689

0.000027

(2R)-1-(2,5-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000065

(2R)-1-(2,5-difluorophenyl)-4-[(4R)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678689

0.00019

(2R)-1-(2,5-difluorophenyl)-4-[(4S)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678689

0.00022

(2R)-1-(2,5-difluorophenyl)-4-[1-(2-methylpropyl)-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678689

0.00025

(2R)-1-(2,5-difluorophenyl)-4-[1-(4-fluorobenzyl)-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678689

0.00018

(2R)-1-(2,5-difluorophenyl)-4-[1-ethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678689

0.00015

(2R)-1-(2,5-difluorophenyl)-4-[1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678689

0.00028

(2R)-1-(2,5-difluorophenyl)-4-[2-(4-fluorophenyl)-1-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678689

0.00003

(2R)-1-(2,5-difluorophenyl)-4-[3-(2,5-difluorophenyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678666

0.00026

(2R)-1-(2,5-difluorophenyl)-4-[3-(2-methylpropyl)-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678689

0.00025

(2R)-1-(2,5-difluorophenyl)-4-[3-(4-fluorobenzyl)-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678689

0.00006

(2R)-1-(2,5-difluorophenyl)-4-[3-(4-fluorophenyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678666

0.00023

(2R)-1-(2,5-difluorophenyl)-4-[3-ethyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678689

0.00013

(2R)-1-(2,5-difluorophenyl)-4-[3-methyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine

Rattus norvegicus

-

-

678689

0.000084

(2R)-1-(2-chloro-4,5-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000145

(2R)-1-(2-chlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.00000093

(2R)-1-(2-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.000098

(2R)-1-(2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

2 entries

0.00000098

(2R)-1-(2-methylphenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.000002

(2R)-1-(3,4-dichlorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.00158

(2R)-1-(3,4-dichlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.0000017

(2R)-1-(3,4-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.000128

(2R)-1-(3,4-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000059

(2R)-1-(3-chlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000002

(2R)-1-(3-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.000135

(2R)-1-(3-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000076

(2R)-1-(4-chloro-2,5-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000003

(2R)-1-(4-chlorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.000264

(2R)-1-(4-chlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.0000031

(2R)-1-(4-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.000272

(2R)-1-(4-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000011

(2R)-1-(4-iodophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.0000015

(2R)-1-(4-nitrophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.000021

(2R)-1-(5-chloro-2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000033

(2R)-1-cyclohexyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.021

(2R)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium

Homo sapiens

-

pH 2

681306

0.00144

(2R)-4-(1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.00035

(2R)-4-(2-benzoylpyrazolidin-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678659

0.000071

(2R)-4-(2-cyclopropyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678691

0.00003

(2R)-4-(3-cyclopropyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678666

0.000037

(2R)-4-(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678666

0.00003

(2R)-4-(3-methyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678634

0.0034

(2R)-4-(4-acetyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.000387

(2R)-4-(4-benzyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.0064

(2R)-4-(4-ethyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.0001

(2R)-4-(5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678691

0.00057

(2R)-4-oxo-1-(2,4,5-trifluorophenyl)-4-[1,4,4-trimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-2-amine

Rattus norvegicus

-

-

678689

0.001018

(2R)-4-oxo-1-(pentafluorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000003

(2R)-4-oxo-1-phenyl-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.00004

(2R)-4-oxo-1-pyridin-2-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.000045

(2R)-4-oxo-1-pyridin-3-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.000051

(2R)-4-oxo-1-pyridin-4-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.00000012

(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-(3,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

681506

0.0000022

(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[2-(trifluoromethyl)phenyl]butan-2-amine

Homo sapiens

P27487

-

681506

0.0000036

(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[3-(trifluoromethyl)phenyl]butan-2-amine

Homo sapiens

P27487

-

681506

0.0000078

(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[4-(trifluoromethyl)phenyl]butan-2-amine

Homo sapiens

P27487

-

681506

0.000068

(2R)-4-oxo-4-(2-phenyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678691

0.000087

(2R)-4-oxo-4-(4-pyrazin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.000423

(2R)-4-oxo-4-(4-pyrimidin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.00385

(2R)-4-oxo-4-pyrazolidin-1-yl-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678659

0.000004

(2R)-4-oxo-4-[(8R)-2-(trifluoromethyl)-8-[4-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678691

0.00000031

(2R)-4-oxo-4-[(8R)-3-(trifluoromethyl)-8-[2-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000005

(2R)-4-oxo-4-[(8R)-8-(1H-1,2,4-triazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678691

0.0000057

(2R)-4-oxo-4-[(8R)-8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.0000004

(2R)-4-oxo-4-[(8R)-8-(pyridin-2-ylmethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

determination of the pharmacokinetic profile

681325

0.000032

(2R)-4-oxo-4-[(8R)-8-prop-2-en-1-yl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000438

(2R)-4-oxo-4-[(8S)-3-(trifluoromethyl)-8-[2-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000123

(2R)-4-oxo-4-[(8S)-8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000132

(2R)-4-oxo-4-[(8S)-8-(pyridin-2-ylmethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.0000015

(2R)-4-oxo-4-[(8S)-8-prop-2-en-1-yl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.00007

(2R)-4-oxo-4-[2-(phenylcarbonyl)-1,2-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

competitive

678659

0.00005

(2R)-4-oxo-4-[2-(phenylcarbonyl)tetrahydropyridazin-1(2H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

the inhibitor displays a greater than 1400fold selectivity over all the enzymes tested including DPP-8 and DPP-9

678659

0.000059

(2R)-4-oxo-4-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678691

0.000805

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,3,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678666

0.000151

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,3,6-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678666

0.000018

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

2 entries

0.000087

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,6-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678666

0.00486

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-[2-(trifluoromethyl)phenyl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000366

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-[3-(trifluoromethyl)phenyl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000511

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-[4-(trifluoromethyl)phenyl]butan-2-amine

Rattus norvegicus

-

-

678666

0.00051

(2R)-4-oxo-4-[4-(phenylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.00041

(2R)-4-oxo-4-[4-(pyridin-3-ylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.000004

(2R)-4-oxo-4-[8-(1H-pyrazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

mixture of diastereomers at position 9

678691

0.000019

(2R)-4-[(2R)-2-benzylpiperazin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

697519

0.00005

(2R)-4-[(4R)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00025

(2R)-4-[(4R)-2-cyclopropyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00037

(2R)-4-[(4R)-2-tert-butyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.0000058

(2R)-4-[(4R)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.0000084

(2R)-4-[(4R)-4-benzyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00011

(2R)-4-[(4R)-4-cyclopropyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00006

(2R)-4-[(4R)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00038

(2R)-4-[(4S)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00049

(2R)-4-[(4S)-2-cyclopropyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00063

(2R)-4-[(4S)-2-tert-butyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00078

(2R)-4-[(4S)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00057

(2R)-4-[(4S)-4-benzyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00034

(2R)-4-[(4S)-4-cyclopropyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00061

(2R)-4-[(4S)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.000014

(2R)-4-[(5R)-5-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

determination of the pharmacokinetic profile

681325

0.000023

(2R)-4-[(5S)-5-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000042

(2R)-4-[(6R)-6-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000091

(2R)-4-[(6S)-6-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.00000046

(2R)-4-[(8R)-8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

determination of the pharmacokinetic profile

681325

0.000004

(2R)-4-[(8R)-8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678691

0.00000018

(2R)-4-[(8R)-8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

determination of the pharmacokinetic profile

681325

0.00000043

(2R)-4-[(8R)-8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000007

(2R)-4-[(8R)-8-(cyclopropylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678691

0.00000066

(2R)-4-[(8R)-8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000005

(2R)-4-[(8R)-8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000025

(2R)-4-[(8R)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678691

0.0000043

(2R)-4-[(8R)-8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

determination of the pharmacokinetic profile

681325

0.000011 - 0.000018

(2R)-4-[(8R)-8-[(1-fluorocyclopropyl)methyl]-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

2 entries

0.0000063

(2R)-4-[(8R)-8-[3,5-bis(trifluoromethyl)benzyl]-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

determination of the pharmacokinetic profile

681325

0.000131

(2R)-4-[(8S)-8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000116

(2R)-4-[(8S)-8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.00032

(2R)-4-[(8S)-8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.00014

(2R)-4-[(8S)-8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000113

(2R)-4-[(8S)-8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000274

(2R)-4-[(8S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678691

0.000088

(2R)-4-[(8S)-8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000587

(2R)-4-[(8S)-8-[3,5-bis(trifluoromethyl)benzyl]-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000045

(2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

2 entries

0.0005

(2R)-4-[2-[(4-methylphenyl)sulfonyl]pyrazolidin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

678659

0.000029

(2R)-4-[3-(difluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678666

0.00049

(2R)-4-[4-(1,3-benzodioxol-5-ylcarbonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride

Homo sapiens

P27487

-

696651

0.0000058

(2R)-4-[4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

697519

0.0031

(2R)-4-[4-(methylsulfonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.00035

(2R)-4-[4-[(4-methylphenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.0015

(2R)-4-[4-[(4-methylpiperazin-1-yl)carbonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.000405

(2R)-4-[4-[(4-nitrophenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

P27487

-

696651

0.000092

(2R)-4-[5,5-dimethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000175

(2R)-4-[8,8-dimethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

681325

0.000002

(2R)-4-[8-(1H-imidazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

mixture of diastereomers at position 8

678691

0.000004

(2R)-4-[8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

697519

0.00000018

(2R)-4-[8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

697519

0.000025

(2R)-4-[8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

697519

0.0000043

(2R)-4-[8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

697519

0.0044

(2R,3R)-1-(2,5-difluorophenyl)-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine

Homo sapiens

-

-

696624

0.0006

(2R,3R)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

696624

0.000046

(2R,3R)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

696624

0.00011

(2R,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.0000016

(2R,3S)-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N1,N1-dimethyl-4-oxobutane-1,3-diamine

Homo sapiens

P27487

-

681506

0.000093

(2R,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluoro-5-hydroxypentan-2-aminium

Rattus norvegicus

-

-

678702

0.00938

(2R,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.00005

(2R,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.00513

(2R,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.000032

(2R,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.01059

(2R,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.00027

(2R,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.00099

(2R,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.00007

(2R,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.000016

(2R,4R)-2-(dihydroxyboranyl)-4-hydroxypyrrolidin-1-yl (4S)-4-hydroxy-L-prolinate

Homo sapiens

-

pH 7.8, temperature not specified in the publication

731436

0.0003

(2R,4R)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

IC50 above 0.0003 mM

697297

0.0003

(2R,4R)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

IC50 above 0.0003 mM

697297

0.0003

(2R,4S)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

IC50 above 0.0003 mM

697297

0.000246

(2R,4S)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.000047

(2S)-1-(3-furyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.000017

(2S)-1-(5-morpholin-4-yl-5-oxo-L-norvalyl)pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000015

(2S)-1-(5-oxo-5-piperidin-1-yl-L-norvalyl)pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000007

(2S)-1-(5-oxo-5-pyrrolidin-1-yl-L-norvalyl)pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000027

(2S)-1-([(2S,4S)-4-[(2E)-but-2-en-1-yl]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.00000013

(2S)-1-([(2S,4S)-4-[(3-chloro-4-cyanophenyl)amino]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697519

0.00001

(2S)-1-([(3R,4R)-4-amino-1-[4-(1,2,3-thiadiazol-4-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile

Homo sapiens

P27487

-

678694

0.00001

(2S)-1-([(3R,4R)-4-amino-1-[4-(1-methyl-1H-pyrazol-4-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile

Homo sapiens

P27487

-

678694

0.0000032

(2S)-1-([(3R,4R)-4-amino-1-[4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile

Homo sapiens

P27487

-

678694

0.0000067

(2S)-1-([(3R,4R)-4-amino-1-[4-(1H-pyrazol-5-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile

Homo sapiens

P27487

-

678694

0.0000054

(2S)-1-([(3R,4R)-4-amino-1-[4-(2H-1,2,3-triazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile

Homo sapiens

P27487

-

678694

0.0000053

(2S)-1-([(3R,4R)-4-amino-1-[4-(3-methyl-1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile

Homo sapiens

P27487

-

678694

0.0000085

(2S)-1-([(3R,4R)-4-amino-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile

Homo sapiens

P27487

-

678694

0.000071

(2S)-1-([[2-methyl-4-oxo-4-(pyrrolidin-1-yl)butan-2-yl]amino]acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.000028

(2S)-1-cyclopentyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.003653

(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxo-3-phenylpropan-2-amine

Homo sapiens

-

-

678693

0.003257

(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxohexan-2-amine

Homo sapiens

-

-

678693

0.000356

(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3,3-dimethyl-1-oxobutan-2-amine

Homo sapiens

-

-

678693

0.000877

(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-(4-chlorophenyl)-1-oxopropan-2-amine

Homo sapiens

-

-

678693

0.001065

(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxobutan-2-amine

Homo sapiens

-

-

678693

0.000112

(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4-methyl-3-(1-methylethyl)-1-oxopentan-2-amine

Homo sapiens

-

-

678693

0.00000054 - 0.0014

(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium

2 entries

0.000298

(2S)-1-[(2S)-2-amino-4-(1,3-dihydro-2H-isoindol-2-yl)-4-oxobutanoyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.00001

(2S)-1-[(2S)-2-amino-6-(1,3-dihydro-2H-isoindol-2-yl)-6-oxohexanoyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.00002

(2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile

2 entries

0.000031

(2S)-1-[(2S,3R)-2-amino-3-ethyl-5-oxo-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]pentanoyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.0098

(2S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

-

-

696624

0.000047

(2S)-1-[(4R)-4-tricyclo[3.3.1.13,7]dec-2-yl-L-prolyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.000984

(2S)-1-[(4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5,5-dimethyl-L-prolyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678634

0.000011

(2S)-1-[(4S)-4-(azocan-1-ylcarbonyl)-L-prolyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.000008

(2S)-1-[([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)acetyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697526

0.000018

(2S)-1-[([4-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.0187

(2S)-1-[3-([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)propanoyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697526

0.000031

(2S)-1-[3-methyl-5-oxo-5-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-L-alloisoleucyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000012

(2S)-1-[3-methyl-5-oxo-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-L-alloisoleucyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000013

(2S)-1-[3-methyl-5-[(2R)-2-methylpyrrolidin-1-yl]-5-oxo-L-alloisoleucyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000012

(2S)-1-[5-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-5-oxo-L-alloisoleucyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000002

(2S)-1-[5-(1,3-dihydro-2H-isoindol-2-yl)-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000016

(2S)-1-[5-(3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-5-oxo-L-alloisoleucyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000005

(2S)-1-[5-(3,4-dihydroisoquinolin-2(1H)-yl)-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000025

(2S)-1-[5-(4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl)-3-methyl-5-oxo-L-alloisoleucyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000006

(2S)-1-[5-(4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl)-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000007

(2S)-1-[5-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.00001

(2S)-1-[5-oxo-5-(1,3-thiazolidin-3-yl)-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000019

(2S)-1-[5-oxo-5-(4-pyridin-4-ylpiperazin-1-yl)-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000006

(2S)-1-[5-oxo-5-[2-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000009

(2S)-1-[5-oxo-5-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000008

(2S)-1-[5-oxo-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-L-alloisoleucyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000005

(2S)-1-[5-oxo-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000008

(2S)-1-[5-oxo-5-[4-(trifluoroacetyl)piperazin-1-yl]-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000014

(2S)-1-[5-[(2R)-2-(methoxyamino)pyrrolidin-1-yl]-3-methyl-5-oxo-L-alloisoleucyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000022

(2S)-1-[5-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000007

(2S)-1-[5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.00004

(2S)-1-[5-[2-(4-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000035

(2S)-1-[5-[6,7-dimethoxy-1-(1-methylethyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile

Rattus norvegicus

-

-

696668

0.000015

(2S)-1-[N-[3-(1,3-dihydro-2H-isoindol-2-yl)-1,1-dimethyl-3-oxopropyl]glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678634

0.000015

(2S)-1-[N-[4-(1,3-dihydro-2H-isoindol-2-yl)-2-methyl-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.000003

(2S)-1-[[(1R,3S,5R,7R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697519

0.000013

(2S)-1-[[(1R,5R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697519

0.000091

(2S)-1-[[(2S,4R)-4-(2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000089

(2S)-1-[[(2S,4R)-4-(2-ethyl-4-hydroxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000038

(2S)-1-[[(2S,4R)-4-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.0000091

(2S)-1-[[(2S,4R)-4-(2-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000053

(2S)-1-[[(2S,4R)-4-(3-hydroxy-2,4,6-trimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.000022

(2S)-1-[[(2S,4R)-4-(3-hydroxy-2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000049 - 0.0000071

