3.4.11.2: membrane alanyl aminopeptidase
This is an abbreviated version!
For detailed information about membrane alanyl aminopeptidase, go to the full flat file.
Word Map on EC 3.4.11.2
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3.4.11.2
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bestatin
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dipeptidyl
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border
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brush
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endopeptidase
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angiotensin
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carboxypeptidase
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enkephalin
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urinary
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midguts
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thuringiensis
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sucrase
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enterocytes
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jejunum
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maltase
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tripeptides
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n-acetyl-beta-d-glucosaminidase
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neuropeptides
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gamma-glutamyl
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metallopeptidases
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leukotriene
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brush-border
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enkephalinase
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nephrotoxicity
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opioids
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angiotensin-converting
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phosphoramidon
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gamma-glutamyltransferase
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thiorphan
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captopril
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transpeptidase
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microvillar
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sexta
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manduca
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coronaviruses
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ectoenzyme
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sucrase-isomaltase
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p-nitroanilide
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dipeptidylpeptidase
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disaccharidase
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3.4.24.11
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arylamidase
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leu-enkephalin
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oxytocinase
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insulin-regulated
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prolidase
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helveticus
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medicine
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lta4
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dppiv
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gamma-glutamyltranspeptidase
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drug development
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diagnostics
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nutrition
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analysis
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pharmacology
- 3.4.11.2
- bestatin
-
dipeptidyl
- border
-
brush
- endopeptidase
- angiotensin
- carboxypeptidase
- enkephalin
- urinary
- midguts
- thuringiensis
- sucrase
- enterocytes
- jejunum
- maltase
- tripeptides
-
n-acetyl-beta-d-glucosaminidase
- neuropeptides
-
gamma-glutamyl
- metallopeptidases
-
leukotriene
-
brush-border
- enkephalinase
-
nephrotoxicity
-
opioids
-
angiotensin-converting
- phosphoramidon
- gamma-glutamyltransferase
- thiorphan
- captopril
- transpeptidase
- microvillar
- sexta
-
manduca
- coronaviruses
-
ectoenzyme
- sucrase-isomaltase
- p-nitroanilide
-
dipeptidylpeptidase
- disaccharidase
-
3.4.24.11
- arylamidase
- leu-enkephalin
- oxytocinase
-
insulin-regulated
- prolidase
- helveticus
- medicine
- lta4
- dppiv
- gamma-glutamyltranspeptidase
- drug development
- diagnostics
- nutrition
- analysis
- pharmacology
Reaction
Release of an N-terminal amino acid, Xaa-/-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide =
Synonyms
