3.4.11.18: methionyl aminopeptidase

This is an abbreviated version!
For detailed information about methionyl aminopeptidase, go to the full flat file.

Reaction

release of N-terminal amino acids, preferentially methionine, from peptides and arylamides =

Synonyms

aminopeptidase, methionine, c1MetAP-Ia, c2MetAP-Ia, c3MetAP-Ib, CoCoEcMetAP, Ebp1, eMet-AP, ErbB-3 receptor binding protein, initiation factor 2 associated 67 kDa glycoprotein, L-methionine aminopeptidase, LdBPK_210960, MAP, MAP-2, MAP-Pfu, MAP11, MAP1D, mAPA, MapB, MetAP, MetAP-1, MetAP-2, MetAP-I, MetAP-II, MetAP1, MetAP1a, MetAP1b, MetAP1c, MetAP1D, MetAP2, methionine amino peptidase type 2, methionine aminopeptidase, methionine aminopeptidase 1, methionine aminopeptidase 1b, methionine aminopeptidase 2, methionine aminopeptidase AbMetAPx, methionine aminopeptidase AbMetAPy, methionine aminopeptidase II, methionine aminopeptidase type 1, methionine aminopeptidase type 1a, methionine aminopeptidase type 1c, methionine aminopeptidase type 2, methionine aminopeptidase type I, methionine aminopeptidase type II, methionine aminopeptidase type-2, methionine aminopeptidase-1, methionine aminopeptidase-2, methionine aminopetidase-2, More, p67, p67eIF2, peptidase M, PVX_094985, TM1478, type 1 methionine aminopeptidase, type 2 methionine aminopeptidase, type I MetAP, type I methionine aminopeptidase, YpdF

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.11 Aminopeptidases

                3.4.11.18 methionyl aminopeptidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
72315	AA Sequence
14	Application
1	CAS Registry Number
63	Cloned(Commentary)
38	Crystallization (Commentary)
843	Disease/ Diagnostics
4	Expression
16	General Information
1	General Stability
694	IC50 Value
955	Inhibitors
67	kcat/KM [mM/s]
116	Ki Value [mM]
130	KM Value [mM]
7	Localization
154	Metals/Ions
49	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
244	Organism
2	Pathway
198	PDB ID
23	pH Optimum
7	pH Range
5	pI Value
1	Posttranslational Modification
110	Protein Variants
45	Purification (Commentary)
2	Reaction
1	Reaction Type
206	Reference
70	Source Tissue
43	Specific Activity [micromol/min/mg]
1	Storage Stability
295	Substrates and Products (Substrate)
40	Subunits
262	Synonyms
12	Temperature Optimum [°C]
4	Temperature Range [°C]
7	Temperature Stability [°C]
124	Turnover Number [1/s]

Posttranslational Modification

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Posttranslational Modification on EC 3.4.11.18 - methionyl aminopeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Posttranslational Modification Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Homo sapiens

P50579

isoform MetAP2 is post-translationally regulated by an allosteric disulfide bond, which controls substrate specificity and catalytic efficiency. Isoform MetAP2 contains a single Cys228-Cys448 disulfide bond that has an -RH-staple configuration and links two beta-loop structures, which are hallmarks of allosteric disulfide bonds. The disulfide bond exists in oxidized and reduced states in the recombinant enzyme. The disulfide has a standard redox potential of -261 mV and is efficiently reduced by the protein reductant, thioredoxin, with a rate constant of 16180 per M and s. The MetAP2 disulfide bond also exists in oxidized and reduced states in glioblastoma tumor cells, and stressing the cells by oxygen or glucose deprivation results in more oxidized enzyme. Oxidized and reduced isoforms have different catalytic efficiencies for hydrolysis of MetAP2 peptide substrates

732132