(2S)-1-[[(2S,4R)-4-(3-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

2 entries

0.0000039

(2S)-1-[[(2S,4R)-4-(3-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.000023

(2S)-1-[[(2S,4R)-4-(4-hydroxy-2,6-dimethoxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000033

(2S)-1-[[(2S,4R)-4-(4-hydroxy-2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000083

(2S)-1-[[(2S,4R)-4-(4-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.000025

(2S)-1-[[(2S,4R)-4-(4-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.000038

(2S)-1-[[(2S,4R)-4-cyclohexylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.00006

(2S)-1-[[(2S,4R)-4-phenylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000017

(2S)-1-[[(2S,4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678634, 697519

0.0000083

(2S)-1-[[(2S,4S)-4-(azepan-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.000004

(2S)-1-[[(2S,4S)-4-(azetidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.0000063

(2S)-1-[[(2S,4S)-4-(hydroxymethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.0000043

(2S)-1-[[(2S,4S)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.0000049

(2S)-1-[[(2S,4S)-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.0000056

(2S)-1-[[(2S,4S)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.0000048

(2S)-1-[[(2S,4S)-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.0000035 - 0.000038

(2S)-1-[[(2S,4S)-4-allylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

2 entries

0.00004

(2S)-1-[[(2S,4S)-4-isobutylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.000017

(2S)-1-[[(2S,4S)-4-phenylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000034 - 0.00005

(2S)-1-[[(2S,4S)-4-propylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

2 entries

0.0000056

(2S)-1-[[(2S,4S,5S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.000013

(2S)-1-[[(2S,4S,5S)-4-(azetidin-1-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.00002

(2S)-1-[[(2S,4S,5S)-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.000013

(2S)-1-[[(2S,4S,5S)-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.0000065

(2S)-1-[[(2S,4S,5S)-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.0000062

(2S)-1-[[(2S,4S,5S)-5-methyl-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.000051

(2S)-1-[[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678634

0.000051

(2S)-1-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.0000033 - 0.0000036

(2S)-1-[[(3R,4R)-4-amino-1-(3-cyano-4-fluorobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile

2 entries

0.0000013

(2S)-1-[[(3R,4R)-4-amino-1-(4-cyano-3-methylbenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697519

0.0000024

(2S)-1-[[(3R,4R)-4-amino-1-(4-cyanobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

P27487

-

678694

0.0000062

(2S)-1-[[(3R,4R)-4-amino-1-(quinolin-3-ylmethyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

P27487

-

678694

0.0000000095

(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2,5-difluoro-4-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.00000000083

(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.0000003

(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-5-(trifluoromethoxy)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.000000012

(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-5-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.0000000003

(2S)-2-(4-[[([(4R)-3-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.0000072

(2S)-2-[2-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.00000048

(2S)-2-[4-[([1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid

Homo sapiens

-

-

697519

0.000000013

(2S)-2-[4-[([1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.00000000048

(2S)-2-[4-[([1-[(3S)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.0000000017

(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-chloro-4-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.0000000018

(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.000000012 - 0.000000081

(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]propanoic acid

2 entries

0.0000000016

(2S)-2-[4-[([1-[(3S)-3-amino-4-(3,4-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.0000000016

(2S)-2-[4-[([1-[(3S)-3-amino-4-(5-chloro-2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.000000033

(2S)-2-[4-[([1-[(3S)-3-amino-4-(5-fluoro-2-methylphenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.0000000081

(2S)-2-[4-[([1-[(3S)-3-amino-4-(pentafluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.000000018

(2S)-2-[4-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid

Homo sapiens

P27487

-

681506

0.00000098

(2S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-amine

Homo sapiens

P27487

-

681506

0.000021

(2S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluoropropan-2-aminium

Rattus norvegicus

-

-

678702

0.0016

(2S)-5-(1,3-dihydro-2H-isoindol-2-yl)-1,5-dioxo-1-(1,3-thiazolidin-3-yl)pentan-2-amine

Rattus norvegicus

-

-

696668

0.00149

(2S,3R)-1-cyclopentylidene-1-fluoro-3-(3-[4-[(trifluoromethyl)sulfonyl]phenyl]-1,2,4-oxadiazol-5-yl)butan-2-aminium

Rattus norvegicus

-

-

678702

0.00009

(2S,3R)-1-cyclopentylidene-1-fluoro-3-[3-[4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-aminium

Rattus norvegicus

-

-

678702

0.001165

(2S,3R)-1-cyclopentylidene-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-fluorobutan-2-aminium

Rattus norvegicus

-

-

678702

0.000731

(2S,3R)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxopentan-2-amine

Homo sapiens

-

-

678693

0.000057

(2S,3R)-3-(3-[2-chloro-4-[(methylsulfonyl)amino]phenyl]-1,2,4-oxadiazol-5-yl)-1-cyclopentylidene-1-fluorobutan-2-aminium

Rattus norvegicus

-

-

678702

0.000645

(2S,3R)-3-[3-(4-bromo-2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluorobutan-2-aminium

Rattus norvegicus

-

-

678702

0.00005

(2S,3R)-3-[3-[2-chloro-4-(ethylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluorobutan-2-aminium

Rattus norvegicus

-

-

678702

0.0000032

(2S,3R)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluoro-5-hydroxypentan-2-aminium

Rattus norvegicus

-

-

678702

0.0000075

(2S,3R)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluorobutan-2-aminium

Rattus norvegicus

-

-

678702

0.000525

(2S,3R)-3-[3-[2-chloro-4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluorobutan-2-aminium

Rattus norvegicus

-

-

678702

0.0011

(2S,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.0018

(2S,3S)-1-oxo-1-pyrrolidin-1-yl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine

Homo sapiens

-

-

696624

0.00011

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-(4-pyridin-4-ylphenyl)butan-2-amine

Homo sapiens

-

-

696624

0.0000014

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-phenylbutan-2-amine

Homo sapiens

P27487

-

681506

0.00000013

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[2'-(trifluoromethyl)biphenyl-4-yl]butan-2-amine

Homo sapiens

P27487

-

681506

0.000000098

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-1,2,4-triazol-3-yl)biphenyl-4-yl]butan-2-amine

Homo sapiens

P27487

-

681506

0.00000014

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-tetrazol-1-yl)biphenyl-4-yl]butan-2-amine

Homo sapiens

P27487

-

681506

0.000000006

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-tetrazol-5-yl)biphenyl-4-yl]butan-2-amine

Homo sapiens

P27487

-

681506

0.00000051

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4'-(trifluoromethyl)biphenyl-4-yl]butan-2-amine

Homo sapiens

P27487

-

681506

0.0000006

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-(trifluoromethyl)phenyl]butan-2-amine

Homo sapiens

P27487

-

681506

0.00044 - 0.00347

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium

2 entries

0.00000011

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(2'-methoxybiphenyl-4-yl)-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000015

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(2'-methylbiphenyl-4-yl)-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000013

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4'-methoxybiphenyl-4-yl)-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000039

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4'-methylbiphenyl-4-yl)-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000078

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methoxyphenyl)-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.000027 - 0.000097

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl](methyl)amino]cyclohexyl)-1-oxobutan-2-aminium

2 entries

0.000074 - 0.00021

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl]amino]cyclohexyl)-1-oxobutan-2-aminium

2 entries

0.000000069

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3'-(1,3,4-oxadiazol-2-yl)biphenyl-4-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000011

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3'-(methylsulfonyl)biphenyl-4-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000042

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4'-(methylsulfonyl)biphenyl-4-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000036

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(methylthio)phenyl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.000054

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00053

(2S,3S)-2-amino-1-((1S,5S)-2-azabicyclo[3.1.0]hexan-2-yl)-3-methylpentan-1-one

Homo sapiens

-

-

678693

0.000000037

(2S,3S)-3-(2',4'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000015

(2S,3S)-3-(2',5'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.000000085

(2S,3S)-3-(2'-chlorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.0000001

(2S,3S)-3-(2'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.0000042

(2S,3S)-3-(2,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.000002

(2S,3S)-3-(2-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.0000011

(2S,3S)-3-(2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000006

(2S,3S)-3-(3',4'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000024

(2S,3S)-3-(3',5'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.0000011

(2S,3S)-3-(3,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.0000037

(2S,3S)-3-(3,5-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.0000028

(2S,3S)-3-(3-chloro-4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.0000011

(2S,3S)-3-(3-chlorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.0000037

(2S,3S)-3-(3-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.0000000091

(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-pyrrolidin-1-ylbutan-2-amine

Homo sapiens

P27487

-

681506

0.0000035

(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-5-pyrrolidin-1-ylpentan-2-amine

Homo sapiens

P27487

-

681506

0.000000065 - 0.000064

(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

2 entries

0.000064

(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Homo sapiens

P27487

-

678662

0.00000025 - 0.000245

(2S,3S)-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

2 entries

0.00000048

(2S,3S)-3-(4-chloro-2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000028

(2S,3S)-3-(4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00046 - 0.00149

(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

2 entries

0.00033 - 0.00051

(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

2 entries

0.00016 - 0.0003

(2S,3S)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

2 entries

0.000000013

(2S,3S)-3-amino-2-(2',4'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000056

(2S,3S)-3-amino-2-(2',5'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000021

(2S,3S)-3-amino-2-(3',4'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000043

(2S,3S)-3-amino-2-(3'-ethynylbiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.00000003

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3R)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.00000039

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-1-ol

Homo sapiens

P27487

-

681506

0.00000011

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.0000000066

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoic acid

Homo sapiens

P27487

-

681506

0.000000068

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N',N'-dimethyl-4-oxobutanehydrazide

Homo sapiens

P27487

-

681506

0.000000012

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.0000001

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(1-methylethyl)-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000093

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(2-hydroxyethyl)-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000045

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methoxy-N-methyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000037

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.00000052

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-morpholin-4-yl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.0000000091

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-(1,3-thiazolidin-3-yl)butanamide

Homo sapiens

P27487

-

681506

0.00000055

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-piperidin-1-ylbutanamide

Homo sapiens

P27487

-

681506

0.0000000074

(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide

Homo sapiens

P27487

-

681506

0.00000023

(2S,3S)-3-amino-4-(1,1-dioxido-1,3-thiazolidin-3-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000029

(2S,3S)-3-amino-4-(3,3-difluoroazetidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000027

(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.0000088

(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)butanamide

Homo sapiens

-

-

697519

0.0000048

(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(trans-4-[1,2,4]triazolo[1,5-a]pyridin-6-ylcyclohexyl)butanamide

Homo sapiens

-

-

697519

0.000000017

(2S,3S)-3-amino-4-(3-fluoroazetidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.0000001

(2S,3S)-3-amino-4-aziridin-1-yl-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000021

(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000019

(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyridin-3-ylphenyl)butanamide

Homo sapiens

P27487

-

681506

0.00000002

(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyridin-4-ylphenyl)butanamide

Homo sapiens

P27487

-

681506

0.0000000022

(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[3'-(2H-tetrazol-2-yl)biphenyl-4-yl]butanamide

Homo sapiens

P27487

-

681506

0.000000059

(2S,3S)-3-amino-N,N-diethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000011

(2S,3S)-3-amino-N-(3,4-dihydro-2H-tetrazol-2-yl)-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.000000071

(2S,3S)-3-amino-N-cyclopropyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.00000011

(2S,3S)-3-amino-N-ethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.00000002

(2S,3S)-3-amino-N-ethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide

Homo sapiens

P27487

-

681506

0.00000012

(2S,3S)-3-biphenyl-4-yl-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.00000014

(2S,3S)-3-[3'-(5-cyclopropyl-2,3-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.000203

(2S,3S)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-oxo-1-pyrrolidin-1-ylbutan-2-aminium

Rattus norvegicus

-

-

678702

0.000615

(2S,3S)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

-

-

696624

0.000017

(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-oxo-1-pyrrolidin-1-ylbutan-2-aminium

Rattus norvegicus

-

-

678702

0.00004

(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

-

-

696624

0.00004

(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Rattus norvegicus

-

-

678702

0.00007

(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-5-hydroxy-1-oxopentan-2-aminium

Rattus norvegicus

-

-

678702

0.000122

(2S,3S)-3-[3-[4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-oxo-1-pyrrolidin-1-ylbutan-2-aminium

Rattus norvegicus

-

-

678702

0.000071

(2S,3S)-3-[4-(3-chloropyridin-4-yl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

-

-

696624

0.0006

(2S,3S)-3-[4-(acetylamino)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Homo sapiens

P27487

-

678662

0.000022 - 0.000047

(2S,3S)-3-[4-[(cyclopropylcarbonyl)(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

2 entries

0.000016 - 0.00004

(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

2 entries

0.000029 - 0.00019

(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

2 entries

0.00021

(2S,3S)-3-[4-[acetyl(methyl)amino]phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Homo sapiens

P27487

-

678662

0.00015

(2S,3S)-3-[4-[acetyl(methyl)amino]phenyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

-

678662

0.00036 - 0.00128

(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium

2 entries

0.00087

(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-[(phenylsulfonyl)amino]phenyl]butan-2-aminium

Homo sapiens

P27487

-

678662

0.000025

(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[methyl[(4-methylphenyl)carbonyl]amino]phenyl)-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

-

678662

0.00043

(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[methyl[(4-methylphenyl)sulfonyl]amino]phenyl)-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

-

678662

0.000012

(2S,3S)-4-(dimethylamino)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

-

678662

0.000022 - 0.0002

(2S,3S)-4-(dimethylamino)-3-(4-[[(3-fluorophenyl)carbonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

4 entries

0.000028

(2S,3S)-4-(dimethylamino)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

-

678662

0.000000044

(2S,3S)-4-azetidin-1-yl-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-amine

Homo sapiens

P27487

-

681506

0.000019

(2S,3S)-4-cyclopropyl-3-[3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Rattus norvegicus

-

-

678702

0.0000046

(2S,3S)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

697519

0.000142

(2S,3S,11bS)-3-(1,1-dioxido-1,2-thiazinan-2-yl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Rattus norvegicus

-

-

703377

0.0000017

(2S,3S,11bS)-3-(2,5-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

702611

0.00373

(2S,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.000004 - 0.0000042

(2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

2 entries

0.000038

(2S,3S,11bS)-3-(3-cyclopropylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

702611

0.000061

(2S,3S,11bS)-3-(3-ethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

702611

0.00052

(2S,3S,11bS)-3-butyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-pyrido[2,1-a]isoquinoline-2,11b-diamine

Homo sapiens

-

pH 8.0, 37°C

679650

0.0000005

(2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

702611

0.0000012

(2S,3S,11bS)-3-[4-(fluoromethyl)pyridin-2-yl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

702611

0.00065

(2S,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.000004 - 0.0000046

(2S,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

2 entries

0.00037

(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.000019

(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylpyridin-2-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

702611

0.0002

(2S,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664, 702611

0.00152

(2S,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.0055

(2S,3S,11bS)-9,10-dimethoxy-3-[3-(propan-2-yl)phenyl]-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

702611

0.000016

(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-2-ethyl-N,N-dimethylpyrrolidine-3-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.00001

(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide

2 entries

0.000015

(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N,2-dimethylpyrrolidine-3-carboxamide

Homo sapiens

-

-

678597

0.000042

(2S,4R)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.000006

(2S,4R)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.0000006

(2S,4S)-1-((2S)-2-amino-3-methylpentanoyl)-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.0000041

(2S,4S)-1-(N-1-adamantylglycyl)-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000031

(2S,4S)-1-(N-2-adamantylglycyl)-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000031

(2S,4S)-1-(N-cyclobutylglycyl)-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000033

(2S,4S)-1-(N-cyclooctylglycyl)-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000026

(2S,4S)-1-(N-cyclopentylglycyl)-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.000033

(2S,4S)-1-(N-cyclopropylglycyl)-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000027

(2S,4S)-1-(N-[2-[(5-chloropyridin-2-yl)amino]ethyl]-glycyl)-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000021

(2S,4S)-1-(O-benzyl-L-threonyl)-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.0000012

(2S,4S)-1-L-alloisoleucyl-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.0000011

(2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.000015

(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.0000029

(2S,4S)-1-[N-(tert-butyl)glycyl]-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.000016

(2S,4S)-1-[N-[(2E)-1,1-dimethyl-3-phenylprop-2-en-1-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.000088

(2S,4S)-1-[N-[1-(1-benzofuran-2-yl)-1-methylethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.000027

(2S,4S)-1-[N-[2-(3,4-dimethoxyphenyl)ethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.000252

(2S,4S)-1-[N-[2-(diethylamino)-1,1-dimethylethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.000018

(2S,4S)-1-[N-[4-(3,6-dihydropyridin-1(2H)-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.000066

(2S,4S)-1-[N-[4-(7-azabicyclo[2.2.1]hept-7-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.00016

(2S,4S)-1-[N-[4-(azepan-1-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.0000049

