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3.2.2.B5: 8-oxoguanine DNA glycosylase

This is an abbreviated version!
For detailed information about 8-oxoguanine DNA glycosylase, go to the full flat file.

Word Map on EC 3.2.2.B5

Reaction

DNA containing 8-oxoguanine
+
H2O
=
DNA with an abasic site
 +
8-oxoguanine

Synonyms

8-oxoG DNA glycosylase, 8-oxoguanine DNA glycosylase, Af0371, Afogg enzyme, archaeal GO glycosylase, GO-glycosylase, MJ0724, MjaOgg2, mjOgg, ogg, Ogg2, oxoG DNA glycosylase, Pa-AGOG, Pa-AGOG DNA glycosylase, PAE2237, SSO0904, TVG_RS00315

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.B5 8-oxoguanine DNA glycosylase

Crystallization

Crystallization on EC 3.2.2.B5 - 8-oxoguanine DNA glycosylase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging-drop vapor diffusion at 12°C. A structural comparison with 8-oxoguanine DNA glycosylase 1 and archaeal GO glycosylase suggests that the C-terminal lysine of 8-oxoguanine DNA glycosylase 2 may play a key role in discriminating between guanine and 8-oxoguanine
hanging-drop, vapor-diffusion method at 12°C. A single crystal of the mutant enzyme K129Q in complex with a 15-mer duplex DNA oligonucleotide containing 8-oxoG paired with C is used to collect a 2.7 A data
crystal structure of the enzyme and that of its complex with 8-oxo-guanosine at 1.0 and 1.7 A resolution, respectively, are grown by sitting drops method
hanging-drop vapor diffusion at 12°C