3.4.11.26: intermediate cleaving peptidase 55

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For detailed information about intermediate cleaving peptidase 55, go to the full flat file.

Reaction

The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase. =

Synonyms

At1g09300, Icp55, YER078c

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.11 Aminopeptidases

                3.4.11.26 intermediate cleaving peptidase 55

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Results	in table
10	AA Sequence
1	Application
3	Cloned(Commentary)
2	Crystallization (Commentary)
4	General Information
3	Inhibitors
3	kcat/KM [mM/s]
1	Ki Value [mM]
3	KM Value [mM]
7	Localization
3	Metals/Ions
4	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
7	Organism
3	PDB ID
1	pH Optimum
2	Protein Variants
1	Purification (Commentary)
1	Reaction
7	Reference
18	Substrates and Products (Substrate)
6	Subunits
8	Synonyms
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.11.26 - intermediate cleaving peptidase 55

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Tyr-Ser-Pro-Nfs1 + H2O

Nfs1 + Tyr-Ser-Pro

Saccharomyces cerevisiae

P40051

the enzyme is involved in the processing pathway of yeast Nfs1 during its translocation into the mitochondrial matrix. Nfs1 from Saccharomyces cerevisiae undergoes two steps of proteolytic processing: first the mitochondrial processing peptidase (MPP) cleaves the precursor between Phe33 and Tyr34. Then Icp55 cleaves between Pro36 and Pro37 removing three amino acids residues (Tyr-Ser-Pro)

709066

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additional information

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Saccharomyces cerevisiae

P40051

Icp55 is critical for stabilization of the mitochondrial proteome. Icp55 removes an amino acid from a characteristic set of N-termini of preprotein intermediates generated by mitochondrial processing peptidase. Thereby Icp55 converts instable intermediates into stable proteins

708076

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