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3.4.11.18: methionyl aminopeptidase

This is an abbreviated version!
For detailed information about methionyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.18

Reaction

release of N-terminal amino acids, preferentially methionine, from peptides and arylamides =

Synonyms

aminopeptidase, methionine, c1MetAP-Ia, c2MetAP-Ia, c3MetAP-Ib, CoCoEcMetAP, Ebp1, eMet-AP, ErbB-3 receptor binding protein, initiation factor 2 associated 67 kDa glycoprotein, L-methionine aminopeptidase, LdBPK_210960, MAP, MAP-2, MAP-Pfu, MAP11, MAP1D, mAPA, MapB, MetAP, MetAP-1, MetAP-2, MetAP-I, MetAP-II, MetAP1, MetAP1a, MetAP1b, MetAP1c, MetAP1D, MetAP2, methionine amino peptidase type 2, methionine aminopeptidase, methionine aminopeptidase 1, methionine aminopeptidase 1b, methionine aminopeptidase 2, methionine aminopeptidase AbMetAPx, methionine aminopeptidase AbMetAPy, methionine aminopeptidase II, methionine aminopeptidase type 1, methionine aminopeptidase type 1a, methionine aminopeptidase type 1c, methionine aminopeptidase type 2, methionine aminopeptidase type I, methionine aminopeptidase type II, methionine aminopeptidase type-2, methionine aminopeptidase-1, methionine aminopeptidase-2, methionine aminopetidase-2, More, p67, p67eIF2, peptidase M, PVX_094985, TM1478, type 1 methionine aminopeptidase, type 2 methionine aminopeptidase, type I MetAP, type I methionine aminopeptidase, YpdF

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.18 methionyl aminopeptidase

Cloned

Cloned on EC 3.4.11.18 - methionyl aminopeptidase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
adenoviral transfer of c-Myc increaseds the expression of MetAP2 in human umbilical vein endothelial cells and reveals that cellular proliferation may involve a cross-talk between c-Myc and MetAP2
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commercial preparation
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expressed in Escherichia coli
expressed in Escherichia coli AS19 and BL21(DE3) cells
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expressed in Escherichia coli BL21(DE3)
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli from plasmid pXL1071
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expressed in Escherichia coli strain BL21(DE3)pLysS
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expressed in Escherichia coli strain BL21, Saccharomyces cerevisiae strain INVSc1, and insect cells, none of the recombinant forms of MetAP2 exhibits enzymatic activity
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expressed in Escherichia coli strain DH5alpha
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expressed in HeLa cells
expressed in NIH-3T3 cells and NL20 cell line
expressed in Saccharomyces cerevisiae strain S228C (ATCC 201388)
expressed in Sf21 insect cells
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expressed in Sf9 cells
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expressed with a baculovirus expression system
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expression in Escherichia coli
expression in Escherichia coli BL21 cells, Pichia pastoris and Saccharomyces cerevisiae, glutathione S-transferase-Met AP I fusion protein
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expression of MetAP2 using the baculovirus transfection system
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expression of the His-tagged isozyme MetAP1a as apoenzyme
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full-length and truncated forms of hMetAP2
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gene mapB or Rv2861c, recombinant expression of isozyme MetAP1c in enzyme-deficient Escherichia coli cells. Plasmid-expressed MtMetAP1c complements the essential function of MetAP in Escherichia coli and supports the cell growth
genes map-1, map-2, and map-3, encoding three isozymes, DNA and amino acid sequence determination and analysis, expression as His-tagged enzymes in Escherichia coli
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genes Rv0734 and Rv2861c, expression of the His-tagged isozymes in Escherichia coli
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glutathione-S-transferase fusion protein expressed in Escherichia coli BL21(DE3), expressed in Arabidopsis
His-tagged protein expressed in Escherichia coli BL21(DE3)
isozymes MetAP1a, MetAP1b, MetAP1c, and MetAP2 are encoded on chromosomes 5, 10, 8, and 14
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mRNA used for rescue assay
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mutant enzymes are expressed in Escherichia coli BL21 Star(DE3) cells
mutant H63A is expressed in Escherichia coli BL21 Star(DE3) cells
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overexpression in Escherichia coli strain BL21(DE3)
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