3.2.2.9: adenosylhomocysteine nucleosidase

This is an abbreviated version!
For detailed information about adenosylhomocysteine nucleosidase, go to the full flat file.

Reaction

Synonyms

(adoHcy)/methylthioadenosine nucleosidase, 5'-dAdo nucleosidase, 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase, 5'-methyladenosine nucleosidase, 5'-methylthioadenosine nucleosidase, 5'-methylthioadenosine nucleosidases, 5'-methylthioadenosine/S-adenosylhomocysteine, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2, 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase, adenosylhomocysteine/methylthioadenosine nucleosidase, adoHcy/MeSAdo nucleosidase, adoHcy/MTA nucleosidase, Bgp, Bgp protein, BW246_00770, Cj0117, glycosaminoglycan-binding protein, K. pneumoniae MTA/SAH nucleosidase, methylthioadenosine nucleosidase, methylthioadenosine/S-adenosylhomocysteine nucleosidase, MKIGIIGA, MTA nucleosidase, MTA/AdoHcy nucleosidase, MTA/SAH nucleosidase, MTAN, Mtan-1, MTAN1, MTAN2, MTN1, MTN2, MtnN, nucleosidase, Pfs, Pfs protein, Pfs-2, Rv0091, S-adenosylhomocysteine nucleosidase, S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase, SAHN

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.2 Hydrolysing N-glycosyl compounds

                3.2.2.9 adenosylhomocysteine nucleosidase

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Results	in table
1	Activating Compound
16542	AA Sequence
13	Application
1	CAS Registry Number
27	Cloned(Commentary)
23	Crystallization (Commentary)
14	General Information
2	General Stability
43	IC50 Value
157	Inhibitors
20	kcat/KM [mM/s]
108	Ki Value [mM]
79	KM Value [mM]
8	Localization
12	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
455	Organism
11	Pathway
131	PDB ID
13	pH Optimum
4	pH Range
42	Protein Variants
30	Purification (Commentary)
6	Reaction
1	Reaction Type
84	Reference
4	Source Tissue
12	Specific Activity [micromol/min/mg]
4	Storage Stability
205	Substrates and Products (Substrate)
20	Subunits
132	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Range [°C]
12	Temperature Stability [°C]
65	Turnover Number [1/s]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 3.2.2.9 - adenosylhomocysteine nucleosidase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

5'-deoxyadenosine + H2O

5-deoxy-D-ribose + adenine

2 entries

5'-methylthioadenosine + H2O

5-methylthio-D-ribose + adenine

5 entries

5'-methylthioadenosine + H2O

?

13 entries

S-adenosyl-L-homocysteine + H2O

?

14 entries

S-adenosyl-L-homocysteine + H2O

adenine + 5-ribosyl-L-homocysteine

3 entries

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

16 entries

additional information

?

-

2 entries

5'-deoxyadenosine + H2O

5-deoxy-D-ribose + adenine

Borreliella burgdorferi

-

-

716263

-

-

?

5'-deoxyadenosine + H2O

5-deoxy-D-ribose + adenine

Escherichia coli

-

-

716263

-

-

?

5'-methylthioadenosine + H2O

5-methylthio-D-ribose + adenine

Arabidopsis thaliana

-

-

716534

-

-

?

5'-methylthioadenosine + H2O

5-methylthio-D-ribose + adenine

Borreliella burgdorferi

-

-

716263

-

-

?

5'-methylthioadenosine + H2O

5-methylthio-D-ribose + adenine

Campylobacter jejuni

Q0PC20

-

715607

-

-

?

5'-methylthioadenosine + H2O

5-methylthio-D-ribose + adenine

Campylobacter jejuni NCTC 11168

Q0PC20

-

715607

-

-

?

5'-methylthioadenosine + H2O

5-methylthio-D-ribose + adenine

Escherichia coli

-

-

715849, 716263

-

-

?

5'-methylthioadenosine + H2O

?

Alcaligenes faecalis

-

-

137135

-

-

?

5'-methylthioadenosine + H2O

?

Bacillus mycoides

-

-

137135

-

-

?

5'-methylthioadenosine + H2O

?

Citrobacter freundii

-

-

137135

-

-

?

5'-methylthioadenosine + H2O

?

