3.4.11.2: membrane alanyl aminopeptidase

This is an abbreviated version!
For detailed information about membrane alanyl aminopeptidase, go to the full flat file.

Reaction

Release of an N-terminal amino acid, Xaa-/-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide =

Synonyms

AAP, Aap 1' aminopeptidase, Aap1 aminopeptidase, Aap1', AlaAP, alanine aminopeptidase, alanine-specific aminopeptidase, alanine/arginine aminopeptidase, alanyl aminopeptidase, alanyl-aminopeptidase, Alpha-aminoacylpeptide hydrolase, amino-oligopeptidase, amino-peptidase N, aminopeptidase D, aminopeptidase M, aminopeptidase M II, aminopeptidase N, aminopeptidase N type 1, aminopeptidase N/CD13, aminopeptidase N3, aminopeptidase, microsomal, aminopeptidase-N, ANPEP, AP-N, Ap1, Ap2, APAse D, APase2, Ape, APN, APN-1, APN-PI, APN/CD13, APN1, APN2, APN3, APN96, basic aminopeptidase, beta-alanyl aminopeptidase, CD13, Cl--activated aminopeptidase, CryIA(C) receptor, Cys-Gly-dipeptidase, cysteinyl-glycinase, dipeptidase, DP, EC 3.4.1. 2, EC 3.4.1.2, EC 3.4.3.5, ENPEP, ePepN, extracellular aminopeptidase, GP 130, GP150, L,(L/D)-aminopeptidase, L-alanine aminopeptidase, LAP, lap3, LeuAP M, leucine aminopeptidase, Leukemia antigen CD13, Lys-AP, Lysyl aminopeptidase, M1 alanine aminopeptidase, mAAP, membrane alanyl aminopeptidase N, membrane alanyl-aminopeptidase, Membrane glycoprotein H11, Membrane protein p161, Microsomal aminopeptidase, microsomal leucine aminopeptidase, More, Myeloid plasma membrane glycoprotein CD13, neutral aminopeptidase, NmAPN, p146, p146 type II alveolar epithelial cell antigen, p161, particle-bound aminopeptidase, PepN, peptidase N, plant aminopeptidase N, puromycin-insensitive neutral aminopeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.11 Aminopeptidases

                3.4.11.2 membrane alanyl aminopeptidase

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Results	in table
15	Activating Compound
41372	AA Sequence
43	Application
1	CAS Registry Number
56	Cloned(Commentary)
7	Crystallization (Commentary)
3258	Disease/ Diagnostics
3	Expression
12	General Information
2	General Stability
639	IC50 Value
1254	Inhibitors
42	kcat/KM [mM/s]
79	Ki Value [mM]
139	KM Value [mM]
171	Localization
110	Metals/Ions
88	Molecular Weight [Da]
111	Natural Substrates/ Products (Substrates)
10	Organic Solvent Stability
257	Organism
4	Pathway
114	PDB ID
50	pH Optimum
3	pH Range
6	pH Stability
5	pI Value
39	Posttranslational Modification
26	Protein Variants
47	Purification (Commentary)
2	Reaction
10	Reaction Type
249	Reference
401	Source Tissue
77	Specific Activity [micromol/min/mg]
3	Storage Stability
577	Substrates and Products (Substrate)
66	Subunits
400	Synonyms
45	Temperature Optimum [°C]
5	Temperature Range [°C]
14	Temperature Stability [°C]
59	Turnover Number [1/s]

Organic Solvent Stability

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Organic Solvent Stability on EC 3.4.11.2 - membrane alanyl aminopeptidase

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ORGANIC SOLVENT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Acetone

Sus scrofa

-

35 vol.%, no denaturation after 100 h, rapid denaturation at higher concentrations

35882

chloroform

Sus scrofa

-

saturated solution in H2O, no denaturation after 100 h, rapid denaturation at higher concentrations

35882

dimethylformamide

Sus scrofa

-

10%, influence on Km and Vmax with various substrates

35884

dimethylsulfoxide

Sus scrofa

-

10%, influence on Km and Vmax with various substrates

35884

dioxane

Sus scrofa

-

20%, influence on Km and Vmax with various substrates

35884

Ethanol

Sus scrofa

-

0-30%, influence on Km and Vmax with various substrates

35884

Methanol

Sus scrofa

-

0-40%, influence on Km and Vmax with various substrates

35884

methyl cellosolve

Sus scrofa

-

0-40%, influence on Km and Vmax with various substrates

35884

propan-1-ol

Sus scrofa

-

0-15%, influence on Km and Vmax with various substrates

35884

toluene

Sus scrofa

-

saturated solution in H2O, no denaturation after 100 h, rapid denaturation at higher concentrations

35882