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3.4.11.22: aminopeptidase I

This is an abbreviated version!
For detailed information about aminopeptidase I, go to the full flat file.

Word Map on EC 3.4.11.22

Reaction

Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates =

Synonyms

A-LAP, AAP, Actinase AS, adipocyte-derived leucine amino-peptidase, Aeromonas proteolytica aminopeptidase, alpha-Aminoacyl-peptide hydrolase, Aminooligopeptidase, Aminopeptidase, aminopeptidase (I), aminopeptidase 1, aminopeptidase ERAP1, aminopeptidase I, aminopeptidase II, Aminopeptidase III, aminopeptidase IV, aminopeptidase regulator of TNFR1 shedding, Aminopeptidase yscI, Aminopeptidase yscII, Aminopeptidase yscXVI, Aminopolypeptidase, Amylorhizin aminopeptidase, Amylorizin, AP, APE1, Ape2 aminopeptidase, API, ARTS-1, Bacillus aminopeptidase I, ColAP, cold-active aminopeptidase, endoplasmic resticulum aminopeptidase associated with antigen processing, endoplasmic reticulum aminopeptidase, endoplasmic reticulum aminopeptidase 1, endoplasmic reticulum aminopeptidase associated with antigen presentation, ER aminopeptidase, ER aminopeptidase 1, ER aminopeptidase associated with antigen processing, ERAAP, ERAP1, Jc-peptidase, L-aminopeptidase, LAP, LAP II, LAP IV, LAP4, LAPase, LAPIV, Leu.AP, Leucin aminopeptidase V, leucine aminopeptidase, leucine aminopeptidase II, Leucine aminopeptidase IV, leucine-aminopeptidase, Leucineaminopeptidase I, Leucyl aminopeptidase, Metallo aminopeptidase, More, non-specific monoaminopeptidase, pApe1p, PILS-AP, Pj-peptidase, Polypeptidase, puromycin-insensitive leucyl-specific aminopeptidase, thermophilic aminopeptidase, vacuolar aminopeptidase 1, vacuolar aminopeptidase I, Yeast aminopeptidase I, YKL103C, yscI

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.22 aminopeptidase I

KM Value

KM Value on EC 3.4.11.22 - aminopeptidase I

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.7
Ala beta-naphthylamide
-
pH 7.5, 21°C, native enzyme
3.5 - 14
Ala-4-nitroanilide
12
Ala-Gly-Gly
-
-
3.2
Ala-Thr-Ala
-
-
2.7
Ala-Thr-Ala methyl ester
-
-
0.253
AYWANATRSG-D-Ala
-
pH 7.5, 37°C
0.09
AYWANATRSGA
-
pH 7.5, 37°C
0.0225
Cystinyl 4-nitroanilide
-
-
1.325
EFAPGNYPAD
-
pH 7.5, 37°C
1.5
EFAPGNYPAK
-
pH 7.5, 37°C
0.148
EFAPGNYPAL
-
pH 7.5, 37°C
1.5
Glu-4-nitroanilide
-
pH 7.5, 21°C, recombinant enzyme
51
Ile-4-nitroanilide
-
pH 7.5, 21°C, recombinant enzyme
0.043 - 0.072
L-Ala-Ala-Pro-Leu-4-nitroanilide
14
L-Ala-Gly-Gly ethyl este
-
-
-
6
L-Ala-L-Th
-
-
-
0.4
L-Ala-p-nitroanilide
-
in 50 mM Tris-HCl, pH 8.1, at 30°C
0.35
L-Leu-4-nitroanilide
-
pH 8.5, 65°C
7
L-Leu-Gly-L-Leu
-
-
-
45
L-leucin-anilide
-
pH 8.0, 25°C, enzyme with Zn2+ and Cd2+ bound
4.6 - 15
L-leucine 4-nitroanilide
32 - 50
L-leucine-4-anisidide
61 - 78
L-leucine-anilide
0.31
L-Phe-4-nitroanilide
-
pH 8.5, 65°C
15
L-Pro-4-nitroanilide
-
pH 7.5, 21°C, recombinant enzyme
0.09
L-Val-4-nitroanilide
-
pH 8.5, 65°C
7
Leu-4-nitroanilide
-
pH 7.5, 21°C, recombinant enzyme
9
Lys-4-nitroanilide
-
pH 7.5, 21°C, recombinant enzyme
0.124
QLESIINFEKA
-
pH 7.5, 37°C
0.7
QLESIINFEKD
-
pH 7.5, 37°C
0.8
QLESIINFEKK
-
pH 7.5, 37°C
0.124
QLESIINFEKL
-
pH 7.5, 37°C
0.138
QLESIINFEKL-amide
-
pH 7.5, 37°C
0.91
QLESIINFEKR
-
pH 7.5, 37°C
0.111
QLESIINFEKY
-
pH 7.5, 37°C
4 - 7
thionoleucine-4-anisidide
4 - 11
thionoleucine-S-anilide
13
Val-4-nitroanilide
-
pH 7.5, 21°C, recombinant enzyme
0.328
WEVYEKCALK
-
at 37°C
0.075
WRVYEKCALK
-
at 37°C
additional information
additional information
-