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3.4.13.9: Xaa-Pro dipeptidase

This is an abbreviated version!
For detailed information about Xaa-Pro dipeptidase, go to the full flat file.

Word Map on EC 3.4.13.9

Reaction

hydrolysis of Xaa-/-Pro dipeptides; also acts on aminoacyl-hydroxyamine analogues. No action on Pro-Pro =

Synonyms

clan MG aminopeptidase P-like metallopeptidase, dipeptidase, proline, DPP8, EC 3.4.3.7, gamma-peptidase, imidodipeptidase, LGAS_0712, M24B peptidase, More, MP50, OPAA, OPAA-2, organophosphate acid anhydrolase, organophosphate anhydrolase/prolidase, organophosphorus acid anhydrolase, PepD, PepE, PepI, PepQ, peptidase D, peptidase-Q, PepX, Pf-peptidase, Pfprol, PH0974, PH1149, Ph1prol, Phprol, PLD, post-proline-cleaving aminopeptidase, prolidase, prolidase homolog 1, prolidase homolog 2, prolidase I, prolidase II, Proline dipeptidase, proline iminopeptidase, proline-specific amino dipeptidase, prolyl dipeptidase, PRS, QPP, quiescent cell proline dipeptidase, serum prolidase, X-Pro dipeptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro dipeptidase, XPD, XPD43, XPP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.13 Dipeptidases
                3.4.13.9 Xaa-Pro dipeptidase

Substrates Products

Substrates Products on EC 3.4.13.9 - Xaa-Pro dipeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-nitrophenyl soman + H2O
?
show the reaction diagram
-
-
-
?
Ala-Ala + H2O
Ala + Ala
show the reaction diagram
-
-
-
-
?
Ala-Phe + H2O
Ala + Phe
show the reaction diagram
-
-
-
-
?
Ala-Pro + H2O
Ala + Pro
show the reaction diagram
Ala-Pro-amino-4-trifluoromethylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
Ala-Pro-amino-4-trifluoromethylcoumarin + H2O
alanine + Pro-4-trifluoromethylcoumarin
show the reaction diagram
Ala-Pro-Gly + H2O
Ala + Pro-Gly
show the reaction diagram
Arg-Pro + H2O
Arg + Pro
show the reaction diagram
Asp-Pro + H2O
Asp + Pro
show the reaction diagram
-
-
-
-
?
Gly-Hyp + H2O
Gly + Hyp
show the reaction diagram
Gly-L-Pro + H2O
Gly + L-Pro
show the reaction diagram
Gly-Pro
?
show the reaction diagram
-
-
-
-
?
Gly-Pro + H2O
Gly + Pro
show the reaction diagram
Gly-Pro + H2O
Glycine + proline
show the reaction diagram
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly + Pro-4-nitroanilide
show the reaction diagram
Gly-Pro-4-trifluoromethylcoumarin-7-amide + H2O
Gly + Pro + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-Ala + H2O
Gly + Pro-Ala
show the reaction diagram
Gly-Pro-Gly + H2O
Gly + Pro-Gly
show the reaction diagram
Gly-Pro-p-nitroanilide + H2O
Gly + Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
glycyl-L-hydroxyproline + H2O
Gly + L-hydroxyproline
show the reaction diagram
His-Pro + H2O
His + Pro
show the reaction diagram
Ile-Pro + H2O
Ile + Pro
show the reaction diagram
L-Ala-L-Pro + H2O
L-Ala + L-Pro
show the reaction diagram
-
-
-
-
?
L-Ala-Pro + H2O
L-Ala + Pro
show the reaction diagram
L-Arg-L-Pro + H2O
L-Arg + L-Pro
show the reaction diagram
-
12.0% activity compared to L-Leu-L-Pro, in the presence of 1 mM ZnCl2
-
-
?
L-Leu-L-Pro + H2O
L-Leu + L-Pro
show the reaction diagram
L-Lys-L-Pro + H2O
L-Lys + L-Pro
show the reaction diagram
-
6.6% activity compared to L-Leu-L-Pro, in the presence of 1 mM ZnCl2
-
-
?
L-Met-L-Pro
L-Met + L-Pro
show the reaction diagram
-
-
-
-
?
L-Met-L-Pro + H2O
L-Met + L-Pro
show the reaction diagram
L-Met-Pro + H2O
L-Met + Pro
show the reaction diagram
-
-
-
-
?
L-Phe-L-Pro + H2O
L-Phe + L-Pro
show the reaction diagram
L-Phe-Pro + H2O
L-Phe + Pro
show the reaction diagram
L-Pro-Gly + H2O
L-Pro + Gly
show the reaction diagram
-
-
-
-
?
L-Pro-L-Ala + H2O
L-Pro + L-Ala
show the reaction diagram
-
-
-
-
?
L-Pro-L-Asp + H2O
L-Pro + L-Asp
show the reaction diagram
-
-
-
-
?
L-Pro-L-Glu + H2O
L-Pro + L-Glu
show the reaction diagram
-
-
-
-
?
L-Pro-L-Leu + H2O
L-Pro + L-Leu
show the reaction diagram
-
-
-
-
?
L-Pro-L-Met + H2O
L-Pro + L-Met
show the reaction diagram
-
-
-
-
?
L-Pro-L-Phe + H2O
L-Pro + L-Phe
show the reaction diagram
-
-
-
-
?
L-Pro-L-Ser + H2O
L-Pro + L-Ser
show the reaction diagram
-
-
-
-
?
L-Pro-L-Val + H2O
L-Pro + L-Val
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro + H2O
L-Val + L-Pro
show the reaction diagram
L-Val-Pro + H2O
L-Val + Pro
show the reaction diagram
Leu-Pro + H2O
Leu + Pro
show the reaction diagram
Lys-Pro + H2O
Lys + Pro
show the reaction diagram
melphalan + H2O
?
show the reaction diagram
Met-Ala-Ala + H2O
Met + Ala-Ala
show the reaction diagram
Met-Pro + H2O
L-Met + L-Pro
show the reaction diagram
-
68% of the activity with Gly-L-Pro
-
-
?
Met-Pro + H2O
Met + Pro
show the reaction diagram
Met-Pro-Ala + H2O
Met + Pro-Ala
show the reaction diagram
Phe-Pro + H2O
Phe + Pro
show the reaction diagram
Phe-Pro-Gly-Pro-Ile + H2O
Phe + Pro-Gly-Pro-Ile
show the reaction diagram
Pro-Ala + H2O
Pro + Ala
show the reaction diagram
Pro-Hyp + H2O
Pro + Hyp
show the reaction diagram
Pro-Pro + H2O
Pro + Pro
show the reaction diagram
prophalan-D + H2O
?
show the reaction diagram
prophalan-L + H2O
?
show the reaction diagram
Ser-Pro + H2O
Ser + Pro
show the reaction diagram
soman + H2O
?
show the reaction diagram
-
organophosphorus acid anhydrolase activity
-
-
?
Thr-Pro + H2O
Thr + Pro
show the reaction diagram
Tyr-Pro + H2O
Tyr + Pro
show the reaction diagram
Tyr-Pro-Phe-Pro-Gly-Pro-Ile + H2O
Tyr + Pro-Phe-Pro-Gly-Pro-Ile
show the reaction diagram
Val-Pro + H2O
Val + Pro
show the reaction diagram
Xaa-Pro + H2O
Xaa + Pro
show the reaction diagram
-
-
?
additional information
?
-