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3.4.11.B3: Sulfolobus solfataricus aminopeptidase

This is an abbreviated version!
For detailed information about Sulfolobus solfataricus aminopeptidase, go to the full flat file.

Reaction

Preferentially hydrolyzes Xaa-/-Yaa-, in which Xaa is preferentially a non-polar amino acid, L-Ala or L-Leu. When Xaa is L-Phe or a polar amino acid residue like L-Gly or a basic amino acid residue like L-Lys and L-Arg the rates of hydrolysis are lower =

Synonyms

intracellular Sulfolobus aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.B3 Sulfolobus solfataricus aminopeptidase

Substrates Products

Substrates Products on EC 3.4.11.B3 - Sulfolobus solfataricus aminopeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glycyl 4-nitroanilide + H2O
glycine + 4-nitroaniline
show the reaction diagram
-
11% of the activity compared to L-Leu-4-nitroanilide
-
-
?
L-alanyl 4-nitroanilide + H2O
L-alanine + 4-nitroaniline
show the reaction diagram
L-arginyl 4-nitroanilide + H2O
L-arginine + 4-nitroaniline
show the reaction diagram
L-leucyl 4-nitroanilide + H2O
L-leucine + 4-nitroaniline
show the reaction diagram
L-lysyl 4-nitroanilide + H2O
L-lysine + 4-nitroaniline
show the reaction diagram
L-methionyl 4-nitroanilide + H2O
L-methionine + 4-nitroaniline
show the reaction diagram
about 70% of the activity compared to L-leucyl 4-nitroanilide
-
-
?
L-phenylalanyl 4-nitroanilide + H2O
L-phenylalanine + 4-nitroaniline
show the reaction diagram
L-prolyl 4-nitroanilide + H2O
L-proline + 4-nitroaniline
show the reaction diagram
about 20% of the activity compared to L-leucyl 4-nitroanilide
-
-
?
additional information
?
-
-
no activity with N-acetyl-L-phenylalanine, N-acetyl-L-leucine, N-benzoyl-L-arginine
-
-
?