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3.4.11.18: methionyl aminopeptidase

This is an abbreviated version!
For detailed information about methionyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.18

Reaction

release of N-terminal amino acids, preferentially methionine, from peptides and arylamides =

Synonyms

aminopeptidase, methionine, c1MetAP-Ia, c2MetAP-Ia, c3MetAP-Ib, CoCoEcMetAP, Ebp1, eMet-AP, ErbB-3 receptor binding protein, initiation factor 2 associated 67 kDa glycoprotein, L-methionine aminopeptidase, LdBPK_210960, MAP, MAP-2, MAP-Pfu, MAP11, MAP1D, mAPA, MapB, MetAP, MetAP-1, MetAP-2, MetAP-I, MetAP-II, MetAP1, MetAP1a, MetAP1b, MetAP1c, MetAP1D, MetAP2, methionine amino peptidase type 2, methionine aminopeptidase, methionine aminopeptidase 1, methionine aminopeptidase 1b, methionine aminopeptidase 2, methionine aminopeptidase AbMetAPx, methionine aminopeptidase AbMetAPy, methionine aminopeptidase II, methionine aminopeptidase type 1, methionine aminopeptidase type 1a, methionine aminopeptidase type 1c, methionine aminopeptidase type 2, methionine aminopeptidase type I, methionine aminopeptidase type II, methionine aminopeptidase type-2, methionine aminopeptidase-1, methionine aminopeptidase-2, methionine aminopetidase-2, More, p67, p67eIF2, peptidase M, PVX_094985, TM1478, type 1 methionine aminopeptidase, type 2 methionine aminopeptidase, type I MetAP, type I methionine aminopeptidase, YpdF

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.18 methionyl aminopeptidase

IC50 Value

IC50 Value on EC 3.4.11.18 - methionyl aminopeptidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.02 - 0.034
((2RS,3R)-3-amino-2-hydroxy-5-ethylthio)pentanoyl-((S)-(-)-(1-naphthyl)ethyl)amide
0.0013 - 0.179
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide
0.00054 - 0.075
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide
0.00076 - 0.201
(2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
0.00062 - 0.12
(2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
0.0002 - 0.08
(2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
0.0004 - 0.15
(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
0.00096 - 0.187
(2R,3R,4S,5R,E)-N-[[1-(cyclopropanecarbonyl)piperidin-3-yl]methyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
0.0229 - 0.095
(3R)-amino-(2S)-hydroxyheptanoyl-Ala-Leu methyl ester
0.0123
(3R)-amino-(2S)-hydroxypentanoic acid
Escherichia coli
-
IC50: 0.0123 mM for the Co2+-substituted enzyme, 0.0115 mM for the Mn2+-substituted enzyme, 0.0093 mM for the Zn2+-substituted enzyme, 0.0223 for the Ni2+-substituted enzyme
0.0000006
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (2R)-3-methyl-1-(2-(1-methylpyrrolidin-2-yl)ethylamino)-1-oxobutan-2-ylcarbamate
Homo sapiens
-
above, in HUVEC
0.000000095
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (R)-1-amino-3-methyl-1-oxobutan-2-ylcarbamate
Homo sapiens
-
in HUVEC
0.0000017
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (R)-3-methyl-1-(morpholinoamino)-1-oxobutan-2-ylcarbamate
Homo sapiens
-
in HUVEC
0.0000006
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (R)-3-methyl-1-oxo-1-(2-(pyrrolidin-1-yl)ethylamino)butan-2-ylcarbamate
Homo sapiens
-
in HUVEC
0.0000017
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl 1-amino-2-methyl-1-oxopropan-2-ylcarbamate
Homo sapiens
-
in HUVEC
0.0000007
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl 1-carbamoylcyclopentylcarbamate
Homo sapiens
-
in HUVEC
0.0000002
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl 2-(1-methylpyrrolidin-2-yl)ethylcarbamate
Homo sapiens
-
above, in HUVEC
0.0000001
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl 2-(pyrrolidin-1-yl)ethylcarbamate
Homo sapiens
-
in HUVEC
0.00000006
