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3.4.11.21: aspartyl aminopeptidase

This is an abbreviated version!
For detailed information about aspartyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.21

Reaction

release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate =

Synonyms

AAP, acid aminopeptidase, acid peptidase, alpha-aspartyl dipeptidase, Aminopeptidase, aminopeptidase A, angiotensinase, APA, Ape4, Ape4 aspartyl aminopeptidase, Ape4 metalloprotease, Asp-AP, AspAP, aspartate aminopeptidase, aspartic aminopeptidase, aspartyl aminopeptidase, aspartyl(glutamyl)-specific aminopeptidase, aspartyl-AP, CNAG_01169, DAP, DNPEP, EC 3.4.11.7, glutamyl (aspartyl)-specific aminopeptidase A, glutamyl aminopeptidase, L-aspartate aminopeptidase, Lb-PepA, Lc-PepA, M18 aspartyl aminopeptidase, M18AAP, More, PepA, peptidase E, PfM18AAP, PvM18AAP, soluble acid aminopeptidase, TgAAP, TGGT1_297970, Yhr113w

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.21 aspartyl aminopeptidase

Disease

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Disease on EC 3.4.11.21 - aspartyl aminopeptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Anti-Glomerular Basement Membrane Disease
Chloride Channel ClC-5 Binds to Aspartyl Aminopeptidase to Regulate Renal Albumin Endocytosis.
Astrocytoma
Differential Effects of Doxazosin on Renin-Angiotensin-System-Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.
Breast Neoplasms
A PAK5-DNPEP-USP4 axis dictates breast cancer growth and metastasis.
Aspartyl Aminopeptidase Suppresses Proliferation, Invasion, and Stemness of Breast Cancer Cells via Targeting CD44.
Neoadjuvant chemotherapy modifies serum angiotensinase activities in women with breast cancer.
Renin-Angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea.
Chagas Disease
[Description of an acidic peptidase, insensitive to classical inhibitors, in protein extracts of Trypanosoma cruzi, from a rural area of Venezuela, where Chagas disease is endemic].
Colorectal Neoplasms
Clinical impact of aspartyl aminopeptidase expression and activity in colorectal cancer.
Coma
Crystal structure of the peptidase domain of Streptococcus ComA, a bifunctional ATP-binding cassette transporter involved in the quorum-sensing pathway.
Hypertension
Angiotensinase A (aminopeptidase A): properties of chromatographically purified isoforms from human kidney.
Hyperthyroidism
Angiotensinase activity in hypothalamus and pituitary of hypothyroid, euthyroid and hyperthyroid adult male rats.
Atrial angiotensinase activity in hypothyroid, euthyroid, and hyperthyroid rats.
Influence of thyroid disorders on kidney angiotensinase activity.
Thyroid Disorders Change the Pattern of Response of Angiotensinase Activities in the Hypothalamus-Pituitary-Adrenal Axis of Male Rats.
Leukemia, Lymphocytic, Chronic, B-Cell
Aspartic Aminopeptidase Is a Novel Biomarker of Aggressive Chronic Lymphocytic Leukemia.
Malaria
Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening.
In silico prediction of anti-malarial hit molecules based on machine learning methods.
The M18 aspartyl aminopeptidase of Plasmodium falciparum binds to human erythrocyte spectrin in vitro.
The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.
X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP.
Malaria, Falciparum
X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP.
Neoplasm Metastasis
A PAK5-DNPEP-USP4 axis dictates breast cancer growth and metastasis.
Neoplasms
Altered glutamyl-aminopeptidase activity and expression in renal neoplasms.
Aspartic Aminopeptidase Is a Novel Biomarker of Aggressive Chronic Lymphocytic Leukemia.
Aspartyl Aminopeptidase Suppresses Proliferation, Invasion, and Stemness of Breast Cancer Cells via Targeting CD44.
Changes in cell-surface peptidase activity in papillary renal cell carcinoma.
Glutamyl- but not aspartyl-aminopeptidase activity is modified in serum of N-methyl nitrosourea-induced rat mammary tumours.
Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1?
The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.
Neuroblastoma
Differential Effects of Doxazosin on Renin-Angiotensin-System-Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.
Proteinuria
Chloride Channel ClC-5 Binds to Aspartyl Aminopeptidase to Regulate Renal Albumin Endocytosis.
Urinary aminopeptidase activities as early and predictive biomarkers of renal dysfunction in cisplatin-treated rats.