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3.4.11.2: membrane alanyl aminopeptidase

This is an abbreviated version!
For detailed information about membrane alanyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.2

Reaction

Release of an N-terminal amino acid, Xaa-/-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide =

Synonyms

AAP, Aap 1' aminopeptidase, Aap1 aminopeptidase, Aap1', AlaAP, alanine aminopeptidase, alanine-specific aminopeptidase, alanine/arginine aminopeptidase, alanyl aminopeptidase, alanyl-aminopeptidase, Alpha-aminoacylpeptide hydrolase, amino-oligopeptidase, amino-peptidase N, aminopeptidase D, aminopeptidase M, aminopeptidase M II, aminopeptidase N, aminopeptidase N type 1, aminopeptidase N/CD13, aminopeptidase N3, aminopeptidase, microsomal, aminopeptidase-N, ANPEP, AP-N, Ap1, Ap2, APAse D, APase2, Ape, APN, APN-1, APN-PI, APN/CD13, APN1, APN2, APN3, APN96, basic aminopeptidase, beta-alanyl aminopeptidase, CD13, Cl--activated aminopeptidase, CryIA(C) receptor, Cys-Gly-dipeptidase, cysteinyl-glycinase, dipeptidase, DP, EC 3.4.1. 2, EC 3.4.1.2, EC 3.4.3.5, ENPEP, ePepN, extracellular aminopeptidase, GP 130, GP150, L,(L/D)-aminopeptidase, L-alanine aminopeptidase, LAP, lap3, LeuAP M, leucine aminopeptidase, Leukemia antigen CD13, Lys-AP, Lysyl aminopeptidase, M1 alanine aminopeptidase, mAAP, membrane alanyl aminopeptidase N, membrane alanyl-aminopeptidase, Membrane glycoprotein H11, Membrane protein p161, Microsomal aminopeptidase, microsomal leucine aminopeptidase, More, Myeloid plasma membrane glycoprotein CD13, neutral aminopeptidase, NmAPN, p146, p146 type II alveolar epithelial cell antigen, p161, particle-bound aminopeptidase, PepN, peptidase N, plant aminopeptidase N, puromycin-insensitive neutral aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.2 membrane alanyl aminopeptidase

Activating Compound

Activating Compound on EC 3.4.11.2 - membrane alanyl aminopeptidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
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50% activation at 10 mM
dithiothreitol
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307% activity in the presence of 10 mM
DTT
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activates 3fold at 10 mM
EDTA
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146% activity in the presence of 10 mM
ethanol
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116% activity in the presence of 1 mM
morphine
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increase in activity in the striatum by 28% compared to untreated rats, and slightly in the hypothalamus and amygdala, withdrawal of the opioid reduces enzyme activity by 42%, overview
transforming growth factor-beta1
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transforming growth factor-beta1 at physiological concentrations (0.16 to 2.5 ng/ml) increases expression of CD13 both at mRNA and membrane protein level in a time- and concentration-dependent manner, increased membrane CD13 expression is associated with an increase of its enzyme activity, actinomycin-D abrogates the transforming growth factor-beta1-induced up-regulation of CD13
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additional information
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