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl isopropylcarbamate
Homo sapiens
-
in HUVEC
0.0000007
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl morpholinocarbamate
Homo sapiens
-
in HUVEC
0.0000011
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl tert-butylcarbamate
Homo sapiens
-
in HUVEC
0.00000025
(3R,5S,6R)-5-methoxy-4-[(3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl (chloroacetyl)carbamate
Homo sapiens
-
in HUVEC
0.00021
(5,5-Dimethyl-4,5-dihydro-thiazol-2-yl)-(3-methyl-pyridin-2-yl)-amine
Escherichia coli
-
IC50 for Co-EcMetAP1: 0.00021 mM
0.000027
(8S)-2-[[(4-fluorophenyl)sulfonyl]amino]-8-methyl-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
Homo sapiens
-
0.000000036
(R)-methyl 2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonylamino)-2-phenylacetate
Homo sapiens
-
in HUVEC
0.00000004
(R)-methyl 2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonylamino)-3-methylbutanoate
Homo sapiens
-
in HUVEC
0.000000038
(R)-methyl 2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonylamino)-4-methylpentanoate
Homo sapiens
-
in HUVEC
0.000000018
(S)-methyl 2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)-carbonylamino)-3-methylbutanoate
Homo sapiens
-
in HUVEC
0.0000013
1-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonyl)-piperidine-4-carboxylic acid
Homo sapiens
-
in HUVEC
0.009 - 0.0359
1-(1H-benzimidazol-2-yl)thiourea
0.00312
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(2-sulfanylmorpholin-4-yl)ethanone
Plasmodium falciparum
-
-
0.00154
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(2-sulfanylphenyl)ethanone
Plasmodium falciparum
-
-
0.00124
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(4-fluoro-2-sulfanylphenyl)ethanone
Plasmodium falciparum
-
-
0.00102
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(4-methoxy-2-sulfanylphenyl)ethanone
Plasmodium falciparum
-
-
0.0011 - 0.0081
1-(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-4-(2,4-dichlorobenzyl)-1,4-diazepane
0.00046
1-benzyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.00099
1-benzyl-2-(pyridin-2-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0005 - 0.0324
1-methyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.00118
1-[2-pyridin-2-yl-6-(trifluoromethyl)-3,4-dihydropyrimidin-4-yl]propane-2-thiol
Plasmodium falciparum
-
-
0.000667
2,2'-bipyridine
Enterococcus faecalis
-
pH 7.5, 30°C
0.00008 - 0.0398
2-(1,3-thiazol-2-yl)-1H-imidazo[4,5-b]pyridine
0.0023 - 0.0101
2-(1,3-thiazol-4-yl)-1H-benzimidazol-5-amine
0.0017 - 0.0455
2-(1,3-thiazol-4-yl)-1H-imidazo[4,5-c]pyridine
0.00078 - 0.0044
2-(1H-benzimidazol-2-yl)pyridin-3-ol
0.0001
2-(2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)-carbonylamino)ethyl)-1,1-dimethylpyrrolidinium iodide
Homo sapiens
-
in HUVEC
0.000016
2-(2-aminoethoxy)-3-ethyl-6-[[(2-propylphenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000046
2-(2-aminoethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000024
2-(2-aminoethoxy)-6-[([2-[3-(diethylamino)propyl]-4-fluorophenyl]sulfonyl)amino]-3-ethylbenzoic acid
Mus musculus
-
0.0058
2-(carboxymethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.0005
2-(prop-1-en-2-yl)-5-[2-(trifluoromethyl)phenyl]furan
Rickettsia prowazekii
pH 7.0, 30°C, Hill slope 2.1
0.0046 - 0.0329
2-(pyrazin-2-yl)-1H-benzimidazole
0.00097 - 0.0093
2-(pyridin-2-yl)-1H-benzimidazol-5-amine
0.00057 - 0.0284
2-(pyridin-2-yl)-1H-benzimidazole
0.00043 - 0.0373
2-(pyridin-2-yl)-1H-benzimidazole-5-carbonitrile
0.00024 - 0.0484
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyrazine
0.00011 - 0.0276
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine
0.00055 - 0.0228
2-(pyridin-2-yl)-1H-imidazo[4,5-c]pyridine
0.0013
2-butyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
