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0.02 - 0.034
((2RS,3R)-3-amino-2-hydroxy-5-ethylthio)pentanoyl-((S)-(-)-(1-naphthyl)ethyl)amide
0.0013 - 0.179
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide
0.00054 - 0.075
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide
0.00076 - 0.201
(2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
0.00062 - 0.12
(2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
0.0002 - 0.08
(2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
0.0004 - 0.15
(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
0.00096 - 0.187
(2R,3R,4S,5R,E)-N-[[1-(cyclopropanecarbonyl)piperidin-3-yl]methyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
0.0229 - 0.095
(3R)-amino-(2S)-hydroxyheptanoyl-Ala-Leu methyl ester
0.0123
(3R)-amino-(2S)-hydroxypentanoic acid
Escherichia coli
-
IC50: 0.0123 mM for the Co2+-substituted enzyme, 0.0115 mM for the Mn2+-substituted enzyme, 0.0093 mM for the Zn2+-substituted enzyme, 0.0223 for the Ni2+-substituted enzyme
0.0000006
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (2R)-3-methyl-1-(2-(1-methylpyrrolidin-2-yl)ethylamino)-1-oxobutan-2-ylcarbamate
Homo sapiens
-
above, in HUVEC
0.000000095
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (R)-1-amino-3-methyl-1-oxobutan-2-ylcarbamate
Homo sapiens
-
in HUVEC
0.0000017
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (R)-3-methyl-1-(morpholinoamino)-1-oxobutan-2-ylcarbamate
Homo sapiens
-
in HUVEC
0.0000006
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (R)-3-methyl-1-oxo-1-(2-(pyrrolidin-1-yl)ethylamino)butan-2-ylcarbamate
Homo sapiens
-
in HUVEC
0.0000017
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl 1-amino-2-methyl-1-oxopropan-2-ylcarbamate
Homo sapiens
-
in HUVEC
0.0000007
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl 1-carbamoylcyclopentylcarbamate
Homo sapiens
-
in HUVEC
0.0000002
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl 2-(1-methylpyrrolidin-2-yl)ethylcarbamate
Homo sapiens
-
above, in HUVEC
0.0000001
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl 2-(pyrrolidin-1-yl)ethylcarbamate
Homo sapiens
-
in HUVEC
0.00000006
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl isopropylcarbamate
Homo sapiens
-
in HUVEC
0.0000007
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl morpholinocarbamate
Homo sapiens
-
in HUVEC
0.0000011
(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl tert-butylcarbamate
Homo sapiens
-
in HUVEC
0.00000025
(3R,5S,6R)-5-methoxy-4-[(3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl (chloroacetyl)carbamate
Homo sapiens
-
in HUVEC
0.00021
(5,5-Dimethyl-4,5-dihydro-thiazol-2-yl)-(3-methyl-pyridin-2-yl)-amine
Escherichia coli
-
IC50 for Co-EcMetAP1: 0.00021 mM
0.000027
(8S)-2-[[(4-fluorophenyl)sulfonyl]amino]-8-methyl-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
Homo sapiens
-
0.000000036
(R)-methyl 2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonylamino)-2-phenylacetate
Homo sapiens
-
in HUVEC
0.00000004
(R)-methyl 2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonylamino)-3-methylbutanoate
Homo sapiens
-
in HUVEC
0.000000038
(R)-methyl 2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonylamino)-4-methylpentanoate
Homo sapiens
-
in HUVEC
0.000000018
(S)-methyl 2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)-carbonylamino)-3-methylbutanoate
Homo sapiens
-
in HUVEC
0.0000013
1-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonyl)-piperidine-4-carboxylic acid
Homo sapiens
-
in HUVEC
0.009 - 0.0359
1-(1H-benzimidazol-2-yl)thiourea
0.00312
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(2-sulfanylmorpholin-4-yl)ethanone
Plasmodium falciparum
-
-
0.00154
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(2-sulfanylphenyl)ethanone
Plasmodium falciparum
-
-
0.00124
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(4-fluoro-2-sulfanylphenyl)ethanone
Plasmodium falciparum
-
-
0.00102
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(4-methoxy-2-sulfanylphenyl)ethanone
Plasmodium falciparum
-
-
0.0011 - 0.0081
1-(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-4-(2,4-dichlorobenzyl)-1,4-diazepane
0.00046
1-benzyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.00099
1-benzyl-2-(pyridin-2-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0005 - 0.0324
1-methyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.00118
1-[2-pyridin-2-yl-6-(trifluoromethyl)-3,4-dihydropyrimidin-4-yl]propane-2-thiol
Plasmodium falciparum
-
-
0.000667
2,2'-bipyridine
Enterococcus faecalis
-
pH 7.5, 30°C
0.00008 - 0.0398
2-(1,3-thiazol-2-yl)-1H-imidazo[4,5-b]pyridine
0.0023 - 0.0101
2-(1,3-thiazol-4-yl)-1H-benzimidazol-5-amine
0.0017 - 0.0455
2-(1,3-thiazol-4-yl)-1H-imidazo[4,5-c]pyridine
0.00078 - 0.0044
2-(1H-benzimidazol-2-yl)pyridin-3-ol
0.0001
2-(2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)-carbonylamino)ethyl)-1,1-dimethylpyrrolidinium iodide
Homo sapiens
-
in HUVEC
0.000016
2-(2-aminoethoxy)-3-ethyl-6-[[(2-propylphenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000046
2-(2-aminoethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000024
2-(2-aminoethoxy)-6-[([2-[3-(diethylamino)propyl]-4-fluorophenyl]sulfonyl)amino]-3-ethylbenzoic acid
Mus musculus
-
0.0058
2-(carboxymethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.0005
2-(prop-1-en-2-yl)-5-[2-(trifluoromethyl)phenyl]furan
Rickettsia prowazekii
pH 7.0, 30°C, Hill slope 2.1
0.0046 - 0.0329
2-(pyrazin-2-yl)-1H-benzimidazole
0.00097 - 0.0093
2-(pyridin-2-yl)-1H-benzimidazol-5-amine
0.00057 - 0.0284
2-(pyridin-2-yl)-1H-benzimidazole
0.00043 - 0.0373
2-(pyridin-2-yl)-1H-benzimidazole-5-carbonitrile
0.00024 - 0.0484
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyrazine
0.00011 - 0.0276
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine
0.00055 - 0.0228
2-(pyridin-2-yl)-1H-imidazo[4,5-c]pyridine
0.0013
2-butyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
Mus musculus
-
0.000015
2-chloro-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.00006
2-ethenyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
Mus musculus
-
0.000038
2-ethoxy-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000011
2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methoxybenzoic acid
Mus musculus
-
0.000016
2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid
Mus musculus
-
0.00107
2-pyridin-2-yl-4-(trifluoromethyl)-6-[2-(trifluoromethyl)benzyl]-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.0039
2-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-5-bromobenzoic acid
Homo sapiens
-
0.000009
2-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
Mus musculus
-
0.0011
2-[(phenylsulfonyl)amino]-5-propylbenzoic acid
Homo sapiens
-
0.02
2-[([4-[(E)-(5-amino-3-imino-3H-pyrazol-4-yl)diazenyl]phenyl]sulfinyl)oxy]hydrazinecarboximidamide
Escherichia coli
-
-
0.0296 - 0.0441
2-[2-(2-amino-4-methylsulfanyl-butyrylsulfanyl)-3-phenyl-propionylamino]-3-hydroxy-propionic acid
0.0286 - 0.0498
2-[2-(2-Amino-4-methylsulfanyl-butyrylsulfanyl)-5-methyl-hexanoylamino]-3-hydroxy-propionic acid
0.0125 - 0.0252
2-[2-(3-Amino-2-hydroxy-heptanoylamino)-propionylamino]-4-methyl-pentanoic acid methyl ester
0.037
2-[4-(2-Cyano-2-ethoxycarbonyl-1-methyl-vinyl)-phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
Escherichia coli
-
IC50 for Co-EcMetAP1: 0.037 mM
0.011
2-[[(4-chlorophenyl)sulfonyl]amino]-5-methylbenzoic acid
Homo sapiens
-
0.00001
2-[[(4-fluorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
Homo sapiens
-
0.00002
2-[[(4-fluorophenyl)sulfonyl]amino]-8-methyl-5,6-dihydronaphthalene-1-carboxylic acid
Homo sapiens
-
0.00035
3,5-dimethyl-2-[(phenylsulfonyl)amino]benzoic acid
Homo sapiens
-
0.0001
3-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonylamino)-N,N,N-trimethylpropan-1-aminium iodide
Homo sapiens
-
in HUVEC
0.015 - 1
3-((2-naphthylmethyl)sulfanyl)-4H-1,2,4-triazole
0.000015
3-((R)-2-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)-carbonylamino)-3-methylbutanamido)benzoic acid
Homo sapiens
-
in HUVEC
0.000034 - 0.00492
3-(2,2,2-trifluoroacetylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00034 - 0.00054
3-(2,2-dimethylpropionylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00068 - 0.00078
3-(2,2-dimethylpropionyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.01178
3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-{[(2-nitrophenyl)methyl]sulfanyl}-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00093
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.01766
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-methylbenzylthio)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.03071
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methoxybenzylthio)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00224
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(4-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.01239
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(4-nitrobenzylthio)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00395
3-(2,4-difluorobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0048
3-(2,6-difluorobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0016
3-(2-acetyloxybenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0016 mM
0.00537
3-(2-bromobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00184