Escherichia coli

-

-

137135, 171850, 171851, 171852, 171854, 171856, 171857, 171858, 171859

-

-

?

5'-methylthioadenosine + H2O

?

Escherichia coli B / ATCC 11303

-

-

171850, 171851

-

-

?

5'-methylthioadenosine + H2O

?

Escherichia coli W-ATCC 963

-

-

137135

-

-

?

5'-methylthioadenosine + H2O

?

Escherichia coli XL1-Blue

-

-

171857

-

-

?

5'-methylthioadenosine + H2O

?

Klebsiella aerogenes

-

-

137135, 171850, 171852, 171856

-

-

?

5'-methylthioadenosine + H2O

?

Klebsiella pneumoniae

-

-

171856, 171859

-

-

?

5'-methylthioadenosine + H2O

?

Proteus vulgaris

-

-

137135

-

-

?

5'-methylthioadenosine + H2O

?

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

171850, 171852

-

-

?

5'-methylthioadenosine + H2O

?

Solanum lycopersicum

-

-

171855

-

-

?

5'-methylthioadenosine + H2O

?

Staphylococcus aureus

-

-

137135

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Alcaligenes faecalis

-

-

137135

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Bacillus mycoides

-

-

137135

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Citrobacter freundii

-

-

137135

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Escherichia coli

-

-

137135, 171850, 171852, 171854, 171856, 171857, 171858, 171859

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Escherichia coli

-

rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 35%

171851

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Escherichia coli B / ATCC 11303

-

-

171850

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Escherichia coli W-ATCC 963

-

-

137135

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Escherichia coli XL1-Blue

-

-

171857

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Klebsiella aerogenes

-

-

137135, 171850, 171852, 171856

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Klebsiella pneumoniae

-

-

171856, 171859

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Micrococcus luteus

-

-

137135

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Proteus vulgaris

-

-

137135

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

171850, 171852

-

-

?

S-adenosyl-L-homocysteine + H2O

?

Staphylococcus aureus

-

-

137135

-

-

?

S-adenosyl-L-homocysteine + H2O

adenine + 5-ribosyl-L-homocysteine

Arabidopsis thaliana

Q7XA67

isozyme AtMTAN2 shows markedly broad substrate specificity for hydrolysis of S-adenosyl-L-homocysteine, while isozyme AtMTAN1 does not

702045

-

-

?

S-adenosyl-L-homocysteine + H2O

adenine + 5-ribosyl-L-homocysteine

Arabidopsis thaliana

Q9T0I8

substrate of isozyme AtMTAN2, isozyme AtMTAN1 can bind but not hydrolyze S-adenosyl-L-homocysteine

709718

-

-

?

S-adenosyl-L-homocysteine + H2O

adenine + 5-ribosyl-L-homocysteine

Escherichia coli

-

-

709718

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Arabidopsis thaliana

Q9T0I8

-

681477

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Arabidopsis thaliana

-

-

716534

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Arabidopsis thaliana

Q9T0I8

-

709718

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Arabidopsis thaliana

Q7XA67

-

702045

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Borreliella burgdorferi

-

-

716263

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Brucella melitensis

-

-

726889

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Campylobacter jejuni

Q0PC20

-

715607

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Campylobacter jejuni NCTC 11168

Q0PC20

-

715607

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Escherichia coli

-

-

171857, 715849, 716263, 727159, 727674

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Escherichia coli XL1-Blue

-

-

171857

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Helicobacter pylori

Q9ZMY2

-

716856

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Helicobacter pylori

-

-

727008

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Neisseria meningitidis

-

-

727159

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Staphylococcus aureus

-

-

727044, 727637

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Staphylococcus aureus NCTC 8325

-

-

727637

-

-

?

S-adenosyl-L-homocysteine + H2O

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Staphylococcus aureus RN4220

-

-

727637

-

-

?

additional information

?

-

Arabidopsis thaliana

Q9T0I8

MTAN is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses

709718

-

-

?

additional information

?

-

Escherichia coli

-

5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase is involved in quorum sensing, recycling 5'-methylthioadenosine from the polyamine pathway via adenine phosphoribosyltransferase and recycling 5-methylthioribose to methionine

669334

-

-

?