Mus musculus
-
0.000015
2-chloro-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.00006
2-ethenyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
Mus musculus
-
0.000038
2-ethoxy-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000011
2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methoxybenzoic acid
Mus musculus
-
0.000016
2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
Mus musculus
-
0.00107
2-pyridin-2-yl-4-(trifluoromethyl)-6-[2-(trifluoromethyl)benzyl]-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.0039
2-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-5-bromobenzoic acid
Homo sapiens
-
0.000009
2-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
Mus musculus
-
0.0011
2-[(phenylsulfonyl)amino]-5-propylbenzoic acid
Homo sapiens
-
0.02
2-[([4-[(E)-(5-amino-3-imino-3H-pyrazol-4-yl)diazenyl]phenyl]sulfinyl)oxy]hydrazinecarboximidamide
Escherichia coli
-
-
0.0296 - 0.0441
2-[2-(2-amino-4-methylsulfanyl-butyrylsulfanyl)-3-phenyl-propionylamino]-3-hydroxy-propionic acid
0.0286 - 0.0498
2-[2-(2-Amino-4-methylsulfanyl-butyrylsulfanyl)-5-methyl-hexanoylamino]-3-hydroxy-propionic acid
0.0125 - 0.0252
2-[2-(3-Amino-2-hydroxy-heptanoylamino)-propionylamino]-4-methyl-pentanoic acid methyl ester
0.037
2-[4-(2-Cyano-2-ethoxycarbonyl-1-methyl-vinyl)-phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
Escherichia coli
-
IC50 for Co-EcMetAP1: 0.037 mM
0.011
2-[[(4-chlorophenyl)sulfonyl]amino]-5-methylbenzoic acid
Homo sapiens
-
0.00001
2-[[(4-fluorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
Homo sapiens
-
0.00002
2-[[(4-fluorophenyl)sulfonyl]amino]-8-methyl-5,6-dihydronaphthalene-1-carboxylic acid
Homo sapiens
-
0.00035
3,5-dimethyl-2-[(phenylsulfonyl)amino]benzoic acid
Homo sapiens
-
0.0001
3-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonylamino)-N,N,N-trimethylpropan-1-aminium iodide
Homo sapiens
-
in HUVEC
0.015 - 1
3-((2-naphthylmethyl)sulfanyl)-4H-1,2,4-triazole
0.000015
3-((R)-2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)-carbonylamino)-3-methylbutanamido)benzoic acid
Homo sapiens
-
in HUVEC
0.000034 - 0.00492
3-(2,2,2-trifluoroacetylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00034 - 0.00054
3-(2,2-dimethylpropionylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00068 - 0.00078
3-(2,2-dimethylpropionyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.01178
3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-{[(2-nitrophenyl)methyl]sulfanyl}-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00093
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.01766
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-methylbenzylthio)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.03071
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methoxybenzylthio)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00224
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(4-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.01239
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(4-nitrobenzylthio)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00395
3-(2,4-difluorobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0048
3-(2,6-difluorobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0016
3-(2-acetyloxybenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0016 mM
0.00537
3-(2-bromobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00184
3-(2-chlorobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00028 - 0.1
3-(2-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00083 - 0.016
3-(2-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00089 - 0.0013
3-(2-iodobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00055 - 0.0017