(2S,4S)-1-[O-(tert-butyl)-L-threonyl]-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.0000025

(2S,4S)-1-[[(3S)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]-4-fluoropyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.0003

(2S,4S)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

IC50 above 0.0003 mM

697297

0.0000006

(2S,4S)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.0000078

(2S,4S)-4-fluoro-1-(N-isopropylglycyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0001

(2S,4S)-4-fluoro-1-(N-methyl-L-isoleucyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

IC50 above 0.0001 mM

697297

0.000032

(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[(2R)-2-methylpyrrolidin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.000024

(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[4-(methylsulfonyl)piperazin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.000039

(2S,4S)-4-fluoro-1-(N-[2-[(4-cyanobenzyl)amino]-1,1-dimethylethyl]glycyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000011

(2S,4S)-4-fluoro-1-(N-[2-[(5-cyanopyridin-2-yl)-amino]ethyl]glycyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.000024

(2S,4S)-4-fluoro-1-(N-[4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.0000047

(2S,4S)-4-fluoro-1-(O-methyl-L-threonyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.000027

(2S,4S)-4-fluoro-1-([[2-methyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-yl]amino]acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.0000007

(2S,4S)-4-fluoro-1-L-valyl-pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.0000008

(2S,4S)-4-fluoro-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.0000022

(2S,4S)-4-fluoro-1-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-ylcarbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.000039

(2S,4S)-4-fluoro-1-[([4-[(3R)-3-fluoropyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.00003

(2S,4S)-4-fluoro-1-[([4-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.00005

(2S,4S)-4-fluoro-1-[([4-[(3S)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.000022

(2S,4S)-4-fluoro-1-[N-(1-methyl-1-pyridin-2-ylethyl)glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000046

(2S,4S)-4-fluoro-1-[N-(2-hydroxy-1,1-dimethylethyl)glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

potent and long-acting DPP-IV inhibitor and effective with single daily dosing

678622

0.000013

(2S,4S)-4-fluoro-1-[N-(2-methoxy-1,1-dimethylethyl)glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000031

(2S,4S)-4-fluoro-1-[N-(3-hydroxy-1-adamantyl)-glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000087

(2S,4S)-4-fluoro-1-[N-(3-isopropoxypropyl)glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000083

(2S,4S)-4-fluoro-1-[N-(3-methoxy-1-adamantyl)-glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000053

(2S,4S)-4-fluoro-1-[N-(5-hydroxy-2-adamantyl)-glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000086

(2S,4S)-4-fluoro-1-[N-[1-(2-furyl)-1-methylethyl]-glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000033

(2S,4S)-4-fluoro-1-[N-[1-(hydroxymethyl)cyclopentyl]glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.000012

(2S,4S)-4-fluoro-1-[N-[1-methyl-1-(2-thienyl)-ethyl]glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.0000028

(2S,4S)-4-fluoro-1-[N-[2-(pyridin-2-ylamino)ethyl]-glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678622

0.000093

(2S,4S)-4-fluoro-1-[N-[2-methyl-4-(4-methylpiperazin-1-yl)-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.00002

(2S,4S)-4-fluoro-1-[N-[2-methyl-4-(morpholin-4-yl)-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.000026

(2S,4S)-4-fluoro-1-[N-[2-methyl-4-oxo-4-(4-oxopiperidin-1-yl)butan-2-yl]glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.000027

(2S,4S)-4-fluoro-1-[N-[2-methyl-4-oxo-4-(piperidin-1-yl)butan-2-yl]glycyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

702623

0.0000012

(2S,4S)-4-fluoro-1-[[(3S)-7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.0000017

(2S,4S)-4-fluoro-1-[[(3S)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

697297

0.000011

(2S,4S,5S)-N-(cyanomethyl)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-N-ethyl-5-methylpyrrolidine-2-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.00006

(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methyl-N-prop-2-yn-1-ylpyrrolidine-2-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.0006

(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methyl-N-propylpyrrolidine-2-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.013

(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methylpyrrolidine-2-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.000025

(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-N,5-dimethylpyrrolidine-2-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.000056

(2S,4S,5S)-N-(cyanomethyl)-N-cyclopropyl-4-isobutyryl-5-methylpyrrolidine-2-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.000024

(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-4-isobutyryl-5-methylpyrrolidine-2-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.000024

(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidine-2-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.000017

(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidine-2-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.000016

(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidine-2-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.000041

(2S,4S,5S)-N-allyl-N-(cyanomethyl)-4-isobutyryl-5-methylpyrrolidine-2-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.000051

(2S,4S,5S)-N4-benzyl-N2-(cyanomethyl)-N2-ethyl-5-methylpyrrolidine-2,4-dicarboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.000121 - 0.000127

(3'S,5'S)-5'-(1,3-thiazolidin-3-ylcarbonyl)-1,3'-bipyrrolidine

2 entries

0.000338

(3,3-difluoro-pyrrolidin-1-yl)-[(2S,4R)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin)-2-yl]-methanone

Homo sapiens

P27487

-

696670

0.0000129

(3,3-difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl)-piperazin-1-yl)-pyrrolidin-2-yl]-methanone

Homo sapiens

P27487

-

696670

0.000032

(3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)methanol

Homo sapiens

-

-

678686

0.0000042 - 0.0000053

(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium

2 entries

0.000046

(3R)-3-amino-1-diaminophosphinyl-2-piperidinone

Rattus norvegicus

-

IC50: 46 nM

664307

0.0000061

(3R)-3-amino-1-[(2S)-2-([[2-(trifluoromethyl)pyrimidin-4-yl]oxy]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

Homo sapiens

-

-

702583

0.0000039

(3R)-3-amino-1-[(2S)-2-([[4-(trifluoromethyl)pyrimidin-2-yl]amino]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

Homo sapiens

-

-

702583

0.000015

(3R)-3-amino-1-[(2S)-2-([[6-(trifluoromethyl)pyridin-3-yl]amino]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

Homo sapiens

-

-

702583

0.00001

(3R)-3-amino-1-[(2S)-2-[(cyclopropylmethoxy)methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

Homo sapiens

-

-

702583

0.0000054

(3R)-3-amino-1-[(2S)-2-[(pyrimidin-2-ylamino)methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

Homo sapiens

-

-

702583

0.0000063

(3R)-3-amino-1-[(2S)-2-[[(5-fluoropyridin-2-yl)amino]methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

Homo sapiens

-

-

702583

0.0000071

(3R)-3-amino-1-[(2S)-2-[[(5-fluoropyrimidin-2-yl)amino]methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

Homo sapiens

-

-

702583

0.00003

(3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

Homo sapiens

-

-

702623

0.000055

(3R)-3-amino-4-(2,5-difluorophenyl)-1-(3-methyl-1,2,4-oxadiazol-5-yl)butan-1-one

Homo sapiens

-

-

696624

0.0000066

(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-dimethyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000151

(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-(2-hydroxyethyl)-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.000008

(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652, 697519

0.0000096

(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-tert-butyl-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000105

(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-[2-(benzyloxy)ethyl]-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000026

(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one

Homo sapiens

-

-

697519

0.0000066

(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000192

(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.000009

(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000207

(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1-ethyl-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000115

(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000116

(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1-(2-oxopropyl)-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.000085

(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one

Homo sapiens

-

-

696624

0.00004

(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

696624

0.00012

(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one

Homo sapiens

-

-

696624

0.00002

(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

696624

0.000062

(3R,4R)-1-(1,3-benzothiazol-2-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.000042

(3R,4R)-1-(1,3-benzothiazol-6-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.000005

(3R,4R)-1-(2-methyl-3-oxo-2,3-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000007

(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000008

(3R,4R)-1-(2-methyl-4-oxo-4H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

pharmacokinetic properties

678679

0.000079

(3R,4R)-1-(2-naphthoyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.0000012 - 0.000002

(3R,4R)-1-(2-oxo-2H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

2 entries

0.00008

(3R,4R)-1-(3,4-difluorobenzyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.000006

(3R,4R)-1-(3-ethyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000006

(3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine

Homo sapiens

-

-

697519

0.000006

(3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

pharmacokinetic properties

678679

0.000014

(3R,4R)-1-(4-cyanopyridin-2-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000008

(3R,4R)-1-(4-cyclopropylpyrido[3,2-d]pyrimidin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000047

(3R,4R)-1-(isoquinolin-3-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.0037

(3R,4R)-1-isoquinolin-1-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.00021

(3R,4R)-1-phenyl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000043

(3R,4R)-1-pteridin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000013

(3R,4R)-1-pyrazino[2,3-b]pyrazin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000058

(3R,4R)-1-pyridin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000144

(3R,4R)-1-pyridin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000125

(3R,4R)-1-pyridin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.00013

(3R,4R)-1-pyrido[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000007

(3R,4R)-1-pyrido[2,3-b]pyrazin-6-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000054

(3R,4R)-1-quinolin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000012

(3R,4R)-1-quinoxalin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000086

(3R,4R)-1-[(5-chloro-1-benzofuran-2-yl)carbonyl]-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.000026

(3R,4R)-1-[1,2,4]triazolo[4,3-a]pyrimidin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

pharmacokinetic properties

678679

0.000031

(3R,4R)-1-[1,2,4]triazolo[4,3-b]pyridazin-6-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000083

(3R,4R)-1-[1-methyl-1-(4-nitrophenyl)ethyl]-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.000022

(3R,4R)-1-[2-(trifluoromethyl)imidazo[1,2-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000005

(3R,4R)-1-[2-(trifluoromethyl)[1,2,4]triazolo[1,5-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000016

(3R,4R)-1-[3-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000111

(3R,4R)-1-[3-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000009

(3R,4R)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000067

(3R,4R)-1-[4-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000463

(3R,4R)-1-[5-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.00065

(3R,4R)-1-[6-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.0184

(3R,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.026

(3R,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0134

(3R,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0052

(3R,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.142

(3R,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0094

(3R,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine

Homo sapiens

-

-

678664

0.0063

(3R,4R)-3-butyl-1-phenylpiperidin-4-amine

Homo sapiens

-

-

678664

0.00049

(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-3-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.000027

(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-3-ylmethyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.000038

(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-6-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.000091

(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1,2,3-thiadiazol-4-yl)benzyl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.00004

(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-1,2,4-triazol-1-yl)benzoyl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.000069

(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.00003

(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-tetrazol-1-yl)benzoyl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.00005

(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-tetrazol-1-yl)benzyl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678694

0.00002 - 0.000021

(3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

2 entries

0.000031

(3R,4S)-1-(6-pyridin-3-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.0027

(3R,4S)-1-acetyl-4-(2,4-dichlorophenyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.0034

(3R,4S)-1-benzyl-4-(2,4-dichlorophenyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.0000021

(3R,4S)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.000261

(3R,4S)-1-[6-(2-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.000057

(3R,4S)-1-[6-(2-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.00018

(3R,4S)-1-[6-(2-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.00019

(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.0029

(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine

Homo sapiens

-

-

678686

0.000051

(3R,4S)-1-[6-(3-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.000047

(3R,4S)-1-[6-(3-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.000014 - 0.00012

(3R,4S)-1-[6-(3-nitrophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

2 entries

0.000006 - 0.000017

(3R,4S)-1-[6-(3-thienyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

2 entries

0.00047

(3R,4S)-1-[6-(4-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.000051

(3R,4S)-1-[6-(4-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.00012

(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.0023

(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine

Homo sapiens

-

-

678686

0.000037

(3R,4S)-1-[6-(6-methoxypyridin-3-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.0000035

(3R,4S)-1-[6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.0000017

(3R,4S)-1-[6-[3-(morpholin-4-ylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.0013

(3R,4S)-1-[6-[3-(trifluoromethoxy)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.000071

(3R,4S)-1-[6-[3-(trifluoromethyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.000009

(3R,4S)-1-[6-[3-fluoro-5-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.00019

(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-(3-fluorobenzyl)pyrrolidine-1-carboxamide

Homo sapiens

P27487

-

678653

0.00022

(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-(3-methoxybenzyl)-N-methylpyrrolidine-1-carboxamide

Homo sapiens

P27487

-

678653

0.00061

(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-ethyl-N-methylpyrrolidine-1-carboxamide

Homo sapiens

P27487

-

678653

0.00028

(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-ethylpyrrolidine-1-carboxamide

Homo sapiens

P27487

-

678653

0.00014

(3R,4S)-4-(2,4-dichlorophenyl)-1-(6-phenylpyridin-2-yl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.0028

(3R,4S)-4-(2,4-dichlorophenyl)-1-phenylpyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.00079

(3R,4S)-4-(2,4-dichlorophenyl)-1-pyridin-2-ylpyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.00021

(3R,4S)-4-(2,4-dichlorophenyl)-1-pyrimidin-2-ylpyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.013

(3R,4S)-4-(2,4-dichlorophenyl)-1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.002

(3R,4S)-4-(2,4-dichlorophenyl)-1-[2-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.000076

(3R,4S)-4-(2,4-dichlorophenyl)-1-[4-(3-thienyl)pyrimidin-2-yl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.00043

(3R,4S)-4-(2,4-dichlorophenyl)-1-[5-(4-methoxyphenyl)pyrimidin-2-yl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.000015

(3R,4S)-4-(2,4-dichlorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.000035

(3R,4S)-4-(2-chloro-4,5-difluorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.000034

(3R,4S)-4-(2-chloro-4-fluorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.00079

(3R,4S)-4-phenyl-1-(6-phenylpyrimidin-4-yl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.0000097

(3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one

Homo sapiens

-

-

697519

0.000139

(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-7-(trifluoromethyl)-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.000126

(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-(2-fluorobenzyl)-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.000296

(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-ethyl-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.000765 - 0.00105

(3R,S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one

Homo sapiens

-

absolute configuration of 3-methyl group not determined

678652

0.000017

(3S)-1-oxo-5-phenyl-1-(1,3-thiazolidin-3-yl)pentan-3-amine

Homo sapiens

P27487

-

681506

0.00046 - 0.00048

(3S)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium

2 entries

0.00013

(3S)-3-amino-1-diaminophosphinyl-2-perhydroazepinone

Rattus norvegicus

-

IC50: 130 nM

664307

0.000094

(3S)-3-amino-1-diaminophosphinyl-2-piperidinone

Rattus norvegicus

-

IC50: 94 nM

664307

0.000011

(3S)-3-amino-1-diaminophosphinyl-2-pyrrolidinone

Rattus norvegicus

-

IC50: 11 nM

664307

0.0088

(3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-1-(3-methyl-1,2,4-oxadiazol-5-yl)-4-oxobutan-1-one

Homo sapiens

-

-

696624

0.000142

(3S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6,6-trimethyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000036

(3S)-N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-4-fluoro-3-methylbutanamide

Rattus norvegicus

-

-

703377

0.0023

(3S,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0033

(3S,4R)-3-butyl-1-(3,4-dichlorophenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0049

(3S,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0947

(3S,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.015

(3S,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0058

(3S,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0357

(3S,4R)-3-butyl-1-(diphenylmethyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0186 - 0.0452

(3S,4R)-3-butyl-1-cyclohexylpiperidin-4-amine

2 entries

0.0015

(3S,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine

Homo sapiens

-

-

678664

0.0021

(3S,4R)-3-butyl-1-[3-methoxy-5-(trifluoromethyl)phenyl]piperidin-4-amine

Homo sapiens

-

-

678664

0.0028

(3S,4R)-3-butyl-1-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-amine

Homo sapiens

-

-

678664

0.000082

(3S,4S)-1-pyrazin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000063

(3S,4S)-1-pyridazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.00009

(3S,4S)-1-pyrimidin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000037

(3S,4S)-1-pyrimidin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.000004

(3S,4S)-5-(dimethylamino)-2-[(3S)-3-fluoropyrrolidin-1-yl]-5-oxo-4-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)pent-1-en-3-aminium

Homo sapiens

P27487

-

678662

0.000006

(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-diethylpyrrolidine-3-carboxamide

Homo sapiens

-

-

678597

0.0000018

(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-dimethylpyrrolidine-3-carboxamide

Homo sapiens

-

-

678597

0.0000049

(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N-methylpyrrolidine-3-carboxamide

Homo sapiens

-

-

678597

0.0000044

(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethylpyrrolidine-3-carboxamide

Homo sapiens

-

-

678597

0.0000035

(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-methylpyrrolidine-3-carboxamide

Homo sapiens

-

-

678597

0.0000057

(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-propylpyrrolidine-3-carboxamide

Homo sapiens

-

-

678597

0.0000077

(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidine-3-carboxamide

Homo sapiens

-

-

678597

0.002587

(3S,5S)-N-(2-phenylethyl)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide

