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3.4.11.2: membrane alanyl aminopeptidase

This is an abbreviated version!
For detailed information about membrane alanyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.2

Reaction

Release of an N-terminal amino acid, Xaa-/-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide =

Synonyms

AAP, Aap 1' aminopeptidase, Aap1 aminopeptidase, Aap1', AlaAP, alanine aminopeptidase, alanine-specific aminopeptidase, alanine/arginine aminopeptidase, alanyl aminopeptidase, alanyl-aminopeptidase, Alpha-aminoacylpeptide hydrolase, amino-oligopeptidase, amino-peptidase N, aminopeptidase D, aminopeptidase M, aminopeptidase M II, aminopeptidase N, aminopeptidase N type 1, aminopeptidase N/CD13, aminopeptidase N3, aminopeptidase, microsomal, aminopeptidase-N, ANPEP, AP-N, Ap1, Ap2, APAse D, APase2, Ape, APN, APN-1, APN-PI, APN/CD13, APN1, APN2, APN3, APN96, basic aminopeptidase, beta-alanyl aminopeptidase, CD13, Cl--activated aminopeptidase, CryIA(C) receptor, Cys-Gly-dipeptidase, cysteinyl-glycinase, dipeptidase, DP, EC 3.4.1. 2, EC 3.4.1.2, EC 3.4.3.5, ENPEP, ePepN, extracellular aminopeptidase, GP 130, GP150, L,(L/D)-aminopeptidase, L-alanine aminopeptidase, LAP, lap3, LeuAP M, leucine aminopeptidase, Leukemia antigen CD13, Lys-AP, Lysyl aminopeptidase, M1 alanine aminopeptidase, mAAP, membrane alanyl aminopeptidase N, membrane alanyl-aminopeptidase, Membrane glycoprotein H11, Membrane protein p161, Microsomal aminopeptidase, microsomal leucine aminopeptidase, More, Myeloid plasma membrane glycoprotein CD13, neutral aminopeptidase, NmAPN, p146, p146 type II alveolar epithelial cell antigen, p161, particle-bound aminopeptidase, PepN, peptidase N, plant aminopeptidase N, puromycin-insensitive neutral aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.2 membrane alanyl aminopeptidase

KM Value

KM Value on EC 3.4.11.2 - membrane alanyl aminopeptidase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.057
3-OH-L-Pro-2-NaI-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.25
4-Br-L-Phe-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C, value above
0.149
4-Cl-L-Phe-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.059
6-Obzl-L-Nle-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.0467
9-(L-leucylamino)-5H-benzo[a]phenoxazin-5-iminium
37°C, pH 7.4
0.038 - 1
Ala-2-naphthylamide
0.35
Ala-4-nitroanilide
pH 7.0, 37°C
3.4
Ala-Gly
-
-
0.6 - 6
Ala-p-nitroanilide
0.1 - 0.33
amino acyl-4-methylcoumarin 7-amide
-
Ala-, Met-, Tyr-, Leu-, Phe-, Arg-, Lys-, Gly-derivatives
0.09
Arg-4-nitroanilide
-
-
2.5
Cys-Gly
-
-
0.322
DL-Ala-2-naphthylamide
-
pH and temperature not specified in the publication
0.74 - 1
Gly-2-naphthylamide
0.74 - 1.72
Gly-4-nitroanilide
0.25
Gly-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C, value higher than
0.0579 - 0.31
Gly-7-amido-4-methylcoumarin
0.161
L-2-amino-3-(2-benzothiazolyl)butyric acid-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.05
L-2-NaI-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.03
L-Abu(Bth)-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.197 - 6.7
L-Ala-2-naphthylamide
0.032 - 14
L-Ala-4-nitroanilide
0.174
L-Ala-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.011 - 0.139
L-Ala-7-amido-4-methylcoumarin
18
L-Ala-D-iso-Gln-meso-DAP(omegaNH2)-D-Ala-D-Ala
-
-
0.445
L-Ala-L-Ala-L-Phe-7-amido-4-methylcoumarin
-
-
0.059
L-allyl-Gly-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
1
L-alpha-aminobutyryl-Gly
-
-
0.06
L-Arg(NO2)-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.025 - 0.099
L-Arg-2-naphthylamide
0.28
L-Arg-4-nitroanilide
-
pH 7.0, 37°C, recombinant enzyme
0.064
L-Arg-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.785
L-Asn-2-naphthylamide
-
-
-
0.117
L-Asp(Bzl)-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.121
L-Cha-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
4.8
L-cystinyl-bis-Gly
-
-
0.117
L-Gln-2-naphthylamide
-
-
0.25
L-Gln-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C, value above
0.05
L-Glu(Bzl)-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
2.33
L-Glu-2-naphthylamide
-
-
0.027
L-hArg-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.041
L-hCha-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.367
L-His-2-naphthylamide
-
-
0.056
L-hLeu-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.1
L-hPhe-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.146
L-hSer(Bzl)-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.079
L-hSer-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.047
L-hTyr-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.048
L-Igl-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.092
L-Ile-2-naphthylamide
-
-
0.17 - 9.23
L-Leu-4-nitroanilide
0.085
L-Leu-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.0329 - 0.27
L-Leu-7-amido-4-methylcoumarin
0.092
L-Lys-2-naphthylamide
-
pH 8.0, 37°C
0.07 - 0.382
L-Lys-4-nitroanilide
0.088
L-Lys-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.02 - 0.068
L-Met-2-naphthylamide
0.31
L-Met-4-nitroanilide
-
pH 8.0, 37°C
0.08
L-Met-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.086 - 0.34
L-Met-7-amido-4-methylcoumarin
0.061
L-neopentyl-Gly-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.052
L-Nle-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.028
L-Nva-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.25
L-Phe-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C, value above
0.121
L-propargyl-Gly-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
7.83
L-Ser-2-naphthylamide
-
pH 8.0, 37°C
0.617
L-Thr-2-naphthylamide
-
-
-
0.046
L-Tyr-7-amido-4-carbamoylmethylcoumarin
-
pH 7.5, 37°C
0.07
L-Val-2-naphthylamide
-
-
0.02 - 0.79
Leu-2-naphthylamide
0.025
Leu-4-methylcoumarin 7-amide
-
-
0.222
Leu-4-nitroanilide
-
-
0.06 - 0.76
Leu-Gly
0.2 - 1
Leu-p-nitroanilide
0.045 - 0.065
Leu5-enkephalin
0.025 - 0.054
Lys-2-naphthylamide
0.06
Lys-4-methylcoumarin 7-amide
-
-
0.18
Lys-4-nitroanilide
pH 7.0, 37°C
0.045 - 0.06
Met5-enkephalin
0.202 - 0.327
Phe-2-naphthylamide
0.11
Phe-4-nitroanilide
-
-
2.1 - 2.9
Phe-Gly
-
-
0.108
Ser-2-naphthylamide
-
-
0.329
Tyr-2-naphthylamide
-
-
additional information
amino acid amides and amino acyl-p-nitroanilides
-