3.4.11.7: glutamyl aminopeptidase
This is an abbreviated version!
For detailed information about glutamyl aminopeptidase, go to the full flat file.
Word Map on EC 3.4.11.7
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3.4.11.7
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apa
-
aminopeptidases
-
renin-angiotensin
-
renin
-
dipeptidyl
-
hypertensive
-
ras
-
amastatin
-
brush
-
angiotensin-converting
-
antihypertensive
-
alanyl
-
bestatin
-
vasopressin
-
pressor
-
dipeptidylpeptidase
-
losartan
-
exopeptidase
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enpep
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arylamide
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intracerebroventricularly
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angiotensinogen
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medicine
-
sucrase-isomaltase
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pyroglutamyl
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3.2.1.20
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puromycin-sensitive
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ras-regulating
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insulin-regulated
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oxytocinase
-
kininase
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beta-naphthylamide
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microvillar
-
synthesis
-
diagnostics
-
drug development
- 3.4.11.7
- apa
- aminopeptidases
-
renin-angiotensin
- renin
-
dipeptidyl
-
hypertensive
- ras
- amastatin
-
brush
-
angiotensin-converting
-
antihypertensive
-
alanyl
- bestatin
- vasopressin
-
pressor
-
dipeptidylpeptidase
- losartan
-
exopeptidase
- enpep
-
arylamide
-
intracerebroventricularly
- angiotensinogen
- medicine
- sucrase-isomaltase
-
pyroglutamyl
-
3.2.1.20
-
puromycin-sensitive
-
ras-regulating
-
insulin-regulated
- oxytocinase
-
kininase
- beta-naphthylamide
- microvillar
- synthesis
- diagnostics
- drug development
Reaction
release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide =
Synonyms
acid aminopeptidase, acidic alpha-aminopeptidase, Aminopeptidase, aminopeptidase A, aminopeptidase A ectopeptidase, aminopeptidase, aspartate, aminopeptidase-A, angiotensinase, angiotensinase A, antigen BP-1/6C3 of mouse B lymphocytes, AP A, APA, Asp-AP, aspartate aminopeptidase, aspartyl aminopeptidase, aspartyl-aminopeptidase, BP-1, BP-1/6C3 antigen, BP1/6C3, Ca2+-activated glutamate aminopeptidase, Differentiation antigen gp160, EAP, ENPEP, GAP, GluAP, glutamyl (aspartyl)-specific aminopeptidase A, glutamyl aminopeptidase, glutamyl aminopeptidase (Lactococcus), glutamyl peptidase, glutamyl-aminopeptidase, glutamyl-AP, hAPA, L-alpha-aspartyl(L-alpha-glutamyl)-peptide hydrolase, L-aspartate aminopeptidase, LAP-A, Lb-PepA, Lc-PepA, leucine aminopeptidase A, M18 aspartyl aminopeptidase, mAPA, membrane aminopeptidase II, membrane-bound aspartyl-AP, MHJ_0125, More, N-terminal acidic amino acid-specific aminopeptidase, PepA, tricorn interacting factor F3, tricorn protease-interacting factor F3, type II Zn2+ membrane-bound aminopeptidase
ECTree
3.4.11.7 glutamyl aminopeptidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.11.7 - glutamyl aminopeptidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
angiotensin II + H2O
Asp + angiotensin III
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angiotensin is the most active compound of the renin-angiotensin-system, RAS, involved in regulation of blood pressure in the brain
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-
?
angiotensin II + H2O
Asp + angiotensin III
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angiotensin is the most active compound of the renin-angiotensin-system, RAS, involved in renal development
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-
?
angiotensin II + H2O
Asp + angiotensin III
-
the enzyme is responsible for the convertion of angiotensin II into angiotensin III in the brain
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-
?
angiotensin II + H2O
Asp + angiotensin III
-
angiotensin is the most active compound of the renin-angiotensin-system, RAS, involved in renal development
-
-
?
angiotensin II + H2O
Asp + angiotensin III
-
angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure
-
-
?
angiotensin II + H2O
Asp + angiotensin III
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aspartyl aminopeptidase and several other aminopeptidases, i.e. angiotensinases, are involved in angiotensin II and cholecystokinin, CCK, metabolism, angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure
-
-
?
angiotensin II + H2O
aspartic acid + angiotensin III
-
angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
aspartic acid + angiotensin III
-
angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
aspartic acid + angiotensin III
-
angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin III + H2O
angiotensin IV + Arg
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the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension
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-
ir
angiotensin III + H2O
angiotensin IV + Arg
-
the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension
-
-
ir
angiotensin III + H2O
angiotensin IV + Arg
-
the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension
-
-
ir
angiotensin III + H2O
angiotensin IV + Arg
-
the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension
-
-
ir
additional information
?
-
-
the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
association between elevated BP-1 expression and cell growth. The enzyme is not involved in immune system development
-
-
?
additional information
?
-
-
The C-terminal domain of aminopeptidase A is an intramolecular chaperone required for the correct folding, cell surface expression, and activity of the enzyme
-
-
?
additional information
?
-
-
the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview
-
-
?
additional information
?
-
the enzyme is involved in angiotensin metabolism
-
-
?
additional information
?
-
-
the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview
-
-
?
additional information
?
-
-
administration of purified enzyme into hypertensive rats leads to a decrease in blood pressure, while enzyme inhibition increases blood pressure
-
-
?
additional information
?
-
-
the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview
-
-
?
additional information
?
-
-
the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
potential biological functions, overview
-
-
?
additional information
?
-
-
the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview
-
-
?
