3.4.11.18: methionyl aminopeptidase

This is an abbreviated version!
For detailed information about methionyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.18

3.4.11.18

microtubule-associated

microtubule

dendritic

hippocampus

tubulin

protein-2

tau

cerebral

aminopeptidases

fumagillin

nestin

neurite

cortical

cytoskeletal

neurofilament

neuroprotective

ischemia

fibrillary

synaptophysin

outgrowth

neurotrophic

neuron-specific

beta-tubulin

neurogenesis

map2

synapsin

antiangiogenic

deformylase

microtubule-binding

calbindin

synthesis

dinuclear

microsporidian

drug development

medicine

Reaction

release of N-terminal amino acids, preferentially methionine, from peptides and arylamides =

Synonyms

aminopeptidase, methionine, c1MetAP-Ia, c2MetAP-Ia, c3MetAP-Ib, CoCoEcMetAP, Ebp1, eMet-AP, ErbB-3 receptor binding protein, initiation factor 2 associated 67 kDa glycoprotein, L-methionine aminopeptidase, LdBPK_210960, MAP, MAP-2, MAP-Pfu, MAP11, MAP1D, mAPA, MapB, MetAP, MetAP-1, MetAP-2, MetAP-I, MetAP-II, MetAP1, MetAP1a, MetAP1b, MetAP1c, MetAP1D, MetAP2, methionine amino peptidase type 2, methionine aminopeptidase, methionine aminopeptidase 1, methionine aminopeptidase 1b, methionine aminopeptidase 2, methionine aminopeptidase AbMetAPx, methionine aminopeptidase AbMetAPy, methionine aminopeptidase II, methionine aminopeptidase type 1, methionine aminopeptidase type 1a, methionine aminopeptidase type 1c, methionine aminopeptidase type 2, methionine aminopeptidase type I, methionine aminopeptidase type II, methionine aminopeptidase type-2, methionine aminopeptidase-1, methionine aminopeptidase-2, methionine aminopetidase-2, More, p67, p67eIF2, peptidase M, PVX_094985, TM1478, type 1 methionine aminopeptidase, type 2 methionine aminopeptidase, type I MetAP, type I methionine aminopeptidase, YpdF

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.11 Aminopeptidases

3.4.11.18 methionyl aminopeptidase

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Results	in table
1	Activating Compound
72315	AA Sequence
14	Application
1	CAS Registry Number
63	Cloned(Commentary)
38	Crystallization (Commentary)
843	Disease/ Diagnostics
4	Expression
16	General Information
1	General Stability
694	IC50 Value
955	Inhibitors
67	kcat/KM [mM/s]
116	Ki Value [mM]
130	KM Value [mM]
7	Localization
154	Metals/Ions
49	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
244	Organism
2	Pathway
198	PDB ID
23	pH Optimum
7	pH Range
5	pI Value
1	Posttranslational Modification
110	Protein Variants
45	Purification (Commentary)
2	Reaction
1	Reaction Type
206	Reference
70	Source Tissue
43	Specific Activity [micromol/min/mg]
1	Storage Stability
295	Substrates and Products (Substrate)
40	Subunits
262	Synonyms
12	Temperature Optimum [°C]
4	Temperature Range [°C]
7	Temperature Stability [°C]
124	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 3.4.11.18 - methionyl aminopeptidase

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100

Escherichia coli

2 min, complete loss of activity

647065

2 entries

50 - 65

Mycolicibacterium smegmatis

the enzyme is stable at 50 °C with half-life of more than 8 h, at 50°C and 55°C, the enzyme shows stable activity over a period of 1 h with only a slight decrease of 10% in activity, at 60 °C the relative activity decreases to 50% within 50 min, whereas at 65°C the relative activity decreases to 19% and declines to 0 after a period of 50 min

695672

Mycobacterium tuberculosis

10 min, inactivation of isozyme MetAP1c, while isozyme MetAP1a retains 50% activity

708243

Geobacillus stearothermophilus

45 min, stable

647069

additional information

2 entries