Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.11.22: aminopeptidase I

This is an abbreviated version!
For detailed information about aminopeptidase I, go to the full flat file.

Word Map on EC 3.4.11.22

Reaction

Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates =

Synonyms

A-LAP, AAP, Actinase AS, adipocyte-derived leucine amino-peptidase, Aeromonas proteolytica aminopeptidase, alpha-Aminoacyl-peptide hydrolase, Aminooligopeptidase, Aminopeptidase, aminopeptidase (I), aminopeptidase 1, aminopeptidase ERAP1, aminopeptidase I, aminopeptidase II, Aminopeptidase III, aminopeptidase IV, aminopeptidase regulator of TNFR1 shedding, Aminopeptidase yscI, Aminopeptidase yscII, Aminopeptidase yscXVI, Aminopolypeptidase, Amylorhizin aminopeptidase, Amylorizin, AP, APE1, Ape2 aminopeptidase, API, ARTS-1, Bacillus aminopeptidase I, ColAP, cold-active aminopeptidase, endoplasmic resticulum aminopeptidase associated with antigen processing, endoplasmic reticulum aminopeptidase, endoplasmic reticulum aminopeptidase 1, endoplasmic reticulum aminopeptidase associated with antigen presentation, ER aminopeptidase, ER aminopeptidase 1, ER aminopeptidase associated with antigen processing, ERAAP, ERAP1, Jc-peptidase, L-aminopeptidase, LAP, LAP II, LAP IV, LAP4, LAPase, LAPIV, Leu.AP, Leucin aminopeptidase V, leucine aminopeptidase, leucine aminopeptidase II, Leucine aminopeptidase IV, leucine-aminopeptidase, Leucineaminopeptidase I, Leucyl aminopeptidase, Metallo aminopeptidase, More, non-specific monoaminopeptidase, pApe1p, PILS-AP, Pj-peptidase, Polypeptidase, puromycin-insensitive leucyl-specific aminopeptidase, thermophilic aminopeptidase, vacuolar aminopeptidase 1, vacuolar aminopeptidase I, Yeast aminopeptidase I, YKL103C, yscI

