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alpha-L-Asp-2-naphthylamide + H2O
L-Asp + 2-naphthylamine
-
-
-
?
alpha-L-Asp-Val-angiotensin II + H2O
Asp + Val-angiotensin II
-
-
-
-
?
alpha-L-aspartate-beta-naphthylamide + H2O
L-aspartate + beta-naphthylamine
high activity
-
-
?
alpha-L-Glu-2-naphthylamide + H2O
alpha-L-Glu + 2-naphthylamine
-
-
-
?
alpha-L-Glu-beta-naphthylamide + H2O
L-Glu + 2-naphthylamine
alpha-L-glutamyl-beta-naphthylamide + H2O
L-glutamine + beta-naphthylamine
best substrate
-
-
?
angiotensin I + H2O
Asp + Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
-
-
-
-
?
angiotensin II
Asp + Arg-Val-Tyr-Ile-His-Pro-Phe
angiotensin II + H2O
angiotensin III + L-Asp
angiotensin II + H2O
Asp + angiotensin III
angiotensin II + H2O
aspartic acid + angiotensin III
angiotensin II + H2O
L-Asp + angiotensin III
-
-
-
-
?
angiotensin II + H2O
L-aspartic acid + angiotensin III
angiotensin III + H2O
? + angiotensin IV
-
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe, low activity in absence of Ca2+
-
-
?
angiotensin III + H2O
angiotensin IV + Arg
Asp-4-methylcoumaryl-7-amide + H2O
Asp + 7-amino-4-methylcoumarin
-
low activity in absence and presence of Ca2+
-
-
?
Asp-4-nitroanilide + H2O
Asp + 4-nitroaniline
-
-
-
-
?
Asp-7-amido-4-methylcoumarin + H2O
Asp + 7-amino-4-methylcoumarin
assay for measuring aspartyl aminopeptidase activity
-
-
?
Asp-beta-naphthylamide + H2O
Asp + naphthylamine
Asp-Phe-NH2 + H2O
Asp + Phe + NH3
-
-
-
-
?
aspartame + H2O
L-Asp + L-Phe methyl ester
-
-
-
-
?
cholecystokinin-8 + H2O
?
cholecystokinin-8 + H2O
Asp + YMGWMDF-NH2
-
i.e. CCK8 or DYMGWMDF-NH2
-
-
?
cholecystokinin-8 + H2O
L-Asp + YMGWMDF-NH2
-
-
-
-
?
chromogranin A + H2O
?
-
-
-
-
?
chromogranin A + H2O
Glu + EEEEMAVVPQGLFRG-NH2
-
i.e. EEEEEMAVVPQGLFRG-NH2
-
-
?
Gln-4-methylcoumaryl-7-amide + H2O
Gln + 7-amino-4-methylcoumarin
-
low activity in absence and presence of Ca2+
-
-
?
Glu-2-naphthylamide + H2O
Glu + 2-naphthylamine
Glu-4-methylcoumaryl-7-amide + H2O
Glu + 7-amino-4-methylcoumarin
Glu-4-nitroanilide + H2O
Glu + 4-nitroaniline
Glu-7-amido-4-methylcoumarin + H2O
Glu + 7-amino-4-methylcoumarin
Glu-beta-naphthylamide + H2O
Glu + naphthylamine
Glu-Glu + H2O
2 Glu
-
many Glu-Xxx and Asp-Xxx dipeptides are substrates
-
-
?
Glu-p-nitroanilide + H2O
Glu + 4-nitroaniline
Glu-p-nitroanilide + H2O
Glu + p-nitroaniline
Glu-p-nitroanilide + H2O
glutamic acid + p-nitroaniline
Gly-7-amido-4-methylcoumarin + H2O
Gly + 7-amino-4-methylcoumarin
-
-
-
?
kallidin + H2O
?
-
-
-
-
?
kallidin + H2O
Lys + bradykinin
-
i.e. Lys-bradykinin or KRPPGFSPFR, the reaction is performed only in absence of Ca2+
i.e. RPPGFSPFR
-
?