Homo sapiens

-

-

678634

0.0000551

(3S,5S)-N-(4-chlorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

2 entries

0.0000549

(3S,5S)-N-(4-methoxyphenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

Rattus norvegicus

-

-

678611

0.000021

(3S,5S)-N-(4-nitrophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

2 entries

0.000171

(3S,5S)-N-benzyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

2 entries

0.001957

(3S,5S)-N-benzyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide

Homo sapiens

-

-

678634

0.00019

(3S,5S)-N-phenyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

2 entries

0.00413

(3S,5S)-N-phenyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide

Homo sapiens

-

-

678634

0.000033

(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000603

(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.000143

(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-6-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000097

(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000373

(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000246

(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-6-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000151

(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000277

(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2-fluorobenzyl)-7-methyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000343

(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.00000149

(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(2-methylbenzyl)-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.000011

(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(pyridin-2-ylmethyl)-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.000397

(3S,7S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one

Homo sapiens

-

-

678652

0.0000016 - 0.0000022

(4-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]phenyl)ethynamine

2 entries

0.000000037

(4-[[([(4R)-3-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)acetic acid

Homo sapiens

P27487

-

681506

0.00000016

(4-[[([(4R)-3-[(3R)-3-amino-4-phenylbutanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)acetic acid

Homo sapiens

P27487

-

681506

0.000638

(4R)-3-([1-[1-(2-phenoxyethyl)piperidin-4-yl]hydrazinyl]acetyl)-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.00071

(4R)-3-([1-[1-(4-cyanobenzyl)piperidin-4-yl]hydrazinyl]acetyl)-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.002228

(4R)-3-([1-[1-(4-fluorobenzyl)piperidin-4-yl]hydrazinyl]acetyl)-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.000698

(4R)-3-([1-[1-(4-nitrobenzyl)piperidin-4-yl]hydrazinyl]acetyl)-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.001459

(4R)-3-([1-[1-(methylsulfonyl)piperidin-4-yl]hydrazinyl]acetyl)-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.004767

(4R)-3-([1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]hydrazinyl]acetyl)-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.003755

(4R)-3-([2-ethyl-1-[1-(methylsulfonyl)piperidin-4-yl]hydrazinyl]acetyl)-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.001022

(4R)-3-[(1-[1-[(2'-cyanobiphenyl-4-yl)methyl]piperidin-4-yl]hydrazinyl)acetyl]-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.001449

(4R)-3-[(1-[1-[(4-chlorophenyl)sulfonyl]piperidin-4-yl]hydrazinyl)acetyl]-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.006677

(4R)-3-[(1-[1-[(4-methoxyphenyl)sulfonyl]piperidin-4-yl]hydrazinyl)acetyl]-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.002701

(4R)-3-[(1-[1-[(4-methylphenyl)sulfonyl]piperidin-4-yl]hydrazinyl)acetyl]-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.001631

(4R)-3-[[1-(1-benzylpiperidin-4-yl)hydrazinyl]acetyl]-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.00176

(4R)-3-[[1-(1-[3-[2-(aminooxy)cyclopropyl]propyl]piperidin-4-yl)hydrazinyl]acetyl]-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.012

(4R)-3-[[1-(piperidin-4-yl)hydrazinyl]acetyl]-1,3-thiazolidine-4-carbonitrile

Rattus norvegicus

-

-

702585

0.000037

(4S)-4-amino-5-[(2S)-2-cyanopyrrolidin-1-yl]-5-oxo-N-phenylpentanamide

Rattus norvegicus

-

-

696668

0.000011

(4S)-4-amino-5-[(2S)-2-cyanopyrrolidin-1-yl]-N-cyclopentyl-5-oxopentanamide

Rattus norvegicus

-

-

696668

0.00024

(6-methylpyridin-2-yl)methyl (3R,4S)-3-amino-4-(2,4-dichlorophenyl)pyrrolidine-1-carboxylate

Homo sapiens

P27487

-

678653

0.0014

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid

Homo sapiens

P27487

-

679651

0.0037

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (1H-benzoimidazol-2-ylmethyl)amide

Homo sapiens

P27487

-

679651

0.0016

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-morpholin-4-ylphenyl)amide

Homo sapiens

P27487

-

679651

0.0091

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-sulfamoyl phenyl)amide

Homo sapiens

P27487

-

679651

0.0013

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-amino benzyl amide

Homo sapiens

P27487

-

679651

0.0016

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-ethoxycarbonyl phenyl ester

Homo sapiens

P27487

-

679651

0.0027

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-methoxycarbonyl benzyl ester

Homo sapiens

P27487

-

679651

0.0019

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-methoxycarbonyl methyl phenyl ester

Homo sapiens

P27487

-

679651

0.0056

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid amide

Homo sapiens

P27487

-

679651

0.0016

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid benzyl amide

Homo sapiens

P27487

-

679651

0.00071

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid benzyl ester

Homo sapiens

P27487

-

679651

0.0016

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid phenyl amide

Homo sapiens

P27487

-

679651

0.0022

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid phenyl ester

Homo sapiens

P27487

-

679651

0.0074

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid(pyridin-2-ylmethyl)amide

Homo sapiens

P27487

-

679651

0.0031

(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-4-sulfamoyl benzyl amide

Homo sapiens

P27487

-

679651

0.00000032

(R)-3-amino-1-((R)-8-((S)-(4-fluorophenyl)(hydroxy)methyl)-3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one

Rattus norvegicus

-

determination of the pharmacokinetic profile

681325

0.00043

(R)-3-amino-1-((S)-8-((S)-(4-fluorophenyl)(hydroxy)methyl)-3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one

Rattus norvegicus

-

-

681325

0.000027

(R)-3-amino-4-(2,5-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one

Mus musculus

-

-

702894

0.00077

(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino) benzoic acid ethyl ester

Homo sapiens

P27487

-

679651

0.0089

(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)benzenesulfonic acid

Homo sapiens

P27487

-

679651

0.0059

(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)benzoic acid

Homo sapiens

P27487

-

679651

0.0014

(R)-4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]benzoic acid

Homo sapiens

P27487

-

679651

0.003

(R)-4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]benzoic acid methyl ester

Homo sapiens

P27487

-

679651

0.0085

(R)-[2-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid

Homo sapiens

P27487

-

679651

0.0048

(R)-[2-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester

Homo sapiens

P27487

-

679651

0.0028

(R)-[3-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid

Homo sapiens

P27487

-

679651

0.002

(R)-[3-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid ethyl ester

Homo sapiens

P27487

-

679651

0.0043

(R)-[3-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid

Homo sapiens

P27487

-

679651

0.0019

(R)-[3-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester

Homo sapiens

P27487

-

679651

0.0025

(R)-[4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid

Homo sapiens

P27487

-

679651

0.0021

(R)-[4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid ethyl ester

Homo sapiens

P27487

-

679651

0.0022

(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(R)-isopropyl acetic acid

Homo sapiens

P27487

-

679651

0.0036

(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(R)-isopropyl acetic acid ethyl ester

Homo sapiens

P27487

-

679651

0.0027

(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(S )-isopropyl acetic acid

Homo sapiens

P27487

-

679651

0.0026

(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(S )-isopropyl acetic acid ethyl ester

Homo sapiens

P27487

-

679651

0.00051

(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid

Homo sapiens

P27487

-

679651

0.00069

(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester

Homo sapiens

P27487

-

679651

0.0001656

(S)-1-(2-(2-(2-oxo-3-(3,4,5-trimethoxyphenyl)imidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000293

(S)-1-(2-(2-(2-oxo-3-p-tolylimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000348

(S)-1-(2-(2-(2-oxo-3-phenylimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0001336

(S)-1-(2-(2-(3-(2-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.000002

(S)-1-(2-(2-(3-(3,4-dimethoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000204

(S)-1-(2-(2-(3-(3,5-dimethoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000601

(S)-1-(2-(2-(3-(3-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000651

(S)-1-(2-(2-(3-(3-methoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000258

(S)-1-(2-(2-(3-(4-chlorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000445

(S)-1-(2-(2-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000824

(S)-1-(2-(2-(3-(4-methoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000535

(S)-1-(2-(2-(3-butyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000686

(S)-1-(2-(2-(3-cyclohexyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000478

(S)-1-(2-(2-(3-isopropyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000681

(S)-1-(2-(2-(3-tert-butyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.001

1-(1-methyl-6-phenyl-1H-benzimidazol-7-yl)methanamine

Homo sapiens

P27487

-

678700

0.0000041 - 0.0000072

1-(2-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.00023

1-(2-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone

Homo sapiens

-

-

678686

0.0000042 - 0.0000072

1-(3,4-dichlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.0313

1-(3,4-dimethoxyphenyl)-3-(3,4-dimethylphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0256

1-(3,4-dimethoxyphenyl)-3-(3-methoxyphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0006

1-(3,4-dimethoxyphenyl)-3-(3-methylphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0148

1-(3,4-dimethoxyphenyl)-3-(4-methylphenyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0089

1-(3,4-dimethoxyphenyl)-3-pyridin-2-ylpiperidin-4-amine

Homo sapiens

-

-

678664

0.0003

1-(3-benzyl-4-oxido-3H-imidazo[4,5-b]pyridin-2-yl)piperidin-3-aminium

Homo sapiens

-

-

678642

0.0000087 - 0.0000103

1-(3-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.000014

1-(3-methyl-1,2,4-thiadiazol-5-yl)-4-[[(2S,3S,5S)-2-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]carbonyl]piperazine

Homo sapiens

-

-

697519

0.000019

1-(3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone

Homo sapiens

-

-

678686

0.0000108 - 0.0000109

1-(4-bromophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.0000122 - 0.0000175

1-(4-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.0000762

1-(4-cyanophenyl)-3-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]urea

2 entries

0.000001 - 0.0000014

1-(4-ethynylpyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.0000135 - 0.0000169

1-(4-fluorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.0000109 - 0.0000176

1-(4-methoxyphenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.0000029

1-(4-nitrophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-1,4-diazepane

2 entries

0.0000082 - 0.000009

1-(4-nitrophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.000016

1-(4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone

Homo sapiens

-

-

678686

0.0000025 - 0.0000031

1-(5-chloropyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.00000092 - 0.0000011

1-(5-nitropyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.00071

1-(6-chloro-2-isobutyl-4-phenyl-3,4-dihydroquinolin-3-yl)methanamine

Homo sapiens

-

pH 8.0, 37°C

679650

0.000021 - 0.0000314

1-(diphenylmethyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.0000305 - 0.0000383

1-benzyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.00046

1-cyclohexyl-2-oxo-2-(1,3-thiazolidin-3-yl)ethanaminium 2,2,2-trifluoro-1-oxoethanide

Homo sapiens

P27487

-

696912

0.0000575 - 0.0000811

1-methyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.000151

1-phenyl-3-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]urea

2 entries

0.0000109 - 0.0000176

1-phenyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.0000027 - 0.0000035

1-pyridin-2-yl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.0000031 - 0.0000039

1-pyridin-4-yl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

2 entries

0.00101

1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4,4-dimethyl-1-oxopentan-2-amine

Homo sapiens

-

-

678693

0.00012

1-[(2S)-2-amino-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butyl]piperidin-2-one

Homo sapiens

-

-

696624

0.000019

1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-4-methylpiperidin-2-one

Rattus norvegicus

-

-

703377

0.0000037

1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-5-methylpiperidin-2-one

Rattus norvegicus

-

-

703377

0.00043

1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]azepan-2-one

Rattus norvegicus

-

-

703377

0.000022 - 0.0078

1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]piperidin-2-one

2 entries

0.0019

1-[(3R)-3-amino-4-phenylbutanoyl]-N-[5-chloro-2-[2-(cyclopropylamino)-2-oxoethoxy]benzyl]-L-prolinamide

Homo sapiens

-

-

697519, 697526

0.0000034

1-[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]indane-5-carbonitrile

Homo sapiens

P27487

-

678694

0.0000052

1-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine

Homo sapiens

P27487

-

696670

0.00000054

1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-benzyl-L-prolinamide

Homo sapiens

P27487

-

681506

0.0000016

1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-[4-(1H-1,2,3-triazol-4-yl)butyl]-L-prolinamide

Homo sapiens

P27487

-

681506

0.000000039

1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-[4-(2,3-dihydro-1H-tetrazol-5-yl)butyl]-L-prolinamide

Homo sapiens

P27487

-

681506

0.00000072

1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-[4-(trifluoromethyl)benzyl]-L-prolinamide

Homo sapiens

P27487

-

681506

0.000024

1-[(3S,4S)-4-amino-1-[4-(3,3-difluoropyrrolidin-1-yl)-1,3,5-triazin-2-yl]pyrrolidin-3-yl]-4,4-difluoropiperidin-2-one

Homo sapiens

-

-

697519

0.0000998

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-1,2,3,4-tetrahydroquinoline

2 entries

0.0000047 - 0.0000072

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[4-(trifluoromethyl)phenyl]piperazine

2 entries

0.0000015

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[4-(trifluoromethyl)pyridin-2-yl]piperazine

Homo sapiens

-

-

697519

0.0000015 - 0.0000018

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine

2 entries

0.0000476 - 0.0000744

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine

2 entries

0.000009

1-[1-(2-chlorobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.000011 - 0.00045

1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium

4 entries

0.000002 - 0.0006

1-[1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium

3 entries

0.00026

1-[1-(2-cyanobenzyl)-5-methyl-4-oxo-4,5-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.000005

1-[1-(2-cyanobenzyl)-6-methyl-7-oxo-3a,6,7,7a-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.0012

1-[1-(3-cyanobenzyl)-6-methyl-7-oxo-6,7-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.000102

1-[1-benzyl-6-(2-chlorophenyl)-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.000098

1-[1-methyl-6-(2-methylphenyl)-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.000011

1-[1-[3-(cyanomethyl)benzyl]-6-methyl-7-oxo-6,7-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.000527

1-[3-[2-[2-cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-1-oxopropyl]-4-[benzothiazol-2-yl]piperazine

Homo sapiens

-

-

681283

0.000025

1-[4,9-dioxo-1-[2-(trifluoromethyl)benzyl]-4,9-dihydro-1H-naphtho[2,3-d]imidazol-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.000029

1-[5-benzyl-1-(3-cyanobenzyl)-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.00005

1-[5-bromo-6-(2-chlorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.000022

1-[5-methyl-4,6-dioxo-1-[2-(trifluoromethoxy)benzyl]-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.00001

1-[5-methyl-4,6-dioxo-1-[2-(trifluoromethyl)benzyl]-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.000066

1-[6-(2,4-dichlorophenyl)-1-ethyl-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.000062

1-[6-(2,4-dichlorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.00063

1-[6-(2,4-dichlorophenyl)-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.00079

1-[6-(2,4-difluorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.00032

1-[6-(2-chloro-5-fluorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.00016

1-[6-(2-chlorophenyl)-1,2-dimethyl-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.000061

1-[6-(2-chlorophenyl)-1-methyl-1H-1,2,3-benzotriazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.000063

1-[6-(2-chlorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.000011

1-[6-(2-chlorophenyl)-1-methyl-2-pyridin-3-yl-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.000097

1-[6-(2-chlorophenyl)-2-ethyl-1-methyl-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.000066

1-[6-(2-chlorophenyl)-2-methoxy-1-methyl-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.002

1-[6-(2-methoxyphenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine

Homo sapiens

P27487

-

678700

0.000002 - 0.000007

1-[7-(2-cyanobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,4,5,6,7-hexahydro-1H-purin-8-yl]piperidin-3-aminium

3 entries

0.000057

1-[7-fluoro-6-methoxy-1-[2-(trifluoromethyl)benzyl]-1H-benzimidazol-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.000012

1-[amino(cyclohexyl)acetyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

pH 8.0, 37°C

679650

0.000012 - 0.000014

1-[[(8R)-7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazin-8-yl]methyl]cyclopropanol

2 entries

0.000109

2,2-bis(4-chlorophenyl)-N-[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-2-methylpropyl]acetamide

Homo sapiens

-

-

678622

0.00032

2-(2-[4-(4-chloro-phenyl)-piperazin-1-yl]-2-oxoethylsulfanyl)-4-hydroxy-6-phenyl-pyrimidine-5-carbonitrile

Homo sapiens

-

pH not specified in the publication, 37°C

731642

0.000582

2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-4-cyano-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide

Homo sapiens

-

-

696621

0.000107

2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide

Homo sapiens

-

-

696621

0.003059

2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-methyl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide

Homo sapiens

-

-

696621

0.000099

2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-1H-imidazole-5-carboxamide

Homo sapiens

-

-

696621

0.000014

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000026

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(2-oxo-2-phenylethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000089

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one

Homo sapiens

-

-

696621

0.000013

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000025

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(11R)-10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000003

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(11S)-10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000021

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one

Homo sapiens

-

-

696621

0.000005

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000001

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000004

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000052

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methoxy-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000019

