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BRENDA support

3.4.14.1: dipeptidyl-peptidase I

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase I, go to the full flat file.

Word Map on EC 3.4.14.1

Reaction

Release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro =

Synonyms

Cat C, CATC, cathepsin C, cathepsin J, CTSC, DAP I, DDPI, dipeptide arylamidase I, dipeptidyl aminopeptidase I, dipeptidyl peptidase I, dipeptidyl peptidase I/cathepsin C, dipeptidyl transferase, DPAP1, DPAP2, DPP I, DPP-I, DPPI, EC 3.4.4.9, hDPPI, PBANKA_146070, PFL2290w

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.1 dipeptidyl-peptidase I

Source Tissue

Source Tissue on EC 3.4.14.1 - dipeptidyl-peptidase I

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
secretion of active enzyme is stimulated by thyrotropin, insulin, and/or somatostatin
Manually annotated by BRENDA team
-
very low cathepsin C activity in culture medium of untreated keratinocytes, suggesting that the constitutive exocytosis of lysosomes is weak in keratinocytes. Treatment with 0.03 mM ionomycin for 50 min induces the release of about 20% of cathepsin C activity. Incubation of keratinocytes for 30 min with 1 mM calcium and 0.01 mM ionomycin causes a significant release of cathepsin C activity
Manually annotated by BRENDA team
-
high activity
Manually annotated by BRENDA team
-
cathepsin C activity in monocyte derived dendritic cells (ex vivo) decreases dramatically as they mature
Manually annotated by BRENDA team
-
gene for cathepsin C is upregulated compared to Barrett's esophagus
Manually annotated by BRENDA team
-
activity of dipeptidyl-peptidase I increases significantly as compared to the normal esophageal mucosa
Manually annotated by BRENDA team
-
epithelium from normal control Barrett's esophagus
Manually annotated by BRENDA team
-
activity of dipeptidyl-peptidase I increases significantly as compared to the normal gastric mucosa
Manually annotated by BRENDA team
-
activity of dipeptidyl-peptidase I increases significantly as compared to the normal gastric mucosa
Manually annotated by BRENDA team
abundant expression in spleen and head kidney
Manually annotated by BRENDA team
-
decrease in enzyme activity compared to normal kidney
Manually annotated by BRENDA team
-
high activity
Manually annotated by BRENDA team
-
cytotoxic
Manually annotated by BRENDA team
additional information