L-Ala-4-methylcoumaryl-7-amide + H2O
L-Ala + 7-amino-4-methylcoumarin
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
?
L-alanine-beta-naphthylamide + H2O
L-alanine + beta-naphthylamine
low activity
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
L-Asp-peptide + H2O
L-Asp + peptide
L-aspartate-beta-naphthylamide + H2O
L-aspartate + beta-naphthylamine
-
-
-
?
L-Glu-2-naphthylamide + H2O
L-Glu + 2-naphthylamine
L-Glu-4-methylcoumaryl-7-amide + H2O
L-Glu + 7-amino-4-methylcoumarin
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
L-Glu-7-amido-4-methylcoumarin + H2O
L-Glu + 7-amino-4-methylcoumarin
L-Glu-beta-naphthylamide + H2O
L-Glu + beta-naphthylamine
-
-
-
?
L-Glu-p-nitroanilide + H2O
L-Glu + p-nitroaniline
-
-
-
?
L-Glu-peptide + H2O
L-Glu + peptide
L-glutamic acid gamma-2-naphthylamide + H2O
L-glutamate + 2-naphthylamide
L-glutamyl beta-naphthylamide + H2O
L-Glu + beta-naphthylamine
L-glutamyl-beta-naphthylamide + H2O
L-glutamine + beta-naphthylamine
-
-
-
?
L-Leu-4-methylcoumaryl-7-amide + H2O
L-Leu + 7-amino-4-methylcoumarin
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
-
-
-
?
L-lysine-beta-naphthylamide + H2O
L-lysine + beta-naphthylamine
low activity
-
-
?
L-Phe-7-amido-4-methylcoumarin + H2O
L-Phe + 7-amino-4-methylcoumarin
-
-
-
?
L-Pro-7-amido-4-methylcoumarin + H2O
L-Pro + 7-amino-4-methylcoumarin
-
-
-
?
L-Tyr-7-amido-4-methylcoumarin + H2O
L-Tyr + 7-amino-4-methylcoumarin
-
-
-
?
L-Val-7-amido-4-methylcoumarin + H2O
L-Val + 7-amino-4-methylcoumarin
-
-
-
?
Leu-7-amido-4-methylcoumarin + H2O
Leu + 7-amino-4-methylcoumarin
assay for measuring aspartyl aminopeptidase activity
-
-
?
milk proteins + H2O
?
-
-
-
-
?
N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O
?
N-(alpha-L-aspartyl)-2-naphthylamide + H2O
L-aspartic acid + 2-naphthylamine
N-(alpha-L-aspartylyl)-2-naphthylamide + H2O
L-aspartic acid + 2-naphthylamine
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
L-glutamic acid + 2-naphthylamine
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
L-glutamic acid + 4-nitroaniline
N-(alpha-L-glutamyl)-beta-naphthylamide + H2O
L-glutamic acid + beta-naphthylamine
N-Glu-L-Phe-4-nitroanilide + H2O
L-Glu + L-Phe-4-nitroanilide
-
-
-
-
?
neurokinin B + H2O
?
-
-
-
-
?
neurokinin B + H2O
Asp + MHDFFVGLM-NH2
-
i.e. DMHDFFVGLM-NH2
-
-
?
additional information
?
-
alpha-L-Glu-beta-naphthylamide + H2O
L-Glu + 2-naphthylamine
-
-
-
?
alpha-L-Glu-beta-naphthylamide + H2O
L-Glu + 2-naphthylamine
-
-
-
-
?
alpha-L-Glu-beta-naphthylamide + H2O
L-Glu + 2-naphthylamine
-
-
-
?
angiotensin I + H2O
?
-
cleavage only in vitro
-
-
?
angiotensin I + H2O
?
-
cleavage only in vitro
-
-
?
angiotensin I + H2O
?
-
cleavage only in vitro
-
-
?
angiotensin I + H2O
?
-
cleavage only in vitro
-
-
?
angiotensin II
Asp + Arg-Val-Tyr-Ile-His-Pro-Phe
-
-
-
?
angiotensin II
Asp + Arg-Val-Tyr-Ile-His-Pro-Phe
-
-
-
?
angiotensin II + H2O
?