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methoxy-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000007

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000001

2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000559

2-(3-aminopiperidin-1-yl)-4-bromo-1-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide

Homo sapiens

-

-

696621

0.0000073

2-(3-but-2-yn-1-yl-4-oxo-2-piperazin-1-yl-3,4-dihydro-5H-imidazo[4,5-d]pyridazin-5-yl)benzonitrile

Homo sapiens

-

-

697519

0.000025

2-(4-[(3R,5S)-5-[(3,3,4,4-tetrafluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine

Homo sapiens

P27487

-

696670

0.000134

2-(4-[(3R,5S)-5-[(3,3-difluoroazetidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine

Homo sapiens

P27487

-

696670

0.0000058 - 0.0000082

2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)-1,3-benzoxazole

3 entries

0.0000056

2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrazine

Homo sapiens

P27487

-

696670

0.0000048

2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyridine-3-carbonitrile

Homo sapiens

P27487

-

696670

0.0000087

2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine

Homo sapiens

P27487

-

696670

0.0000052

2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)[1,3]oxazolo[5,4-b]pyridine

Homo sapiens

P27487

-

696670

0.000041

2-(4-[(3R,5S)-5-[(3-fluoroazetidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine

Homo sapiens

P27487

-

696670

0.0000023

2-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methoxy)pyridine-4-carbonitrile

Homo sapiens

-

-

702583

0.000129

2-([(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]carbonyl)isoindoline

Homo sapiens

-

-

678634

0.00025

2-([2-(4-aminopiperidin-1-yl)-2-oxoethyl]sulfanyl)-4-hydroxy-6-phenylpyrimidine-5-carbonitrile

Homo sapiens

-

pH not specified in the publication, 37°C

731642

0.000013

2-([2-[(3R)-3-aminopiperidin-1-yl]-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000005

2-([2-[(3R)-3-aminopiperidin-1-yl]-5-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000019

2-([2-[(3R)-3-aminopiperidin-1-yl]-6,7-dimethoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000013

2-([2-[(3R)-3-aminopiperidin-1-yl]-6,8-dichloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000005

2-([2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

2 entries

0.000005

2-([2-[(3R)-3-aminopiperidin-1-yl]-6-chloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000004 - 0.000005

2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

3 entries

0.000008

2-([2-[(3R)-3-aminopiperidin-1-yl]-6-methoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000015

2-([2-[(3R)-3-aminopiperidin-1-yl]-7-chloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000004

2-([2-[(3R)-3-aminopiperidin-1-yl]-7-fluoro-6-methoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000029

2-([2-[(3R)-3-aminopiperidin-1-yl]-8-chloro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.00003

2-([2-[(3R)-3-aminopiperidin-1-yl]-8-methoxy-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000018

2-([2-[(3S)-3-aminopiperidin-1-yl]-6-fluoro-7-morpholin-4-yl-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000007

2-([6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl)benzonitrile

Homo sapiens

-

-

697526

0.0000362

2-([8-[(3R)-3-aminopiperidin-1-yl]-3-methyl-7-(3-methylbut-2-en-1-yl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl]methyl)benzonitrile

Homo sapiens

P27487

pH not specified in the publication, 37°C

753236

0.0065

2-ethoxy-4-[2-(methylsulfanyl)ethyl]-1,3,2-oxazaphospholidine 2-sulfide

Homo sapiens

P27487

-

696912

0.000001

2-[(2-aminoethyl)(methyl)amino]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.0000025

2-[(2R)-2-amino-4-oxo-4-(1,3-thiazolidin-3-yl)butyl]benzonitrile

Homo sapiens

P27487

-

681506

0.0000056

2-[(2S,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-2-methylpyrrolidin-3-yl]-N,N-dimethylacetamide

Homo sapiens

-

37°C, pH 7.4

678617

0.00099

2-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-phenylpyrazolidine-1-carboxamide

Homo sapiens

-

-

678659

0.000005

2-[(3R)-3-aminopiperidin-1-yl]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.000014

2-[(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-benzylpiperazin-1-yl]-N-[3-[(methylsulfonyl)amino]phenyl]acetamide

Homo sapiens

-

-

697526

0.0000045

2-[(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylacetamide

Homo sapiens

-

-

678597

0.0000195 - 0.000039

2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

4 entries

0.0000165

2-[(4-cyanobenzyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]acetamide

2 entries

0.0000022

2-[(7-but-2-yn-1-yl-2-methoxy-6-oxo-8-piperazin-1-yl-6,7-dihydro-1H-purin-1-yl)methyl]benzonitrile

Homo sapiens

-

-

697519

0.0000028

2-[(8R)-7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-8-yl]-N,N-dimethylacetamide

Rattus norvegicus

-

determination of the pharmacokinetic profile

681325

0.000377

2-[(8S)-7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-8-yl]-N,N-dimethylacetamide

Rattus norvegicus

-

-

681325

0.0000032

2-[([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)amino]pyridine-3-carbonitrile

Homo sapiens

-

-

702583

0.00051

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-(2-fluorobenzyl)acetamide

Rattus norvegicus

-

-

702585

0.001027

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-(2-methoxyethyl)acetamide

Rattus norvegicus

-

-

702585

0.000185

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-(4,5-dimethyl-1,3-thiazol-2-yl)acetamide

Rattus norvegicus

-

-

702585

0.00009 - 0.000098

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-(4-sulfamoylphenyl)acetamide

2 entries

0.000143

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-(pyrimidin-2-yl)acetamide

Rattus norvegicus

-

-

702585

0.000523

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide

Rattus norvegicus

-

-

702585

0.000506

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-cyclohexylacetamide

Rattus norvegicus

-

-

702585

0.000217 - 0.000236

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-cyclopropylacetamide

2 entries

0.000415

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-[2-(thiophen-2-yl)ethyl]acetamide

Rattus norvegicus

-

-

702585

0.000468

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-[3-(propan-2-yloxy)propyl]acetamide

Rattus norvegicus

-

-

702585

0.000308

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-[4-(trifluoromethyl)phenyl]acetamide

Rattus norvegicus

-

-

702585

0.000817

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.011

2-[4-[(2S)-2-amino-3-phenylpropyl]-3-benzylpiperazin-1-yl]-N-[3-[(methylsulfonyl)amino]phenyl]acetamide

Homo sapiens

-

-

697526

0.000309

2-[4-[(3R,5S)-5-(azetidin-1-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]pyrimidine

Homo sapiens

P27487

-

696670

0.000031

2-[4-[(3R,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]pyrimidine

Homo sapiens

P27487

-

696670

0.000051

2-[4-[(3R,5S)-5-[[(3R)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine

Homo sapiens

P27487

-

696670

0.000309

2-[4-[(3R,5S)-5-[[(3R,4R)-3,4-difluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine

Homo sapiens

P27487

-

696670

0.000013

2-[4-[(3R,5S)-5-[[(3R,4S)-3,4-difluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine

Homo sapiens

P27487

-

696670

0.000031

2-[4-[(3R,5S)-5-[[(3S)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine

Homo sapiens

P27487

-

696670

0.0000012

2-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]nicotinonitrile

2 entries

0.000093

2-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile

Homo sapiens

-

-

678686

0.004

2-[7-(aminomethyl)-1-methyl-1H-benzimidazol-6-yl]benzamide

Homo sapiens

P27487

-

678700

0.0016

2-[7-(aminomethyl)-1-methyl-1H-benzimidazol-6-yl]phenol

Homo sapiens

P27487

-

678700

0.000096

2-[7-(aminomethyl)-6-(2-chlorophenyl)-1H-benzimidazol-1-yl]ethanol

Homo sapiens

P27487

-

678700

0.000002

2-[[(2S)-2-aminopropyl](methyl)amino]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.0000033

2-[[(3S)-3-[[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]acetamide

Homo sapiens

-

-

697297

0.000084

2-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline

Homo sapiens

-

-

678634

0.000073

2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]-5-(trifluoromethyl)isoindoline

Homo sapiens

-

-

678634

0.000109

2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline

Homo sapiens

-

-

678634

0.000228

2-[[(3S,5S)-5-[[(3R)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]carbonyl]isoindoline

Homo sapiens

-

-

678634

0.000245

2-[[(3S,5S)-5-[[(3S)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]carbonyl]isoindoline

Homo sapiens

-

-

678634

0.000049

3-(1-amino-2-oxo-2-pyrrolidin-1-ylethyl)tricyclo[3.3.1.13,7]decan-1-ol

Homo sapiens

-

-

678693

0.000000003

3-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)-1,2,4-oxadiazolidin-5-one

Homo sapiens

P27487

-

681506

0.00025

3-(aminomethyl)-2-isobutyl-4-phenylisoquinolin-1(2H)-one

Homo sapiens

-

pH 8.0, 37°C

679650

0.000007

3-(aminomethyl)-4-(2,4-dichlorophenyl)-7,8-dimethoxy-5H-indeno[1,2-b]pyridin-2-amine

Homo sapiens

-

-

697519

0.00037

3-(aminomethyl)-4-(2,4-dichlorophenyl)quinolin-2-amine

Homo sapiens

-

pH 8.0, 37°C

679650

0.000026

3-([2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[(1S,2R)-2-(3-chlorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000056

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[(1R,2S)-2-(3-chlorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000047

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[(1S,2R)-2-(3-chlorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.00006

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[2-[3-(trifluoromethyl)phenyl]cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000085

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[2-[4-(trifluoromethyl)phenyl]cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000084

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-(2,4-di-fluorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000068

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-(3,4-di-chlorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000063

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-(3,4-di-fluorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000101

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-(3,4-di-methoxyphenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000075

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-(3,5-di-fluorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000042

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-(3-chlorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000064

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-(3-fluorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000073

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-(3-trifluoromethoxyphenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000086

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-(4-chlorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000054

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-(4-fluorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000085

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-phenylcyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000116

3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-N-(3,4-dimethoxyphenyl)-3-methylbutanamide

Homo sapiens

-

-

702623

0.000016

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]-amino)-3-methyl-N-[trans-2-(4-methyl-1,3-thiazol-5-yl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000019

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-(pyridin-2-yl)butanamide

Homo sapiens

-

-

702623

0.000027

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[(1R,2S)-2-(3-chlorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000015

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[(1S,2R)-2-(3-chlorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000017

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[(1S,2R)-2-(3-ethoxyphenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000021

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[(1S,2R)-2-(3-fluorophenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000026

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[(1S,2R)-2-(3-methoxyphenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.00002

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[(1S,2R)-2-(3-trifluoromethoxyphenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000022

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[(1S,2R)-2-(4-methoxyphenyl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000019

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[(1S,2R)-2-phenylcyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000024

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-[trans-2-(pyridin-3-yl)cyclopropyl]butanamide

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000019 - 0.000027

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-N-(3,4-dimethoxyphenyl)-3-methylbutanamide

2 entries

0.000029

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-N-cyclopentyl-3-methylbutanamide

Homo sapiens

-

-

702623

0.00005

3-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzoic acid

Homo sapiens

P27487

-

696651

0.000003

3-but-2-yn-1-yl-2-(1,4-diazepan-1-yl)-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

696621

0.0001

3-but-2-yn-1-yl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one

Homo sapiens

-

-

697519

0.0001 - 0.00036

3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate

5 entries

0.0136

3-butyl-1-(5,6,7,8-tetrahydronaphthalen-1-yl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0035

3-butyl-1-(diphenylmethyl)piperidin-4-amine

Homo sapiens

-

-

678664

0.0053

3-butyl-1-naphthalen-1-ylpiperidin-4-amine

Homo sapiens

-

-

678664

0.0084

3-butyl-1-[3-methoxy-5-(trifluoromethyl)phenyl]piperidin-4-amine

Homo sapiens

-

-

678664

0.0026

3-butyl-1-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-amine

Homo sapiens

-

-

678664

0.00064

3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

697519

0.0000089

3-[(2R)-2-amino-4-oxo-4-(1,3-thiazolidin-3-yl)butyl]benzonitrile

Homo sapiens

P27487

-

681506

0.000538 - 0.000607

3-[(2S)-pyrrolidin-2-ylcarbonyl]-1,3-thiazolidine

2 entries

0.000142

3-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-1,3-oxazinan-2-one

Rattus norvegicus

-

-

703377

0.0000024

3-[(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylpropanamide

Homo sapiens

-

-

678597

0.00142

3-[1-amino-2-(2H-isoindol-2-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol

Homo sapiens

-

-

678693

0.003311

3-[1-amino-2-(4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol

Homo sapiens

-

-

678693

0.000028

3-[1-amino-2-oxo-2-(1,3-thiazolidin-3-yl)ethyl]tricyclo[3.3.1.13,7]decan-1-ol

Homo sapiens

-

-

678693

0.001944

3-[1-amino-2-[(1R,5S)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol

Homo sapiens

-

-

678693

0.0000029 - 0.000607

3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]-5,7-dimethyltricyclo[3.3.1.13,7]decan-1-ol

2 entries

0.00001

3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol

Homo sapiens

-

-

678693

0.000007

3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]-N,N-dimethylbenzamide

Homo sapiens

P27487

-

678653

0.0000018 - 0.000005

3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid

2 entries

0.000037

3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile

Homo sapiens

-

-

678686

0.00007

3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenol

Homo sapiens

-

-

678686

0.0014

3-[6-[(3R,4S)-3-amino-4-phenylpyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile

Homo sapiens

-

-

678686

0.000032

4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide

Homo sapiens

-

-

696624

0.0000001 - 0.0001

4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxamide

2 entries

0.000000056

4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxylic acid

Homo sapiens

P27487

-

681506

0.00000014

4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-sulfonamide

Homo sapiens

P27487

-

681506

0.00000037

4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-carboxylic acid

Homo sapiens

P27487

-

681506

0.0000093

4,4'-([[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]imino]dimethanediyl)dibenzonitrile

2 entries

0.00000011

4-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)-1,3-dihydro-2H-imidazol-2-one

Homo sapiens

P27487

-

681506

0.0000033

4-(4-nitrophenyl)-1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine

2 entries

0.0000125

4-([(1-methylethyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

2 entries

0.000005

4-([1-[(2-oxo-2-thiophen-3-ylethyl)amino]cyclopentyl]methoxy)benzamide

Homo sapiens

-

-

697519

0.000067

4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzamide

Homo sapiens

P27487

-

696651

0.00026

4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzenesulfonamide

Homo sapiens

P27487

-

696651

0.000223

4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzoic acid

Homo sapiens

P27487

-

696651

0.00015

4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]sulfonyl)benzoic acid

Homo sapiens

P27487

-

696651

0.000005

4-([butyl[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

2 entries

0.0000136

4-([methyl[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

2 entries

0.0000343

4-([[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

2 entries

0.000168

4-cyano-N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide

2 entries

0.0000341

4-cyano-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide

2 entries

0.00021 - 0.214

4-nitrobenzyl[(5S)-5-amino-6-oxo-6-(1-pyrrolidinyl)hexyl]carbamate

2 entries

0.0000096

4-phenyl-1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine

2 entries

0.000005

4-[(1-[[2-oxo-2-(3-thienyl)ethyl]amino]cyclopentyl)methoxy]benzamide

Homo sapiens

P27487

-

678650

0.0000147

4-[(2R)-2-amino-4-oxo-4-(1,3-thiazolidin-3-yl)butyl]benzonitrile

Homo sapiens

P27487

-

681506

0.003007

4-[(2S)-2-amino-3-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-oxopropyl]phenol

Homo sapiens

-

-

678693

0.00005

4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-(4-methylphenyl)-1,4-diazepane-1-carboxamide

Homo sapiens

P27487

-

696651

0.001392

4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-phenyl-1,4-diazepane-1-carboxamide

Homo sapiens

P27487

-

696651

0.00028

4-[(3R)-3-[(2-oxo-2-phenylethyl)amino]butyl]benzamide

Homo sapiens

P27487

-

678650

0.0038

4-[(3R)-3-[[2-(2-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide

Homo sapiens

P27487

-

678650

0.000039

4-[(3R)-3-[[2-(3,4-difluorophenyl)-2-oxoethyl]amino]butyl]benzamide

Homo sapiens

P27487

-

678650

0.00082

4-[(3R)-3-[[2-(4-chlorophenyl)-2-oxoethyl]amino]butyl]benzamide

Homo sapiens

P27487

-

678650

0.000084

4-[(3R)-3-[[2-(4-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide

2 entries

0.00011

4-[(3R)-3-[[2-oxo-2-(3-thienyl)ethyl]amino]butyl]benzamide

Homo sapiens

P27487

-

678650

0.0000139 - 0.0000189

4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]morpholine

2 entries

0.0000042

4-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]benzoic acid

Homo sapiens

P27487

-

681506

0.0435

4-[2-(methylsulfanyl)ethyl]-2-phenoxy-1,3,2-oxazaphospholidine 2-sulfide

Homo sapiens

P27487

-

696912

0.0000018

4-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]benzene-1,2-dicarbonitrile

