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3.4.11.7: glutamyl aminopeptidase

This is an abbreviated version!
For detailed information about glutamyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.7

Reaction

release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide =

Synonyms

acid aminopeptidase, acidic alpha-aminopeptidase, Aminopeptidase, aminopeptidase A, aminopeptidase A ectopeptidase, aminopeptidase, aspartate, aminopeptidase-A, angiotensinase, angiotensinase A, antigen BP-1/6C3 of mouse B lymphocytes, AP A, APA, Asp-AP, aspartate aminopeptidase, aspartyl aminopeptidase, aspartyl-aminopeptidase, BP-1, BP-1/6C3 antigen, BP1/6C3, Ca2+-activated glutamate aminopeptidase, Differentiation antigen gp160, EAP, ENPEP, GAP, GluAP, glutamyl (aspartyl)-specific aminopeptidase A, glutamyl aminopeptidase, glutamyl aminopeptidase (Lactococcus), glutamyl peptidase, glutamyl-aminopeptidase, glutamyl-AP, hAPA, L-alpha-aspartyl(L-alpha-glutamyl)-peptide hydrolase, L-aspartate aminopeptidase, LAP-A, Lb-PepA, Lc-PepA, leucine aminopeptidase A, M18 aspartyl aminopeptidase, mAPA, membrane aminopeptidase II, membrane-bound aspartyl-AP, MHJ_0125, More, N-terminal acidic amino acid-specific aminopeptidase, PepA, tricorn interacting factor F3, tricorn protease-interacting factor F3, type II Zn2+ membrane-bound aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.7 glutamyl aminopeptidase