-
-
-
-
?
angiotensin II + H2O
?
-
-
-
?
angiotensin II + H2O
angiotensin III + L-Asp
-
-
-
?
angiotensin II + H2O
angiotensin III + L-Asp
-
-
-
-
?
angiotensin II + H2O
angiotensin III + L-Asp
-
-
-
?
angiotensin II + H2O
angiotensin III + L-Asp
-
-
-
?
angiotensin II + H2O
angiotensin III + L-Asp
-
-
-
?
angiotensin II + H2O
angiotensin III + L-Asp
-
-
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Arg-Val-Tyr-Ile-His-Pro-Phe
-
ir
angiotensin II + H2O
Asp + angiotensin III
-
angiotensin is the most active compound of the renin-angiotensin-system, RAS, involved in regulation of blood pressure in the brain
-
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Arg-Val-Tyr-Ile-His-Pro-Phe
-
ir
angiotensin II + H2O
Asp + angiotensin III
-
angiotensin is the most active compound of the renin-angiotensin-system, RAS, involved in renal development
-
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
Asp + angiotensin III
-
the enzyme is responsible for the convertion of angiotensin II into angiotensin III in the brain
-
-
?
angiotensin II + H2O
Asp + angiotensin III
-
angiotensin is the most active compound of the renin-angiotensin-system, RAS, involved in renal development
-
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Arg-Val-Tyr-Ile-His-Pro-Phe
-
ir
angiotensin II + H2O
Asp + angiotensin III
-
angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure
-
-
?
angiotensin II + H2O
Asp + angiotensin III
-
aspartyl aminopeptidase and several other aminopeptidases, i.e. angiotensinases, are involved in angiotensin II and cholecystokinin, CCK, metabolism, angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure
-
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Arg-Val-Tyr-Ile-His-Pro-Phe
-
ir
angiotensin II + H2O
aspartic acid + angiotensin III
-
-
-
-
?
angiotensin II + H2O
aspartic acid + angiotensin III
-
angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
aspartic acid + angiotensin III
-
-
-
?
angiotensin II + H2O
aspartic acid + angiotensin III
-
-
-
-
?
angiotensin II + H2O
aspartic acid + angiotensin III
-
angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
aspartic acid + angiotensin III
-
angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
aspartic acid + angiotensin III
-
angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
angiotensin III: Arg-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
L-aspartic acid + angiotensin III
-
-
-
-
?
angiotensin II + H2O
L-aspartic acid + angiotensin III
-
-
-
-
?
angiotensin III + H2O
angiotensin IV + Arg
-
the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension
-
-
ir
angiotensin III + H2O
angiotensin IV + Arg
-
the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension
-
-
ir
angiotensin III + H2O
angiotensin IV + Arg
-
the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension
-
-
ir
angiotensin III + H2O
angiotensin IV + Arg
-
the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension
-
-
ir
Asp-Ala + H2O
Asp + Ala
-
-
-
?
Asp-Ala + H2O
Asp + Ala
-
-
-
?
Asp-Ala + H2O
Asp + Ala
-
-
-
-
?
Asp-Ala + H2O
Asp + Ala
-
74% of the activity with Glu-Ala
-
-
?
Asp-beta-naphthylamide + H2O
Asp + naphthylamine
-
dog kidney enzyme 3 times more active compared to Glu-beta-naphthylamide
-
-
?
Asp-beta-naphthylamide + H2O
Asp + naphthylamine
-
-
-
-
?
Asp-beta-naphthylamide + H2O
Asp + naphthylamine
-
-
-
-
?
cholecystokinin-8 + H2O
?
-
i.e. CCK8
-
-
?
cholecystokinin-8 + H2O
?
-
cleavage only in vitro
-
-
?
cholecystokinin-8 + H2O
?
-
CCK8
-
-
?
cholecystokinin-8 + H2O
?
-
-
-
?
cholecystokinin-8 + H2O
?
-
cleavage only in vitro
-
-
?
cholecystokinin-8 + H2O
?