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.22 aminopeptidase I

Substrates Products

Substrates Products on EC 3.4.11.22 - aminopeptidase I

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-(2-[(4-methylbenzene-1-sulfonyl)amino]ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2-[(leucylamino)methyl]piperidine-1-carboxylate + H2O
N-[2-(6-hydroxy-1,3-dioxo-6,6a-dihydro-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-4-methylbenzene-1-sulfonamide + hexahydroimidazo[1,5-a]pyridin-3(2H)-one + 2-amino-4-methylpentanoic acid
show the reaction diagram
two-photon fluorescent probe SNCL, can be applied for monitoring of the activity in living cells and tissues
-
-
?
AAEAAG-NH2 + H2O
L-Ala + AEAAG-NH2
show the reaction diagram
-
-
-
-
?
AAVVAAG-NH2 + H2O
L-Ala + AVVAAG-NH2
show the reaction diagram
-
-
-
-
?
AEAA-NH2 + H2O
L-Ala + EAA-NH2
show the reaction diagram
-
-
-
-
?
Ala 2-naphthylamide + H2O
Ala + 2-naphthylamine
show the reaction diagram
-
-
-
?
Ala 4-nitroanilide + H2O
Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
show the reaction diagram
Ala-Ala-Pro-Tyr-Lys-amide + H2O
Ala + Ala-Pro-Tyr-Lys-amide
show the reaction diagram
Ala-beta-naphthylamide + H2O
Ala + beta-naphthylamine
show the reaction diagram
-
-
-
?
Arg 2-naphthylamide + H2O
Arg + 2-naphthylamine
show the reaction diagram
-
-
-
?
Arg 4-nitroanilide + H2O
Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
Arg-4-nitroanilide + H2O
Arg + 4-nitroaniline
show the reaction diagram
-
-
?
Asp 2-naphthylamide + H2O
Asp + 2-naphthylamine
show the reaction diagram
-
very slight activity
-
?
Asp-4-nitroanilide + H2O
Asp + 4-nitroaniline
show the reaction diagram
-
-
-
?
AYWANATRSG-D-Ala + H2O
L-Ala + AYWANATRSG-D-Ala
show the reaction diagram
-
-
-
-
?
AYWANATRSGA + H2O
L-Ala + YWANATRSGA
show the reaction diagram
-
high activity compared to other peptide substrates
-
-
?
azocasein + H2O
protein fragments of azocasein of MW 71 kDa, 83 kDa, and 22 kDa
show the reaction diagram
-
-
-
-
?
Cystinyl 4-nitroanilide + H2O
Cystine + 4-nitroaniline
show the reaction diagram
-
-
-
?
DRVYIHPFHL + H2O
L-Asp + L-Arg + VYIHPFHL
show the reaction diagram
-
angiotensin I
-
-
?
E-cadherin + H2O
?
show the reaction diagram
-
-
-
-
?
EAA-NH2 + H2O
L-Glu + AA-NH2
show the reaction diagram
-
-
-
-
?
EFAPGNYPAD + H2O
L-Glu + FAPGNYPAD
show the reaction diagram
-
low activity compared to other peptide substrates
-
-
?
EFAPGNYPAK + H2O
L-Glu + FAPGNYPAK
show the reaction diagram
-
low activity compared to other peptide substrates
-
-
?
EFAPGNYPAL + H2O
L-Glu + FAPGNYPAL
show the reaction diagram
-
high activity compared to other peptide substrates
-
-
?
GDRIYVH + H2O
?
show the reaction diagram
-
-
-
-
?
Glu 4-nitroanilide + H2O
Glu + 4-nitroaniline
show the reaction diagram
-
-
-
?
Glu-4-nitroanilide + H2O
Glu + 4-nitroaniline
show the reaction diagram
Glu-Ala-Pro-Tyr-Lys-amide + H2O
Glu + Ala-Pro-Tyr-Lys-amide
show the reaction diagram
Gly 4-nitroanilide + H2O
Gly + 4-nitroaniline
show the reaction diagram
-
-
-
?
Gly-4-nitroanilide + H2O
Gly + 4-nitroaniline
show the reaction diagram
Gly-Ala-Pro-Tyr-Lys-amide + H2O
Gly + Ala-Pro-Tyr-Lys-amide
show the reaction diagram
Gly-Leu-Tyr + H2O
Gly + Leu-Tyr
show the reaction diagram
-
-
-
-
?
HSDAVFTDNYTRLRKQMAVKKYLNSILN + H2O
His + SDAVFTDNYTRLRKQM + AVKKYLN + SILN
show the reaction diagram
-
protein VIP
-
-
?
Ile-4-nitroanilide + H2O
Ile + 4-nitroaniline
show the reaction diagram
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
L-Ala-Ala-Pro-Leu-4-nitroanilide + H2O
L-Ala-Ala-Pro-Leu + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
show the reaction diagram
-
-
-
-
?
L-Ala-Gly-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
L-Ala-Gly-Gly ethyl ester + H2O
L-Ala + Gly-Gly ethyl ester
show the reaction diagram
-
-
-
-
?
L-Ala-L-Asp-L-Phe methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
L-Ala-L-Leu + H2O
L-Ala + L-Leu
