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analysis
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applications using prolidase to detoxify organophosphorous compounds nerve agents include its incorporation into fire-fighting foams and as biosensors for organophosphorous compound detection
biotechnology
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the enzyme is of particular interest because it can be used in many biotechnological applications
degradation
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advantages of using Alteromonas recombinant prolidase in biodecontamination foams due to its high activity against G-type nerve agents, such as soman and sarin
degradation
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prolidase is able to degrade toxic organophosphorus compounds, namely, by cleaving the P-F and P-O bonds in the nerve agents, sarin and soman. Applications using prolidase to detoxify organophosphorous nerve agents include its incorporation into fire-fighting foams and as biosensors for organophosphorous compound detection
degradation
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advantages of using Alteromonas recombinant prolidase in biodecontamination foams due to its high activity against G-type nerve agents, such as soman and sarin
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diagnostics
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cord blood prolidase activity may be a good indicator of fetal maturation and gestational age
diagnostics
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prolidase might be a useful marker for the diagnosis of lymphoma
diagnostics
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prolidase activity may be a useful adjunctive tool in predicting liver fibrosis, especially in the absence of advanced fibrosis and other conditions, which may affect the interpretation of prolidase activity
diagnostics
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prolidase is a marker of collagen turnover
diagnostics
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prolidase is a potential biomarker for melanoma, and the enzyme is a target for drug development in cancer therapy
drug development
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the enzyme is a target in breast cancer therapy
drug development
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the enzyme is used as target enzyme for specific melanoma prodrug activation
drug development
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prolidase is a potential biomarker for melanoma, and the enzyme is a target for drug development in cancer therapy
food industry
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prolidase can be used in dietary industry as bitterness reducing agent
food industry
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prolidases are employed in the cheese-ripening process to improve cheese taste and texture
food industry
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prolidases are employed in the cheese-ripening process to improve cheese taste and texture
food industry
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prolidases are employed in the cheese-ripening process to improve cheese taste and texture
food industry
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prolidases are employed in the cheese-ripening process to improve cheese taste and texture
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medicine
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enzyme is a possible target for doxycyclin-induced inhibition of collagen synthesis in the treatment of osteoarthritis
medicine
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elevated pH-value in vaginal fluid accompanied by high sialidase and high enzyme activity are associated with low and verly low birth weight and early preterm at less than 35 or 32 weeks gestation
medicine
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enzyme activity in normal human erythrocyte is strongly enhanced by Gly, L-Ala, L-Ser with MnCl2 and enhanced by D-Leu and D-Val. L-Val and L-Leu are strong inhibitors. Enzyme activity in a patient with enzyme deficiency is also enhanced by Gly, L-Ala, and L-Ser and by D-Leu and L-Val, L-Leu is inhibitory
medicine
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no statistical difference in serum enzyme activity between postmenopausal osteoporotic, postmenopausal nonosteoporotic and premenopausal healthy women. No significant correlations between serum enzyme level and any biomarkers of bone turnover as well as bone mineral density
medicine
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patients with severe phenotype of enzyme deficiency showing infection, hepatosplenomegaly, thrombocytopenia, classic skin ulcers, and multisystem involvement. Enzyme activity in patients is nearly undetectable due to a single nucleotide mutation c.793 T>C in exon 11, resulting in a premature stop codon at amino acid residue 265
medicine
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teloid tissue shows up to 4fold increase in enzyme activity compared to normal skin. Elevated enzyme activity is accompanied by increase in concentrations of aminoterminal propeptide of type I procollagen and carboxyterminal telopeptide of type I collagen and increased collagen turnover index
medicine
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prolidase activity in bronchial asthma and pathogenesis is significant as a collagen turnover indicator and can be used in both to evaluate pathogenesis and prognosis
medicine
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prolidase-loaded chitosan nanoparticles permit to restore prolidase activity in prolidase deficiency fibroblasts for 8 days
medicine
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serum prolidase activity is significantly associated with the presence and severity of coronary artery disease, elevated serum prolidase activity may be an independent predictor of coronary atherosclerosis
medicine
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the presence of atrial fibrillation in patients with severe mitral stenosis may be associated with the plasma prolidase activity
medicine
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the serum prolidase enzyme activity of patients with steatohepatitis is significantly increased compared with the patients with simple steatosis and controls, serum prolidase enzyme activity is positively correlated with the grade of liver fatty infiltration, lobular inflammation, non-alcoholic fatty liver disease activity score, and stage of fibrosis, serum prolidase enzyme activity is the best predictor for distinguishing steatohepatitis from simple steatosis
medicine
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Recombinant human prolidase is used for enzyme replacement therapy in prolidase deficiency