3.4.11.19: D-stereospecific aminopeptidase
This is an abbreviated version!
For detailed information about D-stereospecific aminopeptidase, go to the full flat file.
Word Map on EC 3.4.11.19
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3.4.11.19
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ochrobactrum
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anthropi
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beta-lactamases
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penicillin-binding
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penicillin-recognizing
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aminopeptidases
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point-group
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d,d-carboxypeptidase
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non-sporulating
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synthesis
- 3.4.11.19
- ochrobactrum
- anthropi
- beta-lactamases
-
penicillin-binding
-
penicillin-recognizing
- aminopeptidases
-
point-group
- d,d-carboxypeptidase
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non-sporulating
- synthesis
Reaction
Release of an N-terminal D-amino acid from a peptide, Xaa-/-Yaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr. D-Amino acid amides and methyl esters also are hydrolysed, as is glycine amide =
Synonyms
D-aminopeptidase, DAP, GdaA, glycine D-alanine aminopeptidase
ECTree
3.4.11.19 D-stereospecific aminopeptidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.11.19 - D-stereospecific aminopeptidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-2-aminobutanamide + H2O
D-aminobutanoic acid + NH3
-
racemic, preferred substrate
-
-
?
D-alanine amide + H2O
D-alanine + NH3
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28.3% of the activity with D-2-aminobutanamide
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-
?
fluoresceyl-Gly-6-aminopenicillanic acid + H2O
?
-
penicillin-binding activity of mutant lacking residues 476-486
-
-
?
glycine amide + H2O
glycine + NH3
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29.6% of the activity with D-2-aminobutanamide
-
-
?
L-2-aminobutyric amide + H2O
D-2-aminobutyric acid + NH3
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in the presence of alpha-amino-epsilon-caprolactam racemase from Achromobacter obae
-
-
?
L-alanine amide + H2O
D-alanine + NH3
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in the presence of alpha-amino-epsilon-caprolactam racemase from Achromobacter obae
-
-
?
L-methionine amide + H2O
D-methionine + NH3
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in the presence of alpha-amino-epsilon-caprolactam racemase from Achromobacter obae
-
-
?
L-serine amide + H2O
D-serine + NH3
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in the presence of alpha-amino-epsilon-caprolactam racemase from Achromobacter obae
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-
?
Nalpha, Nalpha-Ac2-L-Lys-D-Ala-D-Ala + H2O
Nalpha, Nalpha-Ac2-L-Lys-D-Ala + D-Ala
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wild-type, no substrate. Mutant lacking residues 476-486 with or without mutation N275R, small D,D-carboxypeptidase activity
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-
?
Nalpha-Ac-L-Lys-D-Ala-D-Ala + H2O
Nalpha-Ac-L-Lys-D-Ala + D-Ala
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wild-type and mutant lacking residues 476-486, no substrate. Mutant lacking residues 476-486 plus mutation N275R, small D,D-carboxypeptidase activity
-
-
?
D-Ala 4-nitroanilide + H2O
D-Ala + 4-nitroaniline
93% of the activity with Gly 4-nitroanilide
-
-
?
D-Ala 4-nitroanilide + H2O
D-Ala + 4-nitroaniline
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93% of the activity with Gly 4-nitroanilide
-
-
?
L-Ala 4-nitroanilide + H2O
L-Ala + 4-nitroaniline
12% of the activity with Gly 4-nitroanilide
-
-
?
L-Ala 4-nitroanilide + H2O
L-Ala + 4-nitroaniline
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12% of the activity with Gly 4-nitroanilide
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-
?
additional information
?
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enzyme shows strict D-stereospecific aminopeptidase activity. No or very poor activity with beta-Ala 4-nitroanilide, L-Leu 4-nitroanilide, D-Leu 4-nitroanilide,L-Met 4-nitroanilide, L-Pro 4-nitroanilide, L-Val 4-nitroanilide, L-Ile 4-nitroanilide, L-Phe 4-nitroanilide, D-Phe 4-nitroanilide, L-Lys 4-nitroanilide, L-Arg 4-nitroanilide, L-His 4-nitroanilide, L-Asp 4-nitroanilide, L-Glu 4-nitroanilide. No substrates: L-Ala-Gly and L-Cys-Gly dipeptides and L-Cys-Gly-Gly tripeptide
-
-
?
additional information
?
-
-
enzyme shows strict D-stereospecific aminopeptidase activity. No or very poor activity with beta-Ala 4-nitroanilide, L-Leu 4-nitroanilide, D-Leu 4-nitroanilide,L-Met 4-nitroanilide, L-Pro 4-nitroanilide, L-Val 4-nitroanilide, L-Ile 4-nitroanilide, L-Phe 4-nitroanilide, D-Phe 4-nitroanilide, L-Lys 4-nitroanilide, L-Arg 4-nitroanilide, L-His 4-nitroanilide, L-Asp 4-nitroanilide, L-Glu 4-nitroanilide. No substrates: L-Ala-Gly and L-Cys-Gly dipeptides and L-Cys-Gly-Gly tripeptide
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-
?
additional information
?
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substrates beta-Ala-4-nitroanilide, L-Leu-4-nitroanilide, D-Leu-4-nitroanilide, L-Met-4-nitroanilide, L-Pro-4-nitroanilide, L-Val-4-nitroanilide, L-Ile-4-nitroanilide, L-Phe-4-nitroanilide, D-Phe-4-nitroanilide, L-Lys-4-nitroanilide, L-Arg-4-nitroanilide, L-His-4-nitroanilide, L-Asp-4-nitroanilide, L-Glu-4-nitroanilide show less than 0.5% of the activity with Gly-4-nitroanilide, no substrates: L-Ala-Gly and L-Cys-Gly dipeptides and L-Cys-Gly-Gly tripeptide
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-
?
additional information
?
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substrates beta-Ala-4-nitroanilide, L-Leu-4-nitroanilide, D-Leu-4-nitroanilide, L-Met-4-nitroanilide, L-Pro-4-nitroanilide, L-Val-4-nitroanilide, L-Ile-4-nitroanilide, L-Phe-4-nitroanilide, D-Phe-4-nitroanilide, L-Lys-4-nitroanilide, L-Arg-4-nitroanilide, L-His-4-nitroanilide, L-Asp-4-nitroanilide, L-Glu-4-nitroanilide show less than 0.5% of the activity with Gly-4-nitroanilide, no substrates: L-Ala-Gly and L-Cys-Gly dipeptides and L-Cys-Gly-Gly tripeptide
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-
?
additional information
?
-
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strict D-stereospecificity, the enzyme prefers peptides to amino acid arylamides or amino acid amides
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-
?
additional information
?
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Brucella anthropi SCRC C1-38
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strict D-stereospecificity, the enzyme prefers peptides to amino acid arylamides or amino acid amides
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-
?
additional information
?
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D-valine amide, D-proline amide and D-leucine amide show less than 2% of hte activity with D-2-aminobutanamide. No activity with D-arginine amide, D-phenylalanine amide, or with L-amino acid amides
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?