show the reaction diagram
-
-
-
-
?
L-Ala-L-Thr + H2O
L-Ala + L-Thr
show the reaction diagram
-
-
-
-
?
L-Ala-L-Thr-Gly methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
L-Ala-L-Thr-L-Ala + H2O
?
show the reaction diagram
-
-
-
-
?
L-Ala-L-Thr-L-Ala methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
L-Ala-p-nitroanilide + H2O
L-Ala + p-nitroaniline
show the reaction diagram
-
preferred substrate
-
-
?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
show the reaction diagram
L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
L-Arg-L-Phe + H2O
L-Arg + L-Phe
show the reaction diagram
-
-
-
-
?
L-Arg-p-nitroanilide + H2O
L-Arg + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Leu-2-naphthylamide + H2O
L-Leu + 2-naphthylamine
show the reaction diagram
-
preferred substrate
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
show the reaction diagram
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
show the reaction diagram
L-Leu-Gly + H2O
L-Leu + Gly
show the reaction diagram
-
-
-
-
?
L-Leu-Gly-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
L-Leu-Gly-L-Leu + H2O
?
show the reaction diagram
-
-
-
-
?
L-Leu-L-Ala + H2O
L-Leu + L-Ala
show the reaction diagram
-
-
-
-
?
L-Leu-L-Leu + H2O
L-Leu + L-Leu
show the reaction diagram
-
-
-
-
?
L-Leu-L-Phe + H2O
L-Leu + L-Phe
show the reaction diagram
-
-
-
-
?
L-Leu-p-nitroanilide + H2O
L-Leu + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-leucine 4-nitroanilide + H2O
L-leucine + 4-nitroaniline
show the reaction diagram
-
-
-
?
L-leucine-4-anisidide + H2O
L-leucine + anisidine
show the reaction diagram
-
-
-
?
L-leucine-4-methylcoumaryl-7-amide + H2O
L-leucine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-leucine-7-amido-4-methylcoumarin + H2O
L-leucine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
L-leucine-anilide + H2O
L-leucine + aniline
show the reaction diagram
-
-
-
?
L-Lys-2-naphthylamide + H2O
L-Lys + 2-naphthylamine
show the reaction diagram
-
low activity
-
-
?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
show the reaction diagram
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Met-7-amido-4-methylcoumarin + H2O
L-Met + 7-amino-4-methylcoumarin
show the reaction diagram
L-Met-L-Phe + H2O
L-Met + L-Phe
show the reaction diagram
-
-
-
-
?
L-Phe-4-nitroanilide + H2O
L-Phe + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Phe-7-amido-4-methylcoumarin + H2O
L-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
L-Phe-Gly + H2O
L-Phe + Gly
show the reaction diagram
-
-
-
-
?
L-Phe-Gly-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
L-Phe-L-Ala + H2O
L-Phe + L-Ala
show the reaction diagram
-
-
-
-
?
L-Phe-L-Arg + H2O
L-Phe + L-Arg
show the reaction diagram
-
-
-
-
?
L-Phe-L-Ile + H2O
L-Phe + L-Ile
show the reaction diagram
-
-
-
-
?
L-Phe-L-Leu + H2O
L-Phe + L-Leu
show the reaction diagram
-
-
-
-
?
L-Phe-L-Met + H2O
L-Phe + L-Met
show the reaction diagram
-
-
-
-
?
L-Phe-L-Met-D-Arg-L-Phe-NH2 + H2O
L-Phe + L-Phe-L-Met-D-Arg-NH2
show the reaction diagram
-
-
-
-
?
L-Phe-L-Met-L-Arg-L-Phe-NH2 + H2O
L-Phe + L-Phe-L-Met-L-Arg-NH2
show the reaction diagram
-
bioactive molluscan cardioexcitatory neuropeptide
-
-
?
L-Phe-L-Phe + H2O
L-Phe + L-Phe
show the reaction diagram
-
best substrate
-
-
?
L-Phe-L-Trp + H2O
L-Phe + L-Trp
show the reaction diagram
-
-
-
-
?
L-Phe-L-Tyr + H2O
L-Phe + L-Tyr
show the reaction diagram
-
-
-
-
?
L-Pro-4-nitroanilide + H2O
L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Tyr-7-amido-4-methylcoumarin + H2O
L-Tyr + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Tyr-L-Phe + H2O
L-Tyr + L-Phe
show the reaction diagram
-
-
-
-
?
L-Val-4-nitroanilide + H2O
L-Val + 4-nitroaniline
show the reaction diagram
-
low activity
-
-
?
Leu 2-naphthylamide + H2O
Leu + 2-naphthylamine
show the reaction diagram
-
-
-
?
Leu 4-nitroanilide + H2O
Leu + 4-nitroaniline
show the reaction diagram
Leu-4-nitroanilide + H2O
Leu + 4-nitroaniline
