3.4.14.1: dipeptidyl-peptidase I
This is an abbreviated version!
For detailed information about dipeptidyl-peptidase I, go to the full flat file.
Word Map on EC 3.4.14.1
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3.4.14.1
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cathepsins
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lysosomal
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periodontitis
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palmoplantar
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hyperkeratosis
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papain
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papillon-lefevre
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keratoderma
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teeth
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elastase
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granzyme
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exopeptidase
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proteinases
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cystatins
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dentition
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aminopeptidases
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granule-associated
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chymase
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synthesis
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proenzyme
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medicine
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propeptide
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papain-like
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keratosis
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ficin
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ergic-53
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nutrition
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palmar
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analysis
- 3.4.14.1
- cathepsins
- lysosomal
- periodontitis
-
palmoplantar
-
hyperkeratosis
- papain
- papillon-lefevre
- keratoderma
-
teeth
- elastase
-
granzyme
-
exopeptidase
- proteinases
- cystatins
-
dentition
- aminopeptidases
-
granule-associated
- chymase
- synthesis
- proenzyme
- medicine
- propeptide
-
papain-like
- keratosis
- ficin
-
ergic-53
- nutrition
-
palmar
- analysis
Reaction
Release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro =
Synonyms
Cat C, CATC, cathepsin C, cathepsin J, CTSC, DAP I, DDPI, dipeptide arylamidase I, dipeptidyl aminopeptidase I, dipeptidyl peptidase I, dipeptidyl peptidase I/cathepsin C, dipeptidyl transferase, DPAP1, DPAP2, DPP I, DPP-I, DPPI, EC 3.4.4.9, hDPPI, PBANKA_146070, PFL2290w
ECTree
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Source Tissue
Source Tissue on EC 3.4.14.1 - dipeptidyl-peptidase I
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secretion of active enzyme is stimulated by thyrotropin, insulin, and/or somatostatin
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very low cathepsin C activity in culture medium of untreated keratinocytes, suggesting that the constitutive exocytosis of lysosomes is weak in keratinocytes. Treatment with 0.03 mM ionomycin for 50 min induces the release of about 20% of cathepsin C activity. Incubation of keratinocytes for 30 min with 1 mM calcium and 0.01 mM ionomycin causes a significant release of cathepsin C activity
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cathepsin C activity in monocyte derived dendritic cells (ex vivo) decreases dramatically as they mature
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gene for cathepsin C is upregulated compared to Barrett's esophagus
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activity of dipeptidyl-peptidase I increases significantly as compared to the normal esophageal mucosa
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activity of dipeptidyl-peptidase I increases significantly as compared to the normal gastric mucosa
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activity of dipeptidyl-peptidase I increases significantly as compared to the normal gastric mucosa
additional information
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of peripheral blood. DPPI deficiency in patients with Papillon-Lefevre syndrome
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similar mRNA levels of cathepsin C are found throughout the oocyte growth or vitellogenesis period
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transcript is expressed in all the examined tissues
additional information
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transcript is expressed in all the examined tissues
additional information
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almost similar level of IgG, IgM, and IgA antibodies to DPP I and CD13 in patients with mixed connective tissue disease and autism, but not in controls