2 entries

0.000085

4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid

Homo sapiens

P27487

-

678653

0.00013

4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile

Homo sapiens

-

-

678686

0.00034

4-[[(2R)-2-[[2-oxo-2-(3-thienyl)ethyl]amino]propyl]oxy]benzamide

Homo sapiens

P27487

-

678650

0.000081

4-[[(3R,4R)-3-amino-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]methyl]benzonitrile

Homo sapiens

P27487

-

678694

0.0000047

4-[[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]methyl]-2,6-diethylbenzonitrile

Homo sapiens

P27487

-

678694

0.0000011

4-[[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]methyl]-2,6-dimethylbenzonitrile

Homo sapiens

P27487

-

678694

0.0000013

4-[[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]methyl]-2-methylbenzonitrile

Homo sapiens

P27487

-

678694

0.0000336

4-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]benzonitrile

2 entries

0.000004

4-[[2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-4-oxo-3,4-dihydro-5H-imidazo[4,5-d]pyridazin-5-yl]methyl]naphthalene-1-carbonitrile

Homo sapiens

-

-

696621

0.000144

5,6-dichloro-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline

Homo sapiens

-

-

678634

0.000024

5-(3-aminopiperidin-1-yl)-4-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-4H-1,2,4-triazole-3-carboxamide

Homo sapiens

-

-

696621

0.000000095

5-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-yl)-1,2,4-triazolidin-3-one

Homo sapiens

P27487

-

681506

0.01

5-(aminomethyl)-6-(1,3-benzodioxol-5-yl)-2-phenylpyrimidin-4-amine

Homo sapiens

-

-

697519

0.0000001

5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dimethoxyphenyl)pyrimidin-4-amine

Homo sapiens

-

-

697519

0.000003

5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-phenylpyrimidin-4-amine

Homo sapiens

-

-

697519

0.000009

5-(aminomethyl)-6-(2,4-dichlorophenyl)-N2-(2-methoxyethyl)-N2-methylpyrimidine-2,4-diamine

2 entries

0.003081

5-([2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]amino)tricyclo[3.3.1.13,7]decane-1,3-diol

Homo sapiens

-

-

678693

0.00015

5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)pyridine-2-carboxylic acid

Homo sapiens

P27487

-

696651

0.000067

5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)pyridine-3-carboxylic acid

Homo sapiens

P27487

-

696651

0.00026

5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)tetrahydrofuran-2-carboxylic acid

Homo sapiens

P27487

-

696651

0.0000107

5-bromo-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

2 entries

0.0000134

5-chloro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

2 entries

0.00005

5-chloro-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline

Homo sapiens

-

-

678634

0.0000101

5-fluoro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

2 entries

0.000073

5-fluoro-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline

Homo sapiens

-

-

678634

0.0000061

5-methoxy-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

2 entries

0.000072

5-methyl-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline

Homo sapiens

-

-

678634

0.0000103

5-nitro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

2 entries

0.00027

5-[1-amino-2-(3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decane-1,3-diol

Homo sapiens

-

-

678693

0.000014

5-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decane-1,3-diol

Homo sapiens

-

-

678693

0.000078

5-[[(3R,4R)-3-amino-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]methyl]-2-fluorobenzonitrile

Homo sapiens

P27487

-

678694

0.0000099

6-(aminomethyl)-1,3-dimethyl-7-(1-methylpiperazinium)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P27487

pH not specified in the publication, temperature not specified in the publication

731437

0.0000046

6-(aminomethyl)-1,3-dimethyl-7-(morpholin-4-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P27487

pH not specified in the publication, temperature not specified in the publication

731437

0.000002

6-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methoxy)pyridine-3-carbonitrile

Homo sapiens

-

-

702583

0.000004

6-[([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)(methyl)amino]pyridine-3-carbonitrile

Homo sapiens

-

-

702583

0.0000035

6-[([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)amino]pyridine-3-carbonitrile

Homo sapiens

-

-

702583

0.0000016 - 0.0000019

6-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]nicotinonitrile

2 entries

0.000022

6-[[2-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)ethyl]amino]nicotinonitrile

Homo sapiens

-

pH 8.0, 37°C

679650

0.0000024

6-[[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)ethyl]amino]nicotinamide

Homo sapiens

-

-

678622

0.00014 - 0.00078

6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile

3 entries

0.000007 - 0.000022

6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}pyridine-3-carbonitrile

2 entries

0.000052

7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

Homo sapiens

P27487

-

678700

0.000008

7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile

Homo sapiens

P27487

-

678700

0.000032

7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carboxamide

Homo sapiens

P27487

-

678700

0.0000048

7-amino-6-(aminomethyl)-5-(2-bromo-5-fluorophenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P27487

pH not specified in the publication, temperature not specified in the publication

731437

0.00002

7-amino-6-(aminomethyl)-5-(2-fluoro-6-methoxyphenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P27487

pH not specified in the publication, temperature not specified in the publication

731437

0.0039

7-benzyl-3-methyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione

Homo sapiens

-

-

697519, 697526

0.000089

7-but-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one trifluoroacetate

Homo sapiens

-

-

681573

0.0145

7-[(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)amino]-N-[(3R)-1-[3-[(2-cyanophenyl)methyl]-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]piperidin-3-yl]heptanamide

Homo sapiens

P27487

pH not specified in the publication, temperature not specified in the publication

753250

0.000001

7-[(2E)-but-2-en-1-yl]-8-(3,3-dimethylpiperazin-1-yl)-3-methyl-1-(2-oxo-2-phenylethyl)-3,7-dihydro-1H-purine-2,6-dione

Homo sapiens

-

-

697519

0.000234

7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-tert-butyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxamide

Rattus norvegicus

-

-

678666

0.0000012

7-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2H-pyrimido[1,2-b]pyridazin-2-one

Homo sapiens

-

-

697519

0.002

7-[(3R,4R)-3-amino-4-(2-methoxyphenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Homo sapiens

-

-

678686

0.0002

7-[(3R,4S)-3-amino-4-(2-methoxyphenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Homo sapiens

-

-

678686

0.001

7-[(3R,4S)-3-amino-4-(3,4-dichlorophenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Homo sapiens

-

-

678686

0.00014

7-[(3R,4S)-3-amino-4-(4-fluorophenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Homo sapiens

-

-

678686

0.00015

7-[(3R,4S)-3-amino-4-phenylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Homo sapiens

-

-

678686

0.000015

8-(3-aminopiperidin-1-yl)-7-but-2-yn-1-yl-3-methyl-1-(naphthalen-1-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione

Homo sapiens

-

-

696621

0.000002

8-(3-aminopiperidin-1-yl)-7-but-2-yn-1-yl-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione

Homo sapiens

-

-

696621

0.0000235

8-[(3R)-3-aminopiperidin-1-yl]-1-[(1,3-benzothiazol-2-yl)methyl]-3-methyl-7-(3-methylbut-2-en-1-yl)-3,7-dihydro-1H-purine-2,6-dione

Homo sapiens

P27487

pH not specified in the publication, 37°C

753236

0.000006

8-[(3R)-3-aminopiperidin-1-yl]-3-methyl-7-(3-methylbut-2-en-1-yl)-1-(2-oxo-2-phenylethyl)-3,7-dihydro-1H-purine-2,6-dione

Homo sapiens

-

-

697519

0.000001

8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione

Homo sapiens

-

-

697526

0.000001

ABT-279

Homo sapiens

-

-

697519

0.647

Ala-Ala-Leu-Glu-Gln-Thr-Glu-Arg

Homo sapiens

-

pH 8.0, 37°C

753466

0.0000069 - 0.000024

alogliptin

3 entries

0.00000236 - 0.00000553

ASP-8497

4 entries

0.0000026 - 0.0000073

ASP8497

4 entries

0.175

atorvastatin

Sus scrofa

-

37°C, pH 8.0

678708

0.00049

benzyl 4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepane-1-carboxylate

Homo sapiens

P27487

-

696651

0.0000007

benzyl 6-([5-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-(4S)-4-amino-5-oxopentanoyl]amino)hexanoate

Homo sapiens

-

-

697297

0.0000014

benzyl [(5S)-5-amino-6-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-6-oxohexyl]carbamate

Homo sapiens

-

-

697297

0.0133

Berberine

Homo sapiens

P27487

in Tris buffer (pH 7.5, 50 mM), at 37°C

704844

0.000001

BI 1356

2 entries

0.000001

Bl-1356

Homo sapiens

-

-

697489, 697519

0.0000037

BMS-477118

Homo sapiens

-

-

697489

0.0000068

carmegliptin

Rattus norvegicus

-

-

703377

0.0023

D-Val-L-boroPro

Homo sapiens

-

pH 2

681306

0.000022

denagliptin

Homo sapiens

-

-

697519

0.000089

ER-319711-15

Homo sapiens

-

-

697489

0.00049

ethyl (3R,4S)-3-amino-4-(2,4-dichlorophenyl)pyrrolidine-1-carboxylate

Homo sapiens

P27487

-

678653

0.000000076

ethyl 4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxylate

Homo sapiens

P27487

-

681506

0.00000044

ethyl 4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-carboxylate

Homo sapiens

P27487

-

681506

0.000031

ethyl 4-[(4S)-4-amino-5-[(2S)-2-cyanopyrrolidin-1-yl]-5-oxopentanoyl]piperazine-1-carboxylate

Rattus norvegicus

-

-

696668

0.000063

ethyl 4-[3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methylbutanoyl]piperazine-1-carboxylate

Homo sapiens

-

-

702623

0.000219

ethyl 7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate

Rattus norvegicus

-

-

678666

0.00019

ethyl 7-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate

Rattus norvegicus

-

-

678666

0.0000153

ethyl N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]glycinate

2 entries

0.00115

ethyl [(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]carbamate

Rattus norvegicus

-

-

703377

0.00456

ethyl-2-(4-(((S)-1-((S)-2-amino-(4-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate

Homo sapiens

P27487

pH 7.5, temperature not specified in the publication

731640

0.0084

ethyl-2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate

Homo sapiens

P27487

pH 7.5, temperature not specified in the publication

731640

0.00000161

GRC 8200

Homo sapiens

-

-

697489

0.022

L-isoleucinepyrrolidine

Homo sapiens

-

IC50: 0.022 mM

665212

0.0000016 - 0.0012

L-Val-L-boroPro

2 entries

0.0000035

LAF-237

Homo sapiens

-

-

697489

0.000034

LY-2463665

Homo sapiens

-

-

697489

0.329

Lys-Ala-Val-Gly-Glu-Pro-Pro-Leu-Phe

Homo sapiens

-

pH 8.0, 37°C

753466

0.0013

Lys[Z(NO2)]-pyrrolidide

Mus musculus

-

-

697386

0.00041

Lys[Z(NO2)]-thiazolidide

Mus musculus

-

-

697386

0.0003

MCB3937

Homo sapiens

-

-

677326

0.029 - 0.038

metformin

2 entries

0.00000022

methyl (2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoate

Homo sapiens

P27487

-

681506

0.000000087

methyl (4-[[([(4R)-3-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)acetate

Homo sapiens

P27487

-

681506

0.0000036

methyl 4-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]benzenesulfinate

Homo sapiens

P27487

-

681506

0.00000017

methyl 4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]benzoate

Homo sapiens

P27487

-

681506

0.000018

MK-0431

Homo sapiens

-

-

697489

0.00000135

MP-513

Homo sapiens

-

-

697489

0.000021

N,N-diallyl-3-(bicyclo[3.2.0]hept-6-ylsulfonyl)-1H-1,2,4-triazole-1-carboxamide

Homo sapiens

-

pH 8.0, 37°C

679650

0.000134

N-(1,3-benzothiazol-2-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.000119 - 0.000124

N-(2-chloropyridin-3-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

2 entries

0.000359

N-(3-chloro-4-fluorophenyl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.000000027

N-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)-1,1,1-trifluoromethanesulfonamide

Homo sapiens

P27487

-

681506

0.00000015

N-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)methanesulfonamide

Homo sapiens

P27487

-

681506

0.00000071

N-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-yl)methanesulfonamide

Homo sapiens

P27487

-

681506

0.000258

N-(4-chlorophenyl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.000023

N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-b-alanine

2 entries

0.0002

N-(4-cyanophenyl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.000226

N-(5-bromo-1,3-thiazol-2-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.00049

N-(5-chloropyridin-3-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]-2-ethylhydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.03845

N-(5-chloropyridin-3-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]-2-hydroperoxyhydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.000088 - 0.00012

N-(5-chloropyridin-3-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

2 entries

0.00011 - 0.00013

N-(5-cyanopyridin-2-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

2 entries

0.0000015

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-1,1,1-trifluoro-N-methylmethanesulfonamide

Homo sapiens

-

-

702583

0.000012

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-1,1,1-trifluoromethanesulfonamide

Homo sapiens

-

-

702583

0.0000027

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-1-(trifluoromethyl)cyclopropanecarboxamide

Homo sapiens

-

-

702583

0.0000056

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2,2-trifluoroethanesulfonamide

Homo sapiens

-

-

702583

0.0000078

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-difluoro-N-methylpropanamide

Homo sapiens

-

-

702583

0.0000013

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-difluorocyclopropanecarboxamide

Homo sapiens

-

-

702583

0.0000059

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-difluoropropanamide

Homo sapiens

-

-

702583

0.0000037

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-dimethylpropanamide

Homo sapiens

-

-

702583

0.0000063

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2-fluoro-2-methylpropanamide

Homo sapiens

-

-

702583

0.0000035

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-3,3,3-trifluoropropanamide

Homo sapiens

-

-

702583

0.0000068

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-N,2,2-trimethylpropanamide

Homo sapiens

-

-

702583

0.0000027

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-N-cyclopropyl-1,1,1-trifluoromethanesulfonamide

Homo sapiens

-

-

702583

0.0000011

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-N-methylcyclopropanecarboxamide

Homo sapiens

-

-

702583

0.0000022

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclobutanecarboxamide

Homo sapiens

-

-

702583

0.000009

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclohexanecarboxamide

Homo sapiens

-

-

702583

0.000008

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclohexanesulfonamide

2 entries

0.0000048

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclopentanecarboxamide

Homo sapiens

-

-

702583

0.000027

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)methanesulfonamide

Homo sapiens

-

-

702583

0.000027

N-([(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2-(methylsulfonyl)benzamide

Rattus norvegicus

-

-

702578

0.000049

N-([(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2-fluorobenzamide

Rattus norvegicus

-

-

702578

0.000092

N-([(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-3-fluorobenzamide

Rattus norvegicus

-

-

702578

0.000077

N-([(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-4-(methylsulfonyl)benzamide

Rattus norvegicus

-

-

702578

0.000092

N-([(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-4-fluorobenzamide

Rattus norvegicus

-

-

702578

0.00009

N-([(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)benzamide

Rattus norvegicus

-

-

702578

0.000047

N-([(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)pyridine-2-carboxamide

Rattus norvegicus

-

-

702578

0.000087

N-([(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)pyridine-3-carboxamide

Rattus norvegicus

-

-

702578

0.000066

N-([(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)pyridine-4-carboxamide

Rattus norvegicus

-

-

702578

0.000009

N-([(2S)-1-[(3R)-3-amino-4-(3,4,6-trifluorocyclohexa-2,4-dien-1-yl)butanoyl]pyrrolidin-2-yl]methyl)cyclohexanecarboxamide

Rattus norvegicus

-

-

702578

0.000014

N-([(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2-(methylsulfonyl)benzamide

Rattus norvegicus

-

-

702578

0.00000038

N-([(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-3-(methylsulfonyl)benzamide

Rattus norvegicus

-

-

702578

0.000027

N-([(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl]methyl)benzamide

Rattus norvegicus

-

-

702578

0.000012

N-([(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclohexanecarboxamide

Rattus norvegicus

-

-

702578

0.00003

N-([(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclohexanesulfonamide

Rattus norvegicus

-

-

702578

0.000008

N-([(2S)-1-[(3R)-3-amino-4-(5-chlorocyclohexa-2,4-dien-1-yl)butanoyl]pyrrolidin-2-yl]methyl)benzenesulfonamide

Rattus norvegicus

-

-

702578

0.000024

N-([(2S)-1-[(3R)-3-amino-4-(6-fluorocyclohexa-2,4-dien-1-yl)butanoyl]pyrrolidin-2-yl]methyl)-2,5-dichlorobenzenesulfonamide

Rattus norvegicus

-

-

702578

0.000053

N-([(2S)-1-[(3R)-3-amino-4-(6-fluorocyclohexa-2,4-dien-1-yl)butanoyl]pyrrolidin-2-yl]methyl)-2-fluorobenzenesulfonamide