-
cleavage only in vitro
-
-
?
cholecystokinin-8 + H2O
?
-
cleavage only in vitro
-
-
?
Glu-2-naphthylamide + H2O
Glu + 2-naphthylamine
-
synthetic substrate used in the activity assay
-
-
?
Glu-2-naphthylamide + H2O
Glu + 2-naphthylamine
-
synthetic substrate used in the activity assay
-
-
?
Glu-4-methylcoumaryl-7-amide + H2O
Glu + 7-amino-4-methylcoumarin
-
-
-
-
?
Glu-4-methylcoumaryl-7-amide + H2O
Glu + 7-amino-4-methylcoumarin
-
low activity in absence of Ca2+
-
-
?
Glu-4-nitroanilide + H2O
Glu + 4-nitroaniline
-
-
-
-
?
Glu-4-nitroanilide + H2O
Glu + 4-nitroaniline
-
-
-
?
Glu-7-amido-4-methylcoumarin + H2O
Glu + 7-amino-4-methylcoumarin
-
-
-
-
?
Glu-7-amido-4-methylcoumarin + H2O
Glu + 7-amino-4-methylcoumarin
-
activity assay
-
-
?
Glu-7-amido-4-methylcoumarin + H2O
Glu + 7-amino-4-methylcoumarin
-
-
-
-
?
Glu-7-amido-4-methylcoumarin + H2O
Glu + 7-amino-4-methylcoumarin
assay for measuring aspartyl aminopeptidase activity
-
-
?
Glu-7-amido-4-methylcoumarin + H2O
Glu + 7-amino-4-methylcoumarin
-
-
-
-
?
Glu-Ala + H2O
Glu + Ala
-
-
-
?
Glu-Ala + H2O
Glu + Ala
-
-
-
?
Glu-Ala + H2O
Glu + Ala
-
-
-
-
?
Glu-Ala + H2O
Glu + Ala
-
high activity
-
-
?
Glu-beta-naphthylamide + H2O
Glu + naphthylamine
-
aminopeptidase A six times more active compared to Asp-beta-naphthylamide
-
-
?
Glu-beta-naphthylamide + H2O
Glu + naphthylamine
-
-
-
-
?
Glu-beta-naphthylamide + H2O
Glu + naphthylamine
-
-
-
-
?
Glu-beta-naphthylamide + H2O
Glu + naphthylamine
-
-
-
-
?
Glu-beta-naphthylamide + H2O
Glu + naphthylamine
-
-
-
-
?
Glu-Gly + H2O
Glu + Gly
-
-
-
?
Glu-Gly + H2O
Glu + Gly
-
-
-
?
Glu-p-nitroanilide + H2O
Glu + 4-nitroaniline
-
peptidase activity assay
-
-
?
Glu-p-nitroanilide + H2O
Glu + 4-nitroaniline
-
peptidase activity assay
-
-
?
Glu-p-nitroanilide + H2O
Glu + p-nitroaniline
-
-
-
-
?
Glu-p-nitroanilide + H2O
Glu + p-nitroaniline
-
-
-
-
?
Glu-p-nitroanilide + H2O
Glu + p-nitroaniline
-
-
-
-
?
Glu-p-nitroanilide + H2O
Glu + p-nitroaniline
-
activity assay, cleaved p-nitroanilide is measured
-
-
?
Glu-p-nitroanilide + H2O
Glu + p-nitroaniline
-
-
-
-
?
Glu-p-nitroanilide + H2O
Glu + p-nitroaniline
-
-
-
-
?
Glu-p-nitroanilide + H2O
Glu + p-nitroaniline
-
-
-
-
?
Glu-p-nitroanilide + H2O
glutamic acid + p-nitroaniline
-
peptidase activity assay
-
-
?
Glu-p-nitroanilide + H2O
glutamic acid + p-nitroaniline
-
peptidase activity assay
-
-
?
Glu-p-nitroanilide + H2O
glutamic acid + p-nitroaniline
-
peptidase activity assay
-
-
?
Glu-p-nitroanilide + H2O
glutamic acid + p-nitroaniline
-
peptidase activity assay
-
-
?
