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3.4.11.5: prolyl aminopeptidase

This is an abbreviated version!
For detailed information about prolyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.5

Reaction

release of N-terminal proline from a peptide =

Synonyms

aminopeptidase P, aminopeptidase, proline, APP, cytosol aminopeptidase V, EC 3.4.1.4, L-proline aminopeptidase, L-prolyl-peptide hydrolase, More, pamA, PAP, PchPiPA, PepI, pepIP, PEPP, Pf S33 proline aminopeptidase, PfPAP, PIP, PiPA, Plasmodium falciparum S33 proline aminopeptidase, Pro-X aminopeptidase, proline aminopeptidase, proline iminopeptidase, proline-specific aminopeptidase, Prolyl aminopeptidase, TaPAP1, TePAP, Tricorn protease interacting factor F1, TsPAP1, X-pro aminopeptidase (Lactococcus)

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.5 prolyl aminopeptidase

KM Value

KM Value on EC 3.4.11.5 - prolyl aminopeptidase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.45 - 2.92
4-acetyloxyproline-beta-naphthylamide
0.28
Ala-beta-naphthylamide
pH 7.5, 25°C, recombinant enzyme
0.34 - 24.2
Ala-p-nitroanilide
0.22
Gly-p-nitroanilide
-
-
0.24
His-p-nitroanilide
-
-
0.84 - 4.27
hydroxyproline-beta-naphthylamide
0.05 - 0.125
Hyp-2-naphthylamide
27.8
Hyp-Gly
-
-
0.83 - 9.3
L-hydroxyproline-2-naphthylamide
11.5
L-Lys-4-nitroanilide
-
-
0.01 - 0.23
L-Pro-2-naphthylamide
0.095 - 2.15
L-Pro-4-nitroanilide
2.07
L-Pro-L-Ala
-
pH 8.0, 37°C, wild-type enzyme
3.6
L-Pro-L-Leu-Gly-NH2
-
-
-
0.101
L-proline-7-amido-4-methylcoumarin
-
3.39
Leu-p-nitroanilide
-
-
0.42 - 1.58
Pro-2-naphthylamide
0.065
Pro-4-methoxy-beta-naphythylamide
pH 7.4, 37°C
0.037 - 0.054
Pro-4-nitroanilide
0.31 - 2.69
Pro-Ala
0.9
Pro-Asp
-
-
0.0775 - 13.7676
Pro-beta-naphthylamide
0.78
Pro-D-Ala
-
-
1.86
Pro-D-Phe
-
-
0.71 - 1.79
Pro-Gly
0.31 - 5.3
Pro-Leu
1.85
Pro-Leu-Gly-NH2
-
-
1.55
Pro-Lys
-
-
0.04 - 8.29
Pro-p-nitroanilide
0.33 - 1.08
Pro-Phe
1.79
Pro-Phe-Gly-Lys
-
-
0.31
Pro-Phe-NH2
-
-
0.83
Pro-Trp
-
-
0.07 - 1.38
proline beta-naphthylamide
2.15
proline-4-nitroanilide
Vmax: 347.86 micromol/min/mg
0.04
proline-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
8.73
Val-p-nitroanilide
-
-
additional information
additional information
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