3.4.11.18: methionyl aminopeptidase

This is an abbreviated version!
For detailed information about methionyl aminopeptidase, go to the full flat file.

Reaction

release of N-terminal amino acids, preferentially methionine, from peptides and arylamides =

Synonyms

aminopeptidase, methionine, c1MetAP-Ia, c2MetAP-Ia, c3MetAP-Ib, CoCoEcMetAP, Ebp1, eMet-AP, ErbB-3 receptor binding protein, initiation factor 2 associated 67 kDa glycoprotein, L-methionine aminopeptidase, LdBPK_210960, MAP, MAP-2, MAP-Pfu, MAP11, MAP1D, mAPA, MapB, MetAP, MetAP-1, MetAP-2, MetAP-I, MetAP-II, MetAP1, MetAP1a, MetAP1b, MetAP1c, MetAP1D, MetAP2, methionine amino peptidase type 2, methionine aminopeptidase, methionine aminopeptidase 1, methionine aminopeptidase 1b, methionine aminopeptidase 2, methionine aminopeptidase AbMetAPx, methionine aminopeptidase AbMetAPy, methionine aminopeptidase II, methionine aminopeptidase type 1, methionine aminopeptidase type 1a, methionine aminopeptidase type 1c, methionine aminopeptidase type 2, methionine aminopeptidase type I, methionine aminopeptidase type II, methionine aminopeptidase type-2, methionine aminopeptidase-1, methionine aminopeptidase-2, methionine aminopetidase-2, More, p67, p67eIF2, peptidase M, PVX_094985, TM1478, type 1 methionine aminopeptidase, type 2 methionine aminopeptidase, type I MetAP, type I methionine aminopeptidase, YpdF

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.11 Aminopeptidases

                3.4.11.18 methionyl aminopeptidase

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Results	in table
1	Activating Compound
72315	AA Sequence
14	Application
1	CAS Registry Number
63	Cloned(Commentary)
38	Crystallization (Commentary)
843	Disease/ Diagnostics
4	Expression
16	General Information
1	General Stability
694	IC50 Value
955	Inhibitors
67	kcat/KM [mM/s]
116	Ki Value [mM]
130	KM Value [mM]
7	Localization
154	Metals/Ions
49	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
244	Organism
2	Pathway
198	PDB ID
23	pH Optimum
7	pH Range
5	pI Value
1	Posttranslational Modification
110	Protein Variants
45	Purification (Commentary)
2	Reaction
1	Reaction Type
206	Reference
70	Source Tissue
43	Specific Activity [micromol/min/mg]
1	Storage Stability
295	Substrates and Products (Substrate)
40	Subunits
262	Synonyms
12	Temperature Optimum [°C]
4	Temperature Range [°C]
7	Temperature Stability [°C]
124	Turnover Number [1/s]

General Information

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General Information on EC 3.4.11.18 - methionyl aminopeptidase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Plasmodium falciparum

-

blockade of the isozymes can is lethal to cell proliferation

708702

physiological function

15 entries

physiological function

Plasmodium falciparum

-

MetAP functions in the catalytic removal of N-terminal initiator methionine residues from proteins during sythesis, which is essential for the correct folding and trafficking of proteins

708702

physiological function

Escherichia coli

-

MetAP is a ubiquitous enzyme required for cell survival and an attractive target for antibacterial and anticancer drug development. MetAP is involved in protein maturation by catalyzing the hydrolytic excision of the N-terminal methionine from nascent proteins

707860

physiological function

Mycobacterium tuberculosis

-

MetAP is essential for bacterial survival

707703

physiological function

Escherichia coli

-

MetAP plays a critical role in protein maturation by catalyzing the removal of the N-terminal initiator methionine from nascent proteins

707698

physiological function

Homo sapiens

-

MetAP2 is a bifunctional protein that plays a critical role in the regulation of post-translational processing and protein synthesis

709910

physiological function

Escherichia coli

-

methionine aminopeptidase plays an essential role for cell survival

707690

physiological function

Danio rerio

-

knockdown perturbed angiogenesis

717428

physiological function

Hordeum vulgare

E0A9F0

stronger freezing tolerance (transgenic Arabidopsis plants)

718239

physiological function

Homo sapiens

P53582

inhibition of the enzymatic activity of isoform MetAP2 inhibitor fumagillin or siRNA mediated down-regulation of the protein level of MetAP2 both lead to strong signals of unprocessed 14-3-3gamma protein with intact initiator methionine in the immunoblot

732304

physiological function

Mycobacterium tuberculosis variant bovis

A0A0H3M2X0, A0A0H3M9T2

isoform mapA is dispensable for growth of bacteria. Double-deletion mutants of isoforms MapA and MapB as well as the introduction of point mutations into mapB show partial, but not full, redundancy between MapB and MapA

753227

physiological function

Mycobacterium tuberculosis variant bovis

A0A0H3M2X0, A0A0H3M9T2

isoform mapB is indispensable for growth of bacteria. Double-deletion mutants of isoforms MapA and MapB as well as the introduction of point mutations into mapB show partial, but not full, redundancy between MapB and MapA

753227

physiological function

Leishmania donovani

E9BF82

MAP2 is involved in the regulation of programmed cell death in the parasite

755484

physiological function

Homo sapiens

P50579

N-terminally acetylated terminal Met residues followed by a small residue cannot be removed by MetAPs. Yeast Naa50-mediated N-terminal acetylation may act to retain the N-terminal Met residue of proteins otherwise susceptible to MetAP

755358

physiological function

Babesia bovis

S6BKQ9

recombinant enzyme is immunogenic, eliciting a high antibody titer in mice. Recombinant MetAP1 stimulates the production of IFN-gamma and IL-12 but not IL-4 in the host

755640

physiological function

Leishmania donovani BPK282A1

-

MAP2 is involved in the regulation of programmed cell death in the parasite

-