3.4.11.18: methionyl aminopeptidase
This is an abbreviated version!
For detailed information about methionyl aminopeptidase, go to the full flat file.
Word Map on EC 3.4.11.18
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3.4.11.18
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microtubule-associated
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microtubule
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dendritic
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hippocampus
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tubulin
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protein-2
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tau
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cerebral
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aminopeptidases
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fumagillin
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nestin
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neurite
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cortical
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cytoskeletal
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neurofilament
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neuroprotective
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ischemia
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fibrillary
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synaptophysin
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outgrowth
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neurotrophic
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neuron-specific
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beta-tubulin
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neurogenesis
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map2
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synapsin
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antiangiogenic
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deformylase
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microtubule-binding
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calbindin
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synthesis
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dinuclear
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microsporidian
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drug development
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medicine
- 3.4.11.18
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microtubule-associated
- microtubule
- dendritic
- hippocampus
- tubulin
- protein-2
- tau
- cerebral
- aminopeptidases
- fumagillin
- nestin
-
neurite
- cortical
- cytoskeletal
- neurofilament
-
neuroprotective
- ischemia
-
fibrillary
-
synaptophysin
-
outgrowth
-
neurotrophic
-
neuron-specific
- beta-tubulin
-
neurogenesis
- map2
- synapsin
-
antiangiogenic
-
deformylase
-
microtubule-binding
- calbindin
- synthesis
-
dinuclear
-
microsporidian
- drug development
- medicine
Reaction
release of N-terminal amino acids, preferentially methionine, from peptides and arylamides =
Synonyms
aminopeptidase, methionine, c1MetAP-Ia, c2MetAP-Ia, c3MetAP-Ib, CoCoEcMetAP, Ebp1, eMet-AP, ErbB-3 receptor binding protein, initiation factor 2 associated 67 kDa glycoprotein, L-methionine aminopeptidase, LdBPK_210960, MAP, MAP-2, MAP-Pfu, MAP11, MAP1D, mAPA, MapB, MetAP, MetAP-1, MetAP-2, MetAP-I, MetAP-II, MetAP1, MetAP1a, MetAP1b, MetAP1c, MetAP1D, MetAP2, methionine amino peptidase type 2, methionine aminopeptidase, methionine aminopeptidase 1, methionine aminopeptidase 1b, methionine aminopeptidase 2, methionine aminopeptidase AbMetAPx, methionine aminopeptidase AbMetAPy, methionine aminopeptidase II, methionine aminopeptidase type 1, methionine aminopeptidase type 1a, methionine aminopeptidase type 1c, methionine aminopeptidase type 2, methionine aminopeptidase type I, methionine aminopeptidase type II, methionine aminopeptidase type-2, methionine aminopeptidase-1, methionine aminopeptidase-2, methionine aminopetidase-2, More, p67, p67eIF2, peptidase M, PVX_094985, TM1478, type 1 methionine aminopeptidase, type 2 methionine aminopeptidase, type I MetAP, type I methionine aminopeptidase, YpdF
ECTree
3.4.11.18 methionyl aminopeptidaseAdvanced search results
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results (Turnover Number
Turnover Number on EC 3.4.11.18 - methionyl aminopeptidase
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TURNOVER NUMBER [1/s] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.43
L-alanine-4-methylcoumarin-7-amide
presence of Cu2+, pH 8.0, 37°C
1.47
L-alanine-4-methylcoumarin-7-amide
presence of Ni2+, pH 8.0, 37°C
1.5
L-alanine-4-methylcoumarin-7-amide
presence of Ca2+, pH 8.0, 37°C
1.66
L-alanine-4-methylcoumarin-7-amide
presence of Mn2+, pH 8.0, 37°C
1.82
L-alanine-4-methylcoumarin-7-amide
presence of Mg2+, pH 8.0, 37°C
2.13
L-alanine-4-methylcoumarin-7-amide
presence of Co2+, pH 8.0, 37°C
0.078
L-Met 4-nitroanilide
presence of Co2+, pH 8.0, 22°C
0.08
L-Met 4-nitroanilide
presence of Co2+, pH 8.0, 22°C
0.08
L-Met 4-nitroanilide
presence of Ni2+, pH 8.0, 22°C
0.133
L-Met 4-nitroanilide
presence of Ni2+, pH 8.0, 22°C
0.001
L-Met-Gly-L-Met-L-Met
mutant enzyme D97N, Co2+-loaded, in 25 mM HEPES buffer, at 30°C and pH 7.5
0.002
L-Met-Gly-L-Met-L-Met
mutant enzyme D97E, Co2+-loaded, in 25 mM HEPES buffer, at 30°C and pH 7.5
0.003
L-Met-Gly-L-Met-L-Met
mutant enzyme D97A, Co2+-loaded, in 25 mM HEPES buffer, at 30°C and pH 7.5
0.003
L-Met-Gly-L-Met-L-Met
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mutant enzyme H79A, in 25 mM HEPES buffer (pH 7.5) containing 150 mM KCl, in the presence of 3 equivalents of Co2+
1.8
L-Met-Gly-L-Met-L-Met
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mutant enzyme H79A, in 25 mM HEPES buffer (pH 7.5) containing 150 mM KCl, in the presence of 3 equivalents of Co2+