3-(2-methoxybenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00028 - 0.0109
3-(2-methylbut-2-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00039 - 0.0044
3-(2-methylbut-2-enoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.0021 - 0.1
3-(2-nitrobenzoyloxy)pyridine-2-carboxylic acid thiatol-2-ylamide
0.0025 - 0.0034
3-(3-bromo-4-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00591
3-(3-bromobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00192
3-(3-chlorobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00071 - 0.1
3-(3-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.000095 - 0.1
3-(3-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.0017 - 0.00302
3-(3-methoxy-2-nitrobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00022 - 0.00077
3-(3-methylbut-2-enoylamino)pyridien-2-carboxylic acid thiazol-2-ylamide
0.00049 - 0.0026
3-(3-methylbut-2-enoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00015 - 0.00467
3-(3-methylbut-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.0006 - 0.1
3-(3-nitrobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00729
3-(4-bromobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00345
3-(4-chlorobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00136 - 0.1
3-(4-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.0011 - 0.062
3-(4-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00014 - 0.00024
3-(4-methylpent-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00031 - 0.000671
3-(5-methylhex-4-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00601
3-(benzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00013 - 0.00038
3-(but-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00087 - 0.1
3-(cyclohexanecarbonylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00032 - 0.00239
3-(cyclohexanecarbonyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.0082
3-acetyloxypyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0082 mM
0.0328
3-aminopyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 1.7 mM, IC50: 0.0328 mM
0.00089
3-benzoylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00089 mM
0.00103 - 0.00122
3-benzoyloxypyridine-2-carboxylic acid thiazol-2-ylamide
0.0001 - 0.0233
3-But-3-enoylamino-pyridine-2-carboxylic acid thiazol-2-ylamide
0.000015
3-ethyl-2-methoxy-6-[[(2-[[2-(1-methylpyrrolidin-2-yl)ethyl]amino]phenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000018
3-ethyl-2-methoxy-6-[[(2-[[3-(2-methylpiperidin-1-yl)propyl]amino]phenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000067
3-ethyl-2-methyl-6-[(pyridin-2-ylsulfonyl)amino]benzoic acid
Mus musculus
-
0.00032 - 0.00033
3-formylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.000038 - 0.00062
3-hexanoylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.000174 - 0.00102
3-hexanoyloxypyridine-2-carboxylic acid thiazol-2-ylamide
0.00187 - 0.00486
3-hydroxypyridine-2-carboxylic acid thiazol-2-ylamide
0.0015
3-imino-4-[(E)-(4-methoxyphenyl)diazenyl]-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00025
3-imino-4-[(E)-[2-(trifluoromethyl)phenyl]diazenyl]-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00025
3-imino-4-[(E)-[3-(trifluoromethyl)phenyl]diazenyl]-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00192 - 0.0537
3-iso-butoxycarbonylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.00004 - 0.00082
3-phenylacetylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.000054 - 0.0002
3-phenylacetyloxypyridine-2-carboxylic acid thiazol-2-ylamide
0.00026 - 0.00035
3-propionylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.00038 - 0.0054
3-propionyloxypyridine-2-carboxylic acid thiazol-2-ylamide
0.00018 - 0.00335
3-tert-butoxycarbonylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.00058 - 0.25
