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3.4.11.5: prolyl aminopeptidase

This is an abbreviated version!
For detailed information about prolyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.5

Reaction

release of N-terminal proline from a peptide =

Synonyms

aminopeptidase P, aminopeptidase, proline, APP, cytosol aminopeptidase V, EC 3.4.1.4, L-proline aminopeptidase, L-prolyl-peptide hydrolase, More, pamA, PAP, PchPiPA, PepI, pepIP, PEPP, Pf S33 proline aminopeptidase, PfPAP, PIP, PiPA, Plasmodium falciparum S33 proline aminopeptidase, Pro-X aminopeptidase, proline aminopeptidase, proline iminopeptidase, proline-specific aminopeptidase, Prolyl aminopeptidase, TaPAP1, TePAP, Tricorn protease interacting factor F1, TsPAP1, X-pro aminopeptidase (Lactococcus)

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.5 prolyl aminopeptidase

Inhibitors

Inhibitors on EC 3.4.11.5 - prolyl aminopeptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
1-(Ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinone
-
-
2-mercaptoethanol
1 mM ZnCl2 and 5 mM beta-mercapthoethanol, respectively, relative activity: 61%
4-(2-aminoethyl)benzenesulfonyl fluoride
85% inhibition at 1 mM
4-chloromercuribenzoate
4-chloromercuribenzoic acid
4-nitrophenyl iodoacetate
56% inhibition at 1 mM
5,5'-dithiobis(2-nitrobenzoate)
-
-
Al3+
slight inhibition
amastatin
-
0.01 mM
arphamenine A
-
-
Ba2+
slight inhibition
Bathocuproine
-
inhibitor binds specifically to Cu2+
benzamidine
moderate inhibition
Benzamidine hydrochloride
5 mM, 47.6% residual activity
bestatin
beta-mercaptoethanol
-
2 mM
Ca2+
slight inhibition
CuCl2
-
1 mM, 9% residual activity
cysteine
Diazotized sulfanilic acid
-
-
diethyldicarbonate
diethylpyrocarbonate
1 mM, relative activity: 3%
diisopropyl fluorophosphate
diphenylcarbamoyl chloride
oral microorganisms
-
enzymes II and III
E-64
-
1 mM, 16% residual activity
ethanol
-
strong inhibitor
Fe3+
slight inhibition
fragment 2-7 of bradykinin
-
1 mM
glutathione
86% inhibition at 1 mM
heavy metals
-
HgCl2
0.5 mM, relative activity: 31%
hydrochloride
moderate inhibition
iodacetic acid
-
-
iodoacetamide
slight inhibition at 1 mM, 90% inhibition at 10 mM
iodoacetate
-
2.6% remaining activity at 1 mM
iodoacetic acid
L-Hydroxyprolyl-2-naphthylamide
oral microorganisms
-
competitive
leupeptin
0.04 mM, relative activity: 68%
Mg2+
slight inhibition
Mn2+
strong inhibition
N-ethylmaleimide
N-tosyl-L-lysine chloromethyl ketone
N-tosyl-L-phenylalanyl chloromethyl ketone
0.02 mM, relative activity: 69%
Na+
-
slight inhibition at 2 mM NaCl
o-phenanthroline
-
2 mM
p-bromophenacyl bromide
-
-
p-chloromercuribenzenesulfonate
0.1 mM, relative activity: 0%
p-chloromercuribenzoate
p-chloromercuribenzoic acid
p-hydroxymercuribenzoic acid
-
1 mM, 2% residual activity
PbCl2
-
1 mM, 9% residual activity
phenylmethanesulfonyl fluoride
moderate inhibition
phenylmethylsulfonyl fluoride
Phenylmethylsulfonylfluoride
prolinol
Lyophyllum cinerascens
-
-
puromycin
54% inhibition at 1 mM
Tetranitromethane
-
-
ZnCl2
additional information
-