Substrates Products

Substrates Products on EC 3.4.11.7 - glutamyl aminopeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha-L-Asp-2-naphthylamide + H2O
L-Asp + 2-naphthylamine
show the reaction diagram
-
-
-
?
alpha-L-Asp-Val-angiotensin II + H2O
Asp + Val-angiotensin II
show the reaction diagram
-
-
-
-
?
alpha-L-aspartate-beta-naphthylamide + H2O
L-aspartate + beta-naphthylamine
show the reaction diagram
high activity
-
-
?
alpha-L-Glu-2-naphthylamide + H2O
alpha-L-Glu + 2-naphthylamine
show the reaction diagram
-
-
-
?
alpha-L-Glu-beta-naphthylamide + H2O
L-Glu + 2-naphthylamine
show the reaction diagram
alpha-L-glutamyl-beta-naphthylamide + H2O
L-glutamine + beta-naphthylamine
show the reaction diagram
best substrate
-
-
?
angiotensin I + H2O
?
show the reaction diagram
angiotensin I + H2O
Asp + Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
show the reaction diagram
-
-
-
-
?
angiotensin II
Asp + Arg-Val-Tyr-Ile-His-Pro-Phe
show the reaction diagram
angiotensin II + H2O
?
show the reaction diagram
angiotensin II + H2O
angiotensin III + L-Asp
show the reaction diagram
angiotensin II + H2O
Asp + angiotensin III
show the reaction diagram
angiotensin II + H2O
aspartic acid + angiotensin III
show the reaction diagram
angiotensin II + H2O
L-Asp + angiotensin III
show the reaction diagram
-
-
-
-
?
angiotensin II + H2O
L-aspartic acid + angiotensin III
show the reaction diagram
angiotensin III + H2O
? + angiotensin IV
show the reaction diagram
-
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe, low activity in absence of Ca2+
-
-
?
angiotensin III + H2O
angiotensin IV + Arg
show the reaction diagram
Asp-4-methylcoumaryl-7-amide + H2O
Asp + 7-amino-4-methylcoumarin
show the reaction diagram
-
low activity in absence and presence of Ca2+
-
-
?
Asp-4-nitroanilide + H2O
Asp + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Asp-7-amido-4-methylcoumarin + H2O
Asp + 7-amino-4-methylcoumarin
show the reaction diagram
assay for measuring aspartyl aminopeptidase activity
-
-
?
Asp-Ala + H2O
Asp + Ala
show the reaction diagram
Asp-beta-naphthylamide + H2O
Asp + naphthylamine
show the reaction diagram
Asp-Phe-NH2 + H2O
Asp + Phe + NH3
show the reaction diagram
-
-
-
-
?
aspartame + H2O
L-Asp + L-Phe methyl ester
show the reaction diagram
-
-
-
-
?
cholecystokinin-8 + H2O
?
show the reaction diagram
cholecystokinin-8 + H2O
Asp + YMGWMDF-NH2
show the reaction diagram
-
i.e. CCK8 or DYMGWMDF-NH2
-
-
?
cholecystokinin-8 + H2O
L-Asp + YMGWMDF-NH2
show the reaction diagram
-
-
-
-
?
chromogranin A + H2O
?
show the reaction diagram
-
-
-
-
?
chromogranin A + H2O
Glu + EEEEMAVVPQGLFRG-NH2
show the reaction diagram
-
i.e. EEEEEMAVVPQGLFRG-NH2
-
-
?
Gln-4-methylcoumaryl-7-amide + H2O
Gln + 7-amino-4-methylcoumarin
show the reaction diagram
-
low activity in absence and presence of Ca2+
-
-
?
Glu-2-naphthylamide + H2O
Glu + 2-naphthylamine
show the reaction diagram
Glu-4-methylcoumaryl-7-amide + H2O
Glu + 7-amino-4-methylcoumarin
show the reaction diagram
Glu-4-nitroanilide + H2O
Glu + 4-nitroaniline
show the reaction diagram
Glu-7-amido-4-methylcoumarin + H2O
Glu + 7-amino-4-methylcoumarin
show the reaction diagram
Glu-Ala + H2O
Glu + Ala
show the reaction diagram
Glu-beta-naphthylamide + H2O
Glu + naphthylamine
show the reaction diagram
Glu-Glu + H2O
2 Glu
show the reaction diagram
-
many Glu-Xxx and Asp-Xxx dipeptides are substrates
-
-
?
Glu-Gly + H2O
Glu + Gly
show the reaction diagram
Glu-p-nitroanilide + H2O
Glu + 4-nitroaniline
show the reaction diagram
Glu-p-nitroanilide + H2O
Glu + p-nitroaniline
show the reaction diagram
Glu-p-nitroanilide + H2O
glutamic acid + p-nitroaniline
show the reaction diagram
Gly-7-amido-4-methylcoumarin + H2O
Gly + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
kallidin + H2O
?
show the reaction diagram
-
-
-
-
?
kallidin + H2O
Lys + bradykinin
show the reaction diagram
-
i.e. Lys-bradykinin or KRPPGFSPFR, the reaction is performed only in absence of Ca2+
i.e. RPPGFSPFR
-
?
L-Ala-4-methylcoumaryl-7-amide + H2O
L-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
L-alanine-beta-naphthylamide + H2O
L-alanine + beta-naphthylamine
show the reaction diagram
low activity
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
show the reaction diagram
L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
show the reaction diagram
L-Asp-peptide + H2O
L-Asp + peptide
show the reaction diagram
L-aspartate-beta-naphthylamide + H2O
L-aspartate + beta-naphthylamine
show the reaction diagram
-
-
-
?
L-Glu-2-naphthylamide + H2O
L-Glu + 2-naphthylamine
show the reaction diagram
L-Glu-4-methylcoumaryl-7-amide + H2O
L-Glu + 7-amino-4-methylcoumarin
show the reaction diagram
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
show the reaction diagram
L-Glu-7-amido-4-methylcoumarin + H2O
L-Glu + 7-amino-4-methylcoumarin
show the reaction diagram
L-Glu-beta-naphthylamide + H2O
L-Glu + beta-naphthylamine
show the reaction diagram
-
-
-
?
L-Glu-p-nitroanilide + H2O
L-Glu + p-nitroaniline
show the reaction diagram
-
-
-
?
L-Glu-peptide + H2O
L-Glu + peptide
show the reaction diagram
L-glutamic acid gamma-2-naphthylamide + H2O
L-glutamate + 2-naphthylamide
show the reaction diagram
L-glutamyl beta-naphthylamide + H2O
L-Glu + beta-naphthylamine
show the reaction diagram
L-glutamyl-beta-naphthylamide + H2O
L-glutamine + beta-naphthylamine
show the reaction diagram
-
-
-
?
L-Leu-4-methylcoumaryl-7-amide + H2O
L-Leu + 7-amino-4-methylcoumarin
show the reaction diagram
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
L-lysine-beta-naphthylamide + H2O
L-lysine + beta-naphthylamine
show the reaction diagram
low activity
-
-
?
L-Phe-7-amido-4-methylcoumarin + H2O
L-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
L-Pro-7-amido-4-methylcoumarin + H2O
L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
L-Tyr-7-amido-4-methylcoumarin + H2O
L-Tyr + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
L-Val-7-amido-4-methylcoumarin + H2O
L-Val + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Leu-7-amido-4-methylcoumarin + H2O
Leu + 7-amino-4-methylcoumarin
show the reaction diagram
assay for measuring aspartyl aminopeptidase activity
-
-
?
milk proteins + H2O
?
show the reaction diagram
-
-
-
-
?
N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O
?
show the reaction diagram
N-(alpha-L-aspartyl)-2-naphthylamide + H2O
L-aspartic acid + 2-naphthylamine
show the reaction diagram
N-(alpha-L-aspartylyl)-2-naphthylamide + H2O
L-aspartic acid + 2-naphthylamine
show the reaction diagram
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
L-glutamic acid + 2-naphthylamine
show the reaction diagram
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
L-glutamic acid + 4-nitroaniline
show the reaction diagram
N-(alpha-L-glutamyl)-beta-naphthylamide + H2O
L-glutamic acid + beta-naphthylamine
show the reaction diagram
N-Glu-L-Phe-4-nitroanilide + H2O
L-Glu + L-Phe-4-nitroanilide
show the reaction diagram
-
-
-
-
?
neurokinin B + H2O
?
show the reaction diagram
-
-
-
-
?
neurokinin B + H2O
Asp + MHDFFVGLM-NH2
show the reaction diagram
-
i.e. DMHDFFVGLM-NH2
-
-
?
Ser-Ala + H2O
Ser + Ala
show the reaction diagram
additional information
?
-