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3.4.11.24: aminopeptidase S

This is an abbreviated version!
For detailed information about aminopeptidase S, go to the full flat file.

Word Map on EC 3.4.11.24

Reaction

release of an N-terminal amino acid with a preference for large hydrophobic amino-terminus residues =

Synonyms

aminolysin-S, aminopeptidase S, aminopeptidase yscCo-II, AmpS, AP, APCo-II, bacterial leucine aminopeptidase, dinuclear aminopeptidase, dizinc aminopeptidase, double-zinc aminopeptidase, leucine aminopeptidase, M28.003, S9 aminopeptidase, S9AP-St, SAP, SGAP, SGAPase, SSAP, Streptomyces aminopeptidase, Streptomyces dinuclear aminopeptidase, Streptomyces griseus aminopeptidase, Streptomyces griseus leucine aminopeptidase, transaminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.24 aminopeptidase S

Reference

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Reference on EC 3.4.11.24 - aminopeptidase S

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gilboa, R.; Greenblatt, H.M.; Perach, M.; Spungin-Bialik, A.; Lessel, U.; Wohlfahrt, G.; Schomburg, D.; Blumberg, S.; Shoham, G.
Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution
Acta Crystallogr. Sect. D
D56
551-558
2000
Streptomyces griseus, Streptomyces griseus (P80561)
Manually annotated by BRENDA team
Spungin, A.; Blumberg, S.
Streptomyces griseus aminopeptidase is a calcium-activated zinc metalloprotein. Purification and properties of the enzyme
Eur. J. Biochem.
183
471-477
1989
Streptomyces griseus (P80561), Streptomyces griseus
Manually annotated by BRENDA team
Ben-Meir, D.; Spungin, A.; Ashkenazi, R.; Blumberg, S.
Specificity of Streptomyces griseus aminopeptidase and modulation of activity by divalent metal ion binding and substitution
Eur. J. Biochem.
212
107-112
1993
Streptomyces griseus
Manually annotated by BRENDA team
Maras, B.; Greenblatt, H.M.; Shoham, G.; Spungin-Bialik, A.; Blumberg, S.; Barra, D.
Aminopeptidase from Streptomyces griseus: primary structure and comparison with other zinc-containing aminopeptidases
Eur. J. Biochem.
236
843-846
1996
Streptomyces griseus (P80561)
Manually annotated by BRENDA team
Papir, G.; Spungin-Bialik, A.; Ben-Meir, D.; Fudim, E.; Gilboa, R.; Greenblatt, H.M.; Shoham, G.; Lessel, U.; Schomburg, D.; Ashkenazi, R.; Blumberg, S.
Inhibition of Streptomyces griseus aminopeptidase and effects of calcium ions on catalysis and binding--comparisons with the homologous enzyme Aeromonas proteolytica aminopeptidase
Eur. J. Biochem.
258
313-319
1998
Streptomyces griseus
Manually annotated by BRENDA team
Vosbeck, K.D.; Greenberg, B.D.; Awad, W.M., Jr.
The proteolytic enzymes of the K-1 strain of Streptomyces griseus obtained from a commercial preparation (Pronase). Specificity and immobilization of aminopeptidase
J. Biol. Chem.
250
3981-3987
1975
Streptomyces griseus
Manually annotated by BRENDA team
Almog, O.; Greenblatt, H.M.; Spungin, A.; Ben-Meir, D.; Blumberg, S.; Shoham, G.
Crystallization and preliminary crystallographic analysis of Streptomyces griseus aminopeptidase
J. Mol. Biol.
230
342-344
1993
Streptomyces griseus
Manually annotated by BRENDA team
Greenblatt, H.M.; Almog, O.; Maras, B.; Spungin-Bialik, A.; Barra, D.; Blumberg, S.; Shoham, G.
Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 A resolution
J. Mol. Biol.
265
620-636
1997
Streptomyces griseus
Manually annotated by BRENDA team
Ni, S.X.; Cossar, D.; Man, A.; Norek, K.; Miller, D.; Kearse, C.; Tsvetnitsky, V.
Purification and characterization of recombinant Streptomyces griseus aminopeptidase
Protein Expr. Purif.
30
62-68
2003
Streptomyces griseus
Manually annotated by BRENDA team
Gilboa, R.; Spungin-Bialik, A.; Wohlfahrt, G.; Schomburg, D.; Blumberg, S.; Shoham, G.
Interactions of Streptomyces griseus aminopeptidase with amino acid reaction products and their implications toward a catalytic mechanism
Proteins
44
490-504
2001
Streptomyces griseus
Manually annotated by BRENDA team
Reiland, V.; Gilboa, R.; Spungin-Bialik, A.; Schomburg, D.; Shoham, Y.; Blumberg, S.; Shoham, G.
Binding of inhibitory aromatic amino acids to Streptomyces griseus aminopeptidase
Acta Crystallogr. Sect. D
60
1738-1746
2004
Streptomyces griseus
Manually annotated by BRENDA team
Jankiewicz, U.; Bielawski, W.
The properties and functions of bacterial aminopeptidases
Acta Microbiol. Pol.
52
217-231
2003
Streptomyces griseus
Manually annotated by BRENDA team
Arima, J.; Uesugi, Y.; Iwabuchi, M.; Hatanaka, T.
