3.4.11.5: prolyl aminopeptidase
This is an abbreviated version!
For detailed information about prolyl aminopeptidase, go to the full flat file.
Word Map on EC 3.4.11.5
-
3.4.11.5
-
women
-
cervical
-
smear
-
cytology
-
pulmonary
-
artery
-
intraepithelial
-
colposcopy
-
neoplasia
-
hypertension
-
cervix
-
services
-
high-risk
-
high-grade
-
hemodynamic
-
mammography
-
undetermined
-
physician
-
low-grade
-
demographic
-
airway
-
attend
-
dysplasia
-
vaginal
-
gynecologic
-
bethesda
-
insurance
-
triage
-
apnea
-
precancerous
-
endocervical
-
exam
-
hysterectomy
-
mammogram
-
catheterization
-
medicine
-
food industry
-
atypia
-
cytopathology
-
industry
-
biotechnology
-
agriculture
-
low-income
-
nutrition
-
peroxidase-antiperoxidase
-
marital
-
hpv-positive
-
receipt
-
polysomnography
-
intercourse
-
self-efficacy
-
medicaid
-
sociodemographic
-
analysis
-
sleepiness
-
telephone
-
married
- 3.4.11.5
- women
- cervical
-
smear
-
cytology
- pulmonary
- artery
-
intraepithelial
-
colposcopy
- neoplasia
- hypertension
- cervix
-
services
-
high-risk
-
high-grade
-
hemodynamic
-
mammography
-
undetermined
-
physician
-
low-grade
-
demographic
- airway
-
attend
- dysplasia
- vaginal
- gynecologic
-
bethesda
-
insurance
-
triage
- apnea
-
precancerous
- endocervical
-
exam
-
hysterectomy
-
mammogram
-
catheterization
- medicine
- food industry
-
atypia
-
cytopathology
- industry
- biotechnology
- agriculture
-
low-income
- nutrition
-
peroxidase-antiperoxidase
-
marital
-
hpv-positive
-
receipt
-
polysomnography
-
intercourse
-
self-efficacy
-
medicaid
-
sociodemographic
- analysis
- sleepiness
-
telephone
-
married
Reaction
release of N-terminal proline from a peptide =
Synonyms
aminopeptidase P, aminopeptidase, proline, APP, cytosol aminopeptidase V, EC 3.4.1.4, L-proline aminopeptidase, L-prolyl-peptide hydrolase, More, pamA, PAP, PchPiPA, PepI, pepIP, PEPP, Pf S33 proline aminopeptidase, PfPAP, PIP, PiPA, Plasmodium falciparum S33 proline aminopeptidase, Pro-X aminopeptidase, proline aminopeptidase, proline iminopeptidase, proline-specific aminopeptidase, Prolyl aminopeptidase, TaPAP1, TePAP, Tricorn protease interacting factor F1, TsPAP1, X-pro aminopeptidase (Lactococcus)
ECTree
3.4.11.5 prolyl aminopeptidaseAdvanced search results
results (
results (Engineering
Engineering on EC 3.4.11.5 - prolyl aminopeptidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C267A
site-directed mutagenesis, the mutant shows reduced activity compared to wild-type, as well as reduced thermostability
D264A
D264H
mutation in educed catalytic residue, complete inactivation
E198A
site-directed mutagenesis, the mutation abolishes the enzyme activity
E198Q
site-directed mutagenesis, the mutation abolishes the enzyme activity
E227A
site-directed mutagenesis, the mutation abolishes the enzyme activity
F133A
site-directed mutagenesis, the mutant shows reduced activity compared to wild-type, as well as reduced thermostability
F143A
site-directed mutagenesis, the mutant shows highly reduced activity compared to wild-type, as well as reduced thermostability
F223A
site-directed mutagenesis, the mutant shows highly reduced activity compared to wild-type, as well as significantly reduced thermostability
F231A
site-directed mutagenesis, the mutant shows highly reduced activity compared to wild-type, as well as highly reduced thermostability
S107D
C271A
-
site-directed mutagenesis, sensitive to inhibition by 4-chloromercuribenzoic acid
C74A
-
site-directed mutagenesis, sensitive to inhibition by 4-chloromercuribenzoic acid
C74A/C271A
-
site-directed mutagenesis, not sensitive to inhibition by 4-chloromercuribenzoic acid
E204Q
-
site-directed mutagenesis, 4% of the wild-type catalytic efficiency
F139A
-
site-directed mutagenesis, 80fold decreased catalytic activity compared to the wild-type enzyme
R136A
-
site-directed mutagenesis, shows decreased activity compared to the wild-type enzyme, but retains arylamidase activity
Y149A
-
site-directed mutagenesis, unaltered catalytic efficiency compared to the wild-type enzyme
D246A
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
H273A
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
S106A
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
D246A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
H273A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
S106A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
D246A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
H273A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
S106A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
D246A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
H273A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
S106A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
D246A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
H273A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
S106A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
D246A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