4.6
L-Met-Gly-L-Met-L-Met
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wild type enzyme, in 25 mM HEPES buffer (pH 7.5) containing 150 mM KCl, in the presence of 3 equivalents of Mn2+
4.8
L-Met-Gly-L-Met-L-Met
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mutant enzyme H63A, in 25 mM HEPES buffer, pH 7.5, and 150 mM KCl, at 30°C
18.3
L-Met-Gly-L-Met-L-Met
wild type enzyme, Co2+-loaded, in 25 mM HEPES buffer, at 30°C and pH 7.5
18.3
L-Met-Gly-L-Met-L-Met
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wild type enzyme, in 25 mM HEPES buffer (pH 7.5) containing 150 mM KCl, in the presence of 3 equivalents of Co2+
18.3
L-Met-Gly-L-Met-L-Met
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wild type enzyme, in 25 mM HEPES buffer, pH 7.5, and 150 mM KCl, at 30°C
3
L-Met-L-Ala-L-Ser
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mutant enzyme H63A, in 25 mM HEPES buffer, pH 7.5, and 150 mM KCl, at 30°C
11
L-Met-L-Ala-L-Ser
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wild type enzyme, in 25 mM HEPES buffer, pH 7.5, and 150 mM KCl, at 30°C
0.425
L-Met-L-Pro-4-nitroanilide
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truncated mutant lacking N-terminal 89 amino acids, pH 7.5, 22°C
70
L-Met-L-Ser-L-Ser-L-His-L-Arg-L-Trp-L-Asp-L-Trp
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mutant enzyme H63A, in 25 mM HEPES buffer, pH 7.5, and 150 mM KCl, at 30°C
84
L-Met-L-Ser-L-Ser-L-His-L-Arg-L-Trp-L-Asp-L-Trp
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wild type enzyme, in 25 mM HEPES buffer, pH 7.5, and 150 mM KCl, at 30°C
0.006
L-Met-p-nitroanilide
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in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl
0.057
L-Met-p-nitroanilide
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in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl
0.97
L-Met-PSI[C(O)S]Gly-L-Phe
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N-terminally truncated mutant, lacking 66 amino acids, pH 7.0, 22°C
7.31
L-Met-PSI[C(O)S]Gly-L-Phe
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N-terminally truncated mutant lacking 135 amino acids, pH 7.0, 22°C
12.8
L-Met-PSI[C(O)S]Gly-L-Phe
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Zn(II)-form of enzyme, 22°C, pH 7.0
15.8
L-Met-PSI[C(O)S]Gly-L-Phe
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Mn(II)-form of enzyme, 22°C, pH 7.0
16.61
L-Met-PSI[C(O)S]Gly-L-Phe
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N-terminally truncated mutant, lacking 66 amino acids, pH 7.0, 22°C
0.0033
L-methionine 4-nitroanilide
mutant F309M, pH not specified in the publication, temperature not specified in the publication
0.005
L-methionine 4-nitroanilide
pH not specified in the publication, temperature not specified in the publication
0.0483
L-methionine 4-nitroanilide
wild-type, pH not specified in the publication, temperature not specified in the publication
0.014
L-methionine-4-methylcoumarin-7-amide
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recombinant isozyme MetAP1a in presence of Fe2+
0.045
L-methionine-4-methylcoumarin-7-amide
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recombinant isozyme MetAP1a in presence of Ni2+
0.07
L-methionine-4-methylcoumarin-7-amide
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recombinant isozyme MetAP1a in presence of Mn2+
0.36
L-methionine-4-methylcoumarin-7-amide
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recombinant isozyme MetAP1a in presence of Co2+
0.0000508
Met-4-methylcoumaryl-7-amide
after removal of divalent metal ions activated with 0.020 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.000055
Met-4-methylcoumaryl-7-amide
after removal of divalent metal ions activated with 0.020 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.000137
Met-4-methylcoumaryl-7-amide
after removal of divalent metal ions activated with 0.020 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.000159
Met-4-methylcoumaryl-7-amide
after removal of divalent metal ions activated with 0.020 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.000263
Met-4-methylcoumaryl-7-amide
after removal of divalent metal ions activated with 0.0025 mM Fe2+, pH not specified in the publication, temperature not specified in the publication
0.000305
Met-4-methylcoumaryl-7-amide
after removal of divalent metal ions activated with 0.005 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.000312
Met-4-methylcoumaryl-7-amide
after removal of divalent metal ions activated with 0.020 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.000449
Met-4-methylcoumaryl-7-amide
after removal of divalent metal ions activated with 0.0025 mM Fe2+, pH not specified in the publication, temperature not specified in the publication
0.0633
Met-7-amido-4-methylcoumarin
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pH 7.5, 30°C, in presence of 0.01 mM CoCl2
11.7
Met-Ala-Ser
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calculated with 29.5 kDa as molecular mass, pH 7.5, 30°C
1516
Met-Ala-Ser
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calculated with 33.1 kDa as molecular mass, pH 7.5, 30°C
9.63
Met-Gly-Met-Met
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calculated with 29.5 kDa as molecular mass, pH 7.5, 30°C
18.3
Met-Gly-Met-Met
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in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl
188
Met-Gly-Met-Met
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in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl
0.0065
Met-Pro-p-nitroanilide
in 40 mM HEPES, pH 8.0, and 100 mM NaCl, at 23°C
1.82
Met-Pro-p-nitroanilide
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in 40 mM HEPES, pH 8.0, and 100 mM NaCl, at 23°C
additional information
additional information
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turnover-numbers of truncated enzyme
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