3-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazole
0.002
3-[(E)-(5-amino-3-imino-3H-pyrazol-4-yl)diazenyl]-2-hydroxybenzoic acid
Escherichia coli
-
-
0.00175
3-[(E)-(5-amino-3-imino-3H-pyrazol-4-yl)diazenyl]benzoic acid
Escherichia coli
-
-
0.000009
3-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid
Homo sapiens
-
0.000019
3-[(phenylsulfonyl)amino]naphthalene-2-carboxylic acid
Homo sapiens
-
0.0021 - 0.0099
3-[3-(2-methoxyphenyl)acryloyloxy]pyridine-2-carboxylic acid thiazol-2-ylamide
0.000015
3-[[(4-fluorophenyl)sulfonyl]amino]naphthalene-2-carboxylic acid
Homo sapiens
-
0.0000007
4-((((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonylamino)methyl)benzoic acid
Homo sapiens
-
in HUVEC
0.0166
4-(1,3-thiazol-2-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0161 - 0.0246
4-(1-benzyl-1H-1,2,3-triazol-4-yl)benzene-1,2-diol
0.1
4-(1-methyl-1H-imidazol-2-yl)benzene-1,2-diol
Escherichia coli
-
IC50 above 0.1 mM, using Fe2+, Co2+, or Mn2+-activated MetAP enzymes
0.0202 - 0.0624
4-(2,5-dichlorothiophen-3-yl)benzene-1,2-diol
0.0074 - 0.1
4-(2,5-dimethylthiophen-3-yl)benzene-1,2-diol
0.0066 - 0.1
4-(2-aminothiazol-4-yl)benzene-1,2-diol
0.000031 - 0.079
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
0.0073 - 0.0224
4-(3-(2-bromoethyl)thiophen-2-yl)benzene-1,2-diol
0.0092 - 0.1
4-(3-butylthiophen-2-yl)benzene-1,2-diol
0.0129 - 0.0626
4-(3-ethylthiophen-2-yl)benzene-1,2-diol
0.00007 - 0.055
4-(3-methylthiophen-2-yl)benzene-1,2-diol
0.014 - 0.1
4-(3-propylthiophen-2-yl)benzene-1,2-diol
0.0021 - 0.0031
4-(4-bromo-2,5-dimethylthiophen-3-yl)benzene-1,2-diol
0.000152
4-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)morpholine
Plasmodium falciparum
-
-
0.0128 - 0.1
4-(5-chlorothiophen-2-yl)benzene-1,2-diol
0.0106 - 0.0526
4-(5-fluoropyrimidin-2-yl)benzene-1,2-diol
0.0112
4-(5-methoxy-1,3-oxazol-2-yl)benzene-1,2-diol
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.1
4-(5-methoxy-2-phenyl-3,4-dihydropyrimidin-4-yl)morpholine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.00513
4-(5-methoxy-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)morpholine
Plasmodium falciparum
-
-
0.028 - 0.0515
4-(5-methylthiophen-2-yl)benzene-1,2-diol
0.0051 - 0.0237
4-(thiophen-2-yl)benzene-1,2-diol
0.0038 - 0.0404
4-(thiophen-3-yl)benzene-1,2-diol
0.0193
4-pyridin-2-ylbenzene-1,2-diol
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.0255
4-pyrimidin-2-ylbenzene-1,2-diol
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.00055
4-[(E)-(3-chloro-2-methylphenyl)diazenyl]-3-imino-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00055
4-[(E)-(3-fluorophenyl)diazenyl]-3-imino-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00125
4-[(E)-(4-chlorophenyl)diazenyl]-3-imino-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00058
4-[(E)-(4-fluorophenyl)diazenyl]-3-imino-3H-pyrazol-5-amine
Escherichia coli
-
-
0.01 - 0.0388
5,6-dimethyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.0024 - 0.0326
5,6-dimethyl-2-(pyridin-2-yl)-1H-benzimidazole
0.000038
5-((R)-1-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl-pyrrolidin-2-ylmethoxy)-isoquinoline
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0009 - 4
5-(2,3-dichlorophenyl)furan-2-carboxylic acid
0.00275 - 0.05
5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid
0.00053 - 0.05
5-(2,3-dimethylphenyl)furan-2-carboxylic acid
0.00338 - 0.05
5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid
0.00044 - 0.05
5-(2,4-dichlorophenyl)furan-2-carboxylic acid
0.00032 - 0.05
5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid
0.0077 - 0.05
5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid
0.00025 - 0.494
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
