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3.4.11.2: membrane alanyl aminopeptidase

This is an abbreviated version!
For detailed information about membrane alanyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.2

Reaction

Release of an N-terminal amino acid, Xaa-/-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide =

Synonyms

AAP, Aap 1' aminopeptidase, Aap1 aminopeptidase, Aap1', AlaAP, alanine aminopeptidase, alanine-specific aminopeptidase, alanine/arginine aminopeptidase, alanyl aminopeptidase, alanyl-aminopeptidase, Alpha-aminoacylpeptide hydrolase, amino-oligopeptidase, amino-peptidase N, aminopeptidase D, aminopeptidase M, aminopeptidase M II, aminopeptidase N, aminopeptidase N type 1, aminopeptidase N/CD13, aminopeptidase N3, aminopeptidase, microsomal, aminopeptidase-N, ANPEP, AP-N, Ap1, Ap2, APAse D, APase2, Ape, APN, APN-1, APN-PI, APN/CD13, APN1, APN2, APN3, APN96, basic aminopeptidase, beta-alanyl aminopeptidase, CD13, Cl--activated aminopeptidase, CryIA(C) receptor, Cys-Gly-dipeptidase, cysteinyl-glycinase, dipeptidase, DP, EC 3.4.1. 2, EC 3.4.1.2, EC 3.4.3.5, ENPEP, ePepN, extracellular aminopeptidase, GP 130, GP150, L,(L/D)-aminopeptidase, L-alanine aminopeptidase, LAP, lap3, LeuAP M, leucine aminopeptidase, Leukemia antigen CD13, Lys-AP, Lysyl aminopeptidase, M1 alanine aminopeptidase, mAAP, membrane alanyl aminopeptidase N, membrane alanyl-aminopeptidase, Membrane glycoprotein H11, Membrane protein p161, Microsomal aminopeptidase, microsomal leucine aminopeptidase, More, Myeloid plasma membrane glycoprotein CD13, neutral aminopeptidase, NmAPN, p146, p146 type II alveolar epithelial cell antigen, p161, particle-bound aminopeptidase, PepN, peptidase N, plant aminopeptidase N, puromycin-insensitive neutral aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.2 membrane alanyl aminopeptidase

Molecular Weight

Molecular Weight on EC 3.4.11.2 - membrane alanyl aminopeptidase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
-
SDS-PAGE
102000
-
x * 102000, about, isozyme APN2, sequence calculation, x * 104000, about, isozyme APN4, sequence calculation, x * 106000, about, isozyme APN1, sequence calculation, x * 110000, about, isozyme APN3, sequence calculation
104000
-
x * 102000, about, isozyme APN2, sequence calculation, x * 104000, about, isozyme APN4, sequence calculation, x * 106000, about, isozyme APN1, sequence calculation, x * 110000, about, isozyme APN3, sequence calculation
106000
108000
-
2 * 108000, SDS-PAGE
110000
112000
calculated from amino acid sequence
113600
x * 113600, amino acid sequence calculation
120000
120000 - 170000
-
-
130000
131000
-
SDS-PAGE
132000
-
2 * 132000
137000 - 153000
-
light scattering, native PAGE, SDS-PAGE
140000
143000
-
SDS-PAGE
150000
160000
162000
-
SDS-PAGE
166000
-
1 * 170000, mannose-rich precursor, SDS-PAGE, 1 * 166000, complex glycosylated mature enzyme, SDS-PAGE, 1 * 190000, about, recombinant GFP-tagged complex glycosylated mature enzyme, SDS-PAGE
170000
-
1 * 170000, mannose-rich precursor, SDS-PAGE, 1 * 166000, complex glycosylated mature enzyme, SDS-PAGE, 1 * 190000, about, recombinant GFP-tagged complex glycosylated mature enzyme, SDS-PAGE
175000
-
gel filtration
180000
190000
200000
-
gel filtration
206000
-
gel filtration
210800
-
equilibrium centrifugation
230000
-
peptidase I, density gradient centrifugation
240000
-
gel filtration
244000
-
equilibrium centrifugation
260000
-
the protein present in sera of patients with cholestatic diseases is later found to be a high molecular isoform of CD13 (260 kDa)
280000
320000
-
enzyme I, PAGE
46000
-
x * 46000, SDS-PAGE
58000
-
SDS-PAGE
59000
-
gel filtration
61000
-
1 * 61000, SDS-PAGE
66000
71000
-
alpha,beta, 2 * 91000 + 2 * 71000, enzyme I, SDS-PAGE
75000
-
2 * 75000
80000
-
gel filtration, SDS-PAGE
87000
-
1 * 87000, SDS-PAGE
90000
91000
94000
-
1 * 94000 + 1 * 66000, SDS-PAGE
94986
-
1 * 95000, SDS-PAGE, 1 * 94986, calculated
95000
96000
1 * 96000, SDS-PAGE
96400
-
2 * 96400, isozyme APN96, SDS-PAGE
97000
gel filtration
97634
-
x * 97634, sequence calculation
98000
98750
-
mass spectrometry
99000