3-(2-chlorobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00028 - 0.1
3-(2-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00083 - 0.016
3-(2-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00089 - 0.0013
3-(2-iodobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00055 - 0.0017
3-(2-methoxybenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00028 - 0.0109
3-(2-methylbut-2-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00039 - 0.0044
3-(2-methylbut-2-enoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.0021 - 0.1
3-(2-nitrobenzoyloxy)pyridine-2-carboxylic acid thiatol-2-ylamide
0.0025 - 0.0034
3-(3-bromo-4-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00591
3-(3-bromobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00192
3-(3-chlorobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00071 - 0.1
3-(3-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.000095 - 0.1
3-(3-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.0017 - 0.00302
3-(3-methoxy-2-nitrobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00022 - 0.00077
3-(3-methylbut-2-enoylamino)pyridien-2-carboxylic acid thiazol-2-ylamide
0.00049 - 0.0026
3-(3-methylbut-2-enoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00015 - 0.00467
3-(3-methylbut-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.0006 - 0.1
3-(3-nitrobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00729
3-(4-bromobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00345
3-(4-chlorobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00136 - 0.1
3-(4-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.0011 - 0.062
3-(4-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00014 - 0.00024
3-(4-methylpent-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00031 - 0.000671
3-(5-methylhex-4-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00601
3-(benzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00013 - 0.00038
3-(but-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00087 - 0.1
3-(cyclohexanecarbonylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
0.00032 - 0.00239
3-(cyclohexanecarbonyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
0.0082
3-acetyloxypyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0082 mM
0.0328
3-aminopyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 1.7 mM, IC50: 0.0328 mM
0.00089
3-benzoylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00089 mM
0.00103 - 0.00122
3-benzoyloxypyridine-2-carboxylic acid thiazol-2-ylamide
0.0001 - 0.0233
3-But-3-enoylamino-pyridine-2-carboxylic acid thiazol-2-ylamide
0.000015
3-ethyl-2-methoxy-6-[[(2-[[2-(1-methylpyrrolidin-2-yl)ethyl]amino]phenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000018
3-ethyl-2-methoxy-6-[[(2-[[3-(2-methylpiperidin-1-yl)propyl]amino]phenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.000067
3-ethyl-2-methyl-6-[(pyridin-2-ylsulfonyl)amino]benzoic acid
Mus musculus
-
0.00032 - 0.00033
3-formylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.000038 - 0.00062
3-hexanoylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.000174 - 0.00102
3-hexanoyloxypyridine-2-carboxylic acid thiazol-2-ylamide
0.00187 - 0.00486
3-hydroxypyridine-2-carboxylic acid thiazol-2-ylamide
0.0015
3-imino-4-[(E)-(4-methoxyphenyl)diazenyl]-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00025
3-imino-4-[(E)-[2-(trifluoromethyl)phenyl]diazenyl]-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00025
3-imino-4-[(E)-[3-(trifluoromethyl)phenyl]diazenyl]-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00192 - 0.0537
3-iso-butoxycarbonylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.00004 - 0.00082
3-phenylacetylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.000054 - 0.0002
3-phenylacetyloxypyridine-2-carboxylic acid thiazol-2-ylamide
0.00026 - 0.00035
3-propionylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.00038 - 0.0054
3-propionyloxypyridine-2-carboxylic acid thiazol-2-ylamide
0.00018 - 0.00335
3-tert-butoxycarbonylaminopyridine-2-carboxylic acid thiazol-2-ylamide
0.00058 - 0.25
3-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazole
0.002
3-[(E)-(5-amino-3-imino-3H-pyrazol-4-yl)diazenyl]-2-hydroxybenzoic acid
Escherichia coli
-
-
0.00175
3-[(E)-(5-amino-3-imino-3H-pyrazol-4-yl)diazenyl]benzoic acid
Escherichia coli
-
-
0.000009
3-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid
Homo sapiens
-
0.000019
3-[(phenylsulfonyl)amino]naphthalene-2-carboxylic acid
Homo sapiens
-
0.0021 - 0.0099
3-[3-(2-methoxyphenyl)acryloyloxy]pyridine-2-carboxylic acid thiazol-2-ylamide
0.000015
3-[[(4-fluorophenyl)sulfonyl]amino]naphthalene-2-carboxylic acid
Homo sapiens
-
0.0000007
4-((((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yloxy)carbonylamino)methyl)benzoic acid
Homo sapiens
-
in HUVEC
0.0166
4-(1,3-thiazol-2-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0161 - 0.0246
4-(1-benzyl-1H-1,2,3-triazol-4-yl)benzene-1,2-diol
0.1
4-(1-methyl-1H-imidazol-2-yl)benzene-1,2-diol
Escherichia coli
-
IC50 above 0.1 mM, using Fe2+, Co2+, or Mn2+-activated MetAP enzymes
0.0202 - 0.0624
4-(2,5-dichlorothiophen-3-yl)benzene-1,2-diol
0.0074 - 0.1
4-(2,5-dimethylthiophen-3-yl)benzene-1,2-diol
0.0066 - 0.1
4-(2-aminothiazol-4-yl)benzene-1,2-diol
0.000031 - 0.079
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
0.0073 - 0.0224
4-(3-(2-bromoethyl)thiophen-2-yl)benzene-1,2-diol
0.0092 - 0.1
4-(3-butylthiophen-2-yl)benzene-1,2-diol
0.0129 - 0.0626
4-(3-ethylthiophen-2-yl)benzene-1,2-diol
0.00007 - 0.055
4-(3-methylthiophen-2-yl)benzene-1,2-diol
0.014 - 0.1
4-(3-propylthiophen-2-yl)benzene-1,2-diol
0.0021 - 0.0031
4-(4-bromo-2,5-dimethylthiophen-3-yl)benzene-1,2-diol
0.000152
4-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)morpholine
Plasmodium falciparum
-
-
0.0128 - 0.1
4-(5-chlorothiophen-2-yl)benzene-1,2-diol
0.0106 - 0.0526
4-(5-fluoropyrimidin-2-yl)benzene-1,2-diol
0.0112
4-(5-methoxy-1,3-oxazol-2-yl)benzene-1,2-diol
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.1
4-(5-methoxy-2-phenyl-3,4-dihydropyrimidin-4-yl)morpholine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.00513
4-(5-methoxy-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)morpholine
Plasmodium falciparum
-
-
0.028 - 0.0515
4-(5-methylthiophen-2-yl)benzene-1,2-diol
0.0051 - 0.0237
4-(thiophen-2-yl)benzene-1,2-diol
0.0038 - 0.0404
4-(thiophen-3-yl)benzene-1,2-diol
0.0193
4-pyridin-2-ylbenzene-1,2-diol
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.0255
4-pyrimidin-2-ylbenzene-1,2-diol
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.00055
4-[(E)-(3-chloro-2-methylphenyl)diazenyl]-3-imino-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00055
4-[(E)-(3-fluorophenyl)diazenyl]-3-imino-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00125
4-[(E)-(4-chlorophenyl)diazenyl]-3-imino-3H-pyrazol-5-amine
Escherichia coli
-
-
0.00058
4-[(E)-(4-fluorophenyl)diazenyl]-3-imino-3H-pyrazol-5-amine
Escherichia coli
-
-
0.01 - 0.0388
5,6-dimethyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.0024 - 0.0326
5,6-dimethyl-2-(pyridin-2-yl)-1H-benzimidazole
0.000038
5-((R)-1-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl-pyrrolidin-2-ylmethoxy)-isoquinoline
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0009 - 4
5-(2,3-dichlorophenyl)furan-2-carboxylic acid
0.00275 - 0.05
5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid
0.00053 - 0.05
5-(2,3-dimethylphenyl)furan-2-carboxylic acid
0.00338 - 0.05
5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid
0.00044 - 0.05
5-(2,4-dichlorophenyl)furan-2-carboxylic acid
0.00032 - 0.05
5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid
0.0077 - 0.05
5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid
0.00025 - 0.494
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
0.00042 - 0.05
5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid
0.0046 - 0.05
5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid
0.00118 - 0.05
5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid
0.00089 - 0.05
5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid
0.002
5-(2-chlorophenyl)-2-furohydrazide
Escherichia coli
-
Mn2+-activated enzyme (0.004 mM MnCl2), pH 7.5, 21°C
0.00116 - 0.0771
5-(2-chlorophenyl)furan-2-carbohydrazide
0.00051 - 0.394
5-(2-chlorophenyl)furan-2-carboxylic acid
0.00048 - 0.05
5-(2-ethoxyphenyl)furan-2-carboxylic acid
0.00508 - 0.05
5-(2-ethoxyphenyl)thiophene-2-carboxylic acid
0.00055 - 0.2
5-(2-methoxyphenyl)furan-2-carboxylic acid
0.00499 - 0.0477
5-(2-methoxyphenyl)thiophene-2-carboxylic acid
0.00151 - 0.05
5-(2-methylphenyl)thiophene-2-carboxylic acid
0.0154 - 0.1
5-(3,4-dihydroxyphenyl)-N-isopropyl-2-methylthiazole-4-carboxamide
0.0148 - 0.0363
5-(3,4-dihydroxyphenyl)thiophene-2-carbonitrile
0.00067 - 0.05
5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid
0.0091
5-bromo-2-[[(4-chlorophenyl)sulfonyl]amino]benzoic acid
Homo sapiens
-
0.01
5-butyl-2-[(phenylsulfonyl)amino]benzoic acid
Homo sapiens
-
0.0052 - 0.047
5-chloro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.0002
5-chloro-2-(5-chloropyridin-2-yl)-6-methyl-N-((R)-2-phenyl-2-(4-phenylbutylamino)ethyl)pyrimidin-4-amine
Homo sapiens
22°C, pH not specified in the publication
0.000063
5-chloro-2-(5-chloropyridin-2-yl)-N-(2,4-diphenylbutyl)-6-methylpyrimidin-4-amine
Homo sapiens