0.00042 - 0.05
5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid
0.0046 - 0.05
5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid
0.00118 - 0.05
5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid
0.00089 - 0.05
5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid
0.002
5-(2-chlorophenyl)-2-furohydrazide
Escherichia coli
-
Mn2+-activated enzyme (0.004 mM MnCl2), pH 7.5, 21°C
0.00116 - 0.0771
5-(2-chlorophenyl)furan-2-carbohydrazide
0.00051 - 0.394
5-(2-chlorophenyl)furan-2-carboxylic acid
0.00048 - 0.05
5-(2-ethoxyphenyl)furan-2-carboxylic acid
0.00508 - 0.05
5-(2-ethoxyphenyl)thiophene-2-carboxylic acid
0.00055 - 0.2
5-(2-methoxyphenyl)furan-2-carboxylic acid
0.00499 - 0.0477
5-(2-methoxyphenyl)thiophene-2-carboxylic acid
0.00151 - 0.05
5-(2-methylphenyl)thiophene-2-carboxylic acid
0.0154 - 0.1
5-(3,4-dihydroxyphenyl)-N-isopropyl-2-methylthiazole-4-carboxamide
0.0148 - 0.0363
5-(3,4-dihydroxyphenyl)thiophene-2-carbonitrile
0.00067 - 0.05
5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid
0.0091
5-bromo-2-[[(4-chlorophenyl)sulfonyl]amino]benzoic acid
Homo sapiens
-
0.01
5-butyl-2-[(phenylsulfonyl)amino]benzoic acid
Homo sapiens
-
0.0052 - 0.047
5-chloro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.0002
5-chloro-2-(5-chloropyridin-2-yl)-6-methyl-N-((R)-2-phenyl-2-(4-phenylbutylamino)ethyl)pyrimidin-4-amine
Homo sapiens
22°C, pH not specified in the publication
0.000063
5-chloro-2-(5-chloropyridin-2-yl)-N-(2,4-diphenylbutyl)-6-methylpyrimidin-4-amine
Homo sapiens
22°C, pH not specified in the publication
0.0017 - 0.0488
5-chloro-2-(pyridin-2-yl)-1H-benzimidazole
0.000843
5-chloro-4,6-dimethyl-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.000521
5-chloro-4-methyl-2-pyridin-2-yl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.0004 - 0.0008
5-chloro-4-methyl-2-pyridin-2-yl-6-pyrrolidin-1-ylpyrimidine
0.000158
5-chloro-4-methyl-6-(4-methylbenzyl)-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.000112
5-chloro-6-(2-ethylphenyl)-4-methyl-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.0006 - 0.0076
5-chloro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
0.0033
5-chloro-N,6-dimethyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
0.0000177
5-demethylovalicin
Homo sapiens
-
IC50: 17.7 nM, inhibition of recombinant enzyme
0.00009
5-ethyl-2-[(phenylsulfonyl)amino]benzoic acid
Homo sapiens
-
0.000055
5-ethyl-2-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.0043 - 0.0458
5-fluoro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.0015 - 0.0401
5-fluoro-2-(pyridin-2-yl)-1H-benzimidazole
0.1
5-methoxy-2-phenyl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.1
5-methoxy-2-pyridin-2-yl-3,4-dihydropyrimidin-4-ol
Plasmodium falciparum
-
IC50 above 0.1 mM
0.00791
5-methoxy-2-pyridin-2-yl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.0017
5-methoxy-6,6-dimethyl-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.1
5-methoxy-6-methyl-2-phenyl-1,6-dihydropyrimidine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.00217
5-methoxy-6-methyl-6-phenyl-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.00113
5-methoxy-6-[(4-methoxyphenyl)sulfanyl]-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.0132
5-methoxy-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-oxobicyclo[3.1.0]hexane-1-carbaldehyde
Homo sapiens
-
0.0072 - 0.0406
5-methyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.0021 - 0.0326
5-methyl-2-(pyridin-2-yl)-1H-benzimidazole
0.001
5-methyl-2-[(phenylsulfonyl)amino]benzoic acid
Homo sapiens
-
0.0012 - 0.0485
5-nitro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.00016 - 0.0288
5-nitro-2-(pyridin-2-yl)-1H-benzimidazole
0.0039 - 0.0417
5-tert-butyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.0026 - 0.0441
