3.3.2.10: soluble epoxide hydrolase
This is an abbreviated version!
For detailed information about soluble epoxide hydrolase, go to the full flat file.
Word Map on EC 3.3.2.10
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3.3.2.10
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epoxyeicosatrienoic
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arachidonic
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diol
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s-transferase
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hydrolases
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hypertension
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benzoapyrene
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epoxygenase
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styrene
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dihydroxyeicosatrienoic
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enantioselectivity
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phenobarbital
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dhets
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trans-stilbene
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leukotriene
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eicosanoids
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drug-metabolizing
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cyp1a1
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3-methylcholanthrene
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o-deethylase
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oxylipins
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xenobiotic-metabolizing
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dihydrodiols
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enantiopure
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ethoxyresorufin
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lta4
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glycidyl
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arene
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urea-based
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cyclohexene
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ethoxycoumarin
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medicine
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beta-naphthoflavone
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oxirane
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20-hydroxyeicosatetraenoic
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udp-glucuronyltransferase
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20-hete
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cyp2j2
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udp-glucuronosyl
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1-naphthol
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aminopyrine
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edhfs
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analysis
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radiobacter
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3-methylcholanthrene-treated
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butadiene
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udpgt
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hydroxyeicosatetraenoic
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epichlorohydrin
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aldrin
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synthesis
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pentoxyresorufin
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drug development
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agriculture
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adamantyl
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pharmacology
- 3.3.2.10
-
epoxyeicosatrienoic
-
arachidonic
- diol
- s-transferase
- hydrolases
- hypertension
-
benzoapyrene
- epoxygenase
- styrene
-
dihydroxyeicosatrienoic
-
enantioselectivity
- phenobarbital
-
dhets
- trans-stilbene
-
leukotriene
-
eicosanoids
-
drug-metabolizing
- cyp1a1
- 3-methylcholanthrene
-
o-deethylase
- oxylipins
-
xenobiotic-metabolizing
-
dihydrodiols
-
enantiopure
-
ethoxyresorufin
- lta4
-
glycidyl
- arene
-
urea-based
- cyclohexene
-
ethoxycoumarin
- medicine
- beta-naphthoflavone
-
oxirane
-
20-hydroxyeicosatetraenoic
-
udp-glucuronyltransferase
- 20-hete
- cyp2j2
-
udp-glucuronosyl
- 1-naphthol
- aminopyrine
-
edhfs
- analysis
- radiobacter
-
3-methylcholanthrene-treated
- butadiene
-
udpgt
-
hydroxyeicosatetraenoic
- epichlorohydrin
- aldrin
- synthesis
-
pentoxyresorufin
- drug development
- agriculture
-
adamantyl
- pharmacology
Reaction
Synonyms
AnEH, BNSEH1, CEH, Cterm-EH, Cytosolic epoxide hydrolase, EC 3.1.3.76, EC 3.3.2.3, EC 4.2.1.63, EC 4.2.1.64, EET-metabolizing enzyme, EH, EH3, EPHX2, EPHX3, epoxide hydrolase 1, epoxide hydrolase 2, epoxide hydrolase-3, epoxyeicosatrienonic acid-metabolizing enzyme, EPXH1, EPXH2, EPXH2B, hepoxilin hydrolase, hsEH, mEH, More, PNSO hydrolase, PsEH, s-EH, SEH, soluble epoxide hydrolase, soluble-type epoxide hydrolase, SPEH1, SPEH2, TESO hydrolase, TSO hydrolase
ECTree
3.3.2.10 soluble epoxide hydrolaseAdvanced search results
results (
results (KM Value
KM Value on EC 3.3.2.10 - soluble epoxide hydrolase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0015
(3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester
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at pH 7.4 and 37°C
0.01916
3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester 2-oxiraneacetic acid
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at pH 7.0 and 30°C
0.015
4-nitrophenyl (2R,3R)-2,3-epoxy-3-(4-nitrophenyl)propyl carbonate
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pH 7.4, 25°C
0.008
4-nitrophenyl (2S,3S)-2,3-epoxy-3-(4-nitrophenyl)propyl carbonate
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pH 7.4, 25°C
0.0108
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
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pH 7.4, 37°C
0.0147
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
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pH 7.4, 37°C
0.0046
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid
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pH 7.4, 37°C
0.0073
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid
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pH 7.4, 37°C
7.95
(R)-styrene oxide
mutant enzyme E88R/T102A/M368I/K398E/G412D, at pH 6.0 and 10°C
8.33
(S)-styrene oxide
mutant enzyme E88R/T102A/M368I/K398E/G412D, at pH 6.0 and 10°C
0.006
1-myristoyl-sn-glycerol 3-phosphate
mutant enzyme C154Y, at pH 7.4 and 30°C
0.007
1-myristoyl-sn-glycerol 3-phosphate
mutant enzyme R103C, at pH 7.4 and 30°C
0.011
1-myristoyl-sn-glycerol 3-phosphate
wild type enzyme, at pH 7.4 and 30°C
0.012
1-myristoyl-sn-glycerol 3-phosphate
mutant enzyme R287Q, at pH 7.4 and 30°C
0.019
1-myristoyl-sn-glycerol 3-phosphate
mutant enzyme K55R, at pH 7.4 and 30°C
0.007
14,15-epoxyeicosatrienoic acid
wild type enzyme, at pH 7.4 and 30°C
0.0074
14,15-epoxyeicosatrienoic acid
mutant enzyme K55R, at pH 7.4 and 30°C
0.009
14,15-epoxyeicosatrienoic acid
mutant enzyme R287Q, at pH 7.4 and 30°C
0.0092
14,15-epoxyeicosatrienoic acid
mutant enzyme C154Y, at pH 7.4 and 30°C
0.01
14,15-epoxyeicosatrienoic acid
mutant enzyme R103C, at pH 7.4 and 30°C
0.0033
trans-1,3-diphenylpropene oxide
wild type enzyme, at pH 7.4 and 30°C
0.004
trans-1,3-diphenylpropene oxide
mutant enzyme C154Y, at pH 7.4 and 30°C
0.0058
trans-1,3-diphenylpropene oxide
mutant enzyme K55R, at pH 7.4 and 30°C
0.0059
trans-1,3-diphenylpropene oxide
mutant enzyme R103C, at pH 7.4 and 30°C
0.0101
trans-1,3-diphenylpropene oxide
mutant enzyme R287Q, at pH 7.4 and 30°C
0.0253
trans-1,3-diphenylpropene oxide
pH 7.4, 30°C, purified recombinant enzyme
0.008
trans-stilbene oxide
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recombinant fusion protein expressed in E. coli
additional information
additional information
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kinetics, the hydrolysis of the intermediate is the rate-limiting step
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additional information
additional information
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kinetics, the hydrolysis of the intermediate is the rate-limiting step
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additional information
additional information
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kinetics, the hydrolysis of the intermediate is the rate-limiting step
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additional information
additional information
SPEH1 displays no activity on substrate 2'-(2-benzothiazolyl)-6'-hydroxybenzothiazole phosphate, substrate used to assay human sEH N-terminal phosphatise activity
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additional information
additional information
SPEH1 displays no activity on substrate 2'-(2-benzothiazolyl)-6'-hydroxybenzothiazole phosphate, substrate used to assay human sEH N-terminal phosphatise activity
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additional information
additional information
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SPEH1 displays no activity on substrate 2'-(2-benzothiazolyl)-6'-hydroxybenzothiazole phosphate, substrate used to assay human sEH N-terminal phosphatise activity
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additional information
additional information
steady-state enzyme kinetics study, overview
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