Glu-p-nitroanilide + H2O
glutamic acid + p-nitroaniline
-
peptidase activity assay
-
-
?
Glu-p-nitroanilide + H2O
glutamic acid + p-nitroaniline
-
peptidase activity assay
-
-
?
Glu-p-nitroanilide + H2O
glutamic acid + p-nitroaniline
-
peptidase activity assay
-
-
?
Glu-p-nitroanilide + H2O
glutamic acid + p-nitroaniline
-
peptidase activity assay
-
-
?
Glu-p-nitroanilide + H2O
glutamic acid + p-nitroaniline
-
peptidase activity assay
-
-
?
L-Ala-4-methylcoumaryl-7-amide + H2O
L-Ala + 7-amino-4-methylcoumarin
about 50% of the activity with L-Glu-4-methylcoumaryl-7-amide
-
-
?
L-Ala-4-methylcoumaryl-7-amide + H2O
L-Ala + 7-amino-4-methylcoumarin
about 50% of the activity with L-Glu-4-methylcoumaryl-7-amide
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
-
-
-
?
L-Asp-peptide + H2O
L-Asp + peptide
-
-
-
-
?
L-Asp-peptide + H2O
L-Asp + peptide
-
free gamma-carboxyl group of N-terminal amino acid essential
-
-
?
L-Asp-peptide + H2O
L-Asp + peptide
-
-
-
-
?
L-Asp-peptide + H2O
L-Asp + peptide
-
specificity for di- and tri-peptides with Asp or Glu at N-terminal end
-
-
?
L-Glu-2-naphthylamide + H2O
L-Glu + 2-naphthylamine
-
-
-
-
?
L-Glu-2-naphthylamide + H2O
L-Glu + 2-naphthylamine
-
-
-
-
?
L-Glu-2-naphthylamide + H2O
L-Glu + 2-naphthylamine
-
-
-
?
L-Glu-2-naphthylamide + H2O
L-Glu + 2-naphthylamine
-
-
-
-
?
L-Glu-4-methylcoumaryl-7-amide + H2O
L-Glu + 7-amino-4-methylcoumarin
-
-
-
?
L-Glu-4-methylcoumaryl-7-amide + H2O
L-Glu + 7-amino-4-methylcoumarin
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
-
-
-
?
L-Glu-7-amido-4-methylcoumarin + H2O
L-Glu + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Glu-7-amido-4-methylcoumarin + H2O
L-Glu + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Glu-7-amido-4-methylcoumarin + H2O
L-Glu + 7-amino-4-methylcoumarin
-
-
-
?
L-Glu-peptide + H2O
L-Glu + peptide
-
-
-
-
?
L-Glu-peptide + H2O
L-Glu + peptide
-
-
-
-
?
L-Glu-peptide + H2O
L-Glu + peptide
-
specificity for di-and tripeptides with Asp or Glu at N-terminal end
-
-
?
L-glutamic acid gamma-2-naphthylamide + H2O
L-glutamate + 2-naphthylamide
-
-
-
?
L-glutamic acid gamma-2-naphthylamide + H2O
L-glutamate + 2-naphthylamide
-
-
-
?
L-glutamyl beta-naphthylamide + H2O
L-Glu + beta-naphthylamine
-
-
-
?
L-glutamyl beta-naphthylamide + H2O
L-Glu + beta-naphthylamine
-
-
-
?
L-Leu-4-methylcoumaryl-7-amide + H2O
L-Leu + 7-amino-4-methylcoumarin
-
about 20% of the activity with L-Glu-4-methylcoumaryl-7-amide
-
?
L-Leu-4-methylcoumaryl-7-amide + H2O
L-Leu + 7-amino-4-methylcoumarin
-
about 20% of the activity with L-Glu-4-methylcoumaryl-7-amide
-
?
N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O
?
-
-
-
-
?
N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O
?
-
-
-
-
?
N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O
?
-
-
-
-
?
N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O
?
-
-
-
-
?
