3.4.11.3: cystinyl aminopeptidase

This is an abbreviated version!
For detailed information about cystinyl aminopeptidase, go to the full flat file.

Reaction

Release of an N-terminal amino acid, Cys-/-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however =

Synonyms

alpha-Aminoacyl-peptide hydrolase, aminopeptidase, cystyl, AT4 receptor, CAP, CAP-I, CAP-II, CysAP, cysteine aminopeptidase, cystine aminopeptidase, Cystinyl aminopeptidase, cystinylaminopeptidase, cystyl aminopeptidase, cystyl-aminopeptidase, GP160, insulin regulated aminopeptidase, insulin-regulated aminopeptidase, insulin-regulated aminopeptidase IRAP, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, IRAP, IRAP/P-LAP, L-cystine aminopeptidase, LCAP, LeuAP, leucine aminopeptidase/oxytocinase, leucyl-aminopeptidase, leucyl-cystinyl aminopeptidase, LNPEP, M1 aminopeptidase, OTase, oxytocin peptidase, oxytocinase, oxytocinase/insulin-regulated aminopeptidase, oxytocinase/vasopressinase-like leucyl-cystinyl aminopeptidase LNPEP, P-LAP, P-LAP/IRAP, P-LAP/OTase, placental leucil aminopeptidase, Placental leucine aminopeptidase, placental leucine aminopeptidase/oxytocinase, placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase, vasopressinase, vasopresssinase, Vesicle protein of 165 kDa, Vp165, yscXVI

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.11 Aminopeptidases

                3.4.11.3 cystinyl aminopeptidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
5	Activating Compound
11	AA Sequence
14	Application
1	CAS Registry Number
20	Cloned(Commentary)
3	Crystallization (Commentary)
1579	Disease/ Diagnostics
2	Expression
35	General Information
2	General Stability
98	IC50 Value
377	Inhibitors
70	Ki Value [mM]
53	KM Value [mM]
71	Localization
40	Metals/Ions
25	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
105	Organism
12	PDB ID
22	pH Optimum
1	pH Range
10	Posttranslational Modification
33	Protein Variants
16	Purification (Commentary)
1	Reaction
2	Reaction Type
103	Reference
203	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
141	Substrates and Products (Substrate)
10	Subunits
157	Synonyms
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
3	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 3.4.11.3 - cystinyl aminopeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

angiotensin III + H2O

?

2 entries

oxytocin + H2O

?

6 entries

Peptides + H2O

?

Homo sapiens

-

enzyme plays a role in general metabolism of peptides during pregnancy

35907, 35919

-

-

?

Vasopressin + H2O

?

8 entries

vasopressin + H2O

hydrolyzed vasopressin

Mus musculus

-

vasopressin is a physiological substrate

683048

N-terminal processing

-

?

additional information

?

-

13 entries

angiotensin III + H2O

?

Homo sapiens

-

P-LAP/OTase may be involved in maintaining pregnancy homeostasis via metabolizing peptides such as oxytocin and vasopressin

667810

-

-

?

angiotensin III + H2O

?

Homo sapiens

-

the enzyme plays a role in blood pressure regulation via hydrolyzing vasopressin and angiotensin III

664275

-

-

?

oxytocin + H2O

?

Homo sapiens

Q9UIQ6

-

753769

-

-

?

oxytocin + H2O

?

Homo sapiens

-

in the placenta the enzyme is thought to play a role in the prevention of premature labour and maintenance of an adequate blood flow to the uterus

670742

-

-

?

oxytocin + H2O

?

Homo sapiens

-

P-LAP in HUVEC cells regulates effects of oxytocin with resolution

670127

-

-

?

oxytocin + H2O

?

Homo sapiens

Q9UIQ6

a macrocyclic IRAP substrate

752375

-

-

?

oxytocin + H2O

?

Rattus norvegicus

P97629

-

753121, 754445

-

-

?

oxytocin + H2O

?

Rattus norvegicus Wistar

P97629

-

754445

-

-

?

Vasopressin + H2O

?

Homo sapiens

Q9UIQ6

-

753436

-

-

?

Vasopressin + H2O

?

Homo sapiens

-

P-LAP/OTase may be involved in maintaining pregnancy homeostasis via metabolizing peptides such as oxytocin and vasopressin

667810

-

-

?

Vasopressin + H2O

?

Homo sapiens

-

the enzyme plays a role in blood pressure regulation via hydrolyzing vasopressin and angiotensin III

664275

-

-

?

Vasopressin + H2O

?

Homo sapiens

Q9UIQ6

a macrocyclic IRAP substrate

752375

-

-

?

Vasopressin + H2O

?

Mus musculus

Q8C129

inactivation of vasopressin

754109

-

-

?

Vasopressin + H2O

?

Mus musculus C57BL/6J

Q8C129

inactivation of vasopressin

754109

-

-

?

Vasopressin + H2O

?

Rattus norvegicus

P97629

-

753121, 753943, 754445

-

-

?

Vasopressin + H2O

?

Rattus norvegicus Wistar

P97629

-

754445

-

-

?

additional information

?

-

Homo sapiens

-

in individuals with type 2 diabetes the insulin-stimulated translocation of IRAP to the cell-surface of muscle and fat cells is impaired. This defect may lead to decreased cleavage and consequently increased action of peptide hormones that are substrates for IRAP. Impaiered IRAP action may thus play a role in the development of complications in type 2 diabetes

667887

-

-

?

additional information

?

-

Homo sapiens

Q9UIQ6

no activity with 1-deamino-8-D-arginine vasopressin

753436

-

-

?

additional information

?

-

Homo sapiens

-

no activity with 1-deamino-8-D-arginine vasopressin

753436

-

-

?

additional information

?

-

Mus musculus

-

IRAP is required for maintenance of key constituents of endosome-derived vesicles in cardiac muscle cells

670271

-

-

?

additional information

?

-

Mus musculus

-

IRAP is involved in glucose transporter GLUT4 storage vesicle trafficking

683133

-

-

?

additional information

?

-

Mus musculus

Q8C129

recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4

754109

-

-

?

additional information

?

-

Mus musculus

-

recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4

754109

-

-

?

additional information

?

-

Mus musculus C57BL/6J

Q8C129

recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4

754109

-

-

?

additional information

?

-

Ovis aries

-

the enzyme plays an imprtant role for IRAP in reproductive physiology in regulating the action of peptide hormones

670863

-

-

?

additional information

?

-

Rattus norvegicus

-

activity is greatly increased in rats with mammary tumors. The activity may be involved in the promotion and progression of breast cancer through oxytocin, vasopressin and/or renin-angiotensin system misregulation

667213

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme is involved in the metabolism of angiotensin

663814

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme plays a role as a mediator for the effects of angiotensin IV and related peptides on extracellular dopamine levels in striatum

669925

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme plays diverse physiological roles in the rat central nervous system

669637

-

-

?