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3.2.2.7: adenosine nucleosidase

This is an abbreviated version!
For detailed information about adenosine nucleosidase, go to the full flat file.

Word Map on EC 3.2.2.7

Reaction

adenosine
+
H2O
=
D-ribose
 +
adenine

Synonyms

adenosinase, adenosine hydrolase, ANase, N-ribosyladenine ribohydrolase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.7 adenosine nucleosidase

Inhibitors

Inhibitors on EC 3.2.2.7 - adenosine nucleosidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2'-deoxyadenosine
3'-deoxyadenosine
-
Ki: four times weaker than for 2'-deoxyadenosine
6-Methylaminopurine
adenine
adenosine
-
78% inhibition at 0.5 mM
Cu2+
-
marked inhibition at 1 mM
cytokinin
-
plant hormones, inhibition less strong than for adenine
dithiothreitol
-
60% inhibition if enzyme is preincubated with 10 mM
HgCl2
-
strong inhibition at 1 mM
Inosine
-
at 0.2 mM: 8.5% inhibition for form Lf, 10.5% inhibition for form R2, form R1 not inhibited
N6-Benzyladenosine
N6-furfuryladenosine
-
53% inhibition at 0.5 mM
N6-isopentenyladenosine
-
inhibition between 28.6% and 36.7% for forms R1, R2 and Lf at 0.2 mM
p-chloromercuribenzoate
-
20% inhibition at 1 mM
trans-6-(4-hydroxy-3-methyl-2-butenylamino)-9-beta-D-ribofuranosylpurine
-
70% inhibition at 0.5 mM
zeatin riboside
-
competitive inhibition between 32% and 25% for forms R1, R2 and Lf at 0.2 mM
Zn2+
-
marked inhibition at 1 mM