N-(alpha-L-aspartyl)-2-naphthylamide + H2O
L-aspartic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-aspartyl)-2-naphthylamide + H2O
L-aspartic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-aspartylyl)-2-naphthylamide + H2O
L-aspartic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-aspartylyl)-2-naphthylamide + H2O
L-aspartic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-aspartylyl)-2-naphthylamide + H2O
L-aspartic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-aspartylyl)-2-naphthylamide + H2O
L-aspartic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
L-glutamic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
L-glutamic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
L-glutamic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
L-glutamic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
L-glutamic acid + 4-nitroaniline
-
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
L-glutamic acid + 4-nitroaniline
-
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
L-glutamic acid + 4-nitroaniline
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
L-glutamic acid + 4-nitroaniline
-
-
-
-
?
N-(alpha-L-glutamyl)-beta-naphthylamide + H2O
L-glutamic acid + beta-naphthylamine
-
-
-
-
?
N-(alpha-L-glutamyl)-beta-naphthylamide + H2O
L-glutamic acid + beta-naphthylamine
-
-
-
?
N-(alpha-L-glutamyl)-beta-naphthylamide + H2O
L-glutamic acid + beta-naphthylamine
-
-
-
-
?
Ser-Ala + H2O
Ser + Ala
-
-
-
?
Ser-Ala + H2O
Ser + Ala
-
-
-
?
Ser-Ala + H2O
Ser + Ala
-
-
-
-
?
Ser-Ala + H2O
Ser + Ala
-
less than 2% of the activity with Glu-Ala
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolysis of N-(alpha-L-glutamyl)- moieties more efficiently than the hydrolysis of alpha-L-aspartyl derivatives
-
-
?
additional information
?
-
-
slow hydrolysis of Ala-beta-naphthylamide, Arg-beta-naphthylamide
-
-
?
additional information
?
-
-
the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview
-
-
?
additional information
?
-
-
substrate specificity in presence or absence of Ca2+
-
-
?
additional information
?
-
-
substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides
-
-
?
additional information
?
-
the wild-type enzyme has a high specificity for N-terminal Asp and Glu. Enzyme specificities of the enzyme-metal variants with different substrates, overview
-
-
?
additional information
?
-
the wild-type enzyme has a high specificity for N-terminal Asp and Glu. Enzyme specificities of the enzyme-metal variants with different substrates, overview
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates, no activity with Glu-substrate with a blocked N-terminus
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates
-
-
?
additional information
?
-
association between elevated BP-1 expression and cell growth. The enzyme is not involved in immune system development
-
-
?
additional information
?
-
the S1' subsite is hydrophobic whereas the S2' subsite recognizes preferentially negatively charged residues derived from aspartic acid
-
-
?
additional information
?
-
-
The C-terminal domain of aminopeptidase A is an intramolecular chaperone required for the correct folding, cell surface expression, and activity of the enzyme
-
-
?
additional information
?
-
-
the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview
-
-
?
additional information
?
-
the enzyme is involved in angiotensin metabolism
-
-
?
additional information
?
-
-
the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview
-
-
?
additional information
?
-
-
substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides
-
-
?
additional information
?
-
the enzyme catalyzes the hydrolysis of N-(alpha-L-glutamyl)- moieties more efficiently than the hydrolysis of alpha-L-aspartyl derivatives
-
-
?
additional information
?
-
enzyme APA cleaves the N-terminal glutamyl or aspartyl residue from peptide substrates
-
-
?
additional information
?
-
-
enzyme APA cleaves the N-terminal glutamyl or aspartyl residue from peptide substrates
-
-
?
additional information
?
-
-
administration of purified enzyme into hypertensive rats leads to a decrease in blood pressure, while enzyme inhibition increases blood pressure
-
-
?
additional information
?
-
-
the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview
-
-
?
additional information
?
-
-
the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview
-
-
?
additional information
?
-
-
substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolysis of N-(alpha-L-glutamyl)- moieties more efficiently than the hydrolysis of alpha-L-aspartyl derivatives
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates
-
-
?
additional information
?
-
-
the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview
-
-
?
additional information
?
-
-
substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides
-
-
?