22°C, pH not specified in the publication
0.0017 - 0.0488
5-chloro-2-(pyridin-2-yl)-1H-benzimidazole
0.000843
5-chloro-4,6-dimethyl-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.000521
5-chloro-4-methyl-2-pyridin-2-yl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.0004 - 0.0008
5-chloro-4-methyl-2-pyridin-2-yl-6-pyrrolidin-1-ylpyrimidine
0.000158
5-chloro-4-methyl-6-(4-methylbenzyl)-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.000112
5-chloro-6-(2-ethylphenyl)-4-methyl-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.0006 - 0.0076
5-chloro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
0.0033
5-chloro-N,6-dimethyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
0.0000177
5-demethylovalicin
Homo sapiens
-
IC50: 17.7 nM, inhibition of recombinant enzyme
0.00009
5-ethyl-2-[(phenylsulfonyl)amino]benzoic acid
Homo sapiens
-
0.000055
5-ethyl-2-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid
Mus musculus
-
0.0043 - 0.0458
5-fluoro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.0015 - 0.0401
5-fluoro-2-(pyridin-2-yl)-1H-benzimidazole
0.1
5-methoxy-2-phenyl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.1
5-methoxy-2-pyridin-2-yl-3,4-dihydropyrimidin-4-ol
Plasmodium falciparum
-
IC50 above 0.1 mM
0.00791
5-methoxy-2-pyridin-2-yl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.0017
5-methoxy-6,6-dimethyl-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.1
5-methoxy-6-methyl-2-phenyl-1,6-dihydropyrimidine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.00217
5-methoxy-6-methyl-6-phenyl-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.00113
5-methoxy-6-[(4-methoxyphenyl)sulfanyl]-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.0132
5-methoxy-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-oxobicyclo[3.1.0]hexane-1-carbaldehyde
Homo sapiens
-
0.0072 - 0.0406
5-methyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.0021 - 0.0326
5-methyl-2-(pyridin-2-yl)-1H-benzimidazole
0.001
5-methyl-2-[(phenylsulfonyl)amino]benzoic acid
Homo sapiens
-
0.0012 - 0.0485
5-nitro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.00016 - 0.0288
5-nitro-2-(pyridin-2-yl)-1H-benzimidazole
0.0039 - 0.0417
5-tert-butyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
0.0026 - 0.0441
5-tert-butyl-2-(pyridin-2-yl)-1H-benzimidazole
0.00024 - 0.25
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
0.00064 - 0.303
5-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
0.0021 - 0.25
5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
0.03
5-[[(4-chlorophenyl)methyl]sulfanyl]-4H-1,2,4-triazol-3-amine
Rickettsia prowazekii
pH 7.0, 30°C, Hill slope 1.6
0.0575
6-(1,5-dimethylhex-4-en-1-yl)-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one
Homo sapiens
-
0.0013 - 0.0292
6-(1H-benzimidazol-2-yl)pyridin-2(1H)-one
0.00106
6-(2-chlorobenzyl)-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.000938
6-(benzylsulfanyl)-5-chloro-4-methyl-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.00111
6-(phenylsulfanyl)-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.00106
6-benzyl-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.1
6-benzyl-5-chloro-4-methyl-2-pyridin-3-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.0338
6-[(1E)-1,5-dimethylhexa-1,4-dien-1-yl]-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one
Homo sapiens
-
0.00104
6-[(2,4-dichlorophenyl)sulfanyl]-5-methoxy-2-pyridin-2-yl-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.00123
6-[(4-methoxyphenyl)sulfanyl]-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine
Plasmodium falciparum
-
-
0.000026
6-[([2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-ethyl-2-methoxybenzoic acid
Mus musculus
-
0.036
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-(1H-imidazol-4-yl)-3-methoxybenzoic acid
Mus musculus
-
0.001
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-2-yl-3-methoxybenzoic acid
Mus musculus
-
0.00002
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid
Mus musculus
-
0.000015
6-[[(2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-furan-3-yl-2-methoxybenzoic acid
Mus musculus
-
0.000017
6-[[(2-[[3-(dimethylamino)propyl]amino]-4-fluorophenyl)sulfonyl]amino]-3-furan-3-yl-2-methoxybenzoic acid
Mus musculus
-
0.00001
6-[[(2-[[4-(dimethylamino)butyl]amino]phenyl)sulfonyl]amino]-3-ethyl-2-methoxybenzoic acid
Mus musculus
-
0.000078
6-[[(4-fluorophenyl)sulfonyl]amino]-2,3-dimethylbenzoic acid
Mus musculus
-
0.0025
6-[[(4-fluorophenyl)sulfonyl]amino]-2-(1-hydroxyethyl)-3-methylbenzoic acid
Mus musculus
-
0.008
6-[[(4-fluorophenyl)sulfonyl]amino]-2-(hydroxymethyl)-3-methylbenzoic acid
Mus musculus
-
0.000008
6-[[(4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid
Mus musculus
-
0.00028
6-[[(4-fluorophenyl)sulfonyl]amino]-2-methoxy-3-(1H-pyrazol-4-yl)benzoic acid
Mus musculus
-
0.00015
6-[[(4-fluorophenyl)sulfonyl]amino]-3-methyl-2-propylbenzoic acid
Mus musculus
-
0.00038 - 0.0364
8-(pyridin-2-yl)-7H-purine
0.00077 - 0.0215
8-hydroxy quinoline
0.000031
A-310840
Homo sapiens
-
IC50: 0.000031 mM for enzyme with Zn2+, 0.000043 mM for enzyme with Ni2+, 0.000069 mM for enzyme with Co2+, 0.000026 for enzyme with Fe2+, 0.0578 mM for enzyme with Mn2+
0.000121
A-311263
Homo sapiens
-
IC50: 0.000121 mM for enzyme with Zn2+, 0.000107 mM for enzyme with Ni2+, 0.000149 mM for enzyme with Co2+, 0.00011 mM for enzyme with Fe2+, 0.000055 mM for enzyme with Mn2+
0.00012 - 0.00015
A-357300
0.000008 - 0.00002
A-800141
0.0019 - 0.0105
bengamide A
0.0179 - 0.0293
bengamide B
0.0268 - 0.05
bengamide G
0.0371 - 0.05
bengamide L
0.0054 - 0.05
bengamide M
0.0402 - 0.05
bengamide N
0.0027 - 0.05
bengamide O
0.0111 - 0.1
cyclopropyl 5-(3,4-dihydroxyphenyl)-2-methyl-1,3-thiazole-4-carboxylate
0.014
ethyl 5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxylate
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.008
fumagalone
Homo sapiens
-
0.002 - 0.00323
fumarranol
0.00064 - 0.0278
imidazo[2,1-a]isoquinoline-2-carbohydrazide
0.0017 - 0.0025
L-MetStaCys
0.002 - 0.0043
L-MetStaVal
0.000049
L134
Escherichia coli
-
-
0.00013
L288
Escherichia coli
-
-
0.000599 - 0.001455
MCB2379
Staphylococcus aureus
-
IC50: 599 nM in presence of Co2+, 1455 nM in presence of Zn2+
0.0000437 - 0.0003
MCB2813
Staphylococcus aureus
-
IC50: 43.7 nM in presence of Co2+, 300 nM in presence of Zn2+
0.025
methyl N-[(2S,3R)-3-amino-2-hydroxy-3-(4-methylphenyl)propanoyl]-L-alanylleucinate
Escherichia coli
-
-
0.0035
methyl N-[(2S,3R)-3-amino-2-hydroxy-3-[4-(1-methylethyl)phenyl]propanoyl]-L-alanylleucinate
Escherichia coli
-
-
0.012
methyl N-[(2S,3R)-3-amino-2-hydroxyheptanoyl]-L-serylleucinate
Escherichia coli
-
-
0.0017
methyl [[(2S)-2-([(2S,3R)-3-amino-2-hydroxy-3-[4-(trifluoromethyl)phenyl]propanoyl]amino)propanoyl]amino]acetate
Escherichia coli
-
-
0.000093
N-((R)-2-(5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-ylamino)-1-phenylethyl)-3-phenylpropanamide
Homo sapiens
22°C, pH not specified in the publication
0.00054 - 0.0224
N-(1,3-thiazol-2-yl)-1H-benzimidazol-2-amine
0.00072
N-(1,3-thiazol-2-yl)-3-[(N-[2-[2-(2-[2-[(1H-triaziren-1-ylacetyl)amino]ethoxy]ethoxy)ethoxy]-4-[3-(trifluoromethyl)-3H-diaziren-3-yl]benzoyl]glycyl)amino]pyridine-2-carboxamide
Escherichia coli
-
-
0.00006 - 0.0258
N-(1,3-thiazol-2-yl)pyridine-2-carboxamide
0.000199
N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-2-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine
Plasmodium falciparum
-
-
0.1
N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-3-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.1
N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-4-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine
Plasmodium falciparum
-
IC50 above 0.1 mM
0.0029
N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[(2,2-dimethylpropanoyl)amino]pyridine-2-carboxamide
Homo sapiens
MetAP1
0.0035
N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[(3-phenylpropanoyl)amino]pyridine-2-carboxamide
Homo sapiens
MetAP1
0.0064
N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[[(1E)-2-methylpropylidene]amino]pyridine-2-carboxamide
Homo sapiens
MetAP1
0.0028
N-(5-methyl-1,2-oxazol-3-yl)pyridine-2-carboxamide
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.011 - 0.0449
N-(quinolin-8-yl)benzenesulfonamide
0.000804
N-1,3-thiazol-2-yl-3-(N-[(2-2-[(1H-triaziren-1-ylacetyl)amino]ethoxy]-4-[[3-(trifluoromethyl)-[3H-diaziren-3-yl]phenyl)carbonyl]glycyl]amino)pyridine-2-carboxamide
Escherichia coli
-
-
0.03 - 0.2
N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
0.0134
N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxamide
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.001 - 0.0212
N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
0.0012 - 0.0225
N-cyclobutyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
0.011
N-cyclopentyl-5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxamide
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.0009 - 0.0301
N-cyclopentyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
0.0078 - 0.1
N-cyclopropyl-2-(3,4-dihydroxyphenyl)thiophene-3-carboxamide
0.0148
N-cyclopropyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.0238 - 0.034
N-cyclopropyl-5-(3,4-dihydroxyphenyl)thiophene-2-carboxamide
0.0024 - 0.041
phenyl[2-(1,3-thiazol-4-yl)-1H-benzimidazol-5-yl]methanone
0.0013 - 0.007