Rattus norvegicus

-

-

702578

0.000094

N-([(2S)-1-[(3R)-3-amino-4-(6-fluorocyclohexa-2,4-dien-1-yl)butanoyl]pyrrolidin-2-yl]methyl)-3-fluorobenzenesulfonamide

Rattus norvegicus

-

-

702578

0.00002

N-([(2S)-1-[(3R)-3-amino-4-(6-fluorocyclohexa-2,4-dien-1-yl)butanoyl]pyrrolidin-2-yl]methyl)-4-chlorobenzenesulfonamide

Rattus norvegicus

-

-

702578

0.000027

N-([(2S)-1-[(3R)-3-amino-4-(6-fluorocyclohexa-2,4-dien-1-yl)butanoyl]pyrrolidin-2-yl]methyl)-4-fluorobenzenesulfonamide

Rattus norvegicus

-

-

702578

0.000034

N-([(2S)-1-[(3R)-3-amino-4-(6-fluorocyclohexa-2,4-dien-1-yl)butanoyl]pyrrolidin-2-yl]methyl)benzenesulfonamide

Rattus norvegicus

-

-

702578

0.000015

N-[(1S,2R)-2-(3-chlorophenyl)cyclopropyl]-3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methylbutanamide

Homo sapiens

-

-

702623

0.01

N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-2-methylbutanamide

Rattus norvegicus

-

-

703377

0.0000026 - 0.000013

N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-3-methylbutanamide

3 entries

0.000013

N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-3-methylpentanamide

Rattus norvegicus

-

-

703377

0.00051

N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]butanamide

Rattus norvegicus

-

-

703377

0.0022

N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]pentanamide

Rattus norvegicus

-

-

703377

0.00133

N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]propane-1-sulfonamide

Rattus norvegicus

-

-

703377

0.000031

N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-6-(trifluoromethyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Homo sapiens

-

pH 7.5, temperature not specified in the publication

731664

0.000236

N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide

2 entries

0.000013

N-[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-2-methylpropyl]-1-methylcyclohexanecarboxamide

Homo sapiens

-

-

678622

0.0000058

N-[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-2-methylpropyl]-2,2-dimethylpropanamide

Homo sapiens

-

-

678622

0.0113

N-[2-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-2-oxoethyl]-N-methyl-5-oxoprolinamide

Homo sapiens

-

23°C, pH 7.4

678648

0.0000015

N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-1H-1,2,3-benzotriazole-5-carboxamide

Homo sapiens

-

-

678622

0.0000057

N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-1H-benzimidazole-5-carboxamide

Homo sapiens

-

-

678622

0.0000029

N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2,3-dihydro-1-benzofuran-5-carboxamide

Homo sapiens

-

-

678622

0.0000062

N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-N-(4-cyanobenzyl)benzamide

Homo sapiens

-

-

678622

0.0000073

N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-N-isobutylbenzamide

Homo sapiens

-

-

678622

0.000031

N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-N-methylbenzenesulfonamide

Homo sapiens

-

-

678622

0.0000045

N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]benzamide

Homo sapiens

-

-

678622

0.000075

N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]benzenesulfonamide

Homo sapiens

-

-

678622

0.0000082

N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]pyridine-2-carboxamide

Homo sapiens

-

-

678622

0.0000054

N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]thiophene-2-carboxamide

Homo sapiens

-

-

678622

0.011

N-[3-[(2-[4-[(2S)-2-amino-3-phenylpropyl]-3-benzylpiperazin-1-yl]ethyl)amino]phenyl]methanesulfonamide

Homo sapiens

-

-

697519

0.000022

NVP DPP728

Homo sapiens

-

-

697489

0.000011

P-[(3S)-3-amino-2-oxopyrrolidin-1-yl]phosphonic diamide

Homo sapiens

-

pH 8.0, 37°C

679650

0.00042

P32/98

Homo sapiens

-

-

697519

0.00042

P32/P98

Homo sapiens

-

-

697489

0.0000006 - 0.00005

saxagliptin

7 entries

0.00000996 - 0.000087

sitagliptin

11 entries

0.000018

SSR-162369

Homo sapiens

-

-

697489

0.000021

sulphostin

Rattus norvegicus

-

IC50: 21 nM

664307

0.000007

SYR-322

Homo sapiens

-

-

697489

0.001534

tert-butyl 2-(1-acetylpiperidin-4-yl)-2-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinecarboxylate

Rattus norvegicus

-

-

702585

0.004149

tert-butyl 2-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]-2-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]hydrazinecarboxylate

Rattus norvegicus

-

-

702585

0.001793

tert-butyl 2-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]-2-[1-(2,3-dichlorobenzoyl)piperidin-4-yl]hydrazinecarboxylate

Rattus norvegicus

-

-

702585

0.001228

tert-butyl 2-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]-2-[1-(dimethylcarbamoyl)piperidin-4-yl]hydrazinecarboxylate

Rattus norvegicus

-

-

702585

0.00083

tert-butyl 2-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]-2-[1-(morpholin-4-ylacetyl)piperidin-4-yl]hydrazinecarboxylate

Rattus norvegicus

-

-

702585

0.00079

tert-butyl 2-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]-2-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]hydrazinecarboxylate

Rattus norvegicus

-

-

702585

0.000667

tert-butyl 2-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]-2-[1-(pyridin-3-ylacetyl)piperidin-4-yl]hydrazinecarboxylate

Rattus norvegicus

-

-

702585

0.000866

tert-butyl 2-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]-2-[1-[(4-methylcyclohexyl)carbonyl]piperidin-4-yl]hydrazinecarboxylate

Rattus norvegicus

-

-

702585

1.2

TLCK

Rattus norvegicus

-

pH 8.0, 37°C

732205

0.44

Val-pyrrolidide

Homo sapiens

-

recombinant enzyme

679663

0.00000167 - 0.000062

vildagliptin

10 entries

0.451

[(2R)-1-(4-oxo-4-phenylbutanoyl)pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.006871

[(2R)-1-(N-acetyl-N-methylglycyl)pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.000377

[(2R)-1-(N-acetylglycyl)pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.0227

[(2R)-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.182

[(2R)-1-[(2-oxopyridin-1(2H)-yl)acetyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.608

[(2R)-1-[N-(2,2-dimethylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.0043

[(2R)-1-[N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.007391

[(2R)-1-[N-(cyclohexylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.00908

[(2R)-1-[N-(cyclopentylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.000068 - 0.00143

[(2R)-1-[N-(methylsulfonyl)glycyl]pyrrolidin-2-yl]boronic acid

2 entries

0.0384

[(2R)-1-[N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.0046

[(2R)-1-[N-methyl-N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.0195

[(2R)-1-[N-methyl-N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.0095

[(2R)-1-[N-[(2,5-dichlorophenyl)carbonyl]glycyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.0000003

[(2R,4R)-1-(L-arginyl)-4-hydroxypyrrolidin-2-yl]boronic acid

Homo sapiens

-

pH 7.8, temperature not specified in the publication

731436

0.0002

[(2S)-1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidin-2-yl]methanol

Homo sapiens

-

-

696624

0.0092

[(2S)-1-[(3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoyl]pyrrolidin-2-yl]methanol

Homo sapiens

-

-

696624

0.0000699

[(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-2-oxo-1,4-diazepan-1-yl]acetic acid

Homo sapiens

-

-

678652

0.000016

[(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]acetic acid

Homo sapiens

-

-

678597

0.0000163

[(4-cyanobenzyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]acetic acid

2 entries

0.000025

[(R)-amino[(3S)-3-amino-2-oxoazepan-1-yl]phosphoryl]sulfamic acid

Homo sapiens

-

pH 8.0, 37°C

679650

0.000021

[(R)-amino[(3S)-3-amino-2-oxopiperidin-1-yl]phosphoryl]sulfamic acid

Homo sapiens

-

pH 8.0, 37°C

679650

0.0000036

[2-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]phenyl]acetic acid

Homo sapiens

P27487

-

681506

0.0000012

[2-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid

Homo sapiens

P27487

-

681506

0.0004

[2-[7-(aminomethyl)-1-methyl-1H-benzimidazol-6-yl]phenyl]methanol

Homo sapiens

P27487

-

678700

0.0000033

[3-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]phenyl]acetic acid

Homo sapiens

P27487

-

681506

0.0000012

[3-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid

Homo sapiens

P27487

-

681506

0.00000012

[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]acetic acid

Homo sapiens

P27487

-

681506

0.000000054

[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid

Homo sapiens

P27487

-

681506

0.000000074

[4-[([1-[(3S)-3-amino-4-(3,4-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid

Homo sapiens

P27487

-

681506

0.00000051

[4-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid

Homo sapiens

P27487

-

681506

0.000069

[7-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl]methanol

Rattus norvegicus

-

-

678666

additional information

alogliptin

Homo sapiens

-

50% inhibition of DPP-4 activity is observed at an alogliptin plasma concentration of 3.7 ng/ml

697436

0.000039

(1S)-1-cyclohexyl-2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethanamine

Homo sapiens

-

pH 8.0, 37°C

679650

0.000073

(1S)-1-cyclohexyl-2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethanamine

Homo sapiens

-

pH 8.0, 37°C

679650

0.00000027

(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

P27487

-

681506

0.00027

(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine

Homo sapiens

-

-

696624

0.000098

(2R)-1-(2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Homo sapiens

-

-

696624

0.000098

(2R)-1-(2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine

Rattus norvegicus

-

-

678666

0.000018

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

697519

0.000018

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

determination of the pharmacokinetic profile

681325

0.000011

(2R)-4-[(8R)-8-[(1-fluorocyclopropyl)methyl]-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

single diastereoisomer, configuration at F unknown

678691

0.000018

(2R)-4-[(8R)-8-[(1-fluorocyclopropyl)methyl]-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

single diastereoisomer, configuration at F unknown

678691

0.000045

(2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Homo sapiens

-

-

697519

0.000045

(2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine

Rattus norvegicus

-

-

678689

0.00000054

(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium

Homo sapiens

-

pH 2

681306

0.0014

(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium

Homo sapiens

-

pH 8

681306

0.00002

(2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.00002

(2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000049

(2S)-1-[[(2S,4R)-4-(3-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000071

(2S)-1-[[(2S,4R)-4-(3-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000035

(2S)-1-[[(2S,4S)-4-allylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.000038

(2S)-1-[[(2S,4S)-4-allylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000034

(2S)-1-[[(2S,4S)-4-propylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

-

678597

0.00005

(2S)-1-[[(2S,4S)-4-propylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

-

37°C, pH 7.4

678598

0.0000033

(2S)-1-[[(3R,4R)-4-amino-1-(3-cyano-4-fluorobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

P27487

-

678694

0.0000036

(2S)-1-[[(3R,4R)-4-amino-1-(3-cyano-4-fluorobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile

Homo sapiens

P27487

-

678694

0.000000012

(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]propanoic acid

Homo sapiens

P27487

-

681506

0.000000081

(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]propanoic acid

Homo sapiens

P27487

-

681506

0.00044

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium

Homo sapiens

P27487

0% human serum

678662

0.00347

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium

Homo sapiens

P27487

50% human serum

678662

0.000027

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl](methyl)amino]cyclohexyl)-1-oxobutan-2-aminium

Homo sapiens

P27487

0% human serum

678662

0.000097

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl](methyl)amino]cyclohexyl)-1-oxobutan-2-aminium

Homo sapiens

P27487

50% human serum

678662

0.000074

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl]amino]cyclohexyl)-1-oxobutan-2-aminium

Homo sapiens

P27487

0% human serum

678662

0.00021

(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl]amino]cyclohexyl)-1-oxobutan-2-aminium

Homo sapiens

P27487

50% human serum

678662

0.000000065

(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.000064

(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

-

-

697519

0.00000025

(2S,3S)-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

P27487

-

681506

0.000245

(2S,3S)-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine

Homo sapiens

-

-

696624

0.00046

(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Homo sapiens

P27487

0% human serum

678662

0.00149

(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Homo sapiens

P27487

50% human serum

678662

0.00033

(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

0% human serum

678662

0.00051

(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

50% human serum

678662

0.00016

(2S,3S)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Homo sapiens

P27487

-

678662

0.0003

(2S,3S)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Homo sapiens

P27487

-

678662

0.000022

(2S,3S)-3-[4-[(cyclopropylcarbonyl)(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Homo sapiens

P27487

0% human serum

678662

0.000047

(2S,3S)-3-[4-[(cyclopropylcarbonyl)(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Homo sapiens

P27487

50% human serum

678662

0.000016

(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Homo sapiens

P27487

0% human serum

678662

0.00004

(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium

Homo sapiens

P27487

50% human serum

678662

0.000029

(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

0% human serum

678662

0.00019

(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

50% human serum

678662

0.00036

(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium

Homo sapiens

P27487

0% human serum

678662

0.00128

(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium

Homo sapiens

P27487

50% human serum

678662

0.000022

(2S,3S)-4-(dimethylamino)-3-(4-[[(3-fluorophenyl)carbonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

0% human serum

678662

0.000024

(2S,3S)-4-(dimethylamino)-3-(4-[[(3-fluorophenyl)carbonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

0% human serum

678662

0.000092

(2S,3S)-4-(dimethylamino)-3-(4-[[(3-fluorophenyl)carbonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

50% human serum

678662

0.0002

(2S,3S)-4-(dimethylamino)-3-(4-[[(3-fluorophenyl)carbonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium

Homo sapiens

P27487

50% human serum

678662

0.000004

(2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.0000042

(2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

702611

0.000004

(2S,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

678664

0.0000046

(2S,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Homo sapiens

-

-

702611

0.00001

(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide

Homo sapiens

-

-

678597

0.00001

(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide

Homo sapiens

-

37°C, pH 7.4

678617

0.000121

(3'S,5'S)-5'-(1,3-thiazolidin-3-ylcarbonyl)-1,3'-bipyrrolidine

Rattus norvegicus

-

-

678658

0.000127

(3'S,5'S)-5'-(1,3-thiazolidin-3-ylcarbonyl)-1,3'-bipyrrolidine

Homo sapiens

-

-

678658

0.0000042

(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium

Homo sapiens

-

pH 8

681306

0.0000053

(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium

Homo sapiens

-

pH 2

681306

0.0000012

(3R,4R)-1-(2-oxo-2H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

pharmacokinetic properties

678679

0.000002

(3R,4R)-1-(2-oxo-2H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium

Homo sapiens

-

-

678679

0.00002

(3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.000021

(3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.000014

(3R,4S)-1-[6-(3-nitrophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.00012

(3R,4S)-1-[6-(3-nitrophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

-

-

678686

0.000006

(3R,4S)-1-[6-(3-thienyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.000017

(3R,4S)-1-[6-(3-thienyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678653

0.00046

(3S)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium

Homo sapiens

-

pH 8

681306

0.00048

(3S)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium

Homo sapiens

-

pH 2

681306

0.0186

(3S,4R)-3-butyl-1-cyclohexylpiperidin-4-amine

Homo sapiens

-

-

678664

0.0452

(3S,4R)-3-butyl-1-cyclohexylpiperidin-4-amine

Homo sapiens

-

-

678664

0.0000551

(3S,5S)-N-(4-chlorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

Rattus norvegicus

-

-

678611

0.0000551

(3S,5S)-N-(4-chlorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678611

0.000021

(3S,5S)-N-(4-nitrophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

Rattus norvegicus

-

-

678611

0.000021

(3S,5S)-N-(4-nitrophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678611

0.000171

(3S,5S)-N-benzyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

Rattus norvegicus

-

-

678611

0.000171

(3S,5S)-N-benzyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678611

0.00019

(3S,5S)-N-phenyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

Rattus norvegicus

-

-

678611

0.00019

(3S,5S)-N-phenyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine

Homo sapiens

P27487

-

678611

0.0000016

(4-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]phenyl)ethynamine

Homo sapiens

-

-

678658

0.0000022

(4-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]phenyl)ethynamine

Rattus norvegicus

-

-

678658

0.0000041

1-(2-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000072

1-(2-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000042

1-(3,4-dichlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000072

1-(3,4-dichlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000087

1-(3-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000103

1-(3-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000108

1-(4-bromophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000109

1-(4-bromophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000122

1-(4-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000175

1-(4-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000762

1-(4-cyanophenyl)-3-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]urea

Rattus norvegicus

-

-

678611

0.0000762

1-(4-cyanophenyl)-3-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]urea

Homo sapiens

P27487

-

678611

0.000001

1-(4-ethynylpyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000014

1-(4-ethynylpyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000135

1-(4-fluorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000169

1-(4-fluorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000109

1-(4-methoxyphenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000176

1-(4-methoxyphenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000029

1-(4-nitrophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-1,4-diazepane

Homo sapiens

-

-

678658

0.0000029

1-(4-nitrophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-1,4-diazepane

Rattus norvegicus

-

-

678658

0.0000082

1-(4-nitrophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.000009

1-(4-nitrophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000025

1-(5-chloropyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000031

1-(5-chloropyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.00000092

1-(5-nitropyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000011

1-(5-nitropyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.000021

1-(diphenylmethyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000314

1-(diphenylmethyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000305

1-benzyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000383

1-benzyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000575

1-methyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000811

1-methyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.000151

1-phenyl-3-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]urea

Rattus norvegicus

-

-

678611

0.000151

1-phenyl-3-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]urea

Homo sapiens

P27487

-

678611

0.0000109

1-phenyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000176

1-phenyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000027

1-pyridin-2-yl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000035

1-pyridin-2-yl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000031

1-pyridin-4-yl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Homo sapiens

-

-

678658

0.0000039

1-pyridin-4-yl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine

Rattus norvegicus

-

-

678658

0.000022

1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]piperidin-2-one

Rattus norvegicus

-

-

703377

0.0078

1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]piperidin-2-one

Rattus norvegicus

-

-

703377

0.0000998

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-1,2,3,4-tetrahydroquinoline

