3.4.11.16: Xaa-Trp aminopeptidase
This is an abbreviated version!
For detailed information about Xaa-Trp aminopeptidase, go to the full flat file.
Word Map on EC 3.4.11.16
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3.4.11.16
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peptidases
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endopeptidase-24.11
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dipeptidase
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microvillar
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dipeptidyl
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carboxypeptidase
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cell-surface
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ileum
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aminopeptidases
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bestatin
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hydrolysed
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medicine
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amastatin
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brush
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choroid
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3.4.11.7
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microvessels
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endopeptidase-2
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neuropeptide
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brush-border
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angiotensin
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immunoperoxidase
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1,10-phenanthroline
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caco-2
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histochemistry
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jejunum
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actinonin
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plexus
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immunoradiometric
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3.4.24.11
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ectoenzyme
- 3.4.11.16
- peptidases
- endopeptidase-24.11
- dipeptidase
- microvillar
-
dipeptidyl
- carboxypeptidase
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cell-surface
-
ileum
- aminopeptidases
- bestatin
-
hydrolysed
- medicine
- amastatin
-
brush
-
choroid
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3.4.11.7
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microvessels
- endopeptidase-2
-
neuropeptide
-
brush-border
- angiotensin
-
immunoperoxidase
- 1,10-phenanthroline
-
caco-2
-
histochemistry
- jejunum
- actinonin
-
plexus
-
immunoradiometric
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3.4.24.11
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ectoenzyme
Reaction
Release of a variety of N-terminal residues (especially glutamate and leucine) from peptides, provided tryptophan (or at least phenylalanine or tyrosine) is the penultimate residue. Also acts on Glu-/-Trp, Leu-/-Trp and a number of other dipeptides =
Synonyms
aminopeptidase W, aminopeptidase X-Trp
ECTree
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Substrates Products
Substrates Products on EC 3.4.11.16 - Xaa-Trp aminopeptidase
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REACTION DIAGRAM
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time course of activity during cell growth and proliferation
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ir
Peptides + H2O
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involved in intestinal breakdown and uptake of aspartame
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ir
Peptides + H2O
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involved in intestinal digestion of small, pre-digested peptide fragments
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ir
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may be involved in neuropeptide metabolism, may play a minor role in the intestinal metabolism of the artificial sweetener aspartame
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additional information
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the enzyme cleaves Leu-/-Trp, it prefers short peptides with an aromatic residue in the P1' position, with Glu-/-Trp being the best substrate. Dipeptides with Trp, Phe or Tr in the P1' position are rapidly hydrolyzed. The requirement in the P1 position is no stringent. Te enzyme does not hydrolyze N-blocked peptides
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