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3.4.11.2: membrane alanyl aminopeptidase

This is an abbreviated version!
For detailed information about membrane alanyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.2

Reaction

Release of an N-terminal amino acid, Xaa-/-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide =

Synonyms

AAP, Aap 1' aminopeptidase, Aap1 aminopeptidase, Aap1', AlaAP, alanine aminopeptidase, alanine-specific aminopeptidase, alanine/arginine aminopeptidase, alanyl aminopeptidase, alanyl-aminopeptidase, Alpha-aminoacylpeptide hydrolase, amino-oligopeptidase, amino-peptidase N, aminopeptidase D, aminopeptidase M, aminopeptidase M II, aminopeptidase N, aminopeptidase N type 1, aminopeptidase N/CD13, aminopeptidase N3, aminopeptidase, microsomal, aminopeptidase-N, ANPEP, AP-N, Ap1, Ap2, APAse D, APase2, Ape, APN, APN-1, APN-PI, APN/CD13, APN1, APN2, APN3, APN96, basic aminopeptidase, beta-alanyl aminopeptidase, CD13, Cl--activated aminopeptidase, CryIA(C) receptor, Cys-Gly-dipeptidase, cysteinyl-glycinase, dipeptidase, DP, EC 3.4.1. 2, EC 3.4.1.2, EC 3.4.3.5, ENPEP, ePepN, extracellular aminopeptidase, GP 130, GP150, L,(L/D)-aminopeptidase, L-alanine aminopeptidase, LAP, lap3, LeuAP M, leucine aminopeptidase, Leukemia antigen CD13, Lys-AP, Lysyl aminopeptidase, M1 alanine aminopeptidase, mAAP, membrane alanyl aminopeptidase N, membrane alanyl-aminopeptidase, Membrane glycoprotein H11, Membrane protein p161, Microsomal aminopeptidase, microsomal leucine aminopeptidase, More, Myeloid plasma membrane glycoprotein CD13, neutral aminopeptidase, NmAPN, p146, p146 type II alveolar epithelial cell antigen, p161, particle-bound aminopeptidase, PepN, peptidase N, plant aminopeptidase N, puromycin-insensitive neutral aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.2 membrane alanyl aminopeptidase

KI Value

KI Value on EC 3.4.11.2 - membrane alanyl aminopeptidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000341 - 0.0166
(1-amino-2-anilinoethyl)phosphonic acid
0.0547
(1-amino-2-cyclohexylethyl)phosphonic acid
-
-
0.0477
(1-amino-2-cyclopentylethyl)phosphonic acid
-
-
0.000065 - 0.00233
(1-amino-2-[[(4-methoxyphenyl)methyl]amino]ethyl)phosphonic acid
0.0371
(1-amino-3-cyclohexylpropyl)phosphonic acid
-
-
0.0185
(1-amino-3-cyclopentylpropyl)phosphonic acid
-
-
0.0369
(1-amino-3-phenylbutyl)phosphonic acid
-
-
0.00145
(1-amino-3-phenylpropyl)phosphinic acid
-
pH 7.5, 37°C
0.00126
(1-amino-3-phenylpropyl)phosphonic acid
-
pH 7.5, 37°C
0.00146
(1-amino-4-carbamimidamidobutyl)phosphonic acid
-
pH 7.5, 37°C
0.0416
(1-amino-4-cyclohexylbutyl)phosphonic acid
-
-
0.00369
(1-amino-5-phenylpentyl)phosphonic acid
-
-
0.034 - 0.067
1,10-phenanthroline
0.0000077 - 0.000203
2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-iodotyrosine
0.00102
2-[[(1-amino-3-methylbutyl)hydroxyphosphinyl]methyl]-4-methylpentanoic acid
-
pH 8.4, 25°C, 1:1 ratio of the 2 diastereomers
0.000036
2-[[(1-amino-4-phenylbutyl)hydroxyphosphinyl]methyl]-3-(4-hydroxyphenyl)propionic acid
-
pH 8.4, 25°C
0.000276
2-[[(1-amino-4-phenylbutyl)hydroxyphosphinyl]methyl]-3-phenylpropionic acid
-
pH 8.4, 25°C
0.001
2-[[(1-amino-4-phenylbutyl)hydroxyphosphinyl]methyl]-4-methylpentanoic acid
-
pH 8.4, 25°C
0.004
3-amino-1,2,3,4-tetrahydronaphthalene-2-carbohydroxamic acid
-
-
0.00002 - 0.03
3-amino-2-tetralone derivatives
-
not inhibitory or poor inhibitors to EC 3.4.11.7, EC 3.4.11.6, EC 3.4.11.1
0.26
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(2-phenylethyl)oxime
-
-
0.11
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(3-phenylpropyl)oxime
-
-
0.055
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(4-phenylbutyl)oxime
-
-
0.08
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(5-phenylpentyl)oxime
-
-
0.13
3-amino-3,4-dihydro-1H-naphthalen-2-one O-methyloxime
-
-
0.00142
3-[(1-amino-3-methylbutyl)hydroxyphosphinyl]-propionic acid
-
pH 8.4, 25°C
0.000054
3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-(4-hydroxybenzyl)propanoic acid
-
pH 7.5, 37°C
0.000302
3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-benzylpropanoic acid
-
pH 7.5, 37°C
0.02724
4,7-dimethyl-1,10 phenanthroline
-
pH and temperature not specified in the publication
-
0.077
9-(4-hydroxyphenyl)-1,10-phenanthroline
-
pH and temperature not specified in the publication
0.0002
actinonin
-
-
0.00794
alprazolam
-
pH and temperature not specified in the publication
0.0000024 - 0.0125
amastatin
0.0000034 - 0.0988
bestatin
0.014
beta-amino-alpha-hydroxyl-phenyl butanic acid-valine
-
-
0.0094
bradykinin
-
-
0.088
camptothecin
-
pH and temperature not specified in the publication
0.00086 - 0.0022
D-Arg-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
0.02278
dihydroergotamine
-
pH and temperature not specified in the publication
0.00000014 - 0.0000003
EDTA
0.0133
ergotamine
-
pH and temperature not specified in the publication
0.004
isothiochroman-3-one
-
-
0.00096 - 0.00487
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
0.00023
leuhistin
-
-
4.61
Methicillin
-
-
0.169
morphiceptin
-
-
0.0035
N-hydroxy-2-(naphthalen-2-ylsulfanyl)-acetamide
-
-
0.0035
N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide
-
-
0.00251
N-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methy]tyrosine
-
pH 7.5, 37°C
0.67
phenylalanine
-
-
0.000019
probestin
-
-
0.015
psammaplin A
-
pH 7.4, 37°C
0.0125 - 0.447
puromycin
0.000152
sitagliptin
-
pH and temperature not specified in the publication
0.00044
Substance P
-
-
0.00069 - 0.00238
[1-amino-2-(cyclohexylamino)ethyl]phosphonic acid
0.0237
[1-amino-3-(4-hydroxyphenyl)propyl]phosphonic acid
-
-
0.0774
[amino(cyclobutyl)methyl]phosphonic acid
-
-
0.161
[amino(cyclohexyl)methyl]phosphonic acid
-
-
0.178
[amino(cyclopropyl)methyl]phosphonic acid
-
-
0.168
[amino[4-(1-methylethyl)phenyl]methyl]phosphonic acid
-
-
additional information
additional information
-