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3.4.14.5: dipeptidyl-peptidase IV

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase IV, go to the full flat file.

Word Map on EC 3.4.14.5

Reaction

release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline =

Synonyms

(GLP1)-degrading enzyme, ACT3, ADA binding protein, ADA-binding protein, ADABP, adenosine deaminase binding protein, Adenosine deaminase complexing protein, adenosine deaminase-binding protein, amino acyl-prolyl dipeptidyl aminopeptidase, aminopeptidase, glycylproline, Bile canaliculus domain-specific membrane glycoprotein, CD26, CD26 peptidase, CD26/dipeptidyl peptidase, CD26/DP IV, DAP IV, DapB, dapUm, dipeptidyl aminopeptidase IV, dipeptidyl dipeptidase IV, dipeptidyl peptidase 4, dipeptidyl peptidase 8, dipeptidyl peptidase 9, dipeptidyl peptidase IV, dipeptidyl peptidase-4, dipeptidyl peptidase-IV, dipeptidyl-aminopeptidase IV, dipeptidyl-peptidase 4, dipeptidyl-peptidase IV (CD26), dipeptidyl-peptide hydrolase, dipeptidylpeptidase 4a, dipeptidylpeptidase 4b, dipeptidylpeptidase IV, dipeptidylpeptidase IV/CD26, dipeptidylpeptidase-IV, DP IV, DP-IV, DPIV, DPP, DPP IV, DPP IV/CD26, DPP-4, DPP-IV, DPP4, DPP8, DPP9, DPPIV, DppIVA, DppIVB, glucagon-like peptide 1-degrading enzyme, Gly-Pro-naphthylamidase, glycoprotein GP110, glycylproline aminopeptidase, glycylproline-dipeptidyl-aminopeptidase, glycylprolyl aminopeptidase, glycylprolyl dipeptidylaminopeptidase, GP110 glycoprotein, h-DPPIV, hDPPIV, leukocyte antigen CD26, lymphocyte, antigen CD26, More, omega DPPIV, omega enzyme, omega gene product, Pep X, peptidase, dipeptidyl, IV, PepX, postproline dipeptidyl aminopeptidase IV, prolyl-dipeptidyl-aminopeptidase, sipeptidyl peptidase IV, T cell triggering molecule Tp103, T-cell activation antigen CD26, THAM, Thymocyte-activating molecule, TP103, type IV dipeptidyl aminopeptidase, WC10, X-PDAP, X-prolyl dipeptidyl aminopeptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro-dipeptidyl-aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.5 dipeptidyl-peptidase IV

Cloned

Cloned on EC 3.4.14.5 - dipeptidyl-peptidase IV

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, overexpression in Escherichia coli
DNA sequence determination and analysis
DNA sequence determination and analysis, expression of enzyme ectodomain, comprising residues 31-766, in Pichia pastoris strain GS115, secretion to the culture medium
DPP9 is expressed in baculovirus-infected Sf9 insect cells
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expressed in Escherichia coli
expressed in Escherichia coli BL21(DE3) cells
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expressed in Pichia pastoris
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expressed in Pichia pastoris strain GS115
expressed using baculovirus
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expression as soluble extracellular enzyme domain
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expression in Chinese hamster ovary cells
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expression in Escherichia coli
expression in human K562 erythroleukemia cell line, secretion to the medium of the recombinant enzyme
expression in insect cells via baculovirus infection as secreted soluble enzyme with Asp29 to the end without any fusion tag
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expression in of soluble His-tagged enzyme, which is secreted to the cell culture medium and comprises amino acid residues 39-766, in Spodoptera frugiperda Sf21 cells via baculovirus infection
expression of a soluble enzyme form, which comprises amino acid residues 39-766 and is secreted to the medium, in Hi5 insect cells via baculovirus infection
expression of a soluble His-tagged wild-type enzyme and glycosylation mutant extracellular domains, which comprises extracellular domain amino acid residues 39-766 and are secreted to the medium, in Trichoplusia ni Hi5 and Spodoptera frugiperda Sf9 insect cells via baculovirus infection
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expression of soluble His-tagged enzyme wild-type and a selenomethionine forms, which comprise extracellular domain amino acid residues 39-766 and are secreted to the medium, in Trichoplusia ni Hi5 insect cells via baculovirus infection
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expression of wild-type and mutants in CHO cells
expression of wild-type enzyme and mutant enzymes in Sf9 insect cells and in Hi5 insect cells
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overexpression in CHO cells
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overexpression in Escherichia coli
overexpression in Escherichia coli as an N-terminal His-tag fusion protein
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overexpression of a single 82000 Da and a 84000 Da isoform in Escherichia coli
overexpression of the soluble His-tagged protein in Pichia pastoris strain X-33 under control of AOX1 promotor, removal of the membrane anchor, residues 1-36, secretion of the recombinant enzyme extracellular part into the cell culture medium and the periplasm
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