show the reaction diagram
Leu-Ala-Pro-Tyr-Lys-amide + H2O
Leu + Ala-Pro-Tyr-Lys-amide
show the reaction diagram
Leu-beta-naphthylamide + H2O
Leu + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
leucine enkephalin + H2O
?
show the reaction diagram
-
recombinant enzyme, release of Tyr, Gly, Phe and Leu
-
?
LGGGGGGGGGGL + H2O
L-leucine + GGGGGGGGGGL
show the reaction diagram
-
-
-
?
LGGGGGGGGGL + H2O
L-leucine + GGGGGGGGGL
show the reaction diagram
-
-
-
?
LGGGL + H2O
L-leucine + GGGL
show the reaction diagram
-
-
-
?
Lys 2-naphthylamide + H2O
Lys + 2-naphthylamine
show the reaction diagram
-
-
-
?
Lys 4-nitroanilide + H2O
Lys + 4-nitroaniline
show the reaction diagram
-
-
-
?
Lys-4-nitroanilide + H2O
Lys + 4-nitroaniline
show the reaction diagram
Met 4-nitroanilide + H2O
Met + 4-nitroaniline
show the reaction diagram
-
-
-
?
Met-4-nitroanilide + H2O
Met + 4-nitroaniline
show the reaction diagram
occludin + H2O
?
show the reaction diagram
-
-
-
-
?
Phe 2-naphthylamide + H2O
Phe + 2-naphthylamine
show the reaction diagram
-
-
-
?
Phe 4-nitroanilide + H2O
Phe + 4-nitroaniline
show the reaction diagram
-
-
-
?
Phe-4-nitroanilide + H2O
Phe + 4-nitroaniline
show the reaction diagram
-
-
?
Pro 2-naphthylamide + H2O
Pro + 2-naphthylamine
show the reaction diagram
-
-
-
?
Pro 4-nitroanilide + H2O
Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Pro-4-nitroanilide + H2O
Pro + 4-nitroaniline
show the reaction diagram
low activity
-
?
Pro-Ala-Pro-Tyr-Lys-amide + H2O
Pro + Ala-Pro-Tyr-Lys-amide
show the reaction diagram
QITANRELIQQEL + H2O
? + TANRELIQQEL
show the reaction diagram
-
-
intermediate product TANRELIQQEL is further processed
-
?
QLESIINFEK + H2O
L-Gln + LESIINFEK
show the reaction diagram
-
low activity compared to other peptide substrates
-
-
?
QLESIINFEKA + H2O
L-Gln + LESIINFEKA
show the reaction diagram
-
high activity compared to other peptide substrates
-
-
?
QLESIINFEKD + H2O
L-Gln + LESIINFEKD
show the reaction diagram
-
low activity compared to other peptide substrates
-
-
?
QLESIINFEKK + H2O
L-Gln + LESIINFEKK
show the reaction diagram
-
low activity compared to other peptide substrates
-
-
?
QLESIINFEKL + H2O
L-Gln + LESIINFEKL
show the reaction diagram
-
best peptide substrate
-
-
?
QLESIINFEKL-amide + H2O
L-Gln + LESIINFEKL-amide
show the reaction diagram
-
high activity compared to other peptide substrates
-
-
?
QLESIINFEKR + H2O
L-Gln + LESIINFEKR
show the reaction diagram
-
low activity compared to other peptide substrates
-
-
?
QLESIINFEKY + H2O
L-Gln + LESIINFEKY
show the reaction diagram
-
high activity compared to other peptide substrates
-
-
?
QLESIINFELK + H2O
L-Gln + LESIINFELK
show the reaction diagram
-
-
-
-
?
RPKPQQFFGLM + H2O
RPKPQ + QFF + GLM
show the reaction diagram
-
substance P
-
-
?
RPPGFSPFR + H2O
Arg + PPGF + SPFR
show the reaction diagram
-
bradykinin
-
-
?
S-Benzoyl-Cys 4-nitroanilide + H2O
S-Benzoyl-Cys + 4-nitroaniline
show the reaction diagram
-
-
-
?
Ser 2-naphthylamide + H2O
Ser + 2-naphthylamine
show the reaction diagram
-
-
-
?
SIINFEKL + H2O
L-Ser + IINFEKL
show the reaction diagram
-
-
-
-
?
thionoleucine-4-anisidide + H2O
thionoleucine + anisidine
show the reaction diagram
-
-
-
?
thionoleucine-S-anilide + H2O
thionoleucine + aniline
show the reaction diagram
-
-
-
?
TTQRTRALV-NH2 + H2O
L-Thr + TQRTRALV-NH2
show the reaction diagram
-
-
-
-
?
Tyr 2-naphthylamide + H2O
Tyr + 2-naphthylamine
show the reaction diagram
-
-
-
?
Val 2-naphthylamide + H2O
Val + 2-naphthylamine
show the reaction diagram
-
slight activity
-
?
Val 4-nitroanilide + H2O
Val + 4-nitroaniline
show the reaction diagram
-
-
-
?
Val-4-nitroanilide + H2O
Val + 4-nitroaniline
show the reaction diagram
WEVYEKCALK + H2O
L-Trp + EVYEKCALK
show the reaction diagram
-
-
-
-
?
WRVYEKCALK + H2O
L-Trp + RVYEKCALK
show the reaction diagram
-
-
-
-
?
WRVYEKMALKC + H2O
L-Trp + RVYEKMALKC
show the reaction diagram
-
-
-
-
?
additional information
?
-