Pyridine-2-carboxylic acid thiazol-2-ylamide
0.016
quinolin-8-yl 4-methylbenzenesulfonate
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0412 - 0.0417
quinolin-8-yl benzenesulfonate
0.0348 - 0.0428
quinolin-8-yl benzoate
0.0015
tert-butyl [2-(4,5-dihydro-1,3-thiazol-2-ylcarbamoyl)pyridin-3-yl]carbamate
Homo sapiens
MetAP1
0.00047 - 0.0478
thiabendazole
0.0007
XC-11
Plasmodium falciparum
-
isozyme MetAP1b
additional information
additional information
-
0.02
((2RS,3R)-3-amino-2-hydroxy-5-ethylthio)pentanoyl-((S)-(-)-(1-naphthyl)ethyl)amide
Pyrococcus furiosus
-
Co2+-loaded wild type enzyme, in 25 mM HEPES buffer, pH 7.5, containing 150 mM KCl, at 30°C
0.027
((2RS,3R)-3-amino-2-hydroxy-5-ethylthio)pentanoyl-((S)-(-)-(1-naphthyl)ethyl)amide
Pyrococcus furiosus
-
Mn2+-loaded wild type enzyme, in 25 mM HEPES buffer, pH 7.5, containing 150 mM KCl, at 30°C
0.032
((2RS,3R)-3-amino-2-hydroxy-5-ethylthio)pentanoyl-((S)-(-)-(1-naphthyl)ethyl)amide
Escherichia coli
-
Co2+-loaded wild type enzyme, in 25 mM HEPES buffer, pH 7.5, containing 150 mM KCl, at 30°C
0.034
((2RS,3R)-3-amino-2-hydroxy-5-ethylthio)pentanoyl-((S)-(-)-(1-naphthyl)ethyl)amide
Escherichia coli
-
Mn2+-loaded wild type enzyme, in 25 mM HEPES buffer, pH 7.5, containing 150 mM KCl, at 30°C
0.0013
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.045
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Co2+, pH 7.5, 22°C
0.067
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.068
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.141
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Ni2+, pH 7.5, 22°C
0.179
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.00054
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.0042
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.0045
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.0069
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.0079
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Co2+, pH 7.5, 22°C
0.033
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Ni2+, pH 7.5, 22°C
0.075
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Co2+, pH 7.5, 22°C
0.00076
(2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.011
(2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.018
(2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.031
(2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Co2+, pH 7.5, 22°C
0.14
(2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Ni2+, pH 7.5, 22°C
0.201
(2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.00062
(2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.0037
(2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.014
(2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.021
(2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Co2+, pH 7.5, 22°C
0.049
(2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.05
(2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Co2+, pH 7.5, 22°C
0.114
(2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Ni2+, pH 7.5, 22°C
0.12
(2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Ni2+, pH 7.5, 22°C
0.0002
(2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.0067
(2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.0081
(2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Co2+, pH 7.5, 22°C
0.012
(2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.052
(2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Co2+, pH 7.5, 22°C
0.068
(2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.08
(2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Ni2+, pH 7.5, 22°C
0.0004
(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.0055
(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.006
(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Co2+, pH 7.5, 22°C
0.011
(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.026
(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Ni2+, pH 7.5, 22°C
0.039
(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Co2+, pH 7.5, 22°C
0.061
(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.15
(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Ni2+, pH 7.5, 22°C
0.00096
(2R,3R,4S,5R,E)-N-[[1-(cyclopropanecarbonyl)piperidin-3-yl]methyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.088
(2R,3R,4S,5R,E)-N-[[1-(cyclopropanecarbonyl)piperidin-3-yl]methyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Co2+, pH 7.5, 22°C
0.11
(2R,3R,4S,5R,E)-N-[[1-(cyclopropanecarbonyl)piperidin-3-yl]methyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Fe2+, pH 7.5, 22°C
0.187
(2R,3R,4S,5R,E)-N-[[1-(cyclopropanecarbonyl)piperidin-3-yl]methyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
Mycobacterium tuberculosis
-
apoenyme activated by Mn2+, pH 7.5, 22°C
0.0229
(3R)-amino-(2S)-hydroxyheptanoyl-Ala-Leu methyl ester
Escherichia coli
-
IC50: 0.0229 mM
0.095
(3R)-amino-(2S)-hydroxyheptanoyl-Ala-Leu methyl ester
Saccharomyces cerevisiae
-
IC50: 0.095 mM
0.009
1-(1H-benzimidazol-2-yl)thiourea
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0359
1-(1H-benzimidazol-2-yl)thiourea
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0011
1-(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-4-(2,4-dichlorobenzyl)-1,4-diazepane
Homo sapiens
MetAP1
0.0081
1-(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-4-(2,4-dichlorobenzyl)-1,4-diazepane
Homo sapiens
MetAP2
0.0005
1-methyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0243
1-methyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0324
1-methyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00008
2-(1,3-thiazol-2-yl)-1H-imidazo[4,5-b]pyridine
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0398
2-(1,3-thiazol-2-yl)-1H-imidazo[4,5-b]pyridine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0023
2-(1,3-thiazol-4-yl)-1H-benzimidazol-5-amine
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0034
2-(1,3-thiazol-4-yl)-1H-benzimidazol-5-amine
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0101
2-(1,3-thiazol-4-yl)-1H-benzimidazol-5-amine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0017
2-(1,3-thiazol-4-yl)-1H-imidazo[4,5-c]pyridine
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.019
2-(1,3-thiazol-4-yl)-1H-imidazo[4,5-c]pyridine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0455
2-(1,3-thiazol-4-yl)-1H-imidazo[4,5-c]pyridine
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.00078
2-(1H-benzimidazol-2-yl)pyridin-3-ol
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0044
2-(1H-benzimidazol-2-yl)pyridin-3-ol
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0046
2-(pyrazin-2-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0329
2-(pyrazin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00097
2-(pyridin-2-yl)-1H-benzimidazol-5-amine
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0049
2-(pyridin-2-yl)-1H-benzimidazol-5-amine
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0093
2-(pyridin-2-yl)-1H-benzimidazol-5-amine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00057
2-(pyridin-2-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0133
2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0199
2-(pyridin-2-yl)-1H-benzimidazole
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0284
2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00043
2-(pyridin-2-yl)-1H-benzimidazole-5-carbonitrile
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0329
2-(pyridin-2-yl)-1H-benzimidazole-5-carbonitrile
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.033
2-(pyridin-2-yl)-1H-benzimidazole-5-carbonitrile
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0373
2-(pyridin-2-yl)-1H-benzimidazole-5-carbonitrile
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00024
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyrazine
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.022
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyrazine
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0401
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyrazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0484
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyrazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00011
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0188
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0267
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0276
2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00055
2-(pyridin-2-yl)-1H-imidazo[4,5-c]pyridine
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.008
2-(pyridin-2-yl)-1H-imidazo[4,5-c]pyridine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0103
2-(pyridin-2-yl)-1H-imidazo[4,5-c]pyridine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0228
2-(pyridin-2-yl)-1H-imidazo[4,5-c]pyridine
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0296
2-[2-(2-amino-4-methylsulfanyl-butyrylsulfanyl)-3-phenyl-propionylamino]-3-hydroxy-propionic acid
Escherichia coli
-
IC50 for Co-EcMetAP1: 0.0296 mM
0.0365
2-[2-(2-amino-4-methylsulfanyl-butyrylsulfanyl)-3-phenyl-propionylamino]-3-hydroxy-propionic acid
Escherichia coli
-
IC50 for Zn-EcMetAP1: 0.0365 mM
0.0441
2-[2-(2-amino-4-methylsulfanyl-butyrylsulfanyl)-3-phenyl-propionylamino]-3-hydroxy-propionic acid
Escherichia coli
-
IC50 for Mn-EcMetAPa: 0.0441 mM
0.0286
2-[2-(2-Amino-4-methylsulfanyl-butyrylsulfanyl)-5-methyl-hexanoylamino]-3-hydroxy-propionic acid