AAP, Aap 1' aminopeptidase, Aap1 aminopeptidase, Aap1', AlaAP, alanine aminopeptidase, alanine-specific aminopeptidase, alanine/arginine aminopeptidase, alanyl aminopeptidase, alanyl-aminopeptidase, Alpha-aminoacylpeptide hydrolase, amino-oligopeptidase, amino-peptidase N, aminopeptidase D, aminopeptidase M, aminopeptidase M II, aminopeptidase N, aminopeptidase N type 1, aminopeptidase N/CD13, aminopeptidase N3, aminopeptidase, microsomal, aminopeptidase-N, ANPEP, AP-N, Ap1, Ap2, APAse D, APase2, Ape, APN, APN-1, APN-PI, APN/CD13, APN1, APN2, APN3, APN96, basic aminopeptidase, beta-alanyl aminopeptidase, CD13, Cl--activated aminopeptidase, CryIA(C) receptor, Cys-Gly-dipeptidase, cysteinyl-glycinase, dipeptidase, DP, EC 3.4.1. 2, EC 3.4.1.2, EC 3.4.3.5, ENPEP, ePepN, extracellular aminopeptidase, GP 130, GP150, L,(L/D)-aminopeptidase, L-alanine aminopeptidase, LAP, lap3, LeuAP M, leucine aminopeptidase, Leukemia antigen CD13, Lys-AP, Lysyl aminopeptidase, M1 alanine aminopeptidase, mAAP, membrane alanyl aminopeptidase N, membrane alanyl-aminopeptidase, Membrane glycoprotein H11, Membrane protein p161, Microsomal aminopeptidase, microsomal leucine aminopeptidase, More, Myeloid plasma membrane glycoprotein CD13, neutral aminopeptidase, NmAPN, p146, p146 type II alveolar epithelial cell antigen, p161, particle-bound aminopeptidase, PepN, peptidase N, plant aminopeptidase N, puromycin-insensitive neutral aminopeptidase
ECTree
3.4.11.2 membrane alanyl aminopeptidaseAdvanced search results
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results (Engineering
Engineering on EC 3.4.11.2 - membrane alanyl aminopeptidase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
N259D
ectopically expressed in PepN deletion mutant: N259D mutant increases the activity of PepN by 2fold
N259D/Q821E
ectopically expressed in PepN deletion mutant: N259D/Q821E double mutant decreases the activity of PepN
Q821E
ectopically expressed in PepN deletion mutant: N259D mutant increases the activity of PepN by 2fold
L243P
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a natural mutation in the enzyme isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum, the mutant is inactive at physiological temperatures of 32-37°C, persists as a mannose-rich proteinin the endoplasmic reticulum, and is degraded by a ER-associated degradation pathway, overview
E350D
additional information
E350D
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site-directed double strand mutagenesis, no binding of the inhibitor 2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-iodotyrosine
additional information
PEMV virions and a constructed peptide comprised of PEMV CP fused to a proline-rich hinge (-P-) and green fluorescent protein (CP-P-GFP) specifically bind to APN. Recombinant APN expression in Sf9 cells results in internalization of CP-P-GFP, visualized by confocal microscopy, signalizing a functional gut receptor
additional information
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PEMV virions and a constructed peptide comprised of PEMV CP fused to a proline-rich hinge (-P-) and green fluorescent protein (CP-P-GFP) specifically bind to APN. Recombinant APN expression in Sf9 cells results in internalization of CP-P-GFP, visualized by confocal microscopy, signalizing a functional gut receptor
additional information
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immobilization of the extracellular enzyme by pectate and/or alginate on spherical particles of 4 mm diameter, method overview
additional information
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the slamdance mutant, sda, has a modification of the APN structural gene, mutant flies exhibit altered neuronal excitability and are prone to seizures
additional information
construction of 6 mutations for determination of residues involved in Cry1Ac toxin resistance, overview
additional information
construction of transgenic mice expressing the enzyme in kidney, small intestine, liver, and lung on epithelial cell surface, transfection with the human coronavirus-229E is possible only in vitro in murine embryonic and bone marrow dendritic cells, not in vivo in transgenic mice via intranasal, intracranial, or intragastric inoculation, overview
additional information
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construction of transgenic mice expressing the enzyme in kidney, small intestine, liver, and lung on epithelial cell surface, transfection with the human coronavirus-229E is possible only in vitro in murine embryonic and bone marrow dendritic cells, not in vivo in transgenic mice via intranasal, intracranial, or intragastric inoculation, overview
additional information
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expression of wild-type enzyme in human embryonic kidney cells is associated with significant decrease in proliferation, migration and also reduced anchorage-independent growth. Effects are due to downregulated mRNA and protein expression of chemokine receptor CXCR4 and an inhibition of the stromal cell-derived factor (SDF)-1alpha/CXCL12-mediated migration
additional information
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mice with targeted disruption of the aminopeptidase N gene develop with no gross or histological abnormalities. In oxygen-induced retinopathy experiments, enzyme deficient mice have a marked and dose-dependent deficiency of the expected retinal neovascularization
additional information
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enzyme overexpression leads to increased enzyme activity, glycogen accumulation, and upregulation of the HSP70 gene SSA3, gene disruption reduces the glycogen accumulation ability