H273A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
S106A
-
site-directed mutagenesis, active site residue mutant, the enzyme activity is almost completely abolished
-
additional information
D264A
mutation in educed catalytic residue, complete inactivation
S107D
mutation in educed catalytic residue, complete inactivation
additional information
recombinant expression of enzyme Pap in Bacillus subtilis strain WB600. For cell culture, batch fermentation conditions, including the agitation speed, pH and temperature, are systematically optimized based on a kinetic analysis, fermentation kinetics, method optimization, overview. The yield of PAP reaches 174.8 U/ml under the optimized conditions, which is 1.66 times higher than that of the original production. The structure and storage stability of the lyophilized enzyme are significantly increased when protectants are added, and PAP together with alkaline protease and leucine aminopeptidase is used to hydrolyze rice protein. The amount of hydrophobic amino acids is significantly increased, which contributes to a reduction in the bitterness
additional information
Aspergillus oryzae JN-412
-
recombinant expression of enzyme Pap in Bacillus subtilis strain WB600. For cell culture, batch fermentation conditions, including the agitation speed, pH and temperature, are systematically optimized based on a kinetic analysis, fermentation kinetics, method optimization, overview. The yield of PAP reaches 174.8 U/ml under the optimized conditions, which is 1.66 times higher than that of the original production. The structure and storage stability of the lyophilized enzyme are significantly increased when protectants are added, and PAP together with alkaline protease and leucine aminopeptidase is used to hydrolyze rice protein. The amount of hydrophobic amino acids is significantly increased, which contributes to a reduction in the bitterness
-
additional information
-
construction of chimera between the salt-sensitive enzyme from Streptomyces lividans and the salt-resistant enzyme from Streptomyces aureofaciens. The fine tuning of the N-terminal conformation of Streptomyces aureofaciens enzyme by hydrophobic interaction is important for the salt tolerance
additional information
-
construction of chimera between the salt-sensitive enzyme from Streptomyces lividans and the salt-resistant enzyme from Streptomyces aureofaciens. The fine tuning of the N-terminal conformation of Streptomyces aureofaciens enzyme by hydrophobic interaction is important for the salt tolerance
-
additional information
impact of TsPAP1 overexpression on flowering time and the number of siliques due to the enhanced accumulation of proline in transgenic Arabidopsis thaliana plants. The recombinant TsPAP1 protein is expressed without the signal peptide, which could have a negative impact on its activity
additional information
-
construction of chimera between the salt-sensitive enzyme from Streptomyces lividans and the salt-resistant enzyme from Streptomyces aureofaciens. The fine tuning of the N-terminal conformation of Streptomyces aureofaciens enzyme by hydrophobic interaction is important for the salt tolerance
additional information
overexpression of enzyme TaPAP1 from Triticum aestivum in transgenic Arabidopsis thaliana plants, zinc-stressed TaPAP1 transgenic Arabidopsis displays higher survival rate, fresh weight, photosynthetic efficiency, proline levels, and PAP activity compared to wild-type Arabidopsis thaliana plants
additional information
-
disruption of gene results in significantly attenuated virulence of Xanthomonas campestris. Study on expression regulation
additional information
disruption and overexpression of gene pip in Xanthomonas campestris pv. campestris altering the bacterial motility via the c-di-GMP levels, phenotypes, overview
additional information
-
disruption and overexpression of gene pip in Xanthomonas campestris pv. campestris altering the bacterial motility via the c-di-GMP levels, phenotypes, overview
additional information
-
disruption and overexpression of gene pip in Xanthomonas campestris pv. campestris altering the bacterial motility via the c-di-GMP levels, phenotypes, overview
-
additional information
-
disruption and overexpression of gene pip in Xanthomonas campestris pv. campestris altering the bacterial motility via the c-di-GMP levels, phenotypes, overview
-
additional information
-
disruption and overexpression of gene pip in Xanthomonas campestris pv. campestris altering the bacterial motility via the c-di-GMP levels, phenotypes, overview
-
additional information
-
disruption and overexpression of gene pip in Xanthomonas campestris pv. campestris altering the bacterial motility via the c-di-GMP levels, phenotypes, overview
-
additional information
-
disruption and overexpression of gene pip in Xanthomonas campestris pv. campestris altering the bacterial motility via the c-di-GMP levels, phenotypes, overview
-
