3.3.2.10: soluble epoxide hydrolase
This is an abbreviated version!
For detailed information about soluble epoxide hydrolase, go to the full flat file.
Word Map on EC 3.3.2.10
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3.3.2.10
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epoxyeicosatrienoic
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arachidonic
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diol
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s-transferase
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hydrolases
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hypertension
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benzoapyrene
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epoxygenase
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styrene
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dihydroxyeicosatrienoic
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enantioselectivity
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phenobarbital
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dhets
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trans-stilbene
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leukotriene
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eicosanoids
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drug-metabolizing
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cyp1a1
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3-methylcholanthrene
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o-deethylase
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oxylipins
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xenobiotic-metabolizing
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dihydrodiols
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enantiopure
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ethoxyresorufin
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lta4
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glycidyl
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arene
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urea-based
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cyclohexene
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ethoxycoumarin
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medicine
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beta-naphthoflavone
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oxirane
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20-hydroxyeicosatetraenoic
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udp-glucuronyltransferase
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20-hete
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cyp2j2
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udp-glucuronosyl
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1-naphthol
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aminopyrine
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edhfs
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analysis
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radiobacter
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3-methylcholanthrene-treated
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butadiene
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udpgt
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hydroxyeicosatetraenoic
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epichlorohydrin
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aldrin
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synthesis
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pentoxyresorufin
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drug development
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agriculture
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adamantyl
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pharmacology
- 3.3.2.10
-
epoxyeicosatrienoic
-
arachidonic
- diol
- s-transferase
- hydrolases
- hypertension
-
benzoapyrene
- epoxygenase
- styrene
-
dihydroxyeicosatrienoic
-
enantioselectivity
- phenobarbital
-
dhets
- trans-stilbene
-
leukotriene
-
eicosanoids
-
drug-metabolizing
- cyp1a1
- 3-methylcholanthrene
-
o-deethylase
- oxylipins
-
xenobiotic-metabolizing
-
dihydrodiols
-
enantiopure
-
ethoxyresorufin
- lta4
-
glycidyl
- arene
-
urea-based
- cyclohexene
-
ethoxycoumarin
- medicine
- beta-naphthoflavone
-
oxirane
-
20-hydroxyeicosatetraenoic
-
udp-glucuronyltransferase
- 20-hete
- cyp2j2
-
udp-glucuronosyl
- 1-naphthol
- aminopyrine
-
edhfs
- analysis
- radiobacter
-
3-methylcholanthrene-treated
- butadiene
-
udpgt
-
hydroxyeicosatetraenoic
- epichlorohydrin
- aldrin
- synthesis
-
pentoxyresorufin
- drug development
- agriculture
-
adamantyl
- pharmacology
Reaction
Synonyms
AnEH, BNSEH1, CEH, Cterm-EH, Cytosolic epoxide hydrolase, EC 3.1.3.76, EC 3.3.2.3, EC 4.2.1.63, EC 4.2.1.64, EET-metabolizing enzyme, EH, EH3, EPHX2, EPHX3, epoxide hydrolase 1, epoxide hydrolase 2, epoxide hydrolase-3, epoxyeicosatrienonic acid-metabolizing enzyme, EPXH1, EPXH2, EPXH2B, hepoxilin hydrolase, hsEH, mEH, More, PNSO hydrolase, PsEH, s-EH, SEH, soluble epoxide hydrolase, soluble-type epoxide hydrolase, SPEH1, SPEH2, TESO hydrolase, TSO hydrolase
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Localization
Localization on EC 3.3.2.10 - soluble epoxide hydrolase
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additional information
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208900, 208917, 208931, 208934, 660713, 661511, 662565, 663199, 663275, 663434, 695933, 700587, 708022
sEH shows both, peroxisomal and cytosolic localizations in vivo
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208896, 208902, 208904, 208905, 208906, 208910, 208914, 208929, 208930, 208931, 660713, 661024, 661511, 661890, 662085, 663434
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recombinant wild-type enzyme and some recombinant modified enzymes in V79 cells
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in some cell types sEH shows a dual localisation, both cytosolic and peroxisomal
sEH shows both, peroxisomal and cytosolic localizations in vivo, peroxisomal import occurs when expression levels are high or when the Ser-Lys-Met motif (amino acids 553-555) is accessible
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a recombinant modified enzyme in HeLa cells, recombinant wild-type enzyme and recombinant modified enzyme in plant BY-2 cells
in some cell types sEH shows a dual localisation, both cytosolic and peroxisomal
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the enzyme contains an impaired peroxisomal targeting sequence leading to dual localization
the enzyme has no N-terminal membrane anchor in contrast to the microsomal epoxide hydrolase, 3.3.2.9
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the enzyme has no N-terminal membrane anchor in contrast to the microsomal epoxide hydrolase, 3.3.2.9
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657156, 660664, 660702, 660789, 660799, 662594, 700587, 708022, 708324, 709908, 731107, 731442, 731448, 732196, 732301, 732722
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highest level found in smooth endoplasmic reticulum, lower levels observed in rough endoplasmic reticulum, Golgi apparatus, nuclear membrane and plasma membrane. The enzyme is synthesized in membrane-bound polysomes and inserted cotranslationally into the endoplasmic reticulum
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additional information
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human sEH subcellular localization is tissue dependent, not detectable in mitochondria or nucleus
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additional information
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highest level found in smooth endoplasmic reticulum, lower levels observed in rough endoplasmic reticulum, Golgi apparatus, nuclear membrane and plasma membrane. The enzyme is synthesized in membrane-bound polysomes and inserted cotranslationally into the endoplasmic reticulum
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additional information
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highest level found in smooth endoplasmic reticulum, lower levels observed in rough endoplasmic reticulum, Golgi apparatus, nuclear membrane and plasma membrane. The enzyme is synthesized in membrane-bound polysomes and inserted cotranslationally into the endoplasmic reticulum
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additional information
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highest level found in smooth endoplasmic reticulum, lower levels observed in rough endoplasmic reticulum, Golgi apparatus, nuclear membrane and plasma membrane. The enzyme is synthesized in membrane-bound polysomes and inserted cotranslationally into the endoplasmic reticulum
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additional information
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highest level found in smooth endoplasmic reticulum, lower levels observed in rough endoplasmic reticulum, Golgi apparatus, nuclear membrane and plasma membrane. The enzyme is synthesized in membrane-bound polysomes and inserted cotranslationally into the endoplasmic reticulum
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