Escherichia coli
-
IC50 for Co-EcMetAP1: 0.0286 mM
0.0357
2-[2-(2-Amino-4-methylsulfanyl-butyrylsulfanyl)-5-methyl-hexanoylamino]-3-hydroxy-propionic acid
Escherichia coli
-
IC50 for Ni-EcMetAP1: 0.0357 mM
0.0443
2-[2-(2-Amino-4-methylsulfanyl-butyrylsulfanyl)-5-methyl-hexanoylamino]-3-hydroxy-propionic acid
Escherichia coli
-
IC50 for Mn-EcMetAPa: 0.0443 mM
0.0498
2-[2-(2-Amino-4-methylsulfanyl-butyrylsulfanyl)-5-methyl-hexanoylamino]-3-hydroxy-propionic acid
Escherichia coli
-
IC50 for Zn-EcMetAP1: 0.0498 mM
0.0125
2-[2-(3-Amino-2-hydroxy-heptanoylamino)-propionylamino]-4-methyl-pentanoic acid methyl ester
Escherichia coli
-
IC50 for Ni-EcMetAP1: 0.0125 mM
0.0167
2-[2-(3-Amino-2-hydroxy-heptanoylamino)-propionylamino]-4-methyl-pentanoic acid methyl ester
Escherichia coli
-
IC50 for Zn-EcMetAP1: 0.0167 mM
0.0229
2-[2-(3-Amino-2-hydroxy-heptanoylamino)-propionylamino]-4-methyl-pentanoic acid methyl ester
Escherichia coli
-
IC50 for Co-EcMetAP1: 0.0229 mM
0.0252
2-[2-(3-Amino-2-hydroxy-heptanoylamino)-propionylamino]-4-methyl-pentanoic acid methyl ester
Escherichia coli
-
IC50 for Mn-EcMetAPa: 0.0252 mM
0.015
3-((2-naphthylmethyl)sulfanyl)-4H-1,2,4-triazole
Pyrococcus furiosus
-
Co2+-loaded wild type enzyme, in 25 mM HEPES buffer, pH 7.5, containing 150 mM KCl, at 30°C
0.044
3-((2-naphthylmethyl)sulfanyl)-4H-1,2,4-triazole
Escherichia coli
-
Co2+-loaded wild type enzyme, in 25 mM HEPES buffer, pH 7.5, containing 150 mM KCl, at 30°C
1
3-((2-naphthylmethyl)sulfanyl)-4H-1,2,4-triazole
Escherichia coli
-
Mn2+-loaded wild type enzyme, in 25 mM HEPES buffer, pH 7.5, containing 150 mM KCl, at 30°C
1
3-((2-naphthylmethyl)sulfanyl)-4H-1,2,4-triazole
Pyrococcus furiosus
-
Mn2+-loaded wild type enzyme, in 25 mM HEPES buffer, pH 7.5, containing 150 mM KCl, at 30°C
0.000034
3-(2,2,2-trifluoroacetylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.000034 mM
0.00492
3-(2,2,2-trifluoroacetylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00492 mM
0.00034
3-(2,2-dimethylpropionylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00034 mM
0.00054
3-(2,2-dimethylpropionylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00054 mM
0.00068
3-(2,2-dimethylpropionyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00068 mM
0.00078
3-(2,2-dimethylpropionyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00078 mM
0.00028
3-(2-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00028 mM
0.1
3-(2-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50 above 0.1 mM
0.00083
3-(2-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00083 mM
0.016
3-(2-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.016 mM
0.00089
3-(2-iodobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00089 mM
0.0013
3-(2-iodobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0013 mM
0.00055
3-(2-methoxybenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00055 mM
0.0017
3-(2-methoxybenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0017 mM
0.00028
3-(2-methylbut-2-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00028 mM
0.0109
3-(2-methylbut-2-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.0109 mM
0.00039
3-(2-methylbut-2-enoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00039 mM
0.0044
3-(2-methylbut-2-enoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0044 mM
0.0021
3-(2-nitrobenzoyloxy)pyridine-2-carboxylic acid thiatol-2-ylamide
Escherichia coli
-
IC50: 0.0021 mM
0.1
3-(2-nitrobenzoyloxy)pyridine-2-carboxylic acid thiatol-2-ylamide
Escherichia coli
-
IC50 above 0.1 mM
0.0025
3-(3-bromo-4-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0025 mM
0.0034
3-(3-bromo-4-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.0034 mM
0.00071
3-(3-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00071 mM
0.1
3-(3-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50 above 0.1 mM
0.000095
3-(3-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.000095 mM
0.1
3-(3-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50 above 0.1 mM
0.0017
3-(3-methoxy-2-nitrobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0017 mM
0.00302
3-(3-methoxy-2-nitrobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00302 mM
0.00022
3-(3-methylbut-2-enoylamino)pyridien-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00022 mM
0.00077
3-(3-methylbut-2-enoylamino)pyridien-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00077 mM
0.00049
3-(3-methylbut-2-enoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00049 mM
0.0026
3-(3-methylbut-2-enoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0026 mM
0.00015
3-(3-methylbut-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00015 mM
0.00467
3-(3-methylbut-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00467 mM
0.0006
3-(3-nitrobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0006 mM
0.1
3-(3-nitrobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50 above 0.1 mM
0.00136
3-(4-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00136 mM
0.1
3-(4-fluorobenzoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50 above 0.1 mM
0.0011
3-(4-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0011 mM
0.062
3-(4-fluorobenzoyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.062 mM
0.00014
3-(4-methylpent-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00014 mM
0.00024
3-(4-methylpent-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00024 mM
0.00031
3-(5-methylhex-4-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00031 mM
0.000671
3-(5-methylhex-4-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.000671 mM
0.00013
3-(but-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00013 mM
0.00038
3-(but-3-enoylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00038 mM
0.00087
3-(cyclohexanecarbonylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00087 mM
0.1
3-(cyclohexanecarbonylamino)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50 above 0.1 mM
0.00032
3-(cyclohexanecarbonyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00032 mM
0.00239
3-(cyclohexanecarbonyloxy)pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00239 mM
0.00103
3-benzoyloxypyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00103 mM
0.00122
3-benzoyloxypyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00122 mM
0.0001
3-But-3-enoylamino-pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50 for Co-EcMetAP1: 0.0001 mM
0.00076
3-But-3-enoylamino-pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50 for Ni-EcMetAP1: 0.00076 mM
0.0224
3-But-3-enoylamino-pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50 for Zn-EcMetAP1: 0.0224 mM
0.0233
3-But-3-enoylamino-pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50 for Mn-EcMetAPa: 0.0233 mM
0.00032
3-formylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00032 mM
0.00033
3-formylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00033 mM
0.000038
3-hexanoylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.000038 mM
0.00062
3-hexanoylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00062 mM
0.000174
3-hexanoyloxypyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.000174 mM
0.00102
3-hexanoyloxypyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00102 mM
0.00187
3-hydroxypyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00187 mM
0.00486
3-hydroxypyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00486 mM
0.00192
3-iso-butoxycarbonylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00192 mM
0.0537
3-iso-butoxycarbonylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.0537 mM
0.00004
3-phenylacetylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00004 mM
0.00082
3-phenylacetylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00082 mM
0.000054
3-phenylacetyloxypyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.000054 mM
0.0002
3-phenylacetyloxypyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.0002 mM
0.00026
3-propionylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00026 mM
0.00035
3-propionylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00035 mM
0.00038
3-propionyloxypyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00038 mM
0.0054
3-propionyloxypyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0054 mM
0.00018
3-tert-butoxycarbonylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.00018 mM
0.00335
3-tert-butoxycarbonylaminopyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.00335 mM
0.00058
3-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazole
Mycobacterium tuberculosis
pH 7.5, 37°C, with Ni2+
0.002
3-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazole
Mycobacterium tuberculosis
pH 7.5, 37°C, with Co2+
0.25
3-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazole
Mycobacterium tuberculosis
-
above, recombinant isozyme MetAP1a in presence of different divalent metal ions, overview
0.0021
3-[3-(2-methoxyphenyl)acryloyloxy]pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.0021 mM
0.0099
3-[3-(2-methoxyphenyl)acryloyloxy]pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.0099 mM
0.0161
4-(1-benzyl-1H-1,2,3-triazol-4-yl)benzene-1,2-diol
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.0195
4-(1-benzyl-1H-1,2,3-triazol-4-yl)benzene-1,2-diol
Escherichia coli
-
using Co2+-activated MetAP enzyme
0.0246