5-tert-butyl-2-(pyridin-2-yl)-1H-benzimidazole
0.00024 - 0.25
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
0.00064 - 0.303
5-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
0.0021 - 0.25
5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
0.03
5-[[(4-chlorophenyl)methyl]sulfanyl]-4H-1,2,4-triazol-3-amine
Rickettsia prowazekii
pH 7.0, 30°C, Hill slope 1.6
0.0575
6-(1,5-dimethylhex-4-en-1-yl)-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one
Homo sapiens
-
0.0013 - 0.0292
6-(1H-benzimidazol-2-yl)pyridin-2(1H)-one
0.00106
6-(2-chlorobenzyl)-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.000938
6-(benzylsulfanyl)-5-chloro-4-methyl-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.00111
6-(phenylsulfanyl)-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.00106
6-benzyl-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.1
6-benzyl-5-chloro-4-methyl-2-pyridin-3-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.0338
6-[(1E)-1,5-dimethylhexa-1,4-dien-1-yl]-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one
Homo sapiens
-
0.00104
6-[(2,4-dichlorophenyl)sulfanyl]-5-methoxy-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.00123
6-[(4-methoxyphenyl)sulfanyl]-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.000026
6-[([2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-ethyl-2-methoxybenzoic acid
Mus musculus
-
0.036
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-(1H-imidazol-4-yl)-3-methoxybenzoic acid
Mus musculus
-
0.001
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-2-yl-3-methoxybenzoic acid
Mus musculus
-
0.00002
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid
Mus musculus
-
0.000015
6-[[(2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-furan-3-yl-2-methoxybenzoic acid
Mus musculus
-
0.000017
6-[[(2-[[3-(dimethylamino)propyl]amino]-4-fluorophenyl)sulfonyl]amino]-3-furan-3-yl-2-methoxybenzoic acid
Mus musculus
-
0.00001
6-[[(2-[[4-(dimethylamino)butyl]amino]phenyl)sulfonyl]amino]-3-ethyl-2-methoxybenzoic acid
Mus musculus
-
0.000078
6-[[(4-fluorophenyl)sulfonyl]amino]-2,3-dimethylbenzoic acid
Mus musculus
-
0.0025
6-[[(4-fluorophenyl)sulfonyl]amino]-2-(1-hydroxyethyl)-3-methylbenzoic acid
Mus musculus
-
0.008
6-[[(4-fluorophenyl)sulfonyl]amino]-2-(hydroxymethyl)-3-methylbenzoic acid
Mus musculus
-
0.000008
6-[[(4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid
Mus musculus
-
0.00028
6-[[(4-fluorophenyl)sulfonyl]amino]-2-methoxy-3-(1H-pyrazol-4-yl)benzoic acid
Mus musculus
-
0.00015
6-[[(4-fluorophenyl)sulfonyl]amino]-3-methyl-2-propylbenzoic acid
Mus musculus
-
0.00038 - 0.0364
8-(pyridin-2-yl)-7H-purine
0.00077 - 0.0215
8-hydroxy quinoline
0.000031
A-310840
Homo sapiens
-
IC50: 0.000031 mM for enzyme with Zn2+, 0.000043 mM for enzyme with Ni2+, 0.000069 mM for enzyme with Co2+, 0.000026 for enzyme with Fe2+, 0.0578 mM for enzyme with Mn2+
0.000121
A-311263
Homo sapiens
-
IC50: 0.000121 mM for enzyme with Zn2+, 0.000107 mM for enzyme with Ni2+, 0.000149 mM for enzyme with Co2+, 0.00011 mM for enzyme with Fe2+, 0.000055 mM for enzyme with Mn2+
0.00012 - 0.00015
A-357300
0.000008 - 0.00002
A-800141
0.0019 - 0.0105
bengamide A
0.0179 - 0.0293
bengamide B
0.0268 - 0.05
bengamide G
0.0371 - 0.05
bengamide L
0.0054 - 0.05
bengamide M
0.0402 - 0.05
bengamide N
0.0027 - 0.05
bengamide O
0.0111 - 0.1
cyclopropyl 5-(3,4-dihydroxyphenyl)-2-methyl-1,3-thiazole-4-carboxylate
0.014
ethyl 5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxylate
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.008
fumagalone
Homo sapiens
-
0.1 - 11.1
fumagillin
0.002 - 0.00323
fumarranol
0.00064 - 0.0278
imidazo[2,1-a]isoquinoline-2-carbohydrazide
0.0017 - 0.0025
L-MetStaCys
0.002 - 0.0043
