3.4.14.12: Xaa-Xaa-Pro tripeptidyl-peptidase

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For detailed information about Xaa-Xaa-Pro tripeptidyl-peptidase, go to the full flat file.

Reaction

Hydrolysis of Xaa-Xaa-Pro-/-Yaa- releasing the N-terminal tripeptide of a peptide with Pro as the third residue (position P1) and where Yaa is not proline =

Synonyms

prolyl tripeptidyl aminopeptidase, prolyl tripeptidyl peptidase, prolyltripeptidyl aminopeptidase, PTP, PTP39, PtpA

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

3.4.14.12 Xaa-Xaa-Pro tripeptidyl-peptidase

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Results	in table
1	Activating Compound
1513	AA Sequence
2	Application
1	CAS Registry Number
5	Cloned(Commentary)
5	Crystallization (Commentary)
13	Inhibitors
4	Ki Value [mM]
17	KM Value [mM]
2	Localization
1	Metals/Ions
12	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
8	Organism
7	pH Optimum
2	pH Range
2	pI Value
1	Posttranslational Modification
6	Protein Variants
7	Purification (Commentary)
1	Reaction
3	Reaction Type
7	Reference
1	Source Tissue
6	Specific Activity [micromol/min/mg]
2	Storage Stability
45	Substrates and Products (Substrate)
7	Subunits
9	Synonyms
8	Temperature Optimum [°C]
3	Temperature Stability [°C]
12	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.4.14.12 - Xaa-Xaa-Pro tripeptidyl-peptidase

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1,10-phenanthroline

Streptomyces mobaraensis

5 mM, 67% residual activity

669143

3,4-dichloroisocoumarin

2 entries

Ala-Ile-pyrrolidin-2-yl boronic acid

Porphyromonas gingivalis

Q7MUW6

681470

Ala-Ile-pyrrolidine-2-yl boronic acid

Porphyromonas gingivalis

Q7MUW6

681470

diisopropyl fluorophosphate

2 entries

Pefabloc SC

3 entries

Phenylmethylsulfonylfluoride

Streptomyces mobaraensis

1 mM, no residual activity

669143

tosyl-L-lysine chloromethyl ketone

Prevotella nigrescens

1.0 mM, 47% inhibition

647187

additional information

Prevotella nigrescens

1 mM NEM, 5 mM 1,10-phenanthroline, 1 mM EDTA, 0.2 mM E64, 0.4 mM antipain, 0.2 mM leupeptin, 1 mg/ml aprotinin, 0.2 mM bestatin or 1 mM mercaptoethanol; no inhibition by

647187