Rattus norvegicus

-

-

678611

0.0000998

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-1,2,3,4-tetrahydroquinoline

Homo sapiens

P27487

-

678611

0.0000047

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[4-(trifluoromethyl)phenyl]piperazine

Rattus norvegicus

-

-

678658

0.0000072

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[4-(trifluoromethyl)phenyl]piperazine

Homo sapiens

-

-

678658

0.0000015

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine

Homo sapiens

-

-

678658

0.0000018

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine

Rattus norvegicus

-

-

678658

0.0000476

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine

Homo sapiens

-

-

678658

0.0000744

1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine

Rattus norvegicus

-

-

678658

0.000011

1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.000017

1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium

Rattus norvegicus

P14740

in absence of plasma

678642

0.000024

1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium

Rattus norvegicus

P14740

in presence of 18% plasma

678642

0.00045

1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.000002

1-[1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium

Rattus norvegicus

P14740

in absence of plasma

678642

0.000002

1-[1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium

Homo sapiens

-

potent and selective DPPIV inhibitor, but it showed a significant loss of activity in the presence of plasma

678642

0.0006

1-[1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium

Rattus norvegicus

P14740

in presence of 18% plasma

678642

0.000002

1-[7-(2-cyanobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,4,5,6,7-hexahydro-1H-purin-8-yl]piperidin-3-aminium

Homo sapiens

-

-

678642

0.000003

1-[7-(2-cyanobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,4,5,6,7-hexahydro-1H-purin-8-yl]piperidin-3-aminium

Rattus norvegicus

P14740

in absence of plasma

678642

0.000007

1-[7-(2-cyanobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,4,5,6,7-hexahydro-1H-purin-8-yl]piperidin-3-aminium

Rattus norvegicus

P14740

in presence of 18% plasma

678642

0.000012

1-[[(8R)-7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazin-8-yl]methyl]cyclopropanol

Homo sapiens

-

single diastereoisomer, configuration at OH unknown

678691

0.000014

1-[[(8R)-7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazin-8-yl]methyl]cyclopropanol

Homo sapiens

-

single diastereoisomer, configuration at OH unknown

678691

0.0000058

2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)-1,3-benzoxazole

Homo sapiens

P27487

-

696670

0.0000074

2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)-1,3-benzoxazole

Homo sapiens

P27487

-

696670

0.0000082

2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)-1,3-benzoxazole

Homo sapiens

P27487

-

696670

0.000005

2-([2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Homo sapiens

-

-

697526

0.000005

2-([2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000004

2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Homo sapiens

-

-

697519

0.000004

2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Rattus norvegicus

-

-

681305

0.000005

2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile

Homo sapiens

-

-

697526

0.0000195

2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Rattus norvegicus

-

-

678611

0.0000195

2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Homo sapiens

P27487

-

678611

0.000039

2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Rattus norvegicus

-

-

678611

0.000039

2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Homo sapiens

P27487

-

678611

0.0000165

2-[(4-cyanobenzyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]acetamide

Rattus norvegicus

-

-

678611

0.0000165

2-[(4-cyanobenzyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]acetamide

Homo sapiens

P27487

-

678611

0.00009

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-(4-sulfamoylphenyl)acetamide

Rattus norvegicus

-

-

702585

0.000098

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-(4-sulfamoylphenyl)acetamide

Rattus norvegicus

-

-

702585

0.000217

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-cyclopropylacetamide

Rattus norvegicus

-

-

702585

0.000236

2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]-N-cyclopropylacetamide

Rattus norvegicus

-

-

702585

0.0000012

2-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]nicotinonitrile

Homo sapiens

-

-

678658

0.0000012

2-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]nicotinonitrile

Rattus norvegicus

-

-

678658

0.000019

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-N-(3,4-dimethoxyphenyl)-3-methylbutanamide

Homo sapiens

-

-

702623

0.000027

3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-N-(3,4-dimethoxyphenyl)-3-methylbutanamide

Homo sapiens

-

-

702623

0.0001

3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate

Mus musculus

-

recombinant enzyme

679663

0.0001

3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate

Homo sapiens

-

plasma enzyme

679663

0.00013

3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate

Homo sapiens

-

recombinant enzyme

679663

0.00028

3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate

Mus musculus

-

plasma enzyme

679663

0.00036

3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate

Canis lupus familiaris

-

plasma enzyme

679663

0.000538

3-[(2S)-pyrrolidin-2-ylcarbonyl]-1,3-thiazolidine

Homo sapiens

-

-

678658

0.000607

3-[(2S)-pyrrolidin-2-ylcarbonyl]-1,3-thiazolidine

Rattus norvegicus

-

-

678658

0.0000029

3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]-5,7-dimethyltricyclo[3.3.1.13,7]decan-1-ol

Homo sapiens

-

-

678693

0.000607

3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]-5,7-dimethyltricyclo[3.3.1.13,7]decan-1-ol

Homo sapiens

-

-

678693

0.0000018

3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid

Homo sapiens

P27487

-

678653

0.000005

3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid

Homo sapiens

-

-

678686

0.0000001

4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxamide

Homo sapiens

P27487

-

681506

0.0001

4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxamide

Homo sapiens

-

-

696624

0.0000093

4,4'-([[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]imino]dimethanediyl)dibenzonitrile

Rattus norvegicus

-

-

678611

0.0000093

4,4'-([[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]imino]dimethanediyl)dibenzonitrile

Homo sapiens

P27487

-

678611

0.0000033

4-(4-nitrophenyl)-1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine

Homo sapiens

-

-

678658

0.0000033

4-(4-nitrophenyl)-1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine

Rattus norvegicus

-

-

678658

0.0000125

4-([(1-methylethyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

Rattus norvegicus

-

-

678611

0.0000125

4-([(1-methylethyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

Homo sapiens

P27487

-

678611

0.000005

4-([butyl[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

Rattus norvegicus

-

-

678611

0.000005

4-([butyl[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

Homo sapiens

P27487

-

678611

0.0000136

4-([methyl[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

Rattus norvegicus

-

-

678611

0.0000136

4-([methyl[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

Homo sapiens

P27487

-

678611

0.0000343

4-([[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

Rattus norvegicus

-

-

678611

0.0000343

4-([[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile

Homo sapiens

P27487

-

678611

0.000168

4-cyano-N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide

Rattus norvegicus

-

-

678611

0.000168

4-cyano-N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide

Homo sapiens

P27487

-

678611

0.0000341

4-cyano-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide

Rattus norvegicus

-

-

678611

0.0000341

4-cyano-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide

Homo sapiens

P27487

-

678611

0.00021

4-nitrobenzyl[(5S)-5-amino-6-oxo-6-(1-pyrrolidinyl)hexyl]carbamate

Homo sapiens

-

-

681573

0.214

4-nitrobenzyl[(5S)-5-amino-6-oxo-6-(1-pyrrolidinyl)hexyl]carbamate

Homo sapiens

-

recombinant enzyme

679663

0.0000096

4-phenyl-1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine

Homo sapiens

-

-

678658

0.0000096

4-phenyl-1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine

Rattus norvegicus

-

-

678658

0.000084

4-[(3R)-3-[[2-(4-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide

Homo sapiens

-

-

697519

0.000084

4-[(3R)-3-[[2-(4-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide

Homo sapiens

P27487

-

678650

0.0000139

4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]morpholine

Homo sapiens

-

-

678658

0.0000189

4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]morpholine

Rattus norvegicus

-

-

678658

0.0000018

4-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]benzene-1,2-dicarbonitrile

Homo sapiens

-

-

678658

0.0000018

4-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]benzene-1,2-dicarbonitrile

Rattus norvegicus

-

-

678658

0.0000336

4-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]benzonitrile

Rattus norvegicus

-

-

678611

0.0000336

4-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]benzonitrile

Homo sapiens

P27487

-

678611

0.000009

5-(aminomethyl)-6-(2,4-dichlorophenyl)-N2-(2-methoxyethyl)-N2-methylpyrimidine-2,4-diamine

Homo sapiens

-

-

697519

0.000009

5-(aminomethyl)-6-(2,4-dichlorophenyl)-N2-(2-methoxyethyl)-N2-methylpyrimidine-2,4-diamine

Homo sapiens

-

pH 8.0, 37°C

679650

0.0000107

5-bromo-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Rattus norvegicus

-

-

678611

0.0000107

5-bromo-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Homo sapiens

P27487

-

678611

0.0000134

5-chloro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Rattus norvegicus

-

-

678611

0.0000134

5-chloro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Homo sapiens

P27487

-

678611

0.0000101

5-fluoro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Rattus norvegicus

-

-

678611

0.0000101

5-fluoro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Homo sapiens

P27487

-

678611

0.0000061

5-methoxy-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Rattus norvegicus

-

-

678611

0.0000061

5-methoxy-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Homo sapiens

P27487

-

678611

0.0000103

5-nitro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Rattus norvegicus

-

-

678611

0.0000103

5-nitro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline

Homo sapiens

P27487

-

678611

0.0000016

6-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]nicotinonitrile

Homo sapiens

-

-

678658

0.0000019

6-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]nicotinonitrile

Rattus norvegicus

-

-

678658

0.00014

6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile

Homo sapiens

-

i.e. KR-62436, IC50: 0.00014 mM, selective competitive inhibitor, good lead compound for further development as a new anti-diabetic agent, almost completely inhibits DPP-IV mediated degradation of glucagon-like peptide-1

664847

0.00049

6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile

Sus scrofa

-

i.e. KR-62436, IC50: 0.00049 mM, selective competitive inhibitor, good lead compound for further development as a new anti-diabetic agent, almost completely inhibits DPP-IV mediated degradation of glucagon-like peptide-1

664847

0.00078

6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile

Rattus norvegicus

-

i.e. KR-62436, IC50: 0.00078 mM, selective competitive inhibitor, good lead compound for further development as a new anti-diabetic agent, almost completely inhibits DPP-IV mediated degradation of glucagon-like peptide-1

664847

0.000007

6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}pyridine-3-carbonitrile

Homo sapiens

-

enzyme isolated from blood plasma

697519

0.000022

6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}pyridine-3-carbonitrile

Homo sapiens

-

enzyme isolated from Caco-2 cells

697519

0.0000069

alogliptin

Homo sapiens

-

-

697764

0.000007

alogliptin

Homo sapiens

-

-

697522

0.000024

alogliptin

Homo sapiens

-

in 100 mM Tris-HCl, 100 mM NaCl, pH 7.8

699748

0.00000236

ASP-8497

Rattus norvegicus

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.00000386

ASP-8497

Mus musculus

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.0000053

ASP-8497

Homo sapiens

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.00000553

ASP-8497

Canis lupus familiaris

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.0000026

ASP8497

Mus musculus

-

median inhibition concentration, in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% bovine serum albumin, at pH 7.3 and 25°C

700399

0.0000053

ASP8497

Homo sapiens

-

-

697489

0.0000062

ASP8497

Homo sapiens

-

median inhibition concentration, in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% bovine serum albumin, at pH 7.3 and 25°C

700399

0.0000073

ASP8497

Canis lupus familiaris

-

median inhibition concentration, in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% bovine serum albumin, at pH 7.3 and 25°C

700399

0.000001

BI 1356

Homo sapiens

-

-

696621

0.000001

BI 1356

Homo sapiens

-

in 100 mM Tris-HCl, 100 mM NaCl, pH 7.8

699748

0.0000153

ethyl N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]glycinate

Rattus norvegicus

-

-

678611

0.0000153

ethyl N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]glycinate

Homo sapiens

P27487

-

678611

0.0000016

L-Val-L-boroPro

Homo sapiens

-

pH 2

681306

0.0012

L-Val-L-boroPro

Homo sapiens

-

pH 8

681306

0.029

metformin

Mus musculus

-

ob/ob diabetic mice

679662

0.038

metformin

Mus musculus

-

normal mice

679662

0.000119

N-(2-chloropyridin-3-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.000124

N-(2-chloropyridin-3-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.000023

N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-b-alanine

Rattus norvegicus

-

-

678611

0.000023

N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-b-alanine

Homo sapiens

P27487

-

678611

0.000088

N-(5-chloropyridin-3-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.00012

N-(5-chloropyridin-3-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.00011

N-(5-cyanopyridin-2-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.00013

N-(5-cyanopyridin-2-yl)-2-[4-(1-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]hydrazinyl)piperidin-1-yl]acetamide

Rattus norvegicus

-

-

702585

0.000008

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclohexanesulfonamide

Homo sapiens

-

-

702583

0.000008

N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclohexanesulfonamide

Rattus norvegicus

-

-

702578

0.0000026

N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-3-methylbutanamide

Rattus norvegicus

-

-

703377

0.0000093

N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-3-methylbutanamide

Rattus norvegicus

-

-

703377

0.000013

N-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-3-methylbutanamide

Rattus norvegicus

-

-

703377

0.000236

N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide

Rattus norvegicus

-

-

678611

0.000236

N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide

Homo sapiens

P27487

-

678611

0.0000006

saxagliptin

Homo sapiens

-

-

697519

0.00000171

saxagliptin

Rattus norvegicus

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.00000257

saxagliptin

Mus musculus

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.00000337

saxagliptin

Homo sapiens

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.00000422

saxagliptin

Canis lupus familiaris

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.00003

saxagliptin

Homo sapiens

-

-

698213

0.00005

saxagliptin

Homo sapiens

-

in 100 mM Tris-HCl, 100 mM NaCl, pH 7.8

699748

0.00000996

sitagliptin

Homo sapiens

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.0000108

sitagliptin

Canis lupus familiaris

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.0000115

sitagliptin

Rattus norvegicus

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.0000121

sitagliptin

Homo sapiens

-

-

697764

0.000018

sitagliptin

Homo sapiens

-

-

697519

0.000018

sitagliptin

Rattus norvegicus

-

-

678666

0.000018

sitagliptin

Homo sapiens

P27487

-

678674

0.000019

sitagliptin

Homo sapiens

-

in 100 mM Tris-HCl, 100 mM NaCl, pH 7.8

699748

0.0000213

sitagliptin

Mus musculus

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.00003

sitagliptin

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000087

sitagliptin

Homo sapiens

P27487

-

696651

0.00000167

vildagliptin

Rattus norvegicus

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.0000027

vildagliptin

Homo sapiens

-

enzyme isolated from blood plasma

697519

0.00000324

vildagliptin

Mus musculus

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.00000347

vildagliptin

Canis lupus familiaris

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.0000035

vildagliptin

Homo sapiens

-

enzyme isolated from Caco-2 cells

697519

0.00000528

vildagliptin

Homo sapiens

-

in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C

696134

0.0000166

vildagliptin

Homo sapiens

-

in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C

703552

0.0000238

vildagliptin

Homo sapiens

-

-

697764

0.000051

vildagliptin

Rattus norvegicus

-

in 25 mM tris(hydroxymethyl)-aminomethane HCl (pH 7.4), 140 mM NaCl, 10 mM KCl, and 0.1% bovine serum albumin

696746

0.000062

vildagliptin

Homo sapiens

-

in 100 mM Tris-HCl, 100 mM NaCl, pH 7.8

699748

0.000068

[(2R)-1-[N-(methylsulfonyl)glycyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.00143

[(2R)-1-[N-(methylsulfonyl)glycyl]pyrrolidin-2-yl]boronic acid

Homo sapiens

-

23°C, pH 7.4

678648

0.0000163

[(4-cyanobenzyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]acetic acid

Rattus norvegicus

-

-

678611

0.0000163

[(4-cyanobenzyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]acetic acid

Homo sapiens

P27487

-

678611