L-MetStaVal
0.000049
L134
Escherichia coli
-
-
0.00013
L288
Escherichia coli
-
-
0.000599 - 0.001455
MCB2379
Staphylococcus aureus
-
IC50: 599 nM in presence of Co2+, 1455 nM in presence of Zn2+
0.0000437 - 0.0003
MCB2813
Staphylococcus aureus
-
IC50: 43.7 nM in presence of Co2+, 300 nM in presence of Zn2+
0.025
methyl N-[(2S,3R)-3-amino-2-hydroxy-3-(4-methylphenyl)propanoyl]-L-alanylleucinate
Escherichia coli
-
-
0.0035
methyl N-[(2S,3R)-3-amino-2-hydroxy-3-[4-(1-methylethyl)phenyl]propanoyl]-L-alanylleucinate
Escherichia coli
-
-
0.012
methyl N-[(2S,3R)-3-amino-2-hydroxyheptanoyl]-L-serylleucinate
Escherichia coli
-
-
0.0017
methyl [[(2S)-2-([(2S,3R)-3-amino-2-hydroxy-3-[4-(trifluoromethyl)phenyl]propanoyl]amino)propanoyl]amino]acetate
Escherichia coli
-
-
0.000093
N-((R)-2-(5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-ylamino)-1-phenylethyl)-3-phenylpropanamide
Homo sapiens
22°C, pH not specified in the publication
0.00054 - 0.0224
N-(1,3-thiazol-2-yl)-1H-benzimidazol-2-amine
0.00072
N-(1,3-thiazol-2-yl)-3-[(N-[2-[2-(2-[2-[(1H-triaziren-1-ylacetyl)amino]ethoxy]ethoxy)ethoxy]-4-[3-(trifluoromethyl)-3H-diaziren-3-yl]benzoyl]glycyl)amino]pyridine-2-carboxamide
Escherichia coli
-
-
0.00006 - 0.0258
N-(1,3-thiazol-2-yl)pyridine-2-carboxamide
0.000199
N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-2-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine
Plasmodium falciparum
-
-
0.1
N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-3-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.1
N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-4-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.0029
N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[(2,2-dimethylpropanoyl)amino]pyridine-2-carboxamide
Homo sapiens
MetAP1
0.0035
N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[(3-phenylpropanoyl)amino]pyridine-2-carboxamide
Homo sapiens
MetAP1
0.0064
N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[[(1E)-2-methylpropylidene]amino]pyridine-2-carboxamide
Homo sapiens
MetAP1
0.0028
N-(5-methyl-1,2-oxazol-3-yl)pyridine-2-carboxamide
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.011 - 0.0449
N-(quinolin-8-yl)benzenesulfonamide
0.000804
N-1,3-thiazol-2-yl-3-(N-[(2-2-[(1H-triaziren-1-ylacetyl)amino]ethoxy]-4-[[3-(trifluoromethyl)-[3H-diaziren-3-yl]phenyl)carbonyl]glycyl]amino)pyridine-2-carboxamide
Escherichia coli
-
-
0.03 - 0.2
N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
0.0134
N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxamide
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.001 - 0.0212
N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
0.0012 - 0.0225
N-cyclobutyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
0.011
N-cyclopentyl-5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxamide
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.0009 - 0.0301
N-cyclopentyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
0.0078 - 0.1
N-cyclopropyl-2-(3,4-dihydroxyphenyl)thiophene-3-carboxamide
0.0148
N-cyclopropyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.0238 - 0.034
N-cyclopropyl-5-(3,4-dihydroxyphenyl)thiophene-2-carboxamide
0.0024 - 0.041
phenyl[2-(1,3-thiazol-4-yl)-1H-benzimidazol-5-yl]methanone
0.0013 - 0.007
Pyridine-2-carboxylic acid thiazol-2-ylamide
0.016
quinolin-8-yl 4-methylbenzenesulfonate
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0412 - 0.0417
quinolin-8-yl benzenesulfonate
0.0348 - 0.0428
quinolin-8-yl benzoate
0.0015
tert-butyl [2-(4,5-dihydro-1,3-thiazol-2-ylcarbamoyl)pyridin-3-yl]carbamate
Homo sapiens
MetAP1
0.00047 - 0.0478
thiabendazole
0.000001 - 10.6
TNP-470
0.0007
XC-11
Plasmodium falciparum
-
isozyme MetAP1b
additional information
additional information
-