Alteration of leucine aminopeptidase from Streptomyces septatus TH-2 to phenylalanine aminopeptidase by site-directed mutagenesis
Appl. Environ. Microbiol.
71
7229-7235
2005
Streptomyces septatus (Q75V72), Streptomyces septatus TH-2 (Q75V72)
Manually annotated by BRENDA team
Arima, J.; Iwabuchi, M.; Hatanaka, T.
Gene cloning and overproduction of an aminopeptidase from Streptomyces septatus TH-2, and comparison with a calcium-activated enzyme from Streptomyces griseus
Biochem. Biophys. Res. Commun.
317
531-538
2004
Streptomyces griseus, Streptomyces septatus (Q75V72), Streptomyces septatus TH-2 (Q75V72), Streptomyces septatus TH-2
Manually annotated by BRENDA team
Ercan, A.; Park, H.I.; Ming, L.J.
Remarkable enhancement of the hydrolyses of phosphoesters by dinuclear centers: Streptomyces aminopeptidase as a 'natural model system'
Chem. Commun. (Camb.)
1
2501-2502
2000
Streptomyces sp.
-
Manually annotated by BRENDA team
Fundoiano-Hershcovitz, Y.; Rabinovitch, L.; Langut, Y.; Reiland, V.; Shoham, G.; Shoham, Y.
Identification of the catalytic residues in the double-zinc aminopeptidase from Streptomyces griseus
FEBS Lett.
571
192-196
2004
Streptomyces griseus
Manually annotated by BRENDA team
Herrera-Camacho, I.; Lopez-Garcia, A.; Millan-Perez-Pena, L.
Aminopeptidase yscCO-II
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
1
1016-1017
2004
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Awad, W.M., Jr.
Streptomyces griseus aminopeptidase
Handbook of Proteolytic Enzymes (Barrett, A. J. ; Rowlings, N. D. ; Woessner, J. F. , eds. )
1
957-959
2004
Streptomyces griseus, Streptomyces griseus K-1
-
Manually annotated by BRENDA team
Odintsov, S.G.; Sabala, I.; Bourenkov, G.; Rybin, V.; Bochtler, M.
Staphylococcus aureus aminopeptidase S is a founding member of a new peptidase clan
J. Biol. Chem.
280
27792-27799
2005
Staphylococcus aureus, Staphylococcus aureus NCTC8325-4
Manually annotated by BRENDA team
Arima, J.; Uesugi, Y.; Uraji, M.; Yatsushiro, S.; Tsuboi, S.; Iwabuchi, M.; Hatanaka, T.
Modulation of Streptomyces leucine aminopeptidase by calcium: identification and functional analysis of key residues in activation and stabilization by calcium
J. Biol. Chem.
281
5885-5894
2006
Streptomyces griseus (Q5WA30), Streptomyces griseus
Manually annotated by BRENDA team
Hasselgren, C.; Park, H.I.; Ming, L.J.
Metal ion binding and activation of Streptomyces griseus dinuclear aminopeptidase: cadmium(II) binding as a model
J. Biol. Inorg. Chem.
6
120-127
2001
Streptomyces griseus
Manually annotated by BRENDA team
Herrera-Camacho, I.; Morales-Monterrosas, R.; Quiroz-Alvarez, R.
Aminopeptidase yscCo-II: a new cobalt-dependent aminopeptidase from yeast-purification and biochemical characterization
Yeast
16
219-229
2000
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ercan, A.; Park, H.I.; Ming, L.-J.
A moonlighting dizinc aminopeptidase from Streptomyces griseus: mechanisms for peptide hydrolysis and the 4 x 1010-fold acceleration of the alternative phosphodiester hydrolysis
Biochemistry
45
13779-13793
2006
Streptomyces griseus (P80561), Streptomyces griseus
Manually annotated by BRENDA team
Hershcovitz, Y.F.; Gilboa2, R.; Reiland, V.; Shoham, G.; Shoham, Y.
Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus
FEBS J.
274
3864-3876
2007
Streptomyces griseus
Manually annotated by BRENDA team
Arima, J.; Morimoto, M.; Usuki, H.; Mori, N.; Hatanaka, T.
The aminolysis reaction of streptomyces S9 aminopeptidase promotes the synthesis of diverse prolyl dipeptides
Appl. Environ. Microbiol.
76
4109-4112
2010
Streptomyces thermocyaneoviolaceus
Manually annotated by BRENDA team
Usuki, H.; Uesugi, Y.; Arima, J.; Yamamoto, Y.; Iwabuchi, M.; Hatanaka, T.
Engineered transaminopeptidase, aminolysin-S for catalysis of peptide bond formation to give linear and cyclic dipeptides by one-pot reaction
Chem. Commun. (Camb. )
46
580-582
2010
Streptomyces thermocyaneoviolaceus, Streptomyces thermocyaneoviolaceus NBRC14271
Manually annotated by BRENDA team
Arima, J.; Morimoto, M.; Usuki, H.; Mori, N.; Hatanaka, T.
Beta-alanyl peptide synthesis by Streptomyces S9 aminopeptidase
J. Biotechnol.
147
52-58
2010
Streptomyces thermocyaneoviolaceus, Streptomyces thermocyaneoviolaceus NBRC14271
Manually annotated by BRENDA team
Ercan, A.; Tay, W.M.; Grossman, S.H.; Ming, L.J.
Mechanistic role of each metal ion in Streptomyces dinuclear aminopeptidase: PEPTIDE hydrolysis and 7x10(10)-fold rate enhancement of phosphodiester hydrolysis
J. Inorg. Biochem.
104
19-29
2010
Streptomyces griseus
Manually annotated by BRENDA team