4-(1-benzyl-1H-1,2,3-triazol-4-yl)benzene-1,2-diol
Escherichia coli
-
using Mn2+-activated MetAP enzyme
0.0202
4-(2,5-dichlorothiophen-3-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0486
4-(2,5-dichlorothiophen-3-yl)benzene-1,2-diol
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0624
4-(2,5-dichlorothiophen-3-yl)benzene-1,2-diol
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.0074
4-(2,5-dimethylthiophen-3-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.1
4-(2,5-dimethylthiophen-3-yl)benzene-1,2-diol
Escherichia coli
IC50 above 0.1 mM, Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.1
4-(2,5-dimethylthiophen-3-yl)benzene-1,2-diol
Escherichia coli
IC50 above 0.1 mM, Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0066
4-(2-aminothiazol-4-yl)benzene-1,2-diol
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.0066
4-(2-aminothiazol-4-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.1
4-(2-aminothiazol-4-yl)benzene-1,2-diol
Escherichia coli
IC50 above 0.1 mM, Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.000031 - 0.0007
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
Mycobacterium tuberculosis
-
recombinant isozyme MetAP1a in presence of different divalent metal ions, overview
0.00095
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.0025 mM Fe2+, pH not specified in the publication, temperature not specified in the publication
0.013
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0131
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.024
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.032
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.0025 mM Fe2+, pH not specified in the publication, temperature not specified in the publication
0.034
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.039
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.056
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.072
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.005 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.079
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.0073
4-(3-(2-bromoethyl)thiophen-2-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.014
4-(3-(2-bromoethyl)thiophen-2-yl)benzene-1,2-diol
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.0224
4-(3-(2-bromoethyl)thiophen-2-yl)benzene-1,2-diol
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0092
4-(3-butylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0482
4-(3-butylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.1
4-(3-butylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
IC50 above 0.1 mM, Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.0129
4-(3-ethylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0557
4-(3-ethylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0626
4-(3-ethylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.00007 - 0.0023
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Mycobacterium tuberculosis
-
recombinant isozyme MetAP1a in presence of different divalent metal ions, overview
0.00051
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.0025 mM Fe2+, pH not specified in the publication, temperature not specified in the publication
0.00065
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.0025 mM Fe2+, pH not specified in the publication, temperature not specified in the publication
0.008
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.008
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.021
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.022
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.023
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.023
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
-
using Mn2+-activated MetAP enzyme
0.027
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.005 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.03
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.033
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.041
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
-
using Co2+-activated MetAP enzyme
0.0427
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.055
4-(3-methylthiophen-2-yl)benzene-1,2-diol
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.014
4-(3-propylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0343
4-(3-propylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.1
4-(3-propylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
IC50 above 0.1 mM, Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.0021
4-(4-bromo-2,5-dimethylthiophen-3-yl)benzene-1,2-diol
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0024
4-(4-bromo-2,5-dimethylthiophen-3-yl)benzene-1,2-diol
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.0031
4-(4-bromo-2,5-dimethylthiophen-3-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0128
4-(5-chlorothiophen-2-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0448
4-(5-chlorothiophen-2-yl)benzene-1,2-diol
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.1
4-(5-chlorothiophen-2-yl)benzene-1,2-diol
Escherichia coli
IC50 above 0.1 mM, Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.0106
4-(5-fluoropyrimidin-2-yl)benzene-1,2-diol
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.0526
4-(5-fluoropyrimidin-2-yl)benzene-1,2-diol
Escherichia coli
-
using Co2+-activated MetAP enzyme
0.028
4-(5-methylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0327
4-(5-methylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0515
4-(5-methylthiophen-2-yl)benzene-1,2-diol
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.0051
4-(thiophen-2-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0157
4-(thiophen-2-yl)benzene-1,2-diol
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0237
4-(thiophen-2-yl)benzene-1,2-diol
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.0038
4-(thiophen-3-yl)benzene-1,2-diol
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2
0.0275
4-(thiophen-3-yl)benzene-1,2-diol
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0404
4-(thiophen-3-yl)benzene-1,2-diol
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.01
5,6-dimethyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0388
5,6-dimethyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0024
5,6-dimethyl-2-(pyridin-2-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0179
5,6-dimethyl-2-(pyridin-2-yl)-1H-benzimidazole
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0284
5,6-dimethyl-2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0326
5,6-dimethyl-2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0009 - 4
5-(2,3-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.03
5-(2,3-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2,3-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2,3-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00275
5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.0359
5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00053
5-(2,3-dimethylphenyl)furan-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.0264
5-(2,3-dimethylphenyl)furan-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2,3-dimethylphenyl)furan-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2,3-dimethylphenyl)furan-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00338
5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.05
5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00044
5-(2,4-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.0373
5-(2,4-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2,4-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2,4-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00032
5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.05
5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.0077
5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.00889
5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.0099
5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00025
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.0061
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.0071
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.0381
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.25
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Mycobacterium tuberculosis
-
above, recombinant isozyme MetAP1a in presence of different divalent metal ions, overview
0.251
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.005 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.286
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.355
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.0025 mM Fe2+, pH not specified in the publication, temperature not specified in the publication
0.494
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.00042
5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.0095
5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.0286
5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.0046
5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.0097
5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00118
5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.004
5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.0357
5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00089
5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.05
5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00116
5-(2-chlorophenyl)furan-2-carbohydrazide
Escherichia coli
in the presence of 0.005 mM Mn2+
0.00578
5-(2-chlorophenyl)furan-2-carbohydrazide
Escherichia coli
in the presence of 0.01 mM Ni2+
0.00656
5-(2-chlorophenyl)furan-2-carbohydrazide
Escherichia coli
in the presence of 0.1 mM Mn2+
0.058
5-(2-chlorophenyl)furan-2-carbohydrazide
Escherichia coli
in the presence of 0.006 mM Fe2+
0.0771
5-(2-chlorophenyl)furan-2-carbohydrazide
Escherichia coli
in the presence of 0.1 mM Co2+
0.00051
5-(2-chlorophenyl)furan-2-carboxylic acid
Escherichia coli
in the presence of 0.1 mM Mn2+
0.00078
5-(2-chlorophenyl)furan-2-carboxylic acid
Escherichia coli
in the presence of 0.005 mM Mn2+
0.00092
5-(2-chlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.013
5-(2-chlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.02 - 0.25
5-(2-chlorophenyl)furan-2-carboxylic acid
Mycobacterium tuberculosis
-
recombinant isozyme MetAP1a in presence of different divalent metal ions, overview
0.116
5-(2-chlorophenyl)furan-2-carboxylic acid
Escherichia coli
in the presence of 0.006 mM Fe2+
0.138
5-(2-chlorophenyl)furan-2-carboxylic acid
Escherichia coli
in the presence of 0.1 mM Co2+
0.141
5-(2-chlorophenyl)furan-2-carboxylic acid
Escherichia coli
in the presence of 0.01 mM Ni2+
0.186
5-(2-chlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.188
5-(2-chlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.005 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.2
5-(2-chlorophenyl)furan-2-carboxylic acid
Escherichia coli
IC50 above 0.2 mM, in the presence of 0.001 mM Co2+
0.288
5-(2-chlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.0025 mM Fe2+, pH not specified in the publication, temperature not specified in the publication
0.358
5-(2-chlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.0025 mM Fe2+, pH not specified in the publication, temperature not specified in the publication
0.381
5-(2-chlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.394
5-(2-chlorophenyl)furan-2-carboxylic acid
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.00048
5-(2-ethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.0419
5-(2-ethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2-ethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2-ethoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00508
5-(2-ethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.05
5-(2-ethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2-ethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2-ethoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00055
5-(2-methoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.132
5-(2-methoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.2
5-(2-methoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.2
5-(2-methoxyphenyl)furan-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.00499
5-(2-methoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.0273
5-(2-methoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.0457
5-(2-methoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.0477
5-(2-methoxyphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.00151
5-(2-methylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.05
5-(2-methylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(2-methylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(2-methylphenyl)thiophene-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.0154
5-(3,4-dihydroxyphenyl)-N-isopropyl-2-methylthiazole-4-carboxamide
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.0154
5-(3,4-dihydroxyphenyl)-N-isopropyl-2-methylthiazole-4-carboxamide
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.1
5-(3,4-dihydroxyphenyl)-N-isopropyl-2-methylthiazole-4-carboxamide
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0148
5-(3,4-dihydroxyphenyl)thiophene-2-carbonitrile
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0304
5-(3,4-dihydroxyphenyl)thiophene-2-carbonitrile
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0363
5-(3,4-dihydroxyphenyl)thiophene-2-carbonitrile
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.00067
5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid
Escherichia coli
-
Mn(II)-form of the enzyme
0.05
5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid
Escherichia coli
-
Co(II)-form of the enzyme
0.05
5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid
Escherichia coli
-
Fe(II)-form of the enzyme
0.05
5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid
Escherichia coli
-
Ni(II)-form of the enzyme
0.0052
5-chloro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.028
5-chloro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.047
5-chloro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0017
5-chloro-2-(pyridin-2-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0181
5-chloro-2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0488
5-chloro-2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0004
5-chloro-4-methyl-2-pyridin-2-yl-6-pyrrolidin-1-ylpyrimidine
Homo sapiens
MetAP1
0.0008
5-chloro-4-methyl-2-pyridin-2-yl-6-pyrrolidin-1-ylpyrimidine
Homo sapiens
MetAP2
0.0006
5-chloro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
Homo sapiens
MetAP1
0.0076
5-chloro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
Homo sapiens
MetAP2
0.0033
5-chloro-N,6-dimethyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
Homo sapiens
MetAP1
0.0033
5-chloro-N,6-dimethyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
Homo sapiens
MetAP2
0.0043
5-fluoro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0384
5-fluoro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0458
5-fluoro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0015
5-fluoro-2-(pyridin-2-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0149
5-fluoro-2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0347
5-fluoro-2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0401
5-fluoro-2-(pyridin-2-yl)-1H-benzimidazole
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0072
5-methyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0355
5-methyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0406
5-methyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0021
5-methyl-2-(pyridin-2-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0077
5-methyl-2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0194
5-methyl-2-(pyridin-2-yl)-1H-benzimidazole
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0326
5-methyl-2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0012
5-nitro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0485
5-nitro-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00016
5-nitro-2-(pyridin-2-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0288
5-nitro-2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0039
5-tert-butyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0417
5-tert-butyl-2-(1,3-thiazol-4-yl)-1H-benzimidazole
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0026
5-tert-butyl-2-(pyridin-2-yl)-1H-benzimidazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0389
5-tert-butyl-2-(pyridin-2-yl)-1H-benzimidazole
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0441
5-tert-butyl-2-(pyridin-2-yl)-1H-benzimidazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00024
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Mycobacterium tuberculosis
pH 7.5, 37°C, with Ni2+
0.00026
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Mycobacterium tuberculosis
pH 7.5, 37°C, with Co2+
0.00038
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.0004
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.00078
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.002
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Mycobacterium tuberculosis
pH 7.5, 37°C, with Mn2+
0.0049
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.005 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.014
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.064
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.094
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.0025 mM Fe2+, pH not specified in the publication, temperature not specified in the publication
0.128
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.0025 mM Fe2+, pH not specified in the publication, temperature not specified in the publication
0.205 - 0.25
5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Mycobacterium tuberculosis
-
and above, recombinant isozyme MetAP1a in presence of different divalent metal ions, overview
0.00064
5-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.00088
5-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.0013
5-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Mycobacterium tuberculosis
pH 7.5, 37°C, with Ni2+
0.0022
5-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.0025
5-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Mycobacterium tuberculosis
pH 7.5, 37°C, with Ni2+
0.023
5-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.005 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.034
5-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.25
5-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Mycobacterium tuberculosis
-
above, recombinant isozyme MetAP1a in presence of different divalent metal ions, overview
0.303
5-[(4-fluorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.0021
5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.0038
5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Co2+, pH not specified in the publication, temperature not specified in the publication
0.0044
5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.044
5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.005 mM Ni2+, pH not specified in the publication, temperature not specified in the publication
0.103
5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.145
5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Acinetobacter baumannii
after removal of divalent metal ions activated with 0.02 mM Mn2+, pH not specified in the publication, temperature not specified in the publication
0.25
5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine
Mycobacterium tuberculosis
-
above, recombinant isozyme MetAP1a in presence of different divalent metal ions, overview
0.0013
6-(1H-benzimidazol-2-yl)pyridin-2(1H)-one
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0292
6-(1H-benzimidazol-2-yl)pyridin-2(1H)-one
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.00038
8-(pyridin-2-yl)-7H-purine
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0339
8-(pyridin-2-yl)-7H-purine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0364
8-(pyridin-2-yl)-7H-purine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00077
8-hydroxy quinoline
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0056
8-hydroxy quinoline
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0183
8-hydroxy quinoline
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0215
8-hydroxy quinoline
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00012
A-357300
Mus musculus
MetAP2
0.00015
A-357300
Homo sapiens
-
0.000008
A-800141
Mus musculus
MetAP2
0.00002
A-800141
Homo sapiens
-
0.0019
bengamide A
Homo sapiens
MetAP1
0.0105
bengamide A
Homo sapiens
MetAP2
0.0179
bengamide B
Homo sapiens
MetAP2
0.0293
bengamide B
Homo sapiens
MetAP1
0.0268
bengamide G
Homo sapiens
MetAP1
0.05
bengamide G
Homo sapiens
IC50 above 0.05 mM, MetAP2
0.0371
bengamide L
Homo sapiens
MetAP1
0.05
bengamide L
Homo sapiens
IC50 above 0.05 mM, MetAP2
0.0054
bengamide M
Homo sapiens
MetAP1
0.05
bengamide M
Homo sapiens
IC50 above 0.05 mM, MetAP2
0.0402
bengamide N
Homo sapiens
MetAP1
0.05
bengamide N
Homo sapiens
IC50 above 0.05 mM, MetAP2
0.0027
bengamide O
Homo sapiens
MetAP1
0.05
bengamide O
Homo sapiens
IC50 above 0.05 mM, MetAP2
0.0111
cyclopropyl 5-(3,4-dihydroxyphenyl)-2-methyl-1,3-thiazole-4-carboxylate
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0923
cyclopropyl 5-(3,4-dihydroxyphenyl)-2-methyl-1,3-thiazole-4-carboxylate
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.1
cyclopropyl 5-(3,4-dihydroxyphenyl)-2-methyl-1,3-thiazole-4-carboxylate
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.1
fumagillin
Escherichia coli
-
IC50 above 0.1 mM
0.1
fumagillin
Saccharomyces cerevisiae
-
IC50 above 0.1 mM
11.1
fumagillin
Encephalitozoon cuniculi
-
pH 8.5, 37°C, recombinant MetAP2
0.002
fumarranol
Plasmodium falciparum
-
in 20 mM Tris-HCl (pH 7.1) and 100 mM KCl, at 37°C
0.00323
fumarranol
Homo sapiens
-
0.00064
imidazo[2,1-a]isoquinoline-2-carbohydrazide
Escherichia coli
in the presence of 0.005 mM Mn2+
0.00244
imidazo[2,1-a]isoquinoline-2-carbohydrazide
Escherichia coli
in the presence of 0.001 mM Co2+
0.00431
imidazo[2,1-a]isoquinoline-2-carbohydrazide
Escherichia coli
in the presence of 0.1 mM Mn2+
0.00615
imidazo[2,1-a]isoquinoline-2-carbohydrazide
Escherichia coli
in the presence of 0.01 mM Ni2+
0.0174
imidazo[2,1-a]isoquinoline-2-carbohydrazide
Escherichia coli
in the presence of 0.006 mM Fe2+
0.0278
imidazo[2,1-a]isoquinoline-2-carbohydrazide
Escherichia coli
in the presence of 0.1 mM Co2+
0.0017
L-MetStaCys
Pyrococcus furiosus
-
in 25 mM HEPES buffer at 30°C (pH 7.5)
0.0025
L-MetStaCys
Escherichia coli
-
in 25 mM HEPES buffer at 30°C (pH 7.5)
0.002
L-MetStaVal
Pyrococcus furiosus
-
in 25 mM HEPES buffer at 30°C (pH 7.5)
0.0043
L-MetStaVal
Escherichia coli
-
in 25 mM HEPES buffer at 30°C (pH 7.5)
0.00054
N-(1,3-thiazol-2-yl)-1H-benzimidazol-2-amine
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0224
N-(1,3-thiazol-2-yl)-1H-benzimidazol-2-amine
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.00006
N-(1,3-thiazol-2-yl)pyridine-2-carboxamide
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0081
N-(1,3-thiazol-2-yl)pyridine-2-carboxamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0212
N-(1,3-thiazol-2-yl)pyridine-2-carboxamide
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0258
N-(1,3-thiazol-2-yl)pyridine-2-carboxamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.011
N-(quinolin-8-yl)benzenesulfonamide
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0229
N-(quinolin-8-yl)benzenesulfonamide
Staphylococcus aureus
-
pH not specified in the publication, temperature not specified in the publication
0.0398
N-(quinolin-8-yl)benzenesulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0449
N-(quinolin-8-yl)benzenesulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.03
N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.046
N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
Streptococcus pneumoniae
-
pH not specified in the publication, temperature not specified in the publication
0.06
N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
Haemophilus influenzae
-
pH not specified in the publication, temperature not specified in the publication
0.2
N-2-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide
Staphylococcus aureus
-
value above 0.2 mM, pH not specified in the publication, temperature not specified in the publication
0.001
N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.0067
N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
Escherichia coli
-
using Mn2+-activated MetAP enzyme
0.0212
N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
Escherichia coli
-
using Co2+-activated MetAP enzyme
0.0012
N-cyclobutyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.0079
N-cyclobutyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
Escherichia coli
-
using Mn2+-activated MetAP enzyme
0.0225
N-cyclobutyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
Escherichia coli
-
using Co2+-activated MetAP enzyme
0.0009
N-cyclopentyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
Escherichia coli
-
using Fe2+-activated MetAP enzyme
0.0118
N-cyclopentyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
Escherichia coli
-
using Mn2+-activated MetAP enzyme
0.0301
N-cyclopentyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide
Escherichia coli
-
using Co2+-activated MetAP enzyme
0.0078
N-cyclopropyl-2-(3,4-dihydroxyphenyl)thiophene-3-carboxamide
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.1
N-cyclopropyl-2-(3,4-dihydroxyphenyl)thiophene-3-carboxamide
Escherichia coli
IC50 above 0.1 mM, Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.1
N-cyclopropyl-2-(3,4-dihydroxyphenyl)thiophene-3-carboxamide
Escherichia coli
IC50 above 0.1 mM, Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0238
N-cyclopropyl-5-(3,4-dihydroxyphenyl)thiophene-2-carboxamide
Escherichia coli
Fe2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.05 mM FeCl2 with 0.1 mM ascorbic acid
0.0285
N-cyclopropyl-5-(3,4-dihydroxyphenyl)thiophene-2-carboxamide
Escherichia coli
Co2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.01 mM CoCl2
0.034
N-cyclopropyl-5-(3,4-dihydroxyphenyl)thiophene-2-carboxamide
Escherichia coli
Mn2+-loaded wild type enzyme, in 50 mM MOPS (pH 7.0), 0.02 mM MnCl2
0.0024
phenyl[2-(1,3-thiazol-4-yl)-1H-benzimidazol-5-yl]methanone
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.041
phenyl[2-(1,3-thiazol-4-yl)-1H-benzimidazol-5-yl]methanone
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0013
Pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50 for Co-EcMetAP1: 0.0013 mM
0.005
Pyridine-2-carboxylic acid thiazol-2-ylamide
Escherichia coli
-
IC50: 0.005 mM
0.007
Pyridine-2-carboxylic acid thiazol-2-ylamide
Saccharomyces cerevisiae
-
IC50: 0.007 mM
0.0412
quinolin-8-yl benzenesulfonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0417
quinolin-8-yl benzenesulfonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0348
quinolin-8-yl benzoate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0428
quinolin-8-yl benzoate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00047
thiabendazole
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0447
thiabendazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0478
thiabendazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000001
TNP-470
Homo sapiens
-
0.000003
TNP-470
Homo sapiens
-
0.000012
TNP-470
Mus musculus
MetAP2
0.00105
TNP-470
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.015
TNP-470
Leishmania donovani
pH 7.5, 37°C
0.116
TNP-470
Plasmodium falciparum
-
in 20 mM Tris-HCl (pH 7.1) and 100 mM KCl, at 37°C
10.6
TNP-470
Encephalitozoon cuniculi
-
pH 8.5, 37°C, recombinant MetAP2
additional information
additional information
Escherichia coli
-
IC50 values for N-(quinolin-8-yl)methanesulfonamide with different metal ions, overview
-
additional information
additional information
Escherichia coli
-
inhibitor